Biomarkers in medicinePub Date : 2024-02-01Epub Date: 2024-03-05DOI: 10.2217/bmm-2023-0682
Tuğba S Menekşe, İlker Kaçer, Muhammet Hacımustafaoğlu, Murat Gül, Can Ateş
{"title":"C-reactive protein to albumin ratio may predict in-hospital mortality in non-ST elevation myocardial infarction.","authors":"Tuğba S Menekşe, İlker Kaçer, Muhammet Hacımustafaoğlu, Murat Gül, Can Ateş","doi":"10.2217/bmm-2023-0682","DOIUrl":"10.2217/bmm-2023-0682","url":null,"abstract":"<p><p><b>Objective:</b> The authors investigated the value of novel inflammatory markers, systemic immune-inflammation index and C-reactive protein to albumin ratio (CAR), to predict in-hospital mortality in patients with non-ST elevation myocardial infarction (NSTEMI). <b>Materials & methods:</b> A total of 308 patients who underwent percutaneous coronary intervention because of NSTEMI were retrospectively included in the study. Killip classification, Thrombolysis in Myocardial Infarction score, SYNTAX score, and CAR and systemic immune-inflammation index values were calculated. <b>Results:</b> CAR (cutoff: 0.0864; sensitivity: 94.1%; specificity: 40.5%; p = 0.008) and Killip classification (cutoff: 2.5; sensitivity: 64.7%; specificity: 8.9%; p = 0.001) were found to be significantly higher in determining in-hospital mortality. <b>Conclusion:</b> This study revealed that CAR is an inexpensive and significant factor in predicting in-hospital mortality in patients undergoing percutaneous coronary intervention for NSTEMI.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"103-113"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations between neutrophil-to-lymphocyte/platelet-to-lymphocyte and recovery in sudden sensorineural hearing loss.","authors":"Xinmei Huang, Xupei Ni, Jun Shen, Lihua Chen, Liying Xu, Xuxia Tang","doi":"10.2217/bmm-2022-0729","DOIUrl":"10.2217/bmm-2022-0729","url":null,"abstract":"<p><p><b>Aims:</b> This study investigated the nonlinear associations between neutrophil-to-lymphocyte (NLR)/platelet-to-lymphocyte (PLR) and recovery rates in sudden sensorineural hearing loss (SSNHL). <b>Methods:</b> Total of 244 SSNHL patients were included. The primary outcome was recovery rate. <b>Results:</b> A nonlinear association was detected between NLR and recovery rate using the LOWESS method, with a knot of 3. Patients with NLR ≥3 had a higher recovery rate than NLR <3. Using the linear-spline function, NLR was significantly associated with high recovery rate when NLR was <3. However, when NLR was ≥3, this association became nonsignificant. The trend test showed a similar result. PLR was not associated with recovery rate. <b>Conclusion:</b> The association between NLR and recovery rate is nonlinear, with a knot of around three. PLR is not associated with recovery rate.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"115-122"},"PeriodicalIF":2.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sidar Ş Aydın, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Murat Özmen, Oktay Gülcü, Selim Aydemir, Kamuran Kalkan
{"title":"Relationship between platelet/hemoglobin and radial thrombus in patients with coronary angiography via radial access.","authors":"Sidar Ş Aydın, Emrah Aksakal, İbrahim Saraç, Faruk Aydınyılmaz, Murat Özmen, Oktay Gülcü, Selim Aydemir, Kamuran Kalkan","doi":"10.2217/bmm-2023-0394","DOIUrl":"https://doi.org/10.2217/bmm-2023-0394","url":null,"abstract":"<p><p><b>Aim:</b> To predict the development of radial artery thrombus (RAT) in patients with radial approach coronary angiography of platelet-to-hemoglobin ratio (PHR). <b>Materials & methods:</b> This study was designed to evaluate the relationship between RAT and PHR. A total of 1156 patients who had coronary angiography via the transradial approach between 2021 and 2022 in the authors' center were included in the study. <b>Results:</b> Radial thrombus was detected in 52 (4.5%) patients. PHR was higher in the group with thrombus and was statistically significant. In the regression model, PHR was an independent predictor of the development of radial thrombus (p = 0.007). <b>Conclusion:</b> High PHR may be an independent predictor of the development of radial thrombus.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-07-31DOI: 10.1080/17520363.2024.2380246
Yin Jin, Xingchen Ye
{"title":"Prognostic value of C-reactive protein in patients with glioma: a meta-analysis.","authors":"Yin Jin, Xingchen Ye","doi":"10.1080/17520363.2024.2380246","DOIUrl":"10.1080/17520363.2024.2380246","url":null,"abstract":"<p><p><b>Background:</b> In this meta-analysis, we investigated C-reactive protein (CRP)'s role in glioma prognosis prediction.<b>Methods:</b> We conducted the current meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for systematic reviews and meta-analyses. An analysis of the prognostic effect of CRP on glioma was conducted using combined hazard ratios (HRs) and 95% confidence intervals (CIs).<b>Results:</b> The combined data suggested that a higher CRP level was markedly related to poor overall survival in glioma (hazard ratio: 1.73; 95% CI: 1.22-2.46; <i>p</i> = 0.002).<b>Conclusion:</b> According to results in the present meta-analysis, elevated CRP levels were significantly related to inferior overall survival in glioma.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"629-637"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Salivary cysteine levels as a potential biochemical indicator of oral cancer risk in tobacco consumers.","authors":"Ravina Vats, Pooja Yadav, Afsareen Bano, Sapna Wadhwa, Anjali Narwal, Rashmi Bhardwaj","doi":"10.1080/17520363.2024.2403327","DOIUrl":"10.1080/17520363.2024.2403327","url":null,"abstract":"<p><p><b>Aim:</b> Oral cancer is the leading cause of mortality, with a survival rate of less than 5 years, and is predominantly influenced by tobacco mutagens. Invasive diagnostic methods hinder early detection of oral cancer biomarkers. The present study performed salivary biochemical analysis for early oral cancer screening in tobacco consumers.<b>Materials & methods:</b> Three study groups included healthy controls (n = 25), tobacco users (n = 25) and oral cancer patients (n = 25). Salivary total protein, amylase, TNF-α and amino acid levels were evaluated using enzymatic tests, Enzyme linked Immunosorbent Assay (ELISA) and High-Performance Liquid Chromatography (HPLC).<b>Results:</b> Compared with healthy controls, salivary total protein and TNF-α levels were significantly (<i>p</i> = 0.04) higher in oral cancer patients. Salivary amylase levels were significantly lower in tobacco smokers (<i>p</i> = 0.02) and higher in oral cancer patients (<i>p</i> = 0.01). Interestingly, the amino acid cysteine concentration was significantly higher (<i>p</i> = 0.02) in tobacco consumers (62.5 ± 10) than in healthy controls (116.1 ± 28).<b>Conclusion:</b> In high-risk populations, such as tobacco users, salivary biochemical analysis can serve as a promising noninvasive diagnostic method for early oral cancer screening. As a salivary biomarker, the amino acid cysteine exhibits potential as a means of detecting the progression of oral cancer in individuals who consume tobacco.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"877-888"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142341809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-08-13DOI: 10.1080/17520363.2024.2352421
Fatih Kus, Deniz Can Guven, Hasan Cagri Yildirim, Elvin Chalabiyev, Arif Akyildiz, Omer D Tatar, Yigit Berk Sahin, Serez İleri, Ece Karaca, Neyran Kertmen, Zafer Arık
{"title":"KELIM score predicts outcome in patients with platinum-resistant/refractory recurrent ovarian cancer.","authors":"Fatih Kus, Deniz Can Guven, Hasan Cagri Yildirim, Elvin Chalabiyev, Arif Akyildiz, Omer D Tatar, Yigit Berk Sahin, Serez İleri, Ece Karaca, Neyran Kertmen, Zafer Arık","doi":"10.1080/17520363.2024.2352421","DOIUrl":"10.1080/17520363.2024.2352421","url":null,"abstract":"","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"511"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictors of 2-year mortality in geriatric patients hospitalized with COVID-19 in Türkiye: a retrospective cohort study.","authors":"Bahar Bektan Kanat, Gulru Ulugerger Avci, Osman Faruk Bayramlar, Veysel Suzan, Gunay Can, Ilker Inanc Balkan, Sermin Borekci, Bora Korkmazer, Yalim Dikmen, Gokhan Aygun, Deniz Suna Erdincler, Hakan Yavuzer, Alper Doventas","doi":"10.1080/17520363.2024.2352416","DOIUrl":"10.1080/17520363.2024.2352416","url":null,"abstract":"<p><p><b>Aim:</b> To reveal factors affecting 2-year mortality in geriatric patients hospitalized with COVID-19.<b>Methods:</b> Demographic characteristics, clinical and laboratory data, thorax computed tomography (CT) images, second-year survival status, and causes of death were analyzed.<b>Results:</b> The 2-year post-discharge mortality rate of 605 patients was 21.9%. Mean age of patients in the deceased group was 76.8 ± 8.1 years, which was shorter than the life expectancy at birth in Türkiye. Older age (≥85), delirium, some co-morbidities, and atypical thorax CT involvement were associated with a significant increase in 2-year mortality (p < 0.05).<b>Conclusion:</b> This is the first study to evaluate factors associated with 2-year mortality in older COVID-19 patients. Identifying risk factors for long-term mortality in geriatric COVID-19 patients is important.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"555-565"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-03-05DOI: 10.2217/bmm-2023-0671
Lin Wu, Jinyan Zhang, Hui-Min Zhang, Cheng-Yi Wang
{"title":"Study on red blood cell distribution width in children with severe <i>Mycoplasma pneumoniae</i> pneumonia.","authors":"Lin Wu, Jinyan Zhang, Hui-Min Zhang, Cheng-Yi Wang","doi":"10.2217/bmm-2023-0671","DOIUrl":"10.2217/bmm-2023-0671","url":null,"abstract":"<p><p><b>Background:</b> This study aimed to investigate the clinical value of the red blood cell distribution width (RDW) in severe <i>Mycoplasma pneumoniae</i> pneumonia (MPP). <b>Methods:</b> A total of 185 children with diagnosed severe MPP were included. The patients' case records and laboratory examination data were analyzed retrospectively. The children were grouped into quartiles based on RDW. <b>Results:</b> Univariate analysis revealed that RDW was significantly correlated with the Pediatric Risk of Mortality (PRISM) III score, Sepsis-Related Organ Failure Assessment score, incidence of invasive intubation and 30-day in-hospital mortality. After adjustment for the severity of illness, multivariate analysis revealed that the PRISM III score and RDW were factors independently associated with 30-day in-hospital mortality. <b>Conclusion:</b> This study revealed that RDW could be correlated with the long-term prognosis and severity of severe MPP.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"69-77"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between serum homocysteine and postoperative acute kidney injury in patients undergoing cardiac surgery.","authors":"Zheng-Rong Li, Cun-Fei Liu, De-Qun Guo, Yan-Jin Wei","doi":"10.2217/bmm-2023-0611","DOIUrl":"10.2217/bmm-2023-0611","url":null,"abstract":"<p><p><b>Background:</b> To explore the relationship between homocysteine (Hcy) and cardiac surgery-associated acute kidney injury (AKI). <b>Methods:</b> A total of 944 patients who underwent cardiac surgery were enrolled. The association between Hcy levels and the risk of cardiac surgery-associated AKI was evaluated. <b>Results:</b> A total of 135 patients were diagnosed with AKI and the prevalence of AKI was 14.30%. The AKI group had significantly higher levels of Hcy compared with the non-AKI group (16.90 vs 13.56 umol/l; p < 0.001). The incidence rates of AKI increased from 7.2% to 26.72% across increasing Hcy quartiles (p < 0.001). Compared with the first Hcy quartile group, the odds ratio of cardiac surgery-associated AKI was 4.43 (95% CI: 2.27-8.66) in the highest Hcy group. <b>Conclusion:</b> Elevated Hcy level is an independent risk factor for cardiac surgery-associated AKI.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"51-57"},"PeriodicalIF":2.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139734528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biomarkers in medicinePub Date : 2024-01-01Epub Date: 2024-10-17DOI: 10.1080/17520363.2024.2400963
Lingling Wang, Yan Wang, Kang Yang, Xiaowen Hu, Guoliu Ye
{"title":"Roles of microRNA-486-5p in the diagnosis and the association with clinical symptoms of cervical cancer.","authors":"Lingling Wang, Yan Wang, Kang Yang, Xiaowen Hu, Guoliu Ye","doi":"10.1080/17520363.2024.2400963","DOIUrl":"10.1080/17520363.2024.2400963","url":null,"abstract":"<p><p><b>Aim:</b> To explore the predictive value of <i>miR-486-5p</i> in early cervical cancer and the associations of <i>miR-486-5p</i> with different clinical symptoms.<b>Materials & methods:</b> A total of 185 women were recruited. The relative expression levels of serum <i>miR-486-5p</i> were analyzed by real-time polymerase chain reaction. The receiver operator characteristic curves were utilized to reflect the predictive performance of <i>miR-486-5p</i> and squamous cell carcinoma antigen for early cervical cancer. Univariate logistic regression and ranked logistic regression were used to explore the associations of <i>miR-486-5p</i> with different clinical symptoms of early cervical cancer, with odd ratios (ORs) and 95% confidence intervals.<b>Results:</b> Eighty-one women (44.26%) had early cervical cancer. The relative expression of serum <i>miR-486-5p</i> was 1.99-fold higher in early cervical cancer patients than that in controls (<i>p</i> < 0.0001). The predictive performance of <i>miR-486-5p</i> for early cervical cancer was significantly superior to that of squamous cell carcinoma antigen, with an area under the curve of 0.865 (<i>p</i> < 0.001), sensitivity of 1.000 and specificity of 0.804. In addition, overexpressed <i>miR-486-5p</i> was associated with high odds of maximum tumor diameter increase (OR = 1.30, 95% CI: [1.01-1.66]).<b>Conclusion:</b> <i>MiR-486-5p</i> may be a potential biomarker for the early cervical cancer diagnosis, and was linked to the risk of maximum tumor diameter.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"869-876"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11508949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}