Biomarkers in medicine最新文献_第2页

The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder. 同步睡眠试验方案：在快速眼动睡眠行为障碍中检测皮肤磷酸化α -同步核蛋白。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1080/17520363.2026.2641474

Sarrah Marcotte, Todd Levine, Roy Freeman, Christopher H Gibbons

{"title":"The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder.","authors":"Sarrah Marcotte, Todd Levine, Roy Freeman, Christopher H Gibbons","doi":"10.1080/17520363.2026.2641474","DOIUrl":"10.1080/17520363.2026.2641474","url":null,"abstract":"Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a prodromal neurodegenerative disease of misfolded alpha-synuclein (P-SYN) with a high risk of phenoconversion to a clinically apparent synucleinopathy (including Parkinson's disease, multiple system atrophy, or dementia with Lewy bodies) over 15 years.Objectives: To determine rates of cutaneous P-SYN deposition in iRBD, to quantify changes in PSYN deposition over time, and to determine if P-SYN deposition patterns and amounts predict phenoconversion to a specific type of synucleinopathy.Clinical trial protocol: In a prospective, blinded study we will recruit 80 individuals with polysomnography confirmed iRBD or probable RBD using standard diagnostic criteria. Skin biopsies with dual immunohistochemical immunostaining for nerve fibers (protein gene product 9.5) and P-SYN will be completed at 3 sites using standard methodology. Quantitative measures of P-SYN and nerve fiber density will be measured blinded to any clinical data and will be followed longitudinally to determine the final clinical diagnosis.Discussion: Patients with iRBD are an important population to study due to the high rates of phenoconversion to clinically apparent synucleinopathy. Defining the frequency of P-SYN deposition and the risk of phenoconversion will aid in the development of future clinical trials that seek to alter the natural history of synucleinopathies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"199-206"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary DKK3 as a biomarker for pediatric CKD progression: a review of current evidence. 尿DKK3作为儿童CKD进展的生物标志物：对现有证据的回顾

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1080/17520363.2026.2622051

Jan Boeckhaus, Christoph Licht, Matthew Hall, Jun Oh, Thimoteus Speer

{"title":"Urinary DKK3 as a biomarker for pediatric CKD progression: a review of current evidence.","authors":"Jan Boeckhaus, Christoph Licht, Matthew Hall, Jun Oh, Thimoteus Speer","doi":"10.1080/17520363.2026.2622051","DOIUrl":"10.1080/17520363.2026.2622051","url":null,"abstract":"Chronic kidney disease (CKD) is a significant challenge in pediatric care, as it can lead to substantial long-term comorbidities, reduced quality of life and reduced lifetime. Early detection of pediatric CKD is vital for preventive care and maintaining organ function. Therefore, there is a critical need for biomarkers that should ideally offer early detection (before glomerular filtration rate (GFR) decline), possess high specificity for the underlying renal disease process (e.g. tubular or glomerular damage), and show strong prognostic value for predicting disease progression. This narrative review examines the role of Dickkopf-3 (DKK3), a pro-fibrotic protein released by renal tubular cells during pathophysiological stress, in the context of pediatric CKD. In experimental models, DKK3 has been shown to drive renal tubulointerstitial fibrosis by modulating the WNT/β-catenin signaling pathway. There is increasing evidence suggesting that urinary DKK3 (uDKK3) levels could serve as a valuable biomarker for identifying pediatric CKD patients at high risk for rapid disease progression, regardless of the underlying etiology. This review highlights uDKK3 as a potential marker for the early detection and risk stratification of pediatric patients with CKD, which could lead to a personalized approach to monitor CKD beyond estimated GFR and albuminuria.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":"20 4","pages":"241-249"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The CALLY index: an immuno-inflammatory and nutritional index for predicting contrast induced nephropathy in patients with non-ST-elevation myocardial infarction. CALLY指数：预测非st段抬高型心肌梗死患者造影剂肾病的免疫炎症和营养指标。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1080/17520363.2026.2641473

Murat Gul, Muhammet Salih Ates, Erdogan Sokmen, Sinan Inci

{"title":"The CALLY index: an immuno-inflammatory and nutritional index for predicting contrast induced nephropathy in patients with non-ST-elevation myocardial infarction.","authors":"Murat Gul, Muhammet Salih Ates, Erdogan Sokmen, Sinan Inci","doi":"10.1080/17520363.2026.2641473","DOIUrl":"10.1080/17520363.2026.2641473","url":null,"abstract":"Background: The C-reactive protein-albumin-lymphocyte (CALLY) index integrates inflammation, nutrition, and immunity. Its value for predicting contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) is uncertain. We examined whether CALLY predicts CIN in non-ST-elevation myocardial infarction (NSTEMI).Methods: A total of 199 consecutive patients with NSTEMI who underwent PCI were retrospectively analyzed. Independent predictors were identified by multivariable logistic regression; discriminative performance was evaluated with receiver-operating characteristic (ROC) analysis.Results: CIN occurred in 32 patients (16.1%). Patients with CIN had lower CALLY values [0.49 (0.05-1.71) vs. 1.79 (0.51-4.06); p < 0.001], lower HDL-cholesterol, higher baseline creatinine, and lower estimated glomerular filtration rate. In multivariable models, CALLY independently predicted lower CIN risk (odds ratio [OR] 0.781; 95% confidence interval [CI] 0.625-0.977; p = 0.031) alongside baseline creatinine (OR 6.002; 95% CI 1.196-30.123; p = 0.029) and HDL-cholesterol (OR 0.945; 95% CI 0.900-0.993; p = 0.024). CALLY showed moderate discrimination (AUC 0.697; p < 0.001); the optimal cutoff was 1.1074 (sensitivity 61.1%, specificity 62.5%).Conclusion: A lower CALLY index is independently associated with an increased risk of CIN in NSTEMI patients undergoing PCI. The CALLY index may serve as a tool for early risk stratification and targeted preventive strategies in this high-risk population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"213-222"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive role of albumin, neutrophil-to-lymphocyte ratio, and systemic immune inflammation index in pressure ulcer risk among palliative care patients- a retrospective analysis. 白蛋白、中性粒细胞与淋巴细胞比值和全身免疫炎症指数在姑息治疗患者压疮风险中的预测作用——一项回顾性分析

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.1080/17520363.2026.2641466

Gozde Cingiz, Berkay Temel

{"title":"The predictive role of albumin, neutrophil-to-lymphocyte ratio, and systemic immune inflammation index in pressure ulcer risk among palliative care patients- a retrospective analysis.","authors":"Gozde Cingiz, Berkay Temel","doi":"10.1080/17520363.2026.2641466","DOIUrl":"10.1080/17520363.2026.2641466","url":null,"abstract":"Introduction: Pressure ulcers (PUs) are a major concern in palliative care due to patients' immobility and multiple comorbidities. Early identification of at-risk individuals is essential for prevention. Hematological markers such as neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) may assist in risk prediction. Objectives: This study aimed to evaluate the predictive value of inflammatory markers for PU development in palliative care patients retrospectively.Methods: Adult patients hospitalized in a palliative care unit for at least three months and free of PUs at admission were included. They were categorized into two groups: those who developed PUs during follow-up (wPU) and those who did not (woPU). Demographic, clinical, and laboratory variables were compared.Results: A total of 82 patients (mean age: 78.6 ± 11 years) were analyzed. No significant differences were found between groups in terms of age, sex, Charlson Comorbidity Index, or Braden score. The wPU group had significantly lower serum albumin (p = 0.004), and higher NLR (p = 0.04) and SII (p = 0.04) levels.Conclusion: Hypoalbuminemia and elevated NLR independently predict PU development in palliative care, highlighting the importance of nutritional and inflammatory status. Albumin, NLR, and SII had only moderate accuracy but may provide supportive value when combined with clinical risk tools.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"207-212"},"PeriodicalIF":2.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing prostate cancer care through AI-driven multi-omics and biomarker-based strategies. 通过人工智能驱动的多组学和基于生物标志物的策略推进前列腺癌治疗。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-02-24 DOI: 10.1080/17520363.2026.2634063

Ishita Debnath, Moumita Kundu

引用次数: 0

Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness. 甲状腺体积作为PCOS女性早期动脉粥样硬化的标志：与颈动脉内膜-中膜厚度的关系。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-02-16 DOI: 10.1080/17520363.2026.2631622

Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç

{"title":"Thyroid volume as a marker of early atherosclerosis in women with PCOS: association with carotid intima-media thickness.","authors":"Kadircan Karatoprak, Emre Sedar Saygılı, Hayri Bostan, Ersen Karakılıç","doi":"10.1080/17520363.2026.2631622","DOIUrl":"https://doi.org/10.1080/17520363.2026.2631622","url":null,"abstract":"Aim: This study aimed to evaluate the determinants of thyroid volume (TV) in euthyroid women with polycystic ovary syndrome (PCOS) and to assess the association between TV and cardiovascular risk, with a particular focus on carotid intima - media thickness (CIMT).Methods: This cross-sectional study included 100 participants (46 women with PCOS and 54 age-matched healthy controls). Only euthyroid participants were enrolled. TV was measured by ultrasonography, and CIMT was evaluated as a marker of early atherosclerosis. Biochemical markers were recorded. Multiple regression and receiver operating characteristic (ROC) analyses were performed.Results: Women with PCOS had significantly higher TV compared to controls [13.4 ml (IQR: 9.8-17.4) vs. 11.3 ml (IQR: 9.6-12.9), p = 0.041]. TV was positively correlated with BMI (r = 0.485, p < 0.001), waist circumference (r = 0.419, p = 0.004), and HOMA-IR (r = 0.406, p = 0.005). CIMT was independently predicted by total testosterone (β = 0.296, p = 0.040), LH/FSH ratio (β = -0.398, p = 0.005) and TV (β = 0.306, p = 0.036). ROC analysis showed that TV moderately predicted elevated CIMT (AUC = 0.68; optimal cutoff =14.5 mL).Discussion: TV was independently associated with CIMT in euthyroid women with PCOS, suggesting that thyroid morphology may serve as a complementary, noninvasive marker of early atherosclerotic changes.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum BDNF, PD-1, MMP-9 in AECOPD: prognostic value and a dual-axis risk model. 血清BDNF、PD-1、MMP-9在AECOPD中的预后价值和双轴风险模型

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-02-05 DOI: 10.1080/17520363.2026.2620351

Shanshan Liu, Jian Dong, Weiqi Huang, Jing Yan, Lu Liu, Cheng Chen, Xuechun Chen

{"title":"Serum BDNF, PD-1, MMP-9 in AECOPD: prognostic value and a dual-axis risk model.","authors":"Shanshan Liu, Jian Dong, Weiqi Huang, Jing Yan, Lu Liu, Cheng Chen, Xuechun Chen","doi":"10.1080/17520363.2026.2620351","DOIUrl":"https://doi.org/10.1080/17520363.2026.2620351","url":null,"abstract":"Objectives: To investigate longitudinal changes in neuroimmune biomarkers during acute exacerbations of chronic obstructive pulmonary disease (AECOPD), their modulation by standard therapy, and prognostic implications for 90-day outcomes.Materials and methods: In a prospective cohort, 266 hospitalized AECOPD patients were stratified into worsened (n = 53) and stable (n = 213) groups; 80 healthy individuals served as controls. Serum levels of BDNF, PD-1, MMP-9, and cytokines were assessed at admission (T1), pre-discharge (T2), and 90-day follow-up (T3). Mixed-effects models evaluated biomarker trajectories, while Cox regression examined correlations with clinical outcomes.Results: Compared with controls, AECOPD patients exhibited higher IL-6, TNF-α, PD-1, and MMP-9, alongside reduced BDNF and IL-10. Stable patients demonstrated partial biomarker normalization, whereas worsened patients retained a pro-inflammatory profile. Corticosteroids and antibiotics attenuated cytokine elevations, and oxygen therapy facilitated BDNF recovery. Low BDNF and high MMP-9 predicted spirometric decline, while elevated PD-1 and MMP-9 were associated with increased 90-day readmission risk. A dual-axis model incorporating neurotrophic and immune exhaustion markers outperformed GOLD classification for risk prediction.Conclusions: Neuroimmune biomarkers capture recovery heterogeneity in AECOPD. The proposed dual-axis model improves prognostic accuracy and may inform personalized management strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From bench to bedside: the next frontier for biomarkers in COPD precision medicine. 从实验室到床边：COPD精准医学中生物标志物的下一个前沿。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-02-01 Epub Date: 2026-01-26 DOI: 10.1080/17520363.2026.2622047

Maneesh Gaddam, Dedeepya Gullapalli, Muhammad Adrish

引用次数: 0

Preprocedural neutrophil-to-albumin ratio predicts survival in patients undergoing tunneled hemodialysis catheter. 手术前中性粒细胞与白蛋白比值预测隧道式血液透析导管患者的生存。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-02-01 Epub Date: 2026-02-06 DOI: 10.1080/17520363.2026.2626440

Ömer Faruk Rahman, Fevzi Ayyıldız, Selim Durmaz, Cüneyt Akgöl

{"title":"Preprocedural neutrophil-to-albumin ratio predicts survival in patients undergoing tunneled hemodialysis catheter.","authors":"Ömer Faruk Rahman, Fevzi Ayyıldız, Selim Durmaz, Cüneyt Akgöl","doi":"10.1080/17520363.2026.2626440","DOIUrl":"10.1080/17520363.2026.2626440","url":null,"abstract":"Aim: This study aimed to evaluate the impact of preprocedural neutrophil-to-albumin ratio (NAR) on survival among patients undergoing tunneled hemodialysis catheter (THC) placement.Methods: We retrospectively reviewed 60 consecutive patients who underwent right-internal-jugular THC placement between July 2021 and October 2023. Demographics, laboratory variables and survival were collected. NAR and neutrophil-percentage-to-albumin ratio (NPAR) were calculated. Cox regression and Kaplan - Meier analyses explored associations with mortality; receiver-operating-characteristic (ROC) curves defined optimal cutoffs.Results: Mean age was 70 ± 12 years; 24 patients (40%) died, yielding one-year survival of 62.5%. On multivariate Cox regression analysis, after adjustment for all covariates, higher NAR remained an independent predictor of mortality (p <0.001), together with older age and coronary artery disease. The ROC-derived NAR threshold of 175.4 produced an AUC of 0.813 (95% CI: 0.683-0.942). Patients with NAR >175.4 had markedly lower one-year survival than those below the threshold (30.2% vs 88.2%, p <0.001). Catheter patency at one year was 84.8%.Conclusion: Among patients receiving a tunneled hemodialysis catheter, elevated preprocedural NAR levels were associated with increased mortality. NAR, which is an easily and routinely measurable parameter, may serve as a prognostic biomarker in this patient population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"149-157"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive protein to albumin ratio predicts future volume overload in peritoneal dialysis patients: a retrospective cohort study. c反应蛋白与白蛋白比率预测腹膜透析患者未来容量超载：一项回顾性队列研究。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-02-01 Epub Date: 2026-02-23 DOI: 10.1080/17520363.2026.2634065

Tianlei Chen, Feixia Liu, Yun Zou, Min Yang

{"title":"C-reactive protein to albumin ratio predicts future volume overload in peritoneal dialysis patients: a retrospective cohort study.","authors":"Tianlei Chen, Feixia Liu, Yun Zou, Min Yang","doi":"10.1080/17520363.2026.2634065","DOIUrl":"10.1080/17520363.2026.2634065","url":null,"abstract":"Aims: To evaluate the predictive value of the C-reactive protein to albumin ratio (CAR) for 6-month volume overload in peritoneal dialysis (PD) patients.Methods: Retrospective cohort study of 167 stable PD patients without baseline volume overload. CAR was measured at enrollment; volume status was reassessed via bioelectrical impedance analysis (BIA) at 6 months. Multivariate logistic regression, ROC, and restricted cubic spline (RCS) analyses were used.Results: During follow-up, 64 patients (38.3%) developed volume overload. These patients had significantly higher baseline CAR levels (p < 0.001). Multivariate analysis identified diabetes (OR = 11.85) and baseline CAR (OR = 9.72) as independent predictors. The AUC for CAR predicting volume overload was 0.73, which is superior to that of CRP or albumin alone. An optimal CAR cutoff of 1.09 yielded 73.2% sensitivity and 60.7% specificity. RCS analysis indicated a linear dose-response relationship between CAR and volume overload risk (P for non-linearity = 0.501).Conclusion: Baseline CAR is a simple, low-cost biomarker for predicting 6-month volume overload in PD patients, valuable for risk stratification in resource-limited settings.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"191-198"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12947583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0