丙型肝炎病毒感染与类风湿性关节炎之间的关系:一项全国性的横断面研究。

IF 2.1 Q3 RHEUMATOLOGY
Lin Tang, Lei Zhang, Zhonghai Ding, Wenying Xu, Yu Liu, Zhenghong Yu
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引用次数: 0

摘要

背景:感染丙型肝炎病毒(HCV)的患者通常表现为风湿性症状,但其与类风湿关节炎(RA)的关系尚不清楚。本横断面研究的目的是调查成人HCV感染是否与RA风险相关。方法:我们分析2017-2020年国家健康与营养检查调查(NHANES)的数据。通过问卷调查确定HCV感染和RA状况。协变量包括性别、年龄、种族、婚姻状况、体重指数(BMI)、高敏c反应蛋白(hs-CRP)和糖尿病状况。采用多变量logistic回归和亚组分析来评估HCV感染与RA风险之间的关系。结果:在这项以人群为基础的研究中,涉及5825名年龄在18-80岁之间的参与者(包括485名RA患者),我们观察到RA组的HCV感染率明显高于非RA对照组。调整协变量后,多因素logistic回归显示HCV感染与RA风险增加相关(OR = 1.93;结论:本研究表明HCV感染与成人RA的风险相关,强调了在RA患者中进行HCV筛查对改善疾病管理的潜在价值。然而,因果解释受到横断面设计和对自我报告数据的依赖的限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between hepatitis C virus infection and rheumatoid arthritis: a nationwide cross-sectional study.

Background: Patients infected with Hepatitis C Virus (HCV) often present with rheumatic symptoms, but its link to rheumatoid arthritis (RA) remains unclear. The purpose of this cross-sectional study was to investigate whether HCV infection is related to the risk for RA in adults.

Methods: We analyzed data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). HCV infection and RA status were determined through questionnaires. Covariates included gender, age, race, marital status, body mass index (BMI), high-sensitivity C-reactive protein (hs-CRP), and diabetes status. Multivariate logistic regression and subgroup analyses were used to assess the relationship between HCV infection and RA risk.

Results: In this population-based study involving 5,825 participants aged 18-80 years (including 485 RA patients), we observed a significantly higher prevalence of HCV infection in the RA group compared with non-RA controls. After adjusting for covariates, multivariate logistic regression showed that HCV infection was associated with an increased risk of RA (OR = 1.93; 95%CI = 1.07-3.50, p < 0.05).

Conclusion: This study demonstrates that HCV infection is associated with the risk of RA in adults, underscoring the potential value of HCV screening in RA patients for improved disease management. However, causal interpretation is limited by the cross-sectional design and reliance on self-reported data.

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来源期刊
BMC Rheumatology
BMC Rheumatology Medicine-Rheumatology
CiteScore
3.80
自引率
0.00%
发文量
73
审稿时长
15 weeks
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