HOTAIR表达作为多形性胶质母细胞瘤的生物标志物：对现有证据的综合荟萃分析

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarkers in medicine Pub Date : 2025-02-01 Epub Date: 2025-01-27 DOI:10.1080/17520363.2025.2455925

Arefeh Bahranian, Mehdi Koshki, Fargol Farahmandi, Kourosh Eftekharian, Samaneh Hemmati, Mahboobe Sattari, Alireza Zali, Ghodratollah Panahi

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引用次数: 0

摘要

目的：多形性胶质母细胞瘤是一种侵袭性脑肿瘤。这项荟萃分析调查了HOTAIR表达水平与GBM之间的关系。方法：检索文献，研究HOTAIR在GBM患者中的表达情况。对9项研究进行荟萃分析，使用随机效应模型评估标准化平均差（SMD）和95%置信区间（ci）。根据样本来源、国家和研究设计进行亚组分析。此外，我们还进行了meta回归和发表偏倚分析。结果：meta分析发现HOTAIR表达升高与GBM呈正相关（SMD = 8.3, 95% CI 5.8-10.8, p = 0.00）。异质性显著（q值：1174.2,df = 9, I2 = 99.2%, p = 0.00）。亚组分析表明，在美国和中国的组织样本和研究中存在显著关联。meta回归显示，研究设计和国家对观察到的异质性有影响，未发现显著的发表偏倚。结论：该分析证实了HOTAIR表达与GBM之间的显著联系，突出了HOTAIR作为潜在的治疗靶点和生物标志物。需要进一步的研究来阐明这种关联所涉及的生物学机制。

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HOTAIR expression as a biomarker in glioblastoma multiforme: a comprehensive meta-analysis of current evidence.

Purpose: Glioblastoma multiforme (GBM) is an aggressive brain tumor. This meta-analysis investigates the association between HOTAIR expression levels and GBM.

Methods: We searched the literature for studies on HOTAIR expression in GBM patients. A meta-analysis of nine studies assessed standardized mean difference (SMD) and 95% confidence intervals (CIs) using a random-effects model. Subgroup analyses were performed based on sample source, country, and study design. Additionally, we conducted meta-regression and publication bias analyses.

Results: The meta-analysis found a significant positive association between elevated HOTAIR expression and GBM (SMD = 8.3, 95% CI 5.8-10.8, p = 0.00). Considerable heterogeneity was observed (Q-value: 1174.2, df = 9, I² = 99.2%, p = 0.00). Subgroup analyses indicated significant associations in tissue samples and studies from the USA and China. Meta-regression revealed that study design and country contributed to the observed heterogeneity, with no significant publication bias detected.

Conclusion: This analysis confirms the significant link between HOTAIR expression and GBM, highlighting HOTAIR as a potential therapeutic target and biomarker. Further research is necessary to clarify the biological mechanisms involved in this association.

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.