BMC Rheumatology最新文献

{"title":"Studying the effect of self-care education based on conceptual mapping on the pain severity of patients with rheumatoid arthritis: A non-randomized quasi-experimental study.","authors":"Nasrin Rasoulzadeh, Navid Dadashi, Zahra Rooddehghan, Raoofeh Karimi","doi":"10.1186/s41927-025-00553-4","DOIUrl":"10.1186/s41927-025-00553-4","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"107"},"PeriodicalIF":2.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of writing based on self-compassion on body image and psychological distress among women with systemic lupus erythematosus: a randomized clinical trial.","authors":"Kimya Amouei, Arpi Manookian, Seyedeh Tahereh Faezi, Leila Sayadi","doi":"10.1186/s41927-025-00565-0","DOIUrl":"10.1186/s41927-025-00565-0","url":null,"abstract":"<p><strong>Background: </strong>Women with systemic lupus erythematosus (SLE) are at risk for body image (BI) disturbances and its resultant psychological distress (PD). The aim of this study was to examine the effects of self-compassion (SC)-based writing on BI and PD among women with SLE.</p><p><strong>Methods: </strong>In this randomized clinical trial, which was done in 2022-2023, 86 women with SLE were selected and randomly allocated to an intervention group (IG) and a control group (CG). Participants in the IG were instructed to engage in SC-based writing that emphasized the concepts of common humanity, mindfulness, and self-kindness. Six blank pages were provided, each featuring a question related to self-compassion for participants to address. Conversely, the CG was also provided with papers and asked to respond to questions that were unrelated to SC. Data were collected before, immediately after, and one month after the intervention (T1-T3) using a demographic and clinical characteristics questionnaire, the SLE Disease Activity Index, the Body Image Lupus Scale(BILS), the Depression Anxiety Stress Scale, the Self-Compassion Scale, and the Body Image Quality of Life Inventory(BIQLI). The SPSS software (v. 22.0) was employed for data analysis.</p><p><strong>Results: </strong>Groups did not significantly differ from each other respecting baseline demographic and clinical characteristics and baseline mean scores of the main study outcomes. However, there were significant between-group differences respecting the mean scores of BI (P = 0.028), stress (P = 0.003), anxiety (P = 0.003), and SC (P < 0.001) at T2 and the mean scores of stress (P = 0.023), anxiety (P = 0.029), and SC (P < 0.001) at T3. Moreover, between-group differences respecting the other study outcomes at T2 and T3 were insignificant (P > 0.05).</p><p><strong>Conclusions: </strong>SC-based writing significantly increases SC among women with SLE. Patients may be encouraged to engage in SC-based writing through education about this technique. Investigating alternative strategies or implementing the intervention at different time intervals may be beneficial for improving the BILS, PD, and BIQLI.</p><p><strong>Trial registration: </strong>This study was registered in the Iranian Registry of Clinical Trials in February 14, 2022 (code: IRCT20220107053656N1).</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"106"},"PeriodicalIF":2.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of PTPN22 and PADI4 polymorphisms with rheumatoid arthritis in ASWAN.","authors":"Khaled A A Abdelgalil, Nihal Fathi, Fatma H El Nouby, Nour A Mohammed, Loay I Aglan","doi":"10.1186/s41927-025-00566-z","DOIUrl":"10.1186/s41927-025-00566-z","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"105"},"PeriodicalIF":2.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitators influencing participation in digitally-based high-intensity interval training among individuals with axial spondyloarthritis - a qualitative study.","authors":"Anna Torell, Emelie Wiking, Ingrid Larsson, M Charlotte Olsson, Emma Haglund","doi":"10.1186/s41927-025-00567-y","DOIUrl":"10.1186/s41927-025-00567-y","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"104"},"PeriodicalIF":2.5,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of virtual rheumatology care on patient outcomes and hospital admissions: an ambispective study.","authors":"Ummugulsum Gazel, Tommy Han, Seyyid Bilal Acikgoz, Tara Swami, Ricardo Sabido-Sauri, Hart Goldhar, Nataliya Milman, Nancy Maltez, Catherine Ivory, Susan Humphrey-Murto, Sibel Aydin","doi":"10.1186/s41927-025-00558-z","DOIUrl":"10.1186/s41927-025-00558-z","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"103"},"PeriodicalIF":2.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and outcomes of anti-MDA5 dermatomyositis: a retrospective study.","authors":"Tulaton Sodsri, Tananchai Petnak, Thitiporn Suwatanapongched, Chayanin Nitiwarangkul, Nantakarn Pongtarakulpanit, Pintip Ngamjanyaporn","doi":"10.1186/s41927-025-00556-1","DOIUrl":"10.1186/s41927-025-00556-1","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"102"},"PeriodicalIF":2.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High ischemic deficit in computed tomography perfusion is a risk factor for cerebral vascular ischemic events in Takayasu arteritis: a prospective observational study.","authors":"Rongyi Chen, Ying Sun, Ying Liu, Jing Ding, Lindi Jiang","doi":"10.1186/s41927-025-00551-6","DOIUrl":"10.1186/s41927-025-00551-6","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"100"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient characteristics and adverse effects of allogeneic blood transfusion following lower extremity joint replacement in rheumatoid arthritis: a nationwide inpatient sample database study.","authors":"Wenyan Geng, Lulu Ye, Xuegao Yu, Qinfeng Yang, Linlin Wang, Xiaodan Li, Qing Xiao, Jian Wang","doi":"10.1186/s41927-025-00554-3","DOIUrl":"10.1186/s41927-025-00554-3","url":null,"abstract":"<p><strong>Objectives: </strong>Allogeneic blood transfusion is a common therapeutic intervention for patients with rheumatoid arthritis (RA) undergoing lower extremity joint replacement (LEJR). Despite the potential for adverse outcomes associated with blood transfusion, the risks related to this procedure in RA patients remain underexplored, particularly within the framework of a large-scale national dataset.</p><p><strong>Methods: </strong>This study analyzed data from the National Inpatient Sample (NIS) database from 2010 to 2019, identifying 66,674 patients diagnosed with RA who underwent LEJR. These cases were subsequently divided into two groups based on whether they received blood transfusion. Univariate and multivariate logistic regression analyses were conducted on patient demographics, the prevalence of comorbidities, hospital-level characteristics, total financial charges, insurance coverage, and in-hospital mortality rates.</p><p><strong>Results: </strong>The cumulative blood transfusion rate among RA patients undergoing LEJR was 10.9%, showing a declining trend over the study period (from 23.79% in 2010 to 3.67% in 2019). Several factors were associated with an increased likelihood of receiving blood transfusion, including advanced age (≥ 65 years), female sex, deficiency anemia, chronic blood loss anemia, weight loss, coagulopathy, fluid and electrolyte imbalances, neurological disorders, pulmonary circulatory disturbances, congestive heart failure, chronic kidney disease, and uncomplicated diabetes. Moreover, patients who received blood transfusion demonstrated a higher risk of specific complications, including wound infection, acute myocardial infarction, pneumonia, acute kidney injury, urinary tract infection, postoperative delirium, deep vein thrombosis, lower limb nerve injury, sepsis, and respiratory failure.</p><p><strong>Conclusion: </strong>Thorough preoperative assessment is essential for identifying RA patients who were more likely to receive blood transfusion and be subjected to adverse outcomes. Proactive interventions during the perioperative period, coupled with the implementation of a comprehensive blood management strategy, can optimize blood transfusion in RA patients after LEJR.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"101"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avacopan is effective in inducing remission for MPA/GPA, regardless of changes in serum C5a levels: a single-center study in Japan.","authors":"Yusuke Ushio, Hiromi Shimada, Risa Wakiya, Shusaku Nakashima, Taichi Miyagi, Koichi Sugihara, Rina Mino, Mao Mizusaki, Kanako Chujo, Naoto Manabe, Norimitsu Kadowaki, Hiroaki Dobashi","doi":"10.1186/s41927-025-00555-2","DOIUrl":"10.1186/s41927-025-00555-2","url":null,"abstract":"<p><strong>Background: </strong>Avacopan, a selective oral C5a receptor antagonist, was approved for the treatment of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) in 2021. However, there are still limited reports on its efficacy and safety in real-world settings, specifically regarding its impact on the Vasculitis Damage Index (VDI), and its effects on serum biomarkers are poorly understood. This study aimed to evaluate the efficacy and safety of avacopan in remission induction therapy for MPA/GPA in a real-world setting, as well as its effect on serum C5a levels.</p><p><strong>Methods: </strong>This retrospective study investigated patients with MPA/GPA who received remission induction therapy with a 6-month follow-up at our institution, comparing those who received avacopan with those who did not. Efficacy and safety were evaluated by comparing the remission rate, changes in Birmingham Vasculitis Activity Score (BVAS) and VDI score after 6 months, daily glucocorticoid (GC) dose, and incidence of adverse events (AEs). Changes in serum C5a levels, measured using ELISA, were compared between both groups at baseline and 3 months.</p><p><strong>Results: </strong>A total of 66 patients with MPA/GPA were included, with 14 and 52 patients in the avacopan and non-avacopan groups, respectively. The remission rate and decrease in BVAS was comparable between both groups. However, those who received avacopan had a significantly smaller increase in VDI score, significantly lower daily GC dose at 1, 3, and 6 months, and significantly lower incidence of GC-related AEs within 6 months. Serum C5a levels did not significantly change in the avacopan group but significantly decreased in the non-avacopan group. Remission was achieved in the avacopan group regardless of whether serum C5a decreased or increased.</p><p><strong>Conclusions: </strong>Treatment with avacopan appears to effectively suppress the increase in VDI score, enable reduced GC dosage, and lower the incidence of GC-related AEs during remission induction therapy for MPA/GPA in a real-world setting. Furthermore, avacopan may suppress disease activity regardless of serum C5a levels.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"99"},"PeriodicalIF":2.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of socio-demographic factors on health-related quality of life in patients with inflammatory joint diseases.","authors":"Stefka Stoilova, Daniela Taneva, Mariela Geneva-Popova, Teodora Dimcheva, Stanislava Popova-Belova","doi":"10.1186/s41927-025-00550-7","DOIUrl":"10.1186/s41927-025-00550-7","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to describe differences in self-reported health-related quality of life (HRQoL) for patients with inflammatory joint disease (IJD) related to sociodemographic factors.</p><p><strong>Methods: </strong>The data were collected through an anonymous survey in a cross-sectional study of 261 patients with IJD- rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). The patients' health status was assessed using a standard questionnaire [EQ-5D-3L].</p><p><strong>Results: </strong>The results showed no significant differences related to the type of JDC in any domain of patients' quality of life. Among the demographic factors, social status showed a significant association with all aspects of patients' HRQoL: mobility ratings (p = 0.002), self-care ratings (p < 0.001), usual activities (p < 0.001), pain or discomfort (p = 0.039), anxiety or depression (p = 0.001). Anxiety and depression were more common among women than men (p = 0.033). Men rated their health higher on the EQ-VAS scale (p = 0.036). Working patients reported better health than retirees (p = 0.008), and disability pensioners (p < 0.001). Better health was associated with higher levels of education (p < 0.001). Patients with elementary education provided the lowest ratings while patients with higher degrees gave the highest ratings. Patients living in villages reported better health than those from urban areas (p = 0.019). Social class, education, and place of residence accounted for 17.9% of the variance in EQ-VAS scores.</p><p><strong>Conclusion: </strong>Understanding the role of sociodemographic factors is crucial to promote improved patient care and better healthcare resources. The results of our study can serve as a benchmark for future studies to assess the influence of sociodemographic factors among patients with other subtypes of IJD.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":"9 1","pages":"97"},"PeriodicalIF":2.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}