Bio-medical materials and engineering最新文献

{"title":"Electrically stimulated drug release using conductive GelMA/k-carrageenan/rGO blended hydrogel for enhanced biomedical applications.","authors":"Jong Min Lee","doi":"10.1177/09592989251343077","DOIUrl":"https://doi.org/10.1177/09592989251343077","url":null,"abstract":"<p><p>BackgroundHydrogels are hydrophilic polymers with high water content and a porous structure, making them suitable for incorporating water-soluble drugs and functioning as drug delivery systems. Their structural similarity to living tissues renders them valuable for applications in tissue engineering, pharmaceuticals, and medical treatments.ObjectiveThis study aimed to develop a blended hydrogel with improved mechanical strength and biocompatibility, and to enhance its drug release capabilities through electrical stimulation.MethodA conductive hydrogel was synthesized by blending gelatin methacrylate (GelMA), kappa carrageenan (k-carrageenan), and reduced graphene oxide (rGO). The hydrogel's physical integrity, biocompatibility, and drug release performance under electrical stimulation were evaluated.ResultsThe GelMA/k-carrageenan/rGO hydrogel retained its structural stability, demonstrated excellent biocompatibility, and effectively released drugs in response to electrical stimulation.ConclusionThe developed conductive hydrogel presents strong potential for advanced drug delivery systems utilizing electrical stimulation, with promising implications across biomedical and pharmaceutical fields.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251343077"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of electrospun membranes of polylactic acid and polypyrrole as a biosensor for the detection of cholesterol.","authors":"Claudia G Ramírez-Mendoza, Lorena Armenta-Villegas, Jesús M Quiroz-Castillo, Angel U Orozco-Valencia, Dora E Rodríguez-Félix, Rafael Ramírez-Bon, David A Fernández-Benavides, José R Flores-León, Guillermo Suarez-Campos, Ana D Cabrera-González, Damian F Plascencia-Martínez, María M Castillo-Ortega","doi":"10.1177/09592989251341131","DOIUrl":"https://doi.org/10.1177/09592989251341131","url":null,"abstract":"<p><strong>Background: </strong>Hydrogen peroxide (H₂O₂) plays a crucial role in various industries and enzymatic reactions, including cholesterol oxidation. Cholesterol, vital for physiological functions, can lead to cardiovascular and hepatic diseases when present in excess. Accurate detection is crucial, yet current techniques are costly and time-consuming. Biosensors offer a promising alternative due to their sensitivity, speed, and portability in detecting H₂O₂. <b>Objective:</b> This study aims to develop a sensitive, simple, rapid, and cost-effective biosensor for H₂O₂ detection using electrospun membranes coated with polypyrrole (PPy). <b>Methods:</b> Poly(lactic acid) (PLA) membranes were prepared using the electrospinning technique. Subsequently, these membranes were coated with polypyrrole (PPy) through in situ chemical polymerization. The obtained materials were characterized using SEM, contact angle measurements, XPS, and their electrical properties were analyzed. <b>Results</b>: PLA/PPy composite membranes exhibited electrical conductivities on the order of 10^-2 S cm^-1. Upon exposure to H₂O₂ and enzymatic reaction, a significant decrease in their electrical properties was observed, indicating their potential as sensors for detecting this analyte. <b>Conclusions:</b> Electrospun PLA/PPy membranes demonstrate high potential for H₂O₂ detection, owing to their large surface area and high reactivity, thereby enhancing sensor sensitivity. These characteristics make this material a promising option for H₂O₂ detection applications across various industries.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251341131"},"PeriodicalIF":1.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic impact of antioxidant combinations on collagen and elastin synthesis in human dermal fibroblasts.","authors":"Jada Stutts, Kayla Clatterbuck, Chloe Duckworth, Tyera Pemberton, Aillea Elkins, Prabir Patra, William Stoecker, Navin Geria, Nasim Nosoudi","doi":"10.1177/09592989251341159","DOIUrl":"https://doi.org/10.1177/09592989251341159","url":null,"abstract":"<p><strong>Background: </strong>The restoration of collagen and elastin in human dermal fibroblasts plays a crucial role in anti-aging and skin rejuvenation therapies. Numerous studies have examined the effects of various antioxidants on skin health, but there is limited research comparing their combined effects on collagen and elastin synthesis in human dermal fibroblasts. <b>Objective:</b> The objective of this study was to evaluate the individual and combined effects of N-acetylcysteine (NAC), Coenzyme Q10 (CoQ10), Niacinamide (NIAC), Gamma Cyclodextrin (GAMMA), Retinol (RET), Epigallocatechin Gallate (EGCG), and Ellagic Acid (ELA) on collagen type I and elastin synthesis in human dermal fibroblasts (HDFs). <b>Methods:</b> Human dermal fibroblasts were treated with individual and combined antioxidants. The expression of collagen type I and elastin was measured using mRNA analysis, immunofluorescence staining, and matrix protein assays. The study focused on the effects of EGCG in combination with other antioxidants like RET, CoQ10, and NAC to identify synergistic effects. <b>Results:</b> The combination of EGCG + RET and EGCG + CoQ10 showed the most significant increase in both elastin and collagen type I synthesis, surpassing the effects of individual antioxidants. EGCG demonstrated the highest fold change in elastin mRNA expression, while the combination treatments notably enhanced the extracellular matrix restoration in HDFs. <b>Conclusion:</b> The combination of EGCG with CoQ10, Retinol, or NAC presents a promising strategy for enhancing skin elasticity and firmness by promoting both elastin and collagen synthesis. These findings suggest that antioxidant combinations can be developed for effective anti-aging skincare formulations.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251341159"},"PeriodicalIF":1.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing biomaterial application strategies for neurorestoration after ischemic stroke injury: An emerging treatment option.","authors":"Asmaa' Mohd Satar, Farah Amna Othman, Suat Cheng Tan","doi":"10.1177/09592989241306679","DOIUrl":"10.1177/09592989241306679","url":null,"abstract":"<p><p>BackgroundIschemic stroke is a medical condition caused by occlusion of blood vessels in brain, resulting in disruption of blood flow to the brain and triggering irreversible damage to the neuronal cells. While stem cells transplantation has been proposed as a potential alternative therapym for ischemic stroke, its effectiveness is limited due to low cell survival rate and potential side effects following transplantation. To overcome these challenges and enhance therapeutics efficacy, researchers have focused on developing various biomaterials to create a sustainable cellular microenvironment or to modify the properties of donor stem cell which could optimize their reparative functions in injured brain tissues.ObjectiveThis review aims to explore and discuss the different types of biomaterials that have been applied in the treatment of ischemic stroke, shedding light on their potentials as promising therapeutics options for this debilitating condition.MethodsLiterature search was performed to identify publications studying the potential of three biomaterials namely: nanobioparticles, hydrogels and extracellular vesicles for ischemic stroke therapy in vitro, in vivo or in clinical using four databases, namely: PubMed, ScienceDirect, Web of Science and Scopus.Results and discussionThe major benefits obtained from the application of nanobioparticles for ischemic stroke therapy included as the nanocarrier for drug/cell delivery, cell tracking, real time imaging, promote cell proliferation, while hydrogels provided scaffold support and conferred neuroprotection to stem cells, as well as provided neurotropic effects and controlled drug release for localized treatment. Lastly the extracellular vesicles were identified as a cell-free treatment strategy in promoting angiogenesis, neuronal differentiation and neurogenesis for ischemic stroke treatment.ConclusionBiomaterial-based therapies have their own potentials and further clinical investigations are strongly recommended to translate the therapies into more conscientious evidence-based therapy for clinical application.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"151-162"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced detection of Mycobacterium Tuberculosis using nanogold-based silver staining enhancement.","authors":"Lili Quan, Qianrong Yang, Zhu Jin, Rong Li, Han Xiao, Lu Wang","doi":"10.1177/09592989241308792","DOIUrl":"10.1177/09592989241308792","url":null,"abstract":"<p><p>BackgroundTuberculosis (TB) is a global health challenge from a single infectious agent, Mycobacterium tuberculosis (MTB), and it demands improved diagnostics and therapies.ObjectiveThis work explored a novel method for detecting MTB by combining nanogold labeling (NGL) technology with silver staining to enhance sensitivity and specificity.MethodsNanogold particles (NGPs) were characterized using ultraviolet absorption spectroscopy (UVAS), and their morphology was observed via transmission electron microscopy (TEM). The silver staining enhancement (SSE) system was optimized for a reaction time of 11 min. Fifty drug-resistant tuberculosis (DRT) patients were randomly assigned to a control (Ctrl) group receiving conventional nursing and an experimental (Exp) group treated with continuous nursing intervention (CNI). Quality of Life Instrument for Tuberculosis Patients (QLI-TB) scores were compared over 6 months.ResultsUnmarked NGPs were evenly distributed, while labeled NGPs maintained complete morphology with a gray halo. The detection limit was established at 0.582, reaching as low as 1 pmol/L. For sputum specimens, detection rates were 38.7% for culture, 41.94% for PCR, and 43.54% for nanogold SSE, with no significant differences (<i>P </i>> 0.05). However, patients in the Exp group exhibited significant improvements in physical, psychological, and social functions, as well as the tuberculosis-specific module (TSM) compared to the Ctrl group (<i>P </i>< 0.05).ConclusionsWe demonstrated an innovative method for detecting MTB, demonstrating promising results through method optimization and analysis.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"163-173"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-pot method to prepare the guar gum hydrogel dressing and its application in wound repair.","authors":"Xuepeng Guo, Mingming Yin, Zhangqiang Tuo","doi":"10.1177/09592989251326661","DOIUrl":"https://doi.org/10.1177/09592989251326661","url":null,"abstract":"<p><p>BackgroundThe skin serves as a critical barrier, safeguarding the body against external threats including bacteria, viruses, and ultraviolet (UV) radiation. Compromised skin integrity can result in pain, hinder daily activities, and elevate the risk of infections. Clinically, dressings are the conventional treatment for skin injuries. However, these often necessitate frequent replacements and may exacerbate wound trauma during removal. Therefore, there is growing interest in developing innovative dressings such as hydrogels, which are celebrated for their softness, adaptability, permeability, and capacity to sustain a moist wound environment. Guar gum, a galactomannan polysaccharide extensively utilized in the food and biomedical sectors, forms highly viscous, biocompatible hydrogels that are promising for medical applications including capsules and wound dressings. Nonetheless, the mechanical strength and antimicrobial properties of guar gum hydrogels require enhancements for optimal medical efficacy.ObjectiveThis study explores the fortification of guar gum (GG) hydrogels with tannic acid (TA) and citric acid (CA), which are known for their antibacterial, anti-inflammatory, and antioxidant properties, to develop injectable, antimicrobial hydrogel dressings.MethodsEmploying a one-pot synthesis method, this research aimed to create dressings for treating skin injuries in murine models. The hydrogels were characterized using Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR), assessed for antibacterial efficacy against <i>Staphylococcus aureus</i>, and evaluated for biocompatibility and therapeutic effectiveness in mice with full-thickness skin injuries.ResultsThe results demonstrated successful cross-linking, structural stability, and significant enhancement in wound healing, indicating the potential of these GG-CA-TA hydrogel dressings to broaden the scope of guar gum applications in clinical skin restoration.ConclusionIn this study, a kind of Guar gum hydrogel was successfully synthesized by one-pot method, which has great potential in clinical skin repair.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251326661"},"PeriodicalIF":1.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption of enhanced multislice spiral computed tomography combined with magnetic resonance imaging in staging and preoperative assessment of colon cancer patients.","authors":"Cong Liang, Ying Wu, Limei Wang, Junfang Bai, Dan Wang, Fei Zhao","doi":"10.1177/09592989251335125","DOIUrl":"https://doi.org/10.1177/09592989251335125","url":null,"abstract":"<p><p>BackgroundColon cancer (CC) refers to malignant tumor of the digestive tract worldwide and is also among the cancers with high mortality rates.ObjectiveThe aim of this work was to evaluate the diagnostic performance of multislice spiral CT (MSCT), magnetic resonance imaging (MRI), and MSCT + MRI in different stages of colon cancer (CC) (T1-T2, T3, T4). This work compared the differences in sensitivity (<i>Sen</i>), specificity (<i>Spe</i>), accuracy (Acc), and area under the curve (AUC) values among these methods and explored the optimal diagnostic strategy.MethodsA total of 120 patients with CC confirmed by pathological biopsy and 30 individuals suspected of CC but without detected tumors (as controls) were selected. All subjects underwent MSCT, MRI, and combined MSCT + MRI examinations. Statistical analyses of <i>Sen</i>, <i>Spe</i>, <i>Acc</i>, and AUC values were performed.ResultsIn the T1-T2 stage, MSCT had a <i>Sen</i> of 85.2%, <i>Acc</i> of 86.8%, and an AUC value of 0.878; MRI had a <i>Spe</i> of 91.0%, <i>Sen</i> of 81.6%, and an AUC value of 0.865; the combined MSCT + MRI examination had a <i>Sen</i> of 90.6% and an AUC of 0.903. In the T3 stage, MRI had a significantly higher <i>Sen</i> (91.7%) than MSCT (80.0%), with an AUC of 0.887, while the combined MSCT + MRI examination had a <i>Sen</i> of 98.3% and an AUC of 0.942. In the T4 stage, the combined MSCT + MRI examination performed the best, with a <i>Sen</i> of 100% and an AUC of 0.933, and compared with MSCT or MRI alone, the differences were statistically significant (<i>P </i>< 0.05).ConclusionMSCT and MRI each have their own advantages in the diagnosis of different stages of CC. MSCT is suitable for initial screening in the T1-T2 stage, while MRI is more effective in assessing tumor invasiveness in the T3 and higher stages. The combined MSCT + MRI examination can provide more comprehensive diagnostic information, especially in the T4 stage, where it shows the highest <i>Sen</i> and <i>Acc</i>. Selecting the appropriate examination method based on the patient's specific condition and staging needs is of great significance in improving the diagnostic <i>Acc</i> of CC.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251335125"},"PeriodicalIF":1.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using a polyurea resin-bonded mounted wheel, dental resin composites and porcelain are polished precisely.","authors":"Hideaki Sato, Yutaka Kameyama, Ryokichi Shimpo, Yuanyuan Yang, Satoshi Komasa","doi":"10.1177/09592989241313327","DOIUrl":"https://doi.org/10.1177/09592989241313327","url":null,"abstract":"<p><p>BackgroundThe success of dental restorations depends on achieving adequate surface integrity. However, grinding and polishing are generally ineffective because of the special physical and chemical compositions and properties of the composites. Polyurea resin is an elastomer with high elasticity, abrasion resistance, heat resistance, and toughness. When it is used as a bond, grinding wheels with high grain grip strength can be fabricated.ObjectiveWe fabricated a mounted wheel with a polyurea resin as the bond and used it to polish a composite resin and porcelain under clinical polishing conditions. The effects of the approach on the polished surface roughness and morphology were evaluated with respect to the type of mounted wheel, initial surface roughness, abrasive particle size, and polishing time.MethodsThis study fabricates a mounted wheel with polyurea resin as the bond and uses it to polish composite resin and porcelain under clinical polishing conditions. The effects of the approach on the polished surface roughness and morphology are evaluated against the type of mounted wheel, initial surface roughness, abrasive particle size, and polishing time.ResultsAmong single-crystal diamond, siliconcon carbide (GC), and alumina (WA) abrasive grains, diamond abrasive grains produced the best finish for most tested resin composites. However, WA abrasive grains are effective for polishing Estenia (it has the highest filler content). The polishing performance of the porcelain varied with the initial surface roughness and abrasive particle diameter.ConclusionThis study provides guidance for improving and developing mounted wheels for clinical applications.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989241313327"},"PeriodicalIF":1.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical properties of regenerated digital flexor tendon in immature newt following complete transection.","authors":"Yu Masuda-Otsuka, Tomoka Kamiya, Daisuke Suzuki, Toshinori Hayashi, Jeonghyun Kim, Takeo Matsumoto, Eijiro Maeda","doi":"10.1177/09592989251324288","DOIUrl":"https://doi.org/10.1177/09592989251324288","url":null,"abstract":"<p><p>BackgroundAdult newt (9-month-old) has become an emerging research model to study complete regeneration of injured adult tendon. If younger newts exhibit tendon regeneration similar to adult ones, they can be used as an additional experimental model, assuring a high- throughput of experiments using genetic manipulation owing to shorter period of growing.ObjectiveTo examine mechanical properties and tissue structure of tendon in immature Iberian ribbed newt following complete transection.MethodsDigital flexor tendon of the middle finger of the left hindlimb in 4- and 6-month-old Iberian ribbed newt (4mo and 6mo, respectively) was transected. Regenerated tendon was mechanically tested at 6 and 12 weeks postoperatively. Collagen fiber structure was also observed using two-photon microscopy.ResultsIn both 4mo and 6mo newts, regenerated tendon at 6 weeks exhibited significantly lower tensile strength than corresponding normal tendons and had unorganized collagen structure. At 12 weeks, Regenerated tendon in both groups had the strength comparable to normal controls. Additionally, the collagen structure seemed more organized compared to that at 6 weeks and comparable to controls. These phenomena were essentially similar to those in adult newts.Conclusion4mo and 6mo newts can also be used as experimental models of adult tendon regeneration research.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251324288"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial activity of carbonate hydroxyapatite-based honeycomb scaffolds doped with zinc for medical implants.","authors":"Moch Izzul Haq Al Maruf, Wahyu Widiawati, Al Viyah Rahmaidah, Mona Sari, Yusril Yusuf","doi":"10.1177/09592989241313112","DOIUrl":"https://doi.org/10.1177/09592989241313112","url":null,"abstract":"<p><p>BackgroundThe utilization of bioceramics for medical implants necessitates the incorporation of antibacterial properties to mitigate post-surgical inflammation of bone tissue.ObjectiveIn this research, Zn²⁺ ions were introduced as an antibacterial agent into carbonate-hydroxyapatite-based honeycomb Scaffold bioceramics (CHA/HCB), with varying doping concentrations, to investigate the impact of Zn²⁺ on the antibacterial activity of CHA/HCB against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>.MethodsCHA was synthesized from abalone shells through the co-precipitation method, followed by the fabrication of a CHA-based scaffold with HCB using the porogen leaching technique. Subsequently, the Zn ion doping process was executed through the ion exchange method, using concentrations of 0.05 M, 0.1 M, 0.15 M, and 0.2 M. The samples were characterized using XRF and antibacterial test.ResultsThe XRF results revealed that the Ca/P ratio of CHA/HCB was within the range of 1.48-1.85, indicating a declining trend with the introduction of Zn²⁺ as a dopant. Nevertheless, these results remained within acceptable ranges, ensuring compatibility with bone tissue. In terms of antibacterial activity, the measured inhibition zone diameters increased alongside the increase of Zn concentration. The zone diameters ranged from 14.3 to 22.0 mm against <i>Staphylococcus aureus</i> and 13.7 to 21.4 mm against <i>Pseudomonas aeruginosa</i>.ConclusionThe findings suggest that Zn doping in CHA/HCB bioceramics has a potential an antibacterial agent in CHA scaffolds as well as potential for practical applications, particularly in reducing the risk of postoperative infection in bone tissue implantation.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989241313112"},"PeriodicalIF":1.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}