Biomarkers in medicine最新文献_第2页

Predictive accuracy of cytokine pattern with lymphocyte count in infections after chemotherapies for lymphoma. 细胞因子模式与淋巴细胞计数在淋巴瘤化疗后感染中的预测准确性。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-05-22 DOI: 10.1080/17520363.2026.2654370

Lu Zhang, Dan Zhou, Ji Zhou, Wenqun Yang

{"title":"Predictive accuracy of cytokine pattern with lymphocyte count in infections after chemotherapies for lymphoma.","authors":"Lu Zhang, Dan Zhou, Ji Zhou, Wenqun Yang","doi":"10.1080/17520363.2026.2654370","DOIUrl":"10.1080/17520363.2026.2654370","url":null,"abstract":"Aims: To evaluate whether cytokine profiles combined with lymphocyte count could predict infection risk in lymphoma patients undergoing chemotherapy.Patients & methods: This retrospective study included 110 patients with pathologically confirmed lymphoma treated at Xiangtan Central Hospital between January 2022 and December 2023. Peripheral blood samples were collected before chemotherapy to determine lymphocyte count and serum cytokine levels (IFN-γ, TNF-α, IL-6, IL-8, IL-10) using ELISA. Statistical analyses included ROC curve and Kaplan-Meier survival analysis to assess predictive accuracy and treatment outcomes.Results: Sixty-five patients (59.1%) developed infections, including bacterial, fungal, and viral types. Infected patients exhibited significantly lower lymphocyte counts and decreased cytokine levels. A combination of ≥3 decreased cytokines with low lymphocyte count provided stronger predictive power for infection than single indicators.Conclusion: Reduced cytokine levels together with lymphopenia are strong predictors of infection in lymphoma patients receiving chemotherapy. Immune monitoring of cytokine-lymphocyte patterns may facilitate early identification of high-risk individuals and improve infection prevention and treatment strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"697-703"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coagulation factor levels as prognostic biomarkers: differential profiles in pulmonary versus extrapulmonary sepsis-induced ARDS. 凝血因子水平作为预后生物标志物：肺与肺外败血症诱导的ARDS的差异概况

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-17 DOI: 10.1080/17520363.2026.2712931

Xiao Lv, Yanfen Zhong, Jianguang Pan, Tao Lin

{"title":"Coagulation factor levels as prognostic biomarkers: differential profiles in pulmonary versus extrapulmonary sepsis-induced ARDS.","authors":"Xiao Lv, Yanfen Zhong, Jianguang Pan, Tao Lin","doi":"10.1080/17520363.2026.2712931","DOIUrl":"10.1080/17520363.2026.2712931","url":null,"abstract":"Objective: To compare the coagulation factor levels in acute respiratory distress syndrome caused by pulmonary infection (ARDSp) and ARDS caused by extrapulmonary sepsis (ARDSexp) patients.Methods: This study included 112 ARDSp and 88 ARDSexp patients. Coagulation factor levels were compared within 24 hours after the diagnosis of ARDS.Results: In the ARDSexp group, prothrombin time (PT) and activated partial thromboplastin time (APTT) were significantly prolonged, fibrinogen (FIB) levels were significantly decreased, and D-dimer (D-D) levels were significantly increased. Coagulation factors V and VII levels were significantly lower, while factor VIII levels and the degree of thrombocytopenia were substantially higher in the ARDSexp group, in contrast to the ARDSp group. In terms of prognosis, the ARDSexp group had longer mechanical ventilation duration and ICU stay duration, and higher 28-d and 90-d mortality (all p < 0.05). D-D > 7 mg/L, coagulation factor V < 70%, elevated sequential organ failure assessment (SOFA) score, and antithrombin III <60% were independent predictors of 28-d mortality.Conclusion: This study demonstrates that there are visible coagulation phenotypic distinctions between ARDSp patients and ARDSexp patients. Coagulation factor levels can serve as biomarkers for prognostic assessment and provide a theoretical basis for the development of individualized anticoagulation strategies in clinical practice.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"685-696"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum NLR, PLR and MNV characteristics as predictors of anti-VEGF plus glucocorticoid efficacy in nAMD. 血清NLR、PLR和MNV特征作为nAMD患者抗vegf和糖皮质激素疗效的预测因子。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-16 DOI: 10.1080/17520363.2026.2704571

Fangxiu Yuan, Jiaojiao Tu, Xiutao Liu, Ling Wang, Wei Zhou, Yu Jin

{"title":"Serum NLR, PLR and MNV characteristics as predictors of anti-VEGF plus glucocorticoid efficacy in nAMD.","authors":"Fangxiu Yuan, Jiaojiao Tu, Xiutao Liu, Ling Wang, Wei Zhou, Yu Jin","doi":"10.1080/17520363.2026.2704571","DOIUrl":"10.1080/17520363.2026.2704571","url":null,"abstract":"Aim: To evaluate the combined predictive value of serum neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and macular neovascularization (MNV) characteristics for treatment efficacy in neovascular age-related macular degeneration (nAMD) patients receiving anti-VEGF plus glucocorticoid therapy.Patients and methods: This retrospective study included 145 patients (153 eyes) with nAMD receiving conbercept combined with dexamethasone implant. Patients were categorized as Inactive (n = 89) or Active (n = 64) based on post-treatment MNV activity. Baseline NLR, PLR, and MNV morphology were assessed. Multivariate logistic regression identified independent predictors, and ROC analyses evaluated predictive value.Results: Patients with persistent MNV activity showed significantly higher baseline NLR, PLR, MNV area, and fractal dimension (all p < 0.001). Multivariate analysis identified baseline visual acuity, MNV type, fluid volumes, MNV morphological parameters, and inflammatory markers as independent predictors. The combined model incorporating inflammatory markers and MNV characteristics demonstrated superior performance (AUC = 0.92, 95% CI: 0.87-0.96) with 79.69% sensitivity and 91.01% specificity.Conclusion: Combining serum inflammatory markers with MNV morphological characteristics enhanced predictive value for treatment response in nAMD patients receiving combination therapy. This integrated approach may facilitate personalized treatment strategies in nAMD management.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"627-637"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The biomarker compass: a revolution driving precision medicine. 生物标记指南针：一场推动精准医疗的革命。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-20 DOI: 10.1080/17520363.2026.2705371

Scott A Waldman, Andre Terzic

引用次数: 0

Thrombophilia-related gene variants may be linked to polycystic ovary syndrome susceptibility and its related traits. 血栓相关基因变异可能与多囊卵巢综合征易感性及其相关性状有关。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-01 DOI: 10.1080/17520363.2026.2697763

Roshan Dadachanji, Sushma Khavale, Nanda Joshi, Anushree Patil, Srabani Mukherjee

{"title":"Thrombophilia-related gene variants may be linked to polycystic ovary syndrome susceptibility and its related traits.","authors":"Roshan Dadachanji, Sushma Khavale, Nanda Joshi, Anushree Patil, Srabani Mukherjee","doi":"10.1080/17520363.2026.2697763","DOIUrl":"10.1080/17520363.2026.2697763","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy in reproductive-aged women having both gynecological and metabolic comorbidities. PCOS increases the risk of cardiovascular and thromboembolic diseases due to heightened prothrombotic states, suggesting shared genetic determinants with thrombophilia. In addition, convergence of these polymorphisms to insulin resistance, a hallmark feature of PCOS, may exacerbate PCOS risk and further intensify hypercoagulability-associated metabolic and reproductive manifestations.Methods: This case-control study explores the association between MTHFR (C677T), FGB (-148C/T, -249C/T, -455G/A), FXIII (V34L), and FV (FVL, rs6020) and risk of PCOS development and its related traits in PCOS (n = 475) and control (n = 245) women. Clinical, biochemical, and hormonal parameters were estimated for all study participants and genotyping was carried out by direct sequencing.Results: To the best of our knowledge, this is the first time that FGB promoter polymorphisms (-148C/T and -455G/A) were investigated and showed nominal association with reduced risk of PCOS prior to multiple testing correction. Additionally, potential genotype-phenotype trends with metabolic and hormonal parameters were noted in both controls and women with PCOS, with and without insulin resistance.Conclusion: Genetic profiling of thrombophilia-related gene polymorphisms could help monitoring and management of PCOS and its related reproductive and metabolic complications.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"595-611"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in cardiovascular biomarkers: innovations in early detection, risk prediction, and treatment monitoring. 心血管生物标志物的最新进展：早期检测、风险预测和治疗监测方面的创新。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-05 DOI: 10.1080/17520363.2026.2714195

Kyle Roethlin, Hira Usman, Zeeshan Ahmed

{"title":"Recent advances in cardiovascular biomarkers: innovations in early detection, risk prediction, and treatment monitoring.","authors":"Kyle Roethlin, Hira Usman, Zeeshan Ahmed","doi":"10.1080/17520363.2026.2714195","DOIUrl":"10.1080/17520363.2026.2714195","url":null,"abstract":"Cardiovascular disease (CVD) is a major source of morbidity and mortality across the globe. Effective screening and risk stratification of patients can improve long‑term outcomes by allowing physicians to offer fine-tuned advice and treatments. Advances in technology have enabled the study of various biomarkers associated with CVD, allowing researchers to study the molecular processes underlying illness. In this study, we sampled recent advances in the application of Machine Learning (ML) techniques to transcriptome datasets of CVD patients in the hopes of progressing our understanding of underlying pathophysiology, improving our ability to detect disease, and refining our methods of risk stratification of patients. These studies suggest that ML algorithms may help identify complex relationships within high-dimensional datasets to isolate relationships within datasets that were previously missed, enhancing our understanding of disease. However, there are several challenges that need to be addressed before these innovations can reach the clinic. Researchers must verify their results via means that are readily obtainable for physicians and must adequately identify the indications for a particular test so they can integrate into preexisting workflows. We offer potential solutions and suggestions to these issues so that these approaches may eventually contribute to improved patient care.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"723-731"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circ_0024085 and circ_0000339 as potential biomarkers for the diagnosis of ankylosing spondylitis. Circ_0024085和circ_0000339作为诊断强直性脊柱炎的潜在生物标志物。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-17 DOI: 10.1080/17520363.2026.2716195

Xin Li, Can Mu, Shenling Liao, Zehao Wang, Zhenzhen Su, Bin Yang

{"title":"Circ_0024085 and circ_0000339 as potential biomarkers for the diagnosis of ankylosing spondylitis.","authors":"Xin Li, Can Mu, Shenling Liao, Zehao Wang, Zhenzhen Su, Bin Yang","doi":"10.1080/17520363.2026.2716195","DOIUrl":"10.1080/17520363.2026.2716195","url":null,"abstract":"Objective: This study aimed to identify novel circular RNA (circRNA) biomarkers in peripheral blood mononuclear cells (PBMCs) for the diagnosis of ankylosing spondylitis (AS) and to explore their potential pathogenic mechanisms.Methods: High-throughput circRNA sequencing was performed on PBMCs from 3 AS patients and 3 healthy controls. Differentially expressed circRNAs were validated by RT-qPCR in an independent cohort (64 AS patients and 24 healthy individuals). Diagnostic performance was evaluated via ROC curve analysis. Correlations between circRNA expression and clinical inflammatory markers were assessed. Bioinformatics analysis was employed to predict target miRNAs and enriched signaling pathways.Results: A total of 53 circRNAs were differentially expressed in AS PBMCs. Among these, circ_0024085 and circ_0000339 were significantly upregulated in AS (41.6-fold and 27.0-fold, p < 0.05), and demonstrated good diagnostic performance (AUC = 0.815 for the combination). The expression of Circ_0024085 was inversely correlated with erythrocyte sedimentation rate (ESR, p = 0.005) and monocyte count (p = 0.027). Bioinformatic analysis indicated that the target miRNAs of circ_0024085 were significantly enriched in the IL‑4/IL‑13 signaling pathway, while those of circ_0000339 were enriched in the SEMA4D signaling pathway.Conclusion: Our findings identify circ_0024085 and circ_0000339 as potential diagnostic biomarkers for AS. With bioinformatics predictions indicating that Circ_0024085 may exert an anti-inflammatory effect via M2 macrophage polarization, whereas circ_0000339 might contribute to bone damage through SEMA4D signaling.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"663-671"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical validity of CD20 as a biomarker in breast cancer patients using tissue microarrays and whole slide sections. 利用组织微阵列和整片切片分析CD20作为乳腺癌患者生物标志物的有效性。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-07 DOI: 10.1080/17520363.2026.2714196

Demet Özcan, Patricia Switten Nielsen, Jan Alsner, Trine Tramm

{"title":"Analytical validity of CD20 as a biomarker in breast cancer patients using tissue microarrays and whole slide sections.","authors":"Demet Özcan, Patricia Switten Nielsen, Jan Alsner, Trine Tramm","doi":"10.1080/17520363.2026.2714196","DOIUrl":"10.1080/17520363.2026.2714196","url":null,"abstract":"Background: Clinical utility of biomarker-based treatment depends on both analytical and clinical validity. CD20+ B-lymphocytes often form nodular lymphoid structures within tumors, presenting potential analytical issues if using tissue microarrays (TMA). We compared CD20 expression in TMAs and whole-slide sections (WS) using digital image analysis.Materials and methods: Immunohistochemical CD20+ expression was assessed on 1 TMA core/patient and corresponding WS from 221 breast cancer patients. CD20+ area fractions were quantified within four spatial tissue compartments: (1) tumor epithelium; (2) tumor margin; (3) tumor-related stroma; (4) total tumor area. Bland-Altman analysis and t-test compared CD20+ area fractions of WS and TMA.Results: CD20+ cells were predominantly located in the stroma and often formed nodules. Across all compartments, the absolute area fraction of CD20+ was significantly lower in TMAs than in WS. Mean ratios of CD20+ area fractions (WS vs. TMA) ranged from 2.5 (95% confidence interval: 1.7-3.6; p < 0.001) to 6.4 (4.7-8.9; p < 0.001) within the four spatial regions.Conclusions: These findings indicate that TMAs may underestimate the presence of CD20+ cells in breast cancer, presumably due to the formation of nodules. This heterogeneity in distribution is important to consider when exploring the use of CD20 as a potential clinical biomarker.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"705-713"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-virus interaction between IFN-γ rs2069705 polymorphism and Epstein-Barr virus in breast cancer susceptibility among Egyptian women. IFN-γ rs2069705多态性与Epstein-Barr病毒在埃及妇女乳腺癌易感性中的基因-病毒相互作用

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-08-11 DOI: 10.1080/17520363.2026.2716197

Noha E Ibrahim, Mahmoud A W Khader, Mohamed M S Farag, Fatima G Yehia, Amal M El-Feky

{"title":"Gene-virus interaction between IFN-γ rs2069705 polymorphism and Epstein-Barr virus in breast cancer susceptibility among Egyptian women.","authors":"Noha E Ibrahim, Mahmoud A W Khader, Mohamed M S Farag, Fatima G Yehia, Amal M El-Feky","doi":"10.1080/17520363.2026.2716197","DOIUrl":"10.1080/17520363.2026.2716197","url":null,"abstract":"Aims: This study investigated the association between Epstein-Barr virus (EBV) infection and breast cancer (BC) susceptibility and evaluated the role of interferon-gamma (IFN-γ) rs2069705 polymorphism in disease risk and clinicopathological characteristics among Egyptian women.Materials and methods: A case-control study was conducted on 96 histologically confirmed BC patients and 50 age-matched healthy controls. EBV serostatus was assessed by ELISA detection of anti-viral capsid antigen IgG antibodies. IFN-γ rs2069705 (A/G) genotyping was performed using TaqMan real-time PCR assays.Results: EBV seropositivity was significantly higher in BC patients (93.75%) than controls (p = 0.008). Significant associations were observed between IFN-γ rs2069705 polymorphism and BC susceptibility, particularly for AA and AG genotypes and A and G alleles (p < 0.001), whereas the GG genotype showed no significant association. AA and AG genotypes were also associated with unfavorable clinicopathological features.Conclusion: EBV infection and IFN-γ rs2069705 polymorphism may contribute to BC susceptibility and progression among Egyptian women and could serve as potential combined biomarkers for risk assessment and prognosis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"673-683"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum LDH, eosinophils, and IgE in atopic dermatitis severity: a retrospective study. 血清乳酸脱氢酶、嗜酸性粒细胞和IgE与特应性皮炎严重程度的关系：一项回顾性研究。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-07-30 DOI: 10.1080/17520363.2026.2697764

Fan Bai, Wanlong Yu, Yabo Xu, Li Wang, Mingjun Lei, Zan Tian, Xiumei Cheng

{"title":"Serum LDH, eosinophils, and IgE in atopic dermatitis severity: a retrospective study.","authors":"Fan Bai, Wanlong Yu, Yabo Xu, Li Wang, Mingjun Lei, Zan Tian, Xiumei Cheng","doi":"10.1080/17520363.2026.2697764","DOIUrl":"10.1080/17520363.2026.2697764","url":null,"abstract":"Aims: To evaluate serum lactate dehydrogenase (LDH), eosinophils, and total immunoglobulin E (IgE) as accessible adjunctive markers of atopic dermatitis (AD) severity.Materials & methods: This retrospective study included 265 AD patients and 97 healthy controls. SCORAD scores and laboratory biomarkers obtained within 48 hours were analyzed using ordinal logistic regression. A binary logistic model was used for ROC analysis of severe AD.Results: Severe AD was associated with higher LDH, eosinophil counts, and total IgE than mild-moderate AD. LDH and eosinophils correlated with SCORAD scores (r = 0.61 and r = 0.45, both p < 0.001), while IgE showed a significant non-linear quadratic trend (p < 0.001). Older age, longer disease course, LDH, eosinophils, total IgE, and personal atopy (OR = 2.94) were independently associated with greater severity. The combined biomarker model yielded an AUC of 0.88 for severe AD.Conclusion: LDH, eosinophils, and total IgE were independently associated with SCORAD-defined AD severity. Their combined assessment may complement, but not replace, clinical scoring; prospective validation is required.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"621-626"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0