Biomarkers in medicine最新文献_第2页

Progress of GDF-15 in preeclampsia: a review. GDF-15在子痫前期的研究进展

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-28 DOI: 10.1080/17520363.2026.2736041

Mengjie Zhou, Dongyao Zhang, Haoyi Jia, Pengyuan He, Yannan Cao, Xupei Gan, Feifei Li, Xianming Xu

{"title":"Progress of GDF-15 in preeclampsia: a review.","authors":"Mengjie Zhou, Dongyao Zhang, Haoyi Jia, Pengyuan He, Yannan Cao, Xupei Gan, Feifei Li, Xianming Xu","doi":"10.1080/17520363.2026.2736041","DOIUrl":"10.1080/17520363.2026.2736041","url":null,"abstract":"Preeclampsia is a multisystem hypertensive disorder of pregnancy that significantly increases maternal and fetal morbidity and long‑term cardiovascular risk. Growth differentiation factor 15 (GDF‑15) is a stress‑responsive member of the TGF‑β superfamily that is highly expressed in the placenta and secreted into the maternal circulation, where levels rise markedly during gestation. Emerging evidence has positioned GDF‑15 as a potential biomarker for preeclampsia, with multiple studies reporting elevated concentrations in affected women, particularly in early‑onset disease. This review comprehensively examines the molecular mechanisms governing GDF‑15 generation, maturation, and secretion, and delineates its functional roles in placental physiology, including trophoblast invasion, syncytiotrophoblast renewal, endothelial protection, and metabolic regulation. We further explore the genetic architecture of the GDF15 locus, highlighting functional variants such as rs888663 that influence expression levels and may modulate disease susceptibility. The clinical utility of GDF‑15 is critically appraised in the context of established angiogenic markers, with emphasis on its additive predictive value, temporal limitations relative to the aspirin preventive window, and the need for assay standardization. Finally, key unresolved questions are identified, including whether GDF‑15 elevation is pathogenic or compensatory, and how it interacts with the broader network of angiogenic, inflammatory, and metabolic pathways in preeclampsia.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"815-826"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipoprotein(a)-to-HDL-C ratio and risk of repeat revascularization and in-stent restenosis after PCI in patients with chronic coronary syndrome undergoing follow-up coronary imaging. 随访冠脉造影的慢性冠脉综合征患者PCI术后脂蛋白(a) / hdl - c比值与重复血运重建及支架内再狭窄的风险

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-10 DOI: 10.1080/17520363.2026.2732008

Wang Jiale, Liu Longcheng, Lu Peipei, Ma Lihong

{"title":"Lipoprotein(a)-to-HDL-C ratio and risk of repeat revascularization and in-stent restenosis after PCI in patients with chronic coronary syndrome undergoing follow-up coronary imaging.","authors":"Wang Jiale, Liu Longcheng, Lu Peipei, Ma Lihong","doi":"10.1080/17520363.2026.2732008","DOIUrl":"10.1080/17520363.2026.2732008","url":null,"abstract":"Background: We proposed a novel lipoprotein(a)-to-HDL-C ratio (LHR) and examined its association with repeat revascularization and in-stent restenosis (ISR) in patients with chronic coronary syndrome (CCS) after percutaneous coronary intervention (PCI).Methods: A total of 2,238 patients with CCS undergoing DES-PCI who had available follow-up coronary imaging were included and categorized into tertiles according to lnLHR values. The primary outcome was a composite of repeat revascularization and ISR. Kaplan-Meier analysis, multivariable Cox regression, restricted cubic spline analysis, and prediction model evaluation were performed.Results: During a median follow-up of 60 months, 1,031 patients (46.07%) experienced the primary endpoint. Higher lnLHR tertiles were associated with lower event-free survival (p = 0.002). After multivariable adjustment, lnLHR remained independently associated with the primary endpoint (HR, 1.08; 95% CI, 1.02-1.14; p = 0.009), and patients in the highest tertile had a higher risk than those in the lowest tertile (HR, 1.19; 95% CI, 1.02-1.39; p = 0.026). RCS analysis demonstrated a linear association between lnLHR and outcomes. The LHR-based model showed modest discrimination, with AUCs of 0.629 at 3 years and 0.648 at 5 years.Conclusions: An elevated LHR was independently associated with an increased risk of repeat revascularization and ISR after PCI in CCS patients. These findings suggest that LHR may serve as a complementary lipid-related marker for long-term risk stratification in this population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"779-792"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of dynamic changes in C‑reactive protein‑albumin ratio for patients with spontaneous intracerebral hemorrhage. 自发性脑出血患者C反应蛋白-白蛋白比值动态变化的预后价值。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-25 DOI: 10.1080/17520363.2026.2737284

Jia Li, Guo-Min Xie, Yan Mao, Pan-di Chen, Guang-Yao Zhu, Geng-Fan Ye, Mao-Song Chen, Tao Song, Yi Liu

{"title":"Prognostic value of dynamic changes in C‑reactive protein‑albumin ratio for patients with spontaneous intracerebral hemorrhage.","authors":"Jia Li, Guo-Min Xie, Yan Mao, Pan-di Chen, Guang-Yao Zhu, Geng-Fan Ye, Mao-Song Chen, Tao Song, Yi Liu","doi":"10.1080/17520363.2026.2737284","DOIUrl":"10.1080/17520363.2026.2737284","url":null,"abstract":"Background: To examine the predictive value of the C‑reactive protein‑albumin ratio (CAR) measured at distinct time points.Methods: Multivariate logistic regression was applied to examine the links of CAR 1 (at admission), CAR 2 (7th day after admission), and ΔCAR (change between CAR 1 and CAR 2) with 3-month prognosis.Results: CAR 2 (AUC = 0.704, 95%CI: 0.650-0.757) yielded a statistically significantly higher predictive performance for the 3-month prognosis relative to CAR 1 (AUC = 0.624, 95%CI: 0.563-0.685) and ΔCAR (AUC = 0.624, 95%CI: 0.563-0.685) (for CAR 1 or ΔCAR vs. CAR 2, both p < 0.05). The ICH score + CAR 2 (AUC = 0.817, 95%CI: 0.764-0.869) provided significantly increased predictive efficacy versus the ICH score alone (AUC = 0.776, 95%CI: 0.717-0.835) (p = 0.018). Similarly, the predictive performance of the ICH index + CAR 2 (AUC = 0.810, 95%CI: 0.762-0.859) surpassed that of the ICH index alone (AUC = 0.772, 95%CI: 0.721-0.823) (p = 0.004).Conclusions: CAR measured on the 7th day of admission was markedly linked to a poor 3-month prognosis and significantly increased predictive efficacy of existing prognostic scoring systems for patients with ICH. All observed associations and predictive advantages of day-7 CAR are derived from retrospective single-center data; prospective, multicenter cohort studies with independent external datasets are mandatory to verify our findings before any clinical translational use.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"803-813"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis of the relationship between preoperative systemic immune inflammation index and prognosis of patients with biliary tract cancer. 胆道癌患者术前全身免疫炎症指数与预后关系的meta分析。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-08-20 DOI: 10.1080/17520363.2026.2720101

Jiale Liang, Zepu Wang, Dan Lv, Hongfang Tuo

{"title":"Meta-analysis of the relationship between preoperative systemic immune inflammation index and prognosis of patients with biliary tract cancer.","authors":"Jiale Liang, Zepu Wang, Dan Lv, Hongfang Tuo","doi":"10.1080/17520363.2026.2720101","DOIUrl":"10.1080/17520363.2026.2720101","url":null,"abstract":"Objective: To evaluate the prognostic value of preoperative systemic immune-inflammation index (SII) for overall survival, recurrence-free survival, and clinicopathological features in patients with biliary tract cancer (BTC).Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and major Chinese databases. Seventeen studies involving 4,965 patients were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HR) or odds ratios (OR) with 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Subgroup, sensitivity analyses, and funnel plots were conducted to explore heterogeneity and assess robustness.Results: High preoperative SII was significantly associated with worse overall survival (OS) (HR = 1.98, 95% CI = 1.76-2.23, p < 0.001) and recurrence-free survival (RFS) (HR = 1.57, 95% CI = 1.34-1.84, p < 0.001). It also correlated with a higher risk of lymph node metastasis (OR = 1.97, 95% CI = 1.52-2.55, p < 0.001), but showed no significant associations with vascular invasion, tumor differentiation, or perineural invasion.Conclusion: Preoperative SII is an effective prognostic predictor for BTC, where elevated levels indicate poorer survival outcomes and increased likelihood of vascular and lymph node involvement.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"827-835"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in EGFR testing for patients with stage IB or higher lung cancer in the United States. 美国IB期或更高级别肺癌患者EGFR检测的差异

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-24 DOI: 10.1080/17520363.2026.2737285

Bilal Odeh, Alexander Pohlman, Kathy S Albain, Nan Sethakorn, Matthew M Harkenrider, Julia M Coughlin, Zaid M Abdelsattar

{"title":"Variation in EGFR testing for patients with stage IB or higher lung cancer in the United States.","authors":"Bilal Odeh, Alexander Pohlman, Kathy S Albain, Nan Sethakorn, Matthew M Harkenrider, Julia M Coughlin, Zaid M Abdelsattar","doi":"10.1080/17520363.2026.2737285","DOIUrl":"10.1080/17520363.2026.2737285","url":null,"abstract":"Aim: Current guidelines recommend that all patients with stage IB or higher lung adenocarcinoma undergo Epidermal Growth Factor Receptor (EGFR) testing. In this study, we investigate the hospital-level variation of EGFR testing nationally.Methods: We identified patients with stage IB or higher lung adenocarcinoma between 2021-2022 from a national hospital-based dataset. We used hierarchical multivariable regression modeling to adjust for patient-, tumor- and hospital-characteristics and calculate adjusted EGFR testing rates. We grouped hospitals into quintiles for comparison, and Kaplan-Meier analyses to estimate survival.Results: Only 40,434 (43.4%) of 93,158 patients with stage IB or higher adenocarcinoma at 1,277 hospitals were tested for EGFR mutations. Independent predictors of EGFR testing included female sex (aOR = 1.15), tumor stage (Stage IV vs IB aOR = 1.41) and higher median income (aOR = 1.21;all p < 0.001). Hospitals in the lowest quintile had adjusted testing rates of 13.3% vs 70.3% in the highest quintile (p < 0.001). Hospitals with the highest EGFR testing rates had better overall survival (p < 0.001).Conclusion: Contrary to current guidelines, most patients with stage IB adenocarcinoma or higher are not receiving EGFR testing. Patients treated at hospitals with higher testing rates were associated with better survival, although this is likely multifactorial. Quality improvement efforts should target centers for guideline-concordant care.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"793-802"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parameters predicting mortality in antifibrotic-treated IPF patients: mMRC, CPI, TLCO, FVC, GAP. 预测抗纤维化治疗IPF患者死亡率的参数：mMRC、CPI、TLCO、FVC、GAP。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-25 DOI: 10.1080/17520363.2026.2737283

Sevda Aras, Gülistan Karadeniz, Fatma Demirci Üçsular, Enver Yalnız

{"title":"Parameters predicting mortality in antifibrotic-treated IPF patients: mMRC, CPI, TLCO, FVC, GAP.","authors":"Sevda Aras, Gülistan Karadeniz, Fatma Demirci Üçsular, Enver Yalnız","doi":"10.1080/17520363.2026.2737283","DOIUrl":"10.1080/17520363.2026.2737283","url":null,"abstract":"Background: Idiopathic pulmonary fibrosis(IPF) continues to be a fatal disease despite the use of antifibrotic therapy. There is limited data on the prognostic importance of parameters predicting mortality. We aimed to identify independent mortality predictors in antifibrotic-treated IPF patients.Methods: With ethics committee approval, IPF patients receiving consecutively antifibrotic treatment between 1 January 2013-01.01.2023 at Izmir Dr Suat Seren Chest Disease and Surgery Training and Research Hospital were retrospectively screened. The clinical-demographic-radiologic data were recorded. Cox regression and Kaplan-Meier analyses explored associations with mortality; receiver-operating-characteristic (ROC) curves defined optimal cutoffs.Results: The mean age of 381 patients was 68.8 ± 7.8 years. 87% (n = 331) was male. 1-3-5-10 year mortality rates were 8.1%-28.9%-41.7%-47.2%, respectively. In the multivariate regression analysis, the following were identified as independent predictors of increased mortality risk: Symptom progression (Hazard Ratio(HR)=1.64, 95%Confidence Interval (CI):1.13-2.37, p = 0.008), mMRC >2 (HR = 1.62, 95%CI:1.13-2.32, p = 0.009), presence of radiologically honeycombing (HR = 1.91, 95%CI:1.21-3.02, p = 0.006), CPI >49.2 (HR = 1.60, 95% CI:1.15-2.22, p = 0.005), FVC ≤71% (HR = 1.41, 95% CI:1.00-1.99, p = 0.048).Conclusion: Patients with symptom progression, mMRC >2, presence of honeycombing on radiological imaging, FVC ≤71%, and CPI >49.2 have a higher risk of mortality and should be referred for pulmonary rehabilitation and lung transplantation evaluation at an early stage.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"739-747"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From tissue-level circRNA discovery to an equity-ready cervical cancer triage test: a clinical-action framework. 从组织水平环状rna发现到公平准备宫颈癌分诊测试：临床行动框架。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-22 DOI: 10.1080/17520363.2026.2736039

Devadass Jayarajan, Mulavagili Srikanth, Mulavagili Vijayasimha

引用次数: 0

Coagulation Factor VII (FVII 401G>T) and glycoprotein Ib alpha (GP1BA Kozak -5C/T) gene variants as predictors of acute coronary syndrome in Indians: evidence from a case-control study. 凝血因子VII （FVII 401G >t）和糖蛋白1b α (GP1BA Kozak -5C/T)基因变异是印度人急性冠状动脉综合征的预测因子：来自病例对照研究的证据

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-09-10 DOI: 10.1080/17520363.2026.2729224

Sanchita Srivastava, Syed Tasleem Raza, Saliha Rizvi, Irshad Ahmad Wani, Zeba Siddiqi, Ale Eba, Farzana Mahdi

{"title":"Coagulation Factor VII (FVII 401G>T) and glycoprotein Ib alpha (GP1BA Kozak -5C/T) gene variants as predictors of acute coronary syndrome in Indians: evidence from a case-control study.","authors":"Sanchita Srivastava, Syed Tasleem Raza, Saliha Rizvi, Irshad Ahmad Wani, Zeba Siddiqi, Ale Eba, Farzana Mahdi","doi":"10.1080/17520363.2026.2729224","DOIUrl":"10.1080/17520363.2026.2729224","url":null,"abstract":"Background: Acute Coronary Syndrome (ACS) is a major cause of cardiovascular morbidity and mortality. Genetic variants affecting coagulation and platelet function, including Factor VII (FVII 401G>T) and GP1BA (Kozak -5 C/T), may influence ACS susceptibility.Methods: This hospital-based case-control study included 150 ACS patients and 150 age- and sex-matched healthy controls at Era's Lucknow Medical College and Hospital. Clinical, anthropometric, and lipid parameters were recorded, and FVII and GP1BA polymorphisms were genotyped using PCR-RFLP.Results: ACS patients had significantly higher BMI, blood pressure, LDL, VLDL, triglycerides, and total cholesterol, with lower HDL levels (all p<0.001). The FVII TT genotype (22.0% vs. 10.7%; OR=3.00, 95% CI: 1.48-6.10) and T allele (46.3% vs. 34.0%; OR=1.68, 95% CI: 1.21-2.33) were significantly associated with increased ACS risk. GP1BA genotypes and alleles showed no significant association with ACS. Neither polymorphism differed significantly across ACS subtypes.Conclusion: FVII 401G>T may be an important genetic susceptibility marker for ACS in the North Indian population, whereas GP1BA Kozak -5 C/T showed no significant association.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"771-778"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148917990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Looking beyond a single blood eosinophil count in COPD. COPD患者血液中嗜酸性粒细胞计数的变化。

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-08-01 Epub Date: 2026-08-31 DOI: 10.1080/17520363.2026.2726200

Mauro Maniscalco, Salvatore Fuschillo, Marco Vanetti, Antonio Spanevello

引用次数: 0

Serum BDNF, PD-1, MMP-9 in AECOPD: prognostic value and a dual-axis risk model. 血清BDNF、PD-1、MMP-9在AECOPD中的预后价值和双轴风险模型

IF 2.1 4区医学

Biomarkers in medicine Pub Date : 2026-07-01 Epub Date: 2026-02-05 DOI: 10.1080/17520363.2026.2620351

Shanshan Liu, Jian Dong, Weiqi Huang, Jing Yan, Lu Liu, Cheng Chen, Xuechun Chen

{"title":"Serum BDNF, PD-1, MMP-9 in AECOPD: prognostic value and a dual-axis risk model.","authors":"Shanshan Liu, Jian Dong, Weiqi Huang, Jing Yan, Lu Liu, Cheng Chen, Xuechun Chen","doi":"10.1080/17520363.2026.2620351","DOIUrl":"10.1080/17520363.2026.2620351","url":null,"abstract":"Objectives: To investigate longitudinal changes in neuroimmune biomarkers during acute exacerbations of chronic obstructive pulmonary disease (AECOPD), their modulation by standard therapy, and prognostic implications for 90-day outcomes.Materials and methods: In a prospective cohort, 266 hospitalized AECOPD patients were stratified into worsened (n = 53) and stable (n = 213) groups; 80 healthy individuals served as controls. Serum levels of BDNF, PD-1, MMP-9, and cytokines were assessed at admission (T1), pre-discharge (T2), and 90-day follow-up (T3). Mixed-effects models evaluated biomarker trajectories, while Cox regression examined correlations with clinical outcomes.Results: Compared with controls, AECOPD patients exhibited higher IL-6, TNF-α, PD-1, and MMP-9, alongside reduced BDNF and IL-10. Stable patients demonstrated partial biomarker normalization, whereas worsened patients retained a pro-inflammatory profile. Corticosteroids and antibiotics attenuated cytokine elevations, and oxygen therapy facilitated BDNF recovery. Low BDNF and high MMP-9 predicted spirometric decline, while elevated PD-1 and MMP-9 were associated with increased 90-day readmission risk. A dual-axis model incorporating neurotrophic and immune exhaustion markers outperformed GOLD classification for risk prediction.Conclusions: Neuroimmune biomarkers capture recovery heterogeneity in AECOPD. The proposed dual-axis model improves prognostic accuracy and may inform personalized management strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"569-582"},"PeriodicalIF":2.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0