Biomarkers in medicine最新文献_第2页

Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality. 血清白蛋白的表型特异性动态及其对败血症死亡率的影响。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1080/17520363.2025.2521251

Gianni Turcato, Arian Zaboli, Lucia Filippi, Paolo Ferretto, Daniela Milazzo, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Lorenzo Ghiadoni, Christian J Wiedermann

{"title":"Phenotype-specific dynamics of serum albumin and their impact on sepsis mortality.","authors":"Gianni Turcato, Arian Zaboli, Lucia Filippi, Paolo Ferretto, Daniela Milazzo, Michael Maggi, Alessandro Cipriano, Massimo Marchetti, Lorenzo Ghiadoni, Christian J Wiedermann","doi":"10.1080/17520363.2025.2521251","DOIUrl":"10.1080/17520363.2025.2521251","url":null,"abstract":"Aims: To assess the prognostic value of serial serum albumin measurements in septic patients, with a focus on different clinical phenotypes.Methods: We conducted a prospective observational study involving 254 patients with sepsis admitted to an Intermediate Care Unit in Italy (September 2022-June 2024). Patients were classified into four sepsis phenotypes (α, β, γ, δ), and serum albumin levels were measured daily over five days. The primary outcome was 30-day mortality. Logistic regression, Cox models, and AUROC analysis were used to evaluate associations between albumin dynamics, phenotypes, and outcomes.Results: The δ phenotype showed the lowest mean albumin levels (2.2 g/dL) and the highest mortality (45.4%), while phenotype α had the highest albumin and lowest mortality (3.6%). Each 1 g/dL increase in albumin was associated with a 63% mortality risk reduction (HR 0.37; 95% CI: 0.24-0.56). Albumin's predictive performance was strongest in the δ phenotype (AUROC up to 0.95).Conclusion: Serial albumin monitoring may provide prognostic insights in sepsis, especially in phenotypes associated with endothelial dysfunction. These results are hypothesis-generating and may support more personalized treatment strategies.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"529-537"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between lung ultrasound score and risk of mortality among acute respiratory distress syndrome patients: a meta-analysis. 急性呼吸窘迫综合征患者肺超声评分与死亡风险的相关性：一项荟萃分析。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1080/17520363.2025.2529770

Shisu Deng, Xing Liu, Yaxi Zhang, Yanqiong Tang, Jinquan Gao

{"title":"Association between lung ultrasound score and risk of mortality among acute respiratory distress syndrome patients: a meta-analysis.","authors":"Shisu Deng, Xing Liu, Yaxi Zhang, Yanqiong Tang, Jinquan Gao","doi":"10.1080/17520363.2025.2529770","DOIUrl":"10.1080/17520363.2025.2529770","url":null,"abstract":"Purpose: To clarify the relationship of lung ultrasound score (LUS) with the risk of mortality in patients with acute respiratory distress syndrome (ARDS).Methods: Several electronic databases were searched up to 14 October 2024. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined to assess the relationship between LUS and mortality in ARDS patients. Subgroup analysis stratified by the age and grouping method by LUS were further performed. Sensitivity analysis was performed to assess the stability of pooled results and Begg's funnel plot and Egger's test were applied to detect publication bias.Results: Sixteen studies with 1762 patients were included. Overall pooled results demonstrated that elevated LUS was significantly related to increased risk of mortality among ARDS patients (OR = 2.29, 95% CI: 1.45-3.63, P < 0.001). Besides, subgroup analysis stratified by the age (adult: OR = 2.01, p = 0.004; child: OR = 15.29, P < 0.001) and grouping method by LUS (dichotomous: OR = 5.60, p = 0.001; continuous: OR = 1.65, P < 0.001) revealed similar results. Sensitivity analysis indicated that pooled results were stable and Begg's funnel plot and Egger's test (p = 0.946) manifested that no significant publication bias was observed.Conclusion: Our meta-analysis indicates that a higher LUS is significantly associated with increased risk of mortality in ARDS patients.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"629-635"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinformatics-based prediction of hsa-miR-4651 and hsa-miR-608 as novel biomarkers for diagnosing silicosis. 基于生物信息学的hsa-miR-4651和hsa-miR-608作为诊断矽肺的新型生物标志物的预测。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-19 DOI: 10.1080/17520363.2025.2520160

Jing Wu, Yimin Shi, Cuiyun Zuo, Yaping Xu, Ying Wu, Haiyan Gong, Yanyan Ke, Xue Yi

{"title":"Bioinformatics-based prediction of hsa-miR-4651 and hsa-miR-608 as novel biomarkers for diagnosing silicosis.","authors":"Jing Wu, Yimin Shi, Cuiyun Zuo, Yaping Xu, Ying Wu, Haiyan Gong, Yanyan Ke, Xue Yi","doi":"10.1080/17520363.2025.2520160","DOIUrl":"10.1080/17520363.2025.2520160","url":null,"abstract":"Objective: Based on GEO database and bioinformatics to screen silicosis-related differentially expressed genes and analyze the biological functions, in order to provide new ideas and methods for the treatment of silicosis fibrosis.Methods: We predicted microRNAs related to silicosis through bioinformatics and verified the expression of microRNAs in patients with silicosis and healthy people by Real-time Fluorescence Quantitative PCR.Results: Three key genes (LCN2, MMP9, and CCL2) were identified, with hsa-miR-4651, hsa-miR-608, and hsa-miR-3151-5p predicted as their regulatory miRNAs. Hsa-miR-4651 and hsa-miR-608 were significantly upregulated in silicosis patient plasma, indicating their potential as biomarkers for silicosis diagnosis.Conclusions: Hsa-miR-4651 and hsa-miR-608 were identified as potential novel biomarkers for silicosis diagnosis, offering new insights for clinical diagnosis and treatment of silicosis fibrosis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"517-527"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and monitoring of breast cancer with a novel circulating tumor cells enrichment device. 一种新型循环肿瘤细胞富集装置在乳腺癌诊断和监测中的应用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-22 DOI: 10.1080/17520363.2025.2521255

Zhiyun Gong, Jing Yan, Yi Zhang, Yan Chen, Aoshuang Li, Xiaorong Yang, Weizhong Shi, Lin Guo, Tiantian Dai, Feng Dong, Renquan Lu

{"title":"Diagnosis and monitoring of breast cancer with a novel circulating tumor cells enrichment device.","authors":"Zhiyun Gong, Jing Yan, Yi Zhang, Yan Chen, Aoshuang Li, Xiaorong Yang, Weizhong Shi, Lin Guo, Tiantian Dai, Feng Dong, Renquan Lu","doi":"10.1080/17520363.2025.2521255","DOIUrl":"10.1080/17520363.2025.2521255","url":null,"abstract":"Aims: Circulating tumor cells (CTCs) are a critical biomarker for cancer evaluation. The more excellent detection system for CTCs is in demand.Patients & methods: One hundred and thirty-seven breast cancer patients, 97 patients with benign breast diseases, and 42 healthy volunteers were enrolled. Four milliliters of peripheral blood was used for CTCs detection. The performance was assessed by the receiver operator characteristic curve. A short-term follow-up with 23 patients was presented for real-time monitoring.Results: In clinical, CTCs were found in 96.35% of patients with malignant breast cancer and 25.77% of patients with benign breast diseases but not in healthy group, by CytoBot® 2000. The sensitivity and specificity of 89.8% and 98.6%, respectively, when the cutoff value of 1.5 CTCs per 4 ml whole blood. Significant differences of CTC count were found between malignant and nonmalignant group (p < 0.0001), tumor progression (p < 0.0001), and tumor size (p < 0.0001). In follow-up, 82.61% of patients exhibited a reduction in CTC count, which corresponds with medical observation that benefits from treatment. Additionally, CD45+ positive CTC showed with anomalous pattern during treatment.Conclusion: CTCs and this platform both have practical implications in clinical breast cancer diagnosis and monitoring.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"539-550"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyzing the association between MPO levels and glaucoma severity. 分析MPO水平与青光眼严重程度的关系。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-07-01 Epub Date: 2025-06-30 DOI: 10.1080/17520363.2025.2523236

Lingling Chen, Jinxia Wang, Yanping Gao, Wenbo Xiu, Zuo Wang, Gao Zhang, An Li, Yang Chen, Bolin Deng, Fang Lu, Chong He, Lijuan Hu

{"title":"Analyzing the association between MPO levels and glaucoma severity.","authors":"Lingling Chen, Jinxia Wang, Yanping Gao, Wenbo Xiu, Zuo Wang, Gao Zhang, An Li, Yang Chen, Bolin Deng, Fang Lu, Chong He, Lijuan Hu","doi":"10.1080/17520363.2025.2523236","DOIUrl":"10.1080/17520363.2025.2523236","url":null,"abstract":"Aim: To explore the relationship between plasma myeloperoxidase (MPO) and glaucoma, assessing the clinical utility of MPO in glaucoma.Methods: A cross-sectional study involved 127 glaucoma patients and 106 healthy controls. Plasma MPO markers were quantified using enzyme-linked immunosorbent assay (ELISA), comparing levels between glaucoma patients and healthy controls, and analyzing plasma MPO across different glaucoma severity grades.Results: In this study, we observed elevated plasma MPO levels in glaucoma patients (p < 0.001). After correcting for confounders such as age, sex, hypertension, and diabetes, plasma MPO remained independently associated with glaucoma (OR = 1.05, 95% CI: 1.04-1.07, p < 0.001). Plasma MPO may reflect the severity of glaucoma, with significant differences in plasma MPO observed between early and severe stages, but not in the moderate stages. In addition, elevated plasma MPO was associated with higher cup-to-disc ratios. ROC curve analysis demonstrated the validity of glaucoma markers in identifying early glaucoma from severe glaucoma (early versus severe: AUC = 0.633).Conclusion: Elevated plasma MPO levels are independently associated with glaucoma risk, suggesting it might provide insight into disease pathogenesis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"597-604"},"PeriodicalIF":1.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum corin levels and functional capacity in patients with advanced heart failure. 晚期心力衰竭患者血清科林水平与功能能力的关系

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-26 DOI: 10.1080/17520363.2025.2511473

Murat Karaçam, Azmican Kaya, Seda Tanyeri, Ali Furkan Tekatlı, Süleyman Çagan Efe, Cem Doğan, Gülümser Sevgin Halil, Sinan Cerşit, Barkın Kültürsay, Kaan Kırali, Rezzan Deniz Acar

{"title":"Association between serum corin levels and functional capacity in patients with advanced heart failure.","authors":"Murat Karaçam, Azmican Kaya, Seda Tanyeri, Ali Furkan Tekatlı, Süleyman Çagan Efe, Cem Doğan, Gülümser Sevgin Halil, Sinan Cerşit, Barkın Kültürsay, Kaan Kırali, Rezzan Deniz Acar","doi":"10.1080/17520363.2025.2511473","DOIUrl":"10.1080/17520363.2025.2511473","url":null,"abstract":"Background: Corin is a cardiac protease that plays a role in transforming pro-natriuretic peptides into their active biological forms. This study aimed to investigate the relationship between serum corin levels and functional capacity in patients with advanced heart failure.Methods: This cross-sectional study included 88 consecutive patients with LVEF (Left ventricular ejection fraction) <25% who were referred to the tertiary cardiovascular center. Serum corin levels were measured using ELISA (Enzyme-linked immunosorbent assay) prior to CPET (Cardiopulmonary exercise testing). Multivariable linear regression was used to assess the independent association between serum corin levels and peak VO₂ (Peak oxygen consumption).Results: The mean age was 51.3 ± 12.2 years, and 86.4% were male. The mean peak VO₂ was 13.6 ± 3.99 mL/min/kg and the mean serum corin level was 1.7 ± 0.82 ng/mL. In multivariable analysis, serum corin level was an independent predictor of peak VO₂ (Coefficient: 1.206, 95% CI: 0.527-1.880, p = 0.0007).Conclusion: Lower serum corin levels are independently associated with reduced functional capacity in advanced heart failure. Corin may serve as a valuable biomarker to complement CPET in clinical evaluation, risk stratification, and treatment planning.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"395-403"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis. 种族改变了microRNA单核苷酸多态性与儿童急性淋巴细胞白血病风险之间的关系：一项荟萃分析。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-29 DOI: 10.1080/17520363.2025.2511466

Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy

{"title":"Ethnicity modifies the association between microRNA single nucleotide polymorphisms and pediatric acute lymphoblastic leukemia risk: a meta-analysis.","authors":"Sharon Benita Antony, Julius Xavier Scott, Indhumathi Nagarthinam, Vinodhini Subramanian, Teena Koshy","doi":"10.1080/17520363.2025.2511466","DOIUrl":"10.1080/17520363.2025.2511466","url":null,"abstract":"Introduction: MicroRNA (miRNA) single nucleotide polymorphisms (miRNA-SNPs) have been associated with pediatric acute lymphoblastic leukemia (ALL). However, since the results of these individual studies have been inconsistent, we performed a meta-analysis to help establish a statistical significance for the association between miRNA-SNPs and pediatric ALL risk. We also analyzed whether they confer susceptibility across country-specific studies by using different genetic models.Methods: Articles published from 2001 to 2023 were collected from PubMed and Google Scholar databases. Through MetaGenyo, the association between miRNA- SNPs and pediatric ALL risk was calculated by pooled odds ratio [ORs] and 95% CI. A subgroup analysis of pooled ORs in country-specific studies was also performed.Results: Based on the inclusion and exclusion criteria, 14 studies were analyzed to extract data on miR146 rs2910164, miR-196a2 rs11614913, miR-612 rs12803915 and mir-499 rs3746444. While the pooled data analysis did not reveal any association, a subgroup analysis demonstrated country-specific differences in allele frequencies of all the four miRNAs in various genetic models, implying ethnicity-based risk.Conclusion: Our results suggested that miRNA-SNPS can still be considered as a potential risk factor to be explored in more populations.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"435-449"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-trimester neutrophil percentage-to-albumin ratio: a novel predictor for preeclampsia. 妊娠早期中性粒细胞百分比-白蛋白比率：一种新的子痫前期预测指标。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-25 DOI: 10.1080/17520363.2025.2511468

Çağlayan Biçer, Fatih Akkuş, Yusuf Dal

{"title":"First-trimester neutrophil percentage-to-albumin ratio: a novel predictor for preeclampsia.","authors":"Çağlayan Biçer, Fatih Akkuş, Yusuf Dal","doi":"10.1080/17520363.2025.2511468","DOIUrl":"10.1080/17520363.2025.2511468","url":null,"abstract":"Objective: This retrospective study evaluated the predictive power of a new marker for pre-eclampsia (PE), the neutrophil percentage/albumin ratio (NPAR).Methods: A total of 399 participants consisting of 133 pregnant women diagnosed with PE and 266 healthy pregnant controls were included in the study. Data collected included demographic and obstetric history, gestational age at diagnosis, maternal hematological and biochemical parameters, first trimester neutrophil/albumin ratio (NAR) and NPAR values, and neonatal outcomes.Results: The pre-eclampsia group showed significantly higher NAR (mean: 312.30, range: 80.00-1568.00) and NPAR (mean: 3.14 ± 0.81) compared to the control group (mean NAR: 234.40, range: 78.16-725.00; mean NPAR: 2.06 ± 0.38; p = 0.001 for both). Furthermore, early-onset PE was associated with significantly higher NAR (395.00 vs. 256.23, p = 0.001) and NPAR (3.87 vs. 2.80, p = 0.001) compared to late-onset PE. For early-onset PE, NPAR showed a sensitivity of 76.19%, specificity of 92.31%, PPV of 82.05%, NPV of 89.36% and area under the curve (AUC) of 0.897, demonstrating its strong potential as an early predictor of pre-eclampsia.Conclusion: NPAR is elevated in PE compared to healthy pregnancies, demonstrating its potential as a simple yet effective biomarker for predicting PE.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"415-423"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation. 经导管主动脉瓣植入术后血清乳酸水平与住院死亡率的关系。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-12 DOI: 10.1080/17520363.2025.2517524

Osman Uzman, Murat Bastopcu, Mehmet Saygı, Koray Kalenderoğlu, Koray Demir, Kıvanç Keskin, Sait Terzi

{"title":"The relationship of serum lactate level with in-hospital mortality after transcatheter aortic valve implantation.","authors":"Osman Uzman, Murat Bastopcu, Mehmet Saygı, Koray Kalenderoğlu, Koray Demir, Kıvanç Keskin, Sait Terzi","doi":"10.1080/17520363.2025.2517524","DOIUrl":"10.1080/17520363.2025.2517524","url":null,"abstract":"Background: This study assesses the influence of early hyperlactatemia after the transcatheter aortic valve implantation (TAVI) procedure on subsequent outcomes.Methods: Adult patients undergoing elective percutaneous TAVI between 2012 and 2022 in a single tertiary cardiac center were retrospectively included. Peak post-procedure lactate level within 24-h was recorded for 284 patients included in the study. The primary outcome measured was 30-day mortality.Results: 19 patients (6.6%) experienced 30-day mortality. Patients with mortality were characterized by advanced age (p = 0.022) and higher lactate levels after the procedure (5.4 ± 5.4 mmol/L vs 1.3 ± 0.6 mmol/L, p < 0.001). Post-procedure hyperlactatemia was an independent predictor of mortality (OR 3.95, 95% CI 1.35-11.60, p = 0.012). ROC analysis revealed 1.54 mmol/L as a cutoff for mortality with 85.7% specificity and 68.4% sensitivity.Conclusion: The initial 24-hour lactate levels seem to play a valuable role in predicting the likelihood of surviving during the hospital stay after the implantation procedure. Further investigation is required to ascertain the optimal strategies for managing early post-procedure hyperlactatemia in the TAVI population.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"481-489"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictor and prognostic modeling in cardiorenal syndrome type 2: a retrospective study of multicenter. 2型心肾综合征的预测因子和预后模型：一项多中心回顾性研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI: 10.1080/17520363.2025.2520738

Bin Wang, Xie Zheng, Qinghui Fu, Xiaoqian Luo, Sijun Pan

{"title":"Predictor and prognostic modeling in cardiorenal syndrome type 2: a retrospective study of multicenter.","authors":"Bin Wang, Xie Zheng, Qinghui Fu, Xiaoqian Luo, Sijun Pan","doi":"10.1080/17520363.2025.2520738","DOIUrl":"10.1080/17520363.2025.2520738","url":null,"abstract":"Background: Type 2 CRS is characterized by the development of renal dysfunction secondary to chronic cardiac disease. Despite its high morbidity and mortality, there is a lack of robust diagnostic tools and prognostic models to guide clinical management.Methods: This multicenter retrospective study included patients diagnosed with CRS type 2 based on the 2019 American Heart Association definition. Data were collected from electronic medical records of three hospitals between January 2021 and December 2023. Advanced statistical methods, including receiver operating characteristic (ROC) curve analysis, univariate Kaplan-Meier (KM) analysis, and multivariable Cox proportional hazards regression, were utilized to develop a nomogram for predicting patient prognosis.Results: The study included 519 patients with CRS-2. Independent predictors of adverse outcomes included elevated serum creatinine and blood urea nitrogen (BUN) levels, decreased platelet count, elevated B-type natriuretic peptide (BNP), and decreased oxygen partial pressure (PaO2). These findings suggest that close monitoring of these markers is essential in clinical practice to identify patients at high risk of adverse events early on.Conclusion: Our study provides evidence that serum creatinine, BUN, platelet count, BNP, and PaO2 are independent predictors of adverse outcomes in patients with Type 2 CRS.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"491-499"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0