Albumin-bilirubin score: a promising predictor of postoperative distant metastasis in patients with colorectal cancer.

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI:10.1080/17520363.2025.2455928

Xiuying Shi, Shuyi Zhang, Baijun Bao, Hui Cong, Xiaomin Lu, Aijun Shi

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引用次数: 0

Abstract

Aim: The objective of this study was to investigate the prognostic significance of the preoperative serum albumin-bilirubin (ALBI) score in patients with colorectal cancer (CRC).

Methods: Preoperative ALBI data from 1506 CRC patients were categorized into high-value and low-value groups, and the clinicopathological characteristics of these groups were compared. A Cox proportional hazards regression model was employed to investigate the risk factors associated with distant metastasis. The Kaplan-Meier method and log-rank test were utilized to analyze the relationship between ALBI scores and 5-year distant metastasis-free survival (DMFS).

Results: The incidence of distant metastasis in group B (ALBI ≥ -2.4) was significantly higher at 28.81% compared to group A (ALBI < -2.4), which had an incidence of 23.36% (p = 0.018). ALBI score ≥ -2.4 was identified as an independent risk factor for postoperative distant metastasis of CRC (HR = 1.251, 95%CI: 1.021-1.533, p = 0.031). The incidence of 5-year DMFS was significantly lower in the ALBI ≥ -2.4 group compared to that observed in the ALBI < -2.4 group (χ² = 5.97, p = 0.015, log-rank test).

Conclusion: The ALBI score of ≥ -2.4 emerges as an independent risk factor for the occurrence of distant metastases following CRC surgery.

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白蛋白-胆红素评分：结直肠癌患者术后远处转移的一个有希望的预测指标。

目的：探讨术前血清白蛋白-胆红素（ALBI）评分对结直肠癌（CRC）患者预后的意义。方法：将1506例结直肠癌患者的术前ALBI数据分为高价值组和低价值组，比较两组患者的临床病理特征。采用Cox比例风险回归模型探讨与远处转移相关的危险因素。采用Kaplan-Meier法和log-rank检验分析ALBI评分与5年远端无转移生存期（DMFS）的关系。结果：B组（ALBI≥-2.4）远处转移发生率为28.81%，明显高于A组（ALBI < -2.4） 23.36% （p = 0.018）。ALBI评分≥-2.4为结直肠癌术后远处转移的独立危险因素（HR = 1.251, 95%CI: 1.021 ~ 1.533, p = 0.031）。ALBI≥-2.4组5年DMFS发生率显著低于ALBI < -2.4组（χ2 = 5.97, p = 0.015， log-rank检验）。结论：ALBI评分≥-2.4是结直肠癌术后远处转移发生的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.