Biomarkers in medicine最新文献_第2页

Letter to the editor on the article "Clinical relevance of HRR and RAR in pericarditis" by Hatice Eyiol et al. 关于Hatice Eyiol等人的文章“心包炎HRR和RAR的临床相关性”致编辑的信。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-19 DOI: 10.1080/17520363.2025.2508136

Francesca Casarin, Ruggiero Mascolo, Antonio Brucato

引用次数: 0

Serum GP73, Nrf2, CHE in early pregnancy-related liver injury detection via RCS model. RCS模型检测血清GP73、Nrf2、CHE对妊娠早期肝损伤的影响。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-07 DOI: 10.1080/17520363.2025.2516998

Deng Huang, Yanjun Hu, Biwen Dong, Zhi Zheng, Hai Wang, Tingting Liao, Wenhan Wang, Xianjue Zheng, Zitong Xu, Shuqi Xia, Xiaoqing Li, Congcong Sun, Hongping Zhang, Jiayong Zheng

{"title":"Serum GP73, Nrf2, CHE in early pregnancy-related liver injury detection via RCS model.","authors":"Deng Huang, Yanjun Hu, Biwen Dong, Zhi Zheng, Hai Wang, Tingting Liao, Wenhan Wang, Xianjue Zheng, Zitong Xu, Shuqi Xia, Xiaoqing Li, Congcong Sun, Hongping Zhang, Jiayong Zheng","doi":"10.1080/17520363.2025.2516998","DOIUrl":"10.1080/17520363.2025.2516998","url":null,"abstract":"Background: This study assessed serum GP73, Nrf2, and CHE levels in pregnancy-associated liver injury and explored their nonlinear risk relationships using restricted cubic spline (RCS) models to establish diagnostic thresholds for early screening.Methods: Conducted from December 2022 to December 2024, 105 pregnant women with liver injury (research group) and 187 healthy controls were retrospectively analyzed. Multivariate logistic regression, ROC curves, RCS models, and decision curve analysis (DCA) evaluated associations, predictive efficacy, dose-response relationships, and clinical utility of these biomarkers.Results: Elevated GP73 and Nrf2, multiple pregnancies, antipyretic/anti-infective medication use, and malnutrition were risk factors (p < 0.05), while high CHE was protective (p < 0.05). ROC analysis showed AUCs of 0.801 (GP73), 0.785 (Nrf2), and 0.726 (CHE) combined AUC reached 0.951. RCS revealed nonlinear dose-response relationships (p < 0.001), and DCA confirmed clinical significance (net benefit > 0) for individual and combined biomarkers, with the panel showing the highest utility.Conclusion: GP73, Nrf2, and CHE demonstrated nonlinear associations with pregnancy-related liver injury, particularly GP73. Combined measurement enhances clinical value for early prediction.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"455-462"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding risk stratification in acute coronary syndromes with systemic indices: HALP and CALLY. 扩大危险分层急性冠状动脉综合征与系统指标：HALP和CALLY。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-08 DOI: 10.1080/17520363.2025.2517525

Ashok Kumar Pannu

引用次数: 0

Abnormal blood glucose on admission and outcomes in older patients with acute calculous cholecystitis. 老年急性结石性胆囊炎患者入院时血糖异常及预后。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17520363.2025.2501925

Hou Xu, Xiaohong Jiang, Zhiheng Liu, Xueli Zhang, Guijie Liu, Yanchao Gao, Wei Zhang, Jun Liu

{"title":"Abnormal blood glucose on admission and outcomes in older patients with acute calculous cholecystitis.","authors":"Hou Xu, Xiaohong Jiang, Zhiheng Liu, Xueli Zhang, Guijie Liu, Yanchao Gao, Wei Zhang, Jun Liu","doi":"10.1080/17520363.2025.2501925","DOIUrl":"10.1080/17520363.2025.2501925","url":null,"abstract":"Introduction: We investigated the potential correlation between abnormal blood glucose on admission and clinical outcomes of acute calculus cholecystitis in older patients.Areas covered: We included older patients (≥65 years) diagnosed with acute calculus cholecystitis. The first plasma glucose measurement obtained at admission was used. Overall, 280 older patients were evaluated. The results showed that ABG was significantly associated with more severe systemic inflammatory responses (elevated white blood cell count and neutrophil-lymphocyte ratio), a higher incidence of moderate to severe ACC, and the need for invasive treatment (an increased proportion of percutaneous cholecystostomy and combined surgeries). The prolonged hospital stay, 30-day readmission rate and mortality rate of patients in the ABG group were significantly increased, and the incidence of severe postoperative complications (Clavien-Dindo≥grade III) was higher. Multivariate analysis confirmed that ABG was an independent predictor of the severity of ACC (TG18 classification) and 30-day re-admission rate.Expert opinion/commentary: In older patients with acute calculus cholecystitis, abnormal blood glucose on admission is associated with worse outcomes, serving as a novel quantifiable risk criterion to guide treatment selection, particularly for high-risk older adults ineligible for early surgery.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"405-414"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking complete blood count-derived indices during transition to euthymia in bipolar disorder: a longitudinal study. 跟踪全血细胞计数衍生指数在过渡到心境双相情感障碍：纵向研究。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-05-24 DOI: 10.1080/17520363.2025.2511469

Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Ceyhun Yilmaz, Mete Arslan Konak

{"title":"Tracking complete blood count-derived indices during transition to euthymia in bipolar disorder: a longitudinal study.","authors":"Onur Gökçen, Kader Semra Karataş, Merve Akkuş, Feyza Dönmez, Ceyhun Yilmaz, Mete Arslan Konak","doi":"10.1080/17520363.2025.2511469","DOIUrl":"10.1080/17520363.2025.2511469","url":null,"abstract":"Aim: This study aims to investigate changes in the CBC-related inflammatory indices in hospitalized bipolar disorder (BD) patients transitioning from a mood episode to a euthymic state.Method: BD patients hospitalized for mania or depression were assessed during hospitalization and one month post-discharge in euthymia. In both phases, CBC was assessed, along with the administration of YMRS, HDRS-17, and the CGI.Results: Ninety-four patients (58 manic, 36 depressive episodes) met the inclusion criteria at both phases. Significant decreases were observed in WBC (p < 0.001), neutrophils (p = 0.002), platelets (p = 0.038), NLR (neutrophil-to-lymphocyte ratio, p = 0.019), AISI (aggregate index of systemic inflammation, p < 0.001), dNLR (derived neutrophil-to-lymphocyte ratio, p = 0.007), SII (systemic immune inflammation index, p = 0.002), and SIRI (systemic inflammation response index, p = 0.003), while eosinophils (p = 0.003), EMR (eosinophil-to-monocyte ratio, p = 0.002), and ENR (eosinophil-to-neutrophil ratio, p = 0.001) increased. After a Bonferroni correction (p < 0.003125), changes in WBC, neutrophils, AISI, SII, SIRI, EMR, and ENR remained significant. Furthermore, differences were also noted between VPA users and non-users.Conclusion: The study highlights distinctive changes in CBC-related indicators during the transition to euthymia in BD patients. It is the first to investigate specific indices such as AISI, dNLR, EMR, and ENR in BD using a longitudinal design. The findings suggest that CBC-derived inflammation indices are promising tools for monitoring BD clinical progression.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"425-433"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of inflammatory parameters in predicting acute complicated diverticulitis. 炎症参数在预测急性复杂性憩室炎中的作用。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1080/17520363.2025.2517534

Fırat Canlıkarakaya, Serhat Ocaklı, İbrahim Doğan, Bedri Burak Sucu, Nurhak Cihangir Çınkıl

{"title":"The role of inflammatory parameters in predicting acute complicated diverticulitis.","authors":"Fırat Canlıkarakaya, Serhat Ocaklı, İbrahim Doğan, Bedri Burak Sucu, Nurhak Cihangir Çınkıl","doi":"10.1080/17520363.2025.2517534","DOIUrl":"10.1080/17520363.2025.2517534","url":null,"abstract":"Aim: Acute diverticulitis is an inflammatory process associated with pericolonic inflammation involving one or more colonic diverticula and is usually classified as uncomplicated or complicated.Method: This multicenter study retrospectively examined the data of 135 patients who received inpatient treatment for diverticulitis in two tertiary hospitals. Some inflammation scores were calculated with the data obtained from the patients' Complete blood count(CBC) and biochemical laboratory results, and the power of these scores in predicting complicated diverticulitis was examined.Results: A total of 135 patients (57 men and 78 women) were included in this study. In the ROC analysis performed to evaluate the effectiveness of predicting complications, the CRP/Albumin(CAR) score was found to be significant (AUC: 0.762, p = 0.001). For a cutoff value > 0.25, CAR predicted complications with 73% sensitivity and 76% specificity (AUC: 0.762, p = 0.001).Conclusion: Determining the severity of the disease by differentiating complicated from uncomplicated cases will contribute to reducing hospital stay times and related costs. Our study showed that CAR score can be used as a reliable, inexpensive, and rapid marker for predicting complicated diverticulitis in acute diverticulitis.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"463-469"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC. RUNX1启动子rs2071029多态性对辅助化疗诱导的结直肠癌中性粒细胞减少的易感性

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-06-01 Epub Date: 2025-06-10 DOI: 10.1080/17520363.2025.2516996

Xikai Luo, Hao Wang, Zhe Huang, Zhuocheng Lin, Chunpeng Li, Qiwen Wang, Yisheng Wei

{"title":"Susceptibility of RUNX1 promoter rs2071029 polymorphism to adjuvant chemotherapy-induced neutropenia in CRC.","authors":"Xikai Luo, Hao Wang, Zhe Huang, Zhuocheng Lin, Chunpeng Li, Qiwen Wang, Yisheng Wei","doi":"10.1080/17520363.2025.2516996","DOIUrl":"10.1080/17520363.2025.2516996","url":null,"abstract":"Aim: To investigate the susceptibility of Runt-related transcription factor 1 (RUNX1) promoter polymorphism to adjuvant chemotherapy-induced neutropenia (CIN) of colorectal cancer (CRC).Methods: RUNX1 promoter polymorphisms rs2071029 and rs12626613 were genotyped by SnaPshot genotyping and Sanger sequencing. The association of rs2071029 and CIN in 204 CRC patients was analyzed using chi-square test and multivariate logistic regression model. The impact of rs2071029 polymorphism on RUNX1 promoter activity was analyzed by luciferase assay.Results: Rs2071029 and rs12626613 loci were in strong linkage disequilibrium (D ' = 0.957. r2 = 0.878). Compared with rs2071029 CC genotype, TT (OR = 0.250, 95% CI: 0.101∼0.617) had a decreased risk of severe CIN. Compared with mFOLFOX6,and baseline neutrophil counts 2-4 × 109/L, Xelox (OR = 0.169, 95% CI: 0.054∼0.531) and >4 × 109/L(OR = 0.446 95% CI: 0.209∼0.952) had a decreased risk of severe CIN, respectively. Rs2071029T promoter activity was significantly higher than that of rs2071029C promoter (p = 0.014). Stratified analyses revealed that the protective effect of the rs2071029 TT was more pronounced in patients over 60 years (OR = 0.139, 95% CI: 0.031-0.622) and stage II cases (OR = 0.117, 95% CI: 0.018-0.745).Conclusion: RUNX1 promoter rs2071029 polymorphism could be useful as an independent biomarker for CIN in CRC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"471-479"},"PeriodicalIF":1.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-140-5p and cystatin-C expression in patients with vascular cognitive impairment and its clinical value. 血管性认知障碍患者MicroRNA-140-5p和胱抑素- c的表达及其临床价值

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-22 DOI: 10.1080/17520363.2025.2468150

Huiyan Ding, Yufu Han

{"title":"MicroRNA-140-5p and cystatin-C expression in patients with vascular cognitive impairment and its clinical value.","authors":"Huiyan Ding, Yufu Han","doi":"10.1080/17520363.2025.2468150","DOIUrl":"10.1080/17520363.2025.2468150","url":null,"abstract":"Background: Vascular cognitive impairment (VCI) is a cerebrovascular disease leading to mental decline. Appropriate biomarkers must be identified to facilitate the diagnosis of VCI. Therefore, we investigated changes in miR-140-5p and cystatin-C (Cys-C) expression in the serum of patients with VCI.Methods: The miR-140-5p or Cys-C serum expression levels were determined using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) or immunoturbidimetry. MMP-9 and IL-6 expression were detected in both groups. Correlations between serum-exhaled miR-140-5p or Cys-C and IL-6 or MMP-9 were analyzed using Pearson's method. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of miR-140-5p, Cys-C, and miR-140-5p combined with Cys-C for diagnosing VCI.Results: miR-140-5p and Cys-C serum levels were significantly upregulated in patients with VCI, and the increase was more pronounced in patients with vascular dementia (VaD). In addition, miR-140-5p and Cys-C positively correlated with increased IL-6 and MMP-9 expression. The ROC analysis showed that the combination of miR-140-5p and Cys-C demonstrated the AUC was 100.0% (sensitivity: 100%; specificity, 98.3%).Conclusion: The upregulation of miR-140-5p and Cys-C indicates that miR-140-5p and Cys-C may be related VCI development. The combined diagnosis of miR-140-5p has potential diagnostic value for diagnosis and screening of VCI.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

mSEPT9 performs better than CEA in NAT response and MRD assessment and recurrence prediction of stage III CRC. mSEPT9在III期CRC的NAT应答、MRD评估和复发预测方面优于CEA。

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-08 DOI: 10.1080/17520363.2025.2489919

Jianbiao Xu, Yun Shang, Tongmin Wang, Jianlin Song, Wenchuan Zhu, Yunjun Zeng, Jianxun Wang, Li Zhang, Xiaochun Yang

{"title":"mSEPT9 performs better than CEA in NAT response and MRD assessment and recurrence prediction of stage III CRC.","authors":"Jianbiao Xu, Yun Shang, Tongmin Wang, Jianlin Song, Wenchuan Zhu, Yunjun Zeng, Jianxun Wang, Li Zhang, Xiaochun Yang","doi":"10.1080/17520363.2025.2489919","DOIUrl":"10.1080/17520363.2025.2489919","url":null,"abstract":"Aims: This study aimed to investigate the capability of methylated SEPT9 (mSEPT9) assay in assessing the neoadjuvant therapy (NAT) response,the minimal residual disease (MRD) and predicting the recurrence of stage III colorectal cancer (CRC).Materials & methods: We prospectively recruited 124 stage III CRC patients. All patients received pre-surgical NAT and subsequent curative surgery, and were followed up to 627 days. Blood samples were collected before NAT, after NAT and after surgery. Measurements of mSEPT9 and CEA were performed.Results: mSEPT9 exhibited a positive detection rate (PDR) of 82.6% for stage III CRC, significantly higher than that of the carcinoembryonic antigen (CEA) (60.3%,p < 0.001). The levels of mSEPT9 and CEA significantly decreased after NAT. This can be observed for patients with complete response (CR), partial response (PR), stable disease (SD) and tumor regression grade (TRG) 1-3 in mSEPT9 and patients with PR, SD and TRG 2-3 in CEA. Stepwise percentage decrease of marker levels was more prominent in mSEPT9 than in CEA following NAT and surgical treatment. Kaplan-Meier analysis suggested that mSEPT9 significantly stratified the patient recurrence-free survival(RFS) before NAT, after NAT and after surgery. In contrast, CEA significantly stratified RFS after NAT and after surgery, while CEA levels before NAT did not significantly stratify RFS.Conclusion: mSEPT9 exhibits better applicability than CEA in assessment in terms of patient coverage, sensitivity and the pre-NAT recurrence prediction.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"359-370"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NDRG1/2 as a prognostic predictive biomarker of cervical cancer and its correlation with immune infiltration. NDRG1/2作为宫颈癌预后预测生物标志物及其与免疫浸润的相关性

IF 1.9 4区医学

Biomarkers in medicine Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1080/17520363.2025.2483495

Yuan Zhang, Bingjie Li, Jie Li, Jing Zhao, Yan Li, Shan Kang

{"title":"NDRG1/2 as a prognostic predictive biomarker of cervical cancer and its correlation with immune infiltration.","authors":"Yuan Zhang, Bingjie Li, Jie Li, Jing Zhao, Yan Li, Shan Kang","doi":"10.1080/17520363.2025.2483495","DOIUrl":"10.1080/17520363.2025.2483495","url":null,"abstract":"Background: Cervical cancer (CC) is a leading cause of cancer-related death in women. The N-myc down-stream regulatory gene (NDRG) family has an unclear prognostic role in CC.Methods: We analyzed NDRG mRNA and protein levels in CC using public databases. And NDRG1 expression was verified through immunohistochemistry in clinical samples. Additionally, we utilized other bioinformatics tools to analyze the correlations between NDRG and survival, as well as immune infiltration.Results: NDRG1 was elevated, and NDRG2 was reduced in CC tissues. High NDRG1 and low NDRG2/3 correlated with poorer survival and were associated with reduced immune cell infiltration, particularly CD8+ T cells. Genetic alterations in NDRG1/2/3 were primarily amplifications, while DNA hypomethylation of NDRG1 in CC tissues, particularly at specific CpG sites, was associated with prognosis. PPI and enrichment analyses implicated NDRGs in metabolic processes, HIF-1 signaling, and immune regulation, underscoring their roles in CC progression and prognosis.Conclusions: NDRG1/2 present potential as new prognostic biomarkers, shedding light on therapeutic targets for CC.","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"329-339"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0