BMC Rheumatology最新文献

{"title":"Non-specific ST-T abnormalities are associated with major adverse cardiovascular and cerebrovascular events (MACCE) in hospitalized systemic lupus erythematosus patients.","authors":"Chen Jie, Lu Shidie, Zhou Xiaoli","doi":"10.1186/s41927-026-00641-z","DOIUrl":"https://doi.org/10.1186/s41927-026-00641-z","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the prevalence of non-specific ST-segment and T-wave abnormalities (NSSTTA) in patients with SLE and evaluate the predictive value of NSSTTA indices for major adverse cardiovascular and cerebrovascular events (MACCE) in SLE patients.</p><p><strong>Methods: </strong>This study retrospectively enrolled 395 hospitalized SLE patients and 420 controls from health examinations, during the period from January 1, 2014, to December 31, 2024. After propensity score matching (PSM), ECG indices were compared between the SLE group and the control group. Multivariable Cox regression analysis was used to assess the association between NSSTTA and MACCE.</p><p><strong>Results: </strong>Compared with the control cohort, patients with SLE demonstrated significantly higher prevalence rates of NSSTTA (16.7% vs. 6.4%, p < 0.001). Multivariable Cox proportional hazards analysis further identified advancing age (HR = 1.027, 95% CI: 1.002-1.053, p = 0.033), comorbid interstitial lung disease (ILD, HR = 3.024, 95% CI: 1.477-6.193, p = 0.002), non-specific ST-T abnormalities (HR = 3.082, 95% CI: 1.209-7.853, p = 0.018), and elevated serum uric acid (HR = 1.004, 95% CI: 1.001-1.007, p = 0.021) as independent predictors for MACCE in the SLE cohort.</p><p><strong>Conclusions: </strong>NSSTTA are independently associated with adverse outcomes and facilitate cardiovascular risk stratification in patients with SLE.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum ICAM-1 and VCAM-1 as markers of endothelial activation in ankylosing spondylitis and psoriatic arthritis: a cross-sectional study.","authors":"Miroslav Markov, Maria Dimova, Simona Bogdanova, Trifon Chervenkov, Tsvetoslav Georgiev","doi":"10.1186/s41927-026-00640-0","DOIUrl":"https://doi.org/10.1186/s41927-026-00640-0","url":null,"abstract":"<p><strong>Background: </strong>Patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA) have increased cardiovascular risk beyond traditional factors. Endothelial activation is an early and potentially reversible stage of atherogenesis, and circulating adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) have been proposed as markers of vascular involvement in inflammatory diseases. This study aimed to compare serum ICAM-1 and VCAM-1 levels in patients with ankylosing spondylitis and psoriatic arthritis versus controls, and to examine their associations with disease activity, systemic inflammatory burden, cardiovascular risk profile, and treatment status.</p><p><strong>Methods: </strong>This cross-sectional study included 154 participants recruited between 2023 and 2024, including 83 patients with AS, 40 with PsA, and 31 controls. Disease activity was assessed using ASDAS-CRP (AS) and DAS28-CRP (PsA). Inflammatory markers, lipid profile, cardiovascular risk scores, and treatment history were recorded. Serum ICAM-1 and VCAM-1 concentrations were measured by enzyme-linked immunosorbent assay. Group comparisons used Kruskal-Wallis and Mann-Whitney U tests; correlations used Spearman or Pearson coefficients as appropriate. Multivariable linear regression was applied to identify independent predictors of VCAM-1.</p><p><strong>Results: </strong>Serum VCAM-1 and ICAM-1 levels did not differ significantly between AS, PsA, and controls. VCAM-1 showed positive correlations with C-reactive protein (ρ = 0.247, p = 0.002) and erythrocyte sedimentation rate (ρ = 0.163, p = 0.044), whereas ICAM-1 showed no significant associations with inflammatory, metabolic, or vascular parameters. In multivariable analysis, body mass index was the only independent predictor of VCAM-1 (β = 0.198, p = 0.027). In AS, higher disease activity defined by ASDAS-CRP > 2.1 was associated with higher CRP (p = 0.002), ESR (p = 0.04), and VCAM-1 concentrations (p = 0.002). Biologic-naïve patients had higher VCAM-1 levels than treated patients (p = 0.046), while those receiving Janus kinase inhibitors had lower VCAM-1 compared with biologic-naïve individuals (p = 0.014).</p><p><strong>Conclusions: </strong>Although ICAM-1 and VCAM-1 levels were comparable between patients and controls, VCAM-1 reflected inflammatory activity and treatment status, particularly in AS. VCAM-1 may represent a more sensitive marker of endothelial activation than ICAM-1 in treated spondyloarthritis.</p>","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baricitinib in moderate to severe rheumatoid arthritis: dose-dependent efficacy and safety in a randomized clinical trial in a developing country.","authors":"Md Sadikul Islam, Minhaj Rahim Choudhury, Mohammad Abul Kalam Azad, Md Abu Shahin, Syed Atiqul Haq, S M Zobair Hossain, Nabil Amin Khan, Md Atiqur Rahman","doi":"10.1186/s41927-026-00638-8","DOIUrl":"10.1186/s41927-026-00638-8","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-specific antiphospholipid antibody titres in a South Indian cohort: defining cut-off values and implications for diagnosis from a cross-sectional validation study.","authors":"Harikrishnan Bhaskaran, Mithun C B, Jyothi Visalakshy Srikanth, Sandeep Surendran, Gayathri S, Renjitha Bhaskaran, Sekhar V Easwar, Manu Pradeep","doi":"10.1186/s41927-026-00636-w","DOIUrl":"10.1186/s41927-026-00636-w","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and genetic features of CTLA-4 haploinsufficiency: a prospective study in China.","authors":"Guishan Liu, Jingyuan Zhang, Di Wu, Jin Xu, Jiayuan Dai, Min Shen","doi":"10.1186/s41927-026-00637-9","DOIUrl":"10.1186/s41927-026-00637-9","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13151073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deep learning system for diagnosis of rheumatoid arthritis on digital hand photographs.","authors":"Ryosuke Hanaoka, Satoshi Shinohara","doi":"10.1186/s41927-026-00639-7","DOIUrl":"10.1186/s41927-026-00639-7","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13134184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing disease activity in inflammatory arthritis using optical spectral transmission: a systematic review compared to joint ultrasound, MRI, and clinical activity markers.","authors":"Ann-Kathrin Druck, Chandana Keshavamurthy, Mohammed Alhaddad, Andreas V Goules, Andreas Schwarting, Konstantinos Triantafyllias","doi":"10.1186/s41927-026-00635-x","DOIUrl":"10.1186/s41927-026-00635-x","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical phenotype, MRI inflammatory involvement, and treatment patterns in HLA-B27 positive and negative axial spondyloarthritis: a Saudi MRI-based cohort study.","authors":"Abdallah Alqethami, Mohammed Basalama, Samiyah Alsaedi, Khulud Alqahtani, Eman Alsindi, Sabri Alsaeedi, Roaa Mahroos, Maysoon Taher","doi":"10.1186/s41927-026-00632-0","DOIUrl":"10.1186/s41927-026-00632-0","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse association between hydroxychloroquine use and depressive symptoms in systemic lupus erythematosus: a single-center cross-sectional study.","authors":"Xiaoqin Wang, Leilei Yang, Bingjie Gu, Qijie Ren, Dinglei Su, Nan Che","doi":"10.1186/s41927-026-00634-y","DOIUrl":"10.1186/s41927-026-00634-y","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147442556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk scores, non-invasive vascular measures and myositis damage index reveal increased cardiovascular risk in idiopathic inflammatory myopathies: a case-control study.","authors":"Gabriela Paola Garcia-Ordoñez, Carlos Gerardo Ramos-Becerra, Fernanda-Isadora Corona-Meraz, Mario Salazar-Paramo, Felipe Perez-Vazquez, Edgar-Federico Quirarte-Tovar, Christian Juarez-Gomez, Andrea Aguilar-Vazquez, Monica Vazquez-Del Mercado","doi":"10.1186/s41927-026-00633-z","DOIUrl":"10.1186/s41927-026-00633-z","url":null,"abstract":"","PeriodicalId":9150,"journal":{"name":"BMC Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13081314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}