{"title":"中国南宁健康儿童血清白蛋白、总蛋白和前白蛋白的参考区间。","authors":"Mengli Fan, Liling Yi, Siting Li, Chunling Zhu, Liuyi Lu, Qiliu Peng","doi":"10.1080/17520363.2025.2539066","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The diagnosis, treatment, and prognosis of childhood diseases rely on accurately establishing reference intervals (RIs). The aim of this study was to determine the RIs of albumin (ALB), total protein (TP), and prealbumin (PA) in children in Nanning, China, according to age, gender, and ethnicity.</p><p><strong>Methods: </strong>A total of 4001 apparently healthy children aged 0 ~ 18 years from the Nanning area were included. The levels of serum ALB, TP, and PA were measured by an Architect C16000 automatic chemical analyzer. Non-parametric methods were used to determine the 2.5th and 97.5th percentile RIs.</p><p><strong>Results: </strong>Serum TP and PA levels increased with age (<i>p</i> < 0.001), whereas serum ALB level had no correlation with age (<i>p</i> > 0.05). Gender and ethnicity statistical differences were presented in serum ALB and PA except serum TP. Serum levels of ALB and PA in males were higher than those in females (<i>p</i> < 0.001). Serum ALB and PA showed lower concentrations in Zhuang children as compared to Han children (<i>p</i> < 0.05). All verification groups passed the verification of the RIs.</p><p><strong>Conclusions: </strong>Age-, gender- and ethnicity-appropriate RIs for serum ALB, TP, and PA will provide a more accurate evaluation of pediatric-related diseases.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"685-695"},"PeriodicalIF":2.1000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344803/pdf/","citationCount":"0","resultStr":"{\"title\":\"Reference intervals for serum albumin, total protein, and prealbumin in healthy children in Nanning, China.\",\"authors\":\"Mengli Fan, Liling Yi, Siting Li, Chunling Zhu, Liuyi Lu, Qiliu Peng\",\"doi\":\"10.1080/17520363.2025.2539066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>The diagnosis, treatment, and prognosis of childhood diseases rely on accurately establishing reference intervals (RIs). The aim of this study was to determine the RIs of albumin (ALB), total protein (TP), and prealbumin (PA) in children in Nanning, China, according to age, gender, and ethnicity.</p><p><strong>Methods: </strong>A total of 4001 apparently healthy children aged 0 ~ 18 years from the Nanning area were included. The levels of serum ALB, TP, and PA were measured by an Architect C16000 automatic chemical analyzer. Non-parametric methods were used to determine the 2.5th and 97.5th percentile RIs.</p><p><strong>Results: </strong>Serum TP and PA levels increased with age (<i>p</i> < 0.001), whereas serum ALB level had no correlation with age (<i>p</i> > 0.05). Gender and ethnicity statistical differences were presented in serum ALB and PA except serum TP. Serum levels of ALB and PA in males were higher than those in females (<i>p</i> < 0.001). Serum ALB and PA showed lower concentrations in Zhuang children as compared to Han children (<i>p</i> < 0.05). All verification groups passed the verification of the RIs.</p><p><strong>Conclusions: </strong>Age-, gender- and ethnicity-appropriate RIs for serum ALB, TP, and PA will provide a more accurate evaluation of pediatric-related diseases.</p>\",\"PeriodicalId\":9182,\"journal\":{\"name\":\"Biomarkers in medicine\",\"volume\":\" \",\"pages\":\"685-695\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344803/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomarkers in medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/17520363.2025.2539066\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers in medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17520363.2025.2539066","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Reference intervals for serum albumin, total protein, and prealbumin in healthy children in Nanning, China.
Aim: The diagnosis, treatment, and prognosis of childhood diseases rely on accurately establishing reference intervals (RIs). The aim of this study was to determine the RIs of albumin (ALB), total protein (TP), and prealbumin (PA) in children in Nanning, China, according to age, gender, and ethnicity.
Methods: A total of 4001 apparently healthy children aged 0 ~ 18 years from the Nanning area were included. The levels of serum ALB, TP, and PA were measured by an Architect C16000 automatic chemical analyzer. Non-parametric methods were used to determine the 2.5th and 97.5th percentile RIs.
Results: Serum TP and PA levels increased with age (p < 0.001), whereas serum ALB level had no correlation with age (p > 0.05). Gender and ethnicity statistical differences were presented in serum ALB and PA except serum TP. Serum levels of ALB and PA in males were higher than those in females (p < 0.001). Serum ALB and PA showed lower concentrations in Zhuang children as compared to Han children (p < 0.05). All verification groups passed the verification of the RIs.
Conclusions: Age-, gender- and ethnicity-appropriate RIs for serum ALB, TP, and PA will provide a more accurate evaluation of pediatric-related diseases.
期刊介绍：
Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory.
Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice.
As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications.
Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest.
Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.
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