BMC Rheumatology最新文献

{"title":"The associations between age, familial occurrence of fibromyalgia, and symptom severity in fibromyalgia: a cross-sectional study from a Finnish health center.","authors":"Gretel Raudasoja, Aleksi Varinen","doi":"10.1186/s41927-026-00651-x","DOIUrl":"https://doi.org/10.1186/s41927-026-00651-x","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia is a functional syndrome characterized by musculoskeletal pain and a variety of associated symptoms. Previous research has shown that close relatives are at a higher risk of developing the syndrome compared to the general population. Previous findings also suggest that symptoms tend to decrease with age. Our primary objective is to examine whether having a close relative with fibromyalgia is associated with greater symptom severity among patients in primary care. In addition, we assess the relationship between age and symptom severity.</p><p><strong>Methods: </strong>The study is based on a cross-sectional design. The data were collected at the Nokia Health Centre, Finland, in 2016. Patients meeting the ACR 2010 criteria were included in this study (n = 91). We used three validated questionnaires to assess disease severity (PSD, FIQ and EQ-VAS) and patient-reported information on fibromyalgia in a close relative.</p><p><strong>Results: </strong>The independent-samples t-test was used to examine the association. Participants were divided into four age groups, and differences in symptom severity between age groups were assessed using one-way analysis of variance (ANOVA). There were no statistically significant differences between family history and symptom severity, nor age groups and symptom severity. Furthermore, there was no statistically significant linear association between age and symptom severity, nor between symptom severity and family history of fibromyalgia. These findings remained unchanged after adjusting for family history. However, given the lack of statistical significance and our small sample size, these observations should be interpreted cautiously.</p><p><strong>Conclusions: </strong>Symptom severity and functional limitations appeared broadly similar across age groups in our sample, which may suggest that increasing age is not necessarily associated with substantial symptom relief. However, these findings should be interpreted with caution given the cross-sectional design and small sample size.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parity, body mass index, smoking and risk of rheumatoid arthritis: data from the Australian Longitudinal Study on Women's Health.","authors":"Louise Koller-Smith, Ahmed Mehdi, Syeda Farah Zahir, Lyn March, Leigh Tooth, Gita D Mishra, Ranjeny Thomas","doi":"10.1186/s41927-026-00643-x","DOIUrl":"https://doi.org/10.1186/s41927-026-00643-x","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13141528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of non-radiographic to radiographic axial spondyloarthritis: a risk model based on a chinese cohort study.","authors":"Rui-Ying Deng, Xiao-Jia Xu, Jian-Hua Peng, Feng-Cai Shen, Yao Gong, Dan-Min Wang, Hong-Jin Liang, Shu-Xin Huang, Zhao-Peng Chen, Wen-Long Wu, Ze-Xin Zheng, Ling Lin, Zhi-Duo Hou","doi":"10.1186/s41927-026-00652-w","DOIUrl":"https://doi.org/10.1186/s41927-026-00652-w","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the progression from non-radiographic axial spondyloarthritis (nr-axSpA) to radiographic axial spondyloarthritis (r-axSpA) in a Chinese cohort, identify associated risk factors in both clinical and imaging arms, and enable risk stratification based on these factors.</p><p><strong>Methods: </strong>Overall, 572 patients with nr-axSpA were enrolled with a median follow-up of 5 years. Cox proportional hazard regression analyses were conducted to identify potential risk factors associated with the progression from nr-axSpA to r-axSpA in both clinical and imaging arms. A risk-scoring system was then developed by assigning each independent predictor a weight based on its regression coefficient. Patients were subsequently categorized into low-, medium-, and high-risk groups according to their cumulative scores.</p><p><strong>Results: </strong>By the end of follow-up, 40.2% of nr-axSpA patients had progressed to r-axSpA, more frequently in the imaging arm than in the clinical arm (56.1% vs. 17.4%, P < 0.001). Multivariate Cox regression analysis showed that unilateral grade II radiographic sacroiliitis and high disease activity (ASDAS-CRP > 2.1) were significant predictors of progression in both the imaging arm (HR = 2.00, 95% CI 1.40-2.86 and HR = 2.38, 95% CI 1.30-4.34, respectively) and the clinical arm (HR = 6.28, 95% CI 2.73-14.48 and HR = 3.68, 95% CI 1.08-12.51, respectively). HLA-B27 positivity (HR = 2.67, 95% CI 1.72-4.11) in the imaging arm and a family history of spondyloarthritis (HR = 2.72, 95% CI 1.18-6.28) in the clinical arm were associated with increased progression risk. Based on these factors, a predictive model classified patients into low-, medium-, and high-risk groups. In the imaging arm, the model achieved AUCs of 0.839, 0.777, and 0.807 for 3-, 5-, and 10-year progression rates, respectively; in the clinical arm, the corresponding AUCs were 0.660, 0.780, and 0.820.</p><p><strong>Conclusions: </strong>In the imaging arm, nr-axSpA patients progress to r-axSpA more rapidly and frequently than those in the clinical arm. Risk factors include unilateral grade II sacroiliitis, high disease activity, HLA-B27 positivity, and SpA family history. A risk scoring system was developed for progression prediction and personalized management. Large-scale prospective multicenter studies are needed to validate its clinical utility across diverse populations.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of disease duration on forefoot involvement in rheumatoid arthritis remission: clinical, ultrasound, and radiographic insights.","authors":"Rebeca Bueno Fermoso, Jose Luis Maté-Muñoz, Carmen Martínez Rincón, Juan Miguel López González, Rubén Sánchez-Gómez, Maria Luz González Fernández","doi":"10.1186/s41927-026-00649-5","DOIUrl":"https://doi.org/10.1186/s41927-026-00649-5","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) frequently affects the forefoot, causing pain and deformity even in remission. Subclinical inflammation may persist and vary with disease duration. This study aimed to compare clinical, ultrasound, and radiographic features of the forefoot in RA remission with metatarsalgia according to disease duration (< 10 vs. ≥ 10 years).</p><p><strong>Methods: </strong>Cross-sectional study including 84 RA patients in remission (DAS28 < 2.6) with metatarsalgia: 33 with < 10 and 51 with ≥ 10 years of disease duration. Clinical, biomechanical, ultrasound (B-mode and Power Doppler (PD), and radiographic variables were assessed by blinded evaluators.</p><p><strong>Results: </strong>The ≥ 10-year group showed greater structural burden. Total synovitis was similar between groups, more frequent at central metatarsophalangeal joints (MTPs) (particularly MTP2 in < 10 years), and PD was rare (6%). The overall pattern was consistent with early MTP1/5 involvement and progressive structural accumulation at MTP2-4, with higher odds of erosions (OR 3.5-5.0), joint space narrowing (JSN; OR 2.8-4.4), and subluxations (MTP2 OR 5.31; MTP3 OR 2.50) in the ≥ 10-year group.</p><p><strong>Conclusions: </strong>In RA remission with metatarsalgia, our findings are consistent with early structural involvement at MTP1/MTP5 and more frequent B-mode synovitis at central joints, with progressive structural burden at MTP2-4 as disease duration increases. PD positivity was uncommon (6%), whereas ultrasound remained essential to detect synovitis. Our findings support systematic assessment of all MTP joints (MTP1-5), with particular attention to MTP1/MTP5 in earlier disease and careful structural evaluation of central rays in longer disease duration. As a cross-sectional study, temporal or causal sequences cannot be inferred.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative biologic use and postoperative outcomes in patients with inflammatory arthritis: a systematic review.","authors":"Samantha Brady, Johanna Taylor, Katie Carlisle, Joy Adamson, Helen Fulbright, Catherine Hewitt, Laura Mandefield, Kulveer Mankia, Hemant Pandit, Andrew Mott","doi":"10.1186/s41927-026-00650-y","DOIUrl":"https://doi.org/10.1186/s41927-026-00650-y","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of continuing versus stopping biologic disease-modifying anti-rheumatic drugs (bDMARDs) during the perioperative period on surgical site infections (SSIs), delayed wound healing, and disease flares in patients with inflammatory arthritis (IA) undergoing elective non-orthopaedic surgery.</p><p><strong>Methods: </strong>We conducted a systematic review of observational studies assessing the perioperative management of bDMARDs in IA patients undergoing elective non-orthopaedic surgery. Searches were conducted across seven databases and trial registries from the year 2000 onwards. Eligible studies compared outcomes in patients who continued versus stopped biologic therapy. Risk of bias was assessed using the ROBINS-I tool and due to heterogeneity data were synthesised narratively.</p><p><strong>Results: </strong>Eight observational studies met the inclusion criteria. All studies were at moderate or serious risk of bias. Four studies compared infections with two suggesting higher infection rates in the stop biologic group. Two studies assessed delayed wound healing, both suggesting higher rates in the stop group. Disease flares were more common in patients who stopped biologics in all three of the studies reporting this outcome. No studies assessed health-related quality of life.</p><p><strong>Conclusions: </strong>The available observational evidence does not demonstrate a consistent increase in postoperative infection or wound complications related to biologic continuation, however, confidence in these findings is limited by serious risk of bias and outcome heterogeneity. High-quality randomised controlled trials are needed to inform the perioperative management guidelines for IA patients undergoing elective non-orthopaedic procedures.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating uncertainty: Experience of individuals living with systemic lupus erythematosus.","authors":"Sital Gautam, Susan Maharjan, Babita Budhathoki, Anju Poudel","doi":"10.1186/s41927-026-00647-7","DOIUrl":"https://doi.org/10.1186/s41927-026-00647-7","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-sparing strategies in polymyalgia rheumatica: a systematic review and meta-analysis of tocilizumab with practical guidance for tapering.","authors":"Musa Khan Bungish, Maheen Mohsan, Hareem Farooq, Muhammad Talha Shaukat, Wania Ur Rehman, Ahmed Talal Murtaza, Arooj Fatima, M Hasnat Akhtar, Hassan Farooq, Amna Mufti, Salman Sarwar, Aqeeb Ur Rehman, Aleenah Mohsin","doi":"10.1186/s41927-026-00625-z","DOIUrl":"https://doi.org/10.1186/s41927-026-00625-z","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147762416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Correlations among quality of life, spinal mobility, and disease activity in early-treated axial spondyloarthritis: a single-center cross-sectional study.","authors":"Tinh Khampaen, Thanuchporn Kafaksom, Nichapa Dechapaphapitak, Nattakirana Tongdee, Parawee Chevaisrakul","doi":"10.1186/s41927-026-00644-w","DOIUrl":"10.1186/s41927-026-00644-w","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147670041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carpal tunnel syndrome in systemic sclerosis: prevalence, clinical correlates, and diagnostic performance of ultrasound compared with nerve conduction studies.","authors":"Daniela Nicoleta Popescu, Claudiu C Popescu, Oana Morari, Daniela Anghel, Alina Dima, Ioana Adriana Catanoiu, Alice Rakoczy, Magda Ileana Parvu, Mirela Alina Enache, Cătălin Codreanu, Luminita Enache","doi":"10.1186/s41927-026-00645-9","DOIUrl":"https://doi.org/10.1186/s41927-026-00645-9","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world treatment courses after anti-TNF de-escalation in older adults with rheumatoid arthritis: a medicare cohort study.","authors":"Jiha Lee, Jonathan Martindale, Una E Makris, Julie P W Bynum","doi":"10.1186/s41927-026-00642-y","DOIUrl":"https://doi.org/10.1186/s41927-026-00642-y","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}