BMC Rheumatology最新文献

{"title":"Associations between interleukin-37 gene polymorphisms and susceptibility and clinical outcomes of rheumatoid arthritis: a meta-analysis and systematic review.","authors":"Zihan Zhao, Wenwen Yu, Huapei Qiu, Yuehong Chen","doi":"10.1186/s41927-026-00624-0","DOIUrl":"10.1186/s41927-026-00624-0","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight loss ameliorates symptoms of osteoarthritis and is correlated with alterations in soluble bone and cartilage markers: an analysis of patient-reported outcomes and biomarkers.","authors":"Anne-Christine Bay-Jensen, Khaled Mohamed, Peder Frederiksen, Asger Bihlet, Christian Thudium, Kim Henriksen, Morten Karsdal","doi":"10.1186/s41927-026-00628-w","DOIUrl":"10.1186/s41927-026-00628-w","url":null,"abstract":"<p><strong>Background: </strong>Drug development for osteoarthritis (OA) has faced significant challenges, mainly due to the lack of alignment between joint structure observations and patient-reported outcomes (PROs), such as pain. Weight loss has been linked to positive effects on symptomatic outcomes. Blood-based biomarkers indicating collagen and extracellular matrix turnover can be used to measure injury severity in specific tissues, offering a more precise assessment of disease progression. This study aimed to explore the relationship between obesity and PROs and its impact on serum and urinary biomarkers of bone (CTX-I and osteocalcin), synovial (type III collagen degradation and C3M), and cartilage (type II collagen degradation, CTX-II, and C2M) turnover.</p><p><strong>Methods: </strong>This post hoc exploratory analysis examined data from 806 patients with persistent knee OA pain who participated in two clinical trial of oral salmon calcitonin (NCT00704847 [2008-06] and NCT00486434 [2007-06]. Participants were categorized by baseline BMI (lean, overweight, and obese) and two-year weight change (gain/loss ≥5%). Biomarkers were measured at baseline and at the 2-year follow-up.</p><p><strong>Results: </strong>The cohort primarily consisted of white women, with a median age of 64 years and a median BMI of 29 kg/m². WOMAC total scores, function, and stiffness were significantly higher in obese patients than in overweight and lean patients; however, pain scores did not differ significantly. WOMAC total, function, and pain scores significantly improved in patients who lost or maintained their weight compared with those who gained weight. The bone resorption biomarker CTX-I increased by 1.58-fold [95% CI 1.39, 1.81], 1.37-fold [1.28, 1.47], and 1.11-fold [0.95, 1.28] in the weight loss, stable weight, and weight gain groups, respectively. The cartilage degradation marker C2M increased by 1.15-fold [0.95, 1.39], whereas the interstitial matrix degradation marker C3M decreased by 0.84-fold [0.73, 0.97] in the weight loss group.</p><p><strong>Conclusion: </strong>Obesity exacerbates OA symptoms. While weight loss improves symptoms and reduces synovial inflammation, measured by biomarkers, it may also heighten the risk of excessive bone and cartilage loss, when using specific collagen degradation biomarkers. This study is a post-hoc analysis of data from the CSMC trials with clinicaltrial.gov numbers NCT00704847 (2008-06-24) and NCT00486434 (2007-06-14).</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-course prednisone and methotrexate in a cohort of patients with polymyalgia rheumatica: a potential therapeutic approach.","authors":"Edoardo Conticini, Raffaele Truscelli, Silvia Grazzini, Paolo Falsetti, Caterina Baldi, Alessandra Cartocci, Luca Cantarini, Bruno Frediani","doi":"10.1186/s41927-026-00626-y","DOIUrl":"10.1186/s41927-026-00626-y","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular joint disorders in patients with systemic sclerosis: a cross-sectional study.","authors":"Kiana Azadpeyma, Seyed Habib Zayeni, Pooneh Ghavidel Parsa, Pedram Hajibagheri, Maryam Basirat","doi":"10.1186/s41927-026-00629-9","DOIUrl":"10.1186/s41927-026-00629-9","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13041254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rheumatry registry: design and data collection methods.","authors":"Mehrdad Mahalleh, Mahdi Mahmoudi, Mohammad Tanhaei, Ahmadreza Jamshidi","doi":"10.1186/s41927-026-00627-x","DOIUrl":"10.1186/s41927-026-00627-x","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation of the Bulgarian Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire: linking quality of life with disease activity in axial spondyloarthritis.","authors":"Daliya Tsvetanova Pencheva, Ellie Johnstone, Mariusz T Grzeda, Vladimira Boyadzhieva, Nikolay Stoilov, Mariana Ivanova","doi":"10.1186/s41927-026-00631-1","DOIUrl":"10.1186/s41927-026-00631-1","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13037290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of IV cyclophosphamide and mycophenolate mofetil in the treatment of childhood-onset lupus nephritis in a resource-limited setting.","authors":"Adrienne Katrin M Guiang-Valerio, Ma Theresa M Collante, Christine B Bernal","doi":"10.1186/s41927-026-00630-2","DOIUrl":"10.1186/s41927-026-00630-2","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13001190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence (AI) in rheumatology: a comparative evaluation of the ChatGPT and DeepSeek application.","authors":"Maria Polyzou, Xenofon Baraliakos","doi":"10.1186/s41927-026-00618-y","DOIUrl":"10.1186/s41927-026-00618-y","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"10 1","pages":"13"},"PeriodicalIF":2.5,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12896147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"What do you want this information for?\": cognitive interviews with arthritis researchers to inform the development of a health equity-focused demographic survey for outcomes research.","authors":"Megan M Thomas, Niki Oveisi, Charlene E Ronquillo, Mark Harrison, Cheryl Barnabe, Codie Primeau, J Antonio Avina-Zubieta, Anna Samson, Michael Kuluva, Natasha Trehan, Nikki Bhatti, Ani Methi, Mary A De Vera","doi":"10.1186/s41927-026-00614-2","DOIUrl":"10.1186/s41927-026-00614-2","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of effective contraceptive use among patients with rheumatic diseases: a descriptive study.","authors":"Mayalen Uthurriague, Charlotte Delattre, Thomas Barnetche, Estibaliz Lazaro, Marie-Elise Truchetet, Claude Hocke, Nadia Mehsen-Cetre, Valérie Bernard, Christophe Richez","doi":"10.1186/s41927-026-00616-0","DOIUrl":"10.1186/s41927-026-00616-0","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}