{"title":"Clinical relevance of HRR (hemoglobin to RDW) and RAR (RDW to albumin) in pericarditis.","authors":"Hatice Eyiol, Azmi Eyiol, Ahmet Taha Sahin","doi":"10.1080/17520363.2025.2471743","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>This study evaluated the Hemoglobin to Red Cell Distribution Width Ratio (HRR) and Red Cell Distribution Width to Albumin Ratio (RAR) in acute pericarditis patients, exploring associations with clinical parameters.</p><p><strong>Methods: </strong>A retrospective cohort study included 257 patients diagnosed with acute pericarditis (2015-2023). Data on hemoglobin, RDW, albumin, treatments, hospital stay, and recurrence were analyzed using SPSS 27.0.</p><p><strong>Results: </strong>The mean age was 41 years. HRR averaged 1.067 ± 0.142, and RAR was 0.311. Men had higher hemoglobin and albumin levels, while women had higher platelet and HDL levels. Lower HRR correlated with severe conditions and recurrence, while higher RAR was linked to disease severity and recurrence. Both markers were strongly associated with pericardial effusion and IV steroid need.</p><p><strong>Conclusion: </strong>HRR and RAR are valuable biomarkers in acute pericarditis, aiding in assessing disease severity and guiding treatment.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-8"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers in medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17520363.2025.2471743","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Clinical relevance of HRR (hemoglobin to RDW) and RAR (RDW to albumin) in pericarditis.
Aim: This study evaluated the Hemoglobin to Red Cell Distribution Width Ratio (HRR) and Red Cell Distribution Width to Albumin Ratio (RAR) in acute pericarditis patients, exploring associations with clinical parameters.
Methods: A retrospective cohort study included 257 patients diagnosed with acute pericarditis (2015-2023). Data on hemoglobin, RDW, albumin, treatments, hospital stay, and recurrence were analyzed using SPSS 27.0.
Results: The mean age was 41 years. HRR averaged 1.067 ± 0.142, and RAR was 0.311. Men had higher hemoglobin and albumin levels, while women had higher platelet and HDL levels. Lower HRR correlated with severe conditions and recurrence, while higher RAR was linked to disease severity and recurrence. Both markers were strongly associated with pericardial effusion and IV steroid need.
Conclusion: HRR and RAR are valuable biomarkers in acute pericarditis, aiding in assessing disease severity and guiding treatment.
期刊介绍：
Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory.
Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice.
As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications.
Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest.
Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.
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