{"title":"TyG指数在预测急性冠状动脉综合征后左室低射血分数中的作用。","authors":"Ozlem Ozbek, Erdal Belen","doi":"10.1080/17520363.2025.2485017","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical and demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event.</p><p><strong>Methods & results: </strong>This retrospective cohort study included patients hospitalized with a diagnosis of ACS. The TyG index was calculated using the formula: TyG = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total of 2,135 patients were included in the study (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or reduced LVEF was associated with immigrant population (<i>p</i> = 0.004), diabetes mellitus (<i>p</i> = 0.017), previous coronary artery disease (CAD) (<i>p</i> < 0.001), ST-elevation myocardial infarction (STEMI) (<i>p</i> < 0.001) and high (≥4.95) TyG index (<i>p</i> < 0.001). Reduced LVEF (≤40%) was independently associated with an immigrant status (<i>p</i> = 0.031), previous CAD (<i>p</i> = 0.001), peripheral artery disease (<i>p</i> = 0.038), renal diseases (<i>p</i> = 0.011), STEMI (<i>p</i> < 0.001) and high (≥5.10) TyG index (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The TyG index shows potential as an independent risk factor for low LVEF after ACS.However, its relatively low sensitivity and specificity suggest that it may have a supportive role in risk stratification. Further research is needed to confirm its utility as a reliable prognostic marker for heart failure in ACS patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"267-275"},"PeriodicalIF":1.9000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980486/pdf/","citationCount":"0","resultStr":"{\"title\":\"The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome.\",\"authors\":\"Ozlem Ozbek, Erdal Belen\",\"doi\":\"10.1080/17520363.2025.2485017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical and demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event.</p><p><strong>Methods & results: </strong>This retrospective cohort study included patients hospitalized with a diagnosis of ACS. The TyG index was calculated using the formula: TyG = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total of 2,135 patients were included in the study (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or reduced LVEF was associated with immigrant population (<i>p</i> = 0.004), diabetes mellitus (<i>p</i> = 0.017), previous coronary artery disease (CAD) (<i>p</i> < 0.001), ST-elevation myocardial infarction (STEMI) (<i>p</i> < 0.001) and high (≥4.95) TyG index (<i>p</i> < 0.001). Reduced LVEF (≤40%) was independently associated with an immigrant status (<i>p</i> = 0.031), previous CAD (<i>p</i> = 0.001), peripheral artery disease (<i>p</i> = 0.038), renal diseases (<i>p</i> = 0.011), STEMI (<i>p</i> < 0.001) and high (≥5.10) TyG index (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The TyG index shows potential as an independent risk factor for low LVEF after ACS.However, its relatively low sensitivity and specificity suggest that it may have a supportive role in risk stratification. Further research is needed to confirm its utility as a reliable prognostic marker for heart failure in ACS patients.</p>\",\"PeriodicalId\":9182,\"journal\":{\"name\":\"Biomarkers in medicine\",\"volume\":\" \",\"pages\":\"267-275\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980486/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomarkers in medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/17520363.2025.2485017\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers in medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17520363.2025.2485017","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/29 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The role of TyG index in predicting low left ventricular ejection fraction after acute coronary syndrome.
Aims: This study aimed to investigate whether triglyceride-glucose (TyG) index and other clinical and demographic parameters are associated with left ventricular ejection fraction (LVEF) following an acute coronary syndrome (ACS) event.
Methods & results: This retrospective cohort study included patients hospitalized with a diagnosis of ACS. The TyG index was calculated using the formula: TyG = ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A total of 2,135 patients were included in the study (mean age: 57.49 ± 11.45 years, 78.64% male). Multivariable logistic regression revealed that mildly reduced or reduced LVEF was associated with immigrant population (p = 0.004), diabetes mellitus (p = 0.017), previous coronary artery disease (CAD) (p < 0.001), ST-elevation myocardial infarction (STEMI) (p < 0.001) and high (≥4.95) TyG index (p < 0.001). Reduced LVEF (≤40%) was independently associated with an immigrant status (p = 0.031), previous CAD (p = 0.001), peripheral artery disease (p = 0.038), renal diseases (p = 0.011), STEMI (p < 0.001) and high (≥5.10) TyG index (p < 0.001).
Conclusions: The TyG index shows potential as an independent risk factor for low LVEF after ACS.However, its relatively low sensitivity and specificity suggest that it may have a supportive role in risk stratification. Further research is needed to confirm its utility as a reliable prognostic marker for heart failure in ACS patients.
期刊介绍：
Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory.
Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice.
As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications.
Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest.
Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.
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