Bio-medical materials and engineering最新文献

{"title":"\"Surface modification of Mg-Zn-Ca-Mn biodegradable biomaterials by ionic nitriding\".","authors":"Sergio Rubén Gonzaga Segura, Horacio Martínez Valencia, Manuel Eduardo Serrano Nava, Arturo Molina Ocampo, Eduardo Lira Díaz, Eduardo Servín Fernández","doi":"10.1177/09592989261493870","DOIUrl":"https://doi.org/10.1177/09592989261493870","url":null,"abstract":"<p><p>BackgroundMagnesium-based alloys have emerged as promising biodegradable materials for temporary biomedical implants due to their biocompatibility, low density, and elastic modulus similar to natural bone. However, their rapid degradation in physiological environments limits their clinical application, making surface modification strategies necessary to improve corrosion resistance and mechanical performance.ObjectiveThe aim of this study was to evaluate the effect of ionic nitriding on the microstructure, corrosion resistance, mechanical properties, and cytocompatibility of Mg-Zn-Ca-Mn biodegradable alloys.MethodsMg-Zn-Ca-Mn quaternary alloys were synthesized by powder metallurgy and subsequently surface modified by ionic nitriding. The microstructure and phase composition were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray diffraction (XRD). Corrosion behavior was evaluated through electrochemical tests in Hank's solution, while mechanical properties were assessed using Vickers microhardness measurements. Cytocompatibility was analyzed by indirect cytotoxicity tests using fibroblast and keratinocyte cells.ResultsThe nitrided alloys exhibited improved corrosion resistance, evidenced by lower corrosion current densities and more noble corrosion potentials compared with pure magnesium. In addition, ionic nitriding increased the Vickers microhardness by approximately 42-48%. Cytotoxicity assays showed that the Mg64-Zn30-Ca5-Mn1 alloy and its nitrided counterpart-maintained cell viability above 70%, indicating acceptable cytocompatibility.ConclusionIonic nitriding is an effective surface modification technique to enhance the corrosion resistance, mechanical properties, and biological performance of Mg-Zn-Ca-Mn biodegradable alloys, demonstrating their potential for use as temporary biomedical implant materials.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989261493870"},"PeriodicalIF":1.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional inorganic nanomaterials for gastrointestinal disease management: Recent developments and future perspectives.","authors":"Bin Ye, Lulu Lv, Jing Bao, Shan Yu","doi":"10.1177/09592989261489483","DOIUrl":"https://doi.org/10.1177/09592989261489483","url":null,"abstract":"<p><p>BackgroundGastrointestinal (GI) diseases such as inflammatory bowel disease, colorectal cancer, gastric disorders, and infections are a major health burden worldwide, and their pathophysiology is complex, involving dynamic pH gradients, mucus barriers, microbiota interactions, and oxidative stress.ObjectiveThis review discusses recent developments in the design and use of functional inorganic nanomaterials for gastrointestinal disease management.MethodsMetal and metal oxide nanoparticles, mesoporous silica systems, and hybrid nanostructures are reviewed, with major emphasis on structure-property-function relationships, stimuli-responsive behavior, redox modulation by nanozymes, diagnostic applications, targeted therapy, and theranostics. Safety considerations, biodistribution patterns, and translational barriers are also critically discussed.ResultsFunctional inorganic nanomaterials have emerged as promising platforms because they are physicochemically stable, possess tunable surfaces, exhibit catalytic activity, and provide multimodal attributes. These properties support their application in diagnosis, targeted treatment, and theranostic management of GI diseases.ConclusionOverall, this review provides a complete and critical insight into recent developments and future perspectives for translating functional inorganic nanomaterials from the laboratory to clinical application in gastrointestinal disease management.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989261489483"},"PeriodicalIF":1.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomechanics-based conceptual design of spring knee-aids to reduce joint loading during high knee-flexion tasks.","authors":"John Z Wu, Kevin D Moore, Liying Zheng, Ting Xia, Donald R Peterson","doi":"10.1177/09592989261487142","DOIUrl":"10.1177/09592989261487142","url":null,"abstract":"<p><p>BackgroundOccupational activities that require high knee-flexion tasks are associated with a higher prevalence of knee osteoarthritis (OA) compared to the general population. Spring knee-aids have been used to protect the knee joints during dynamic high knee-flexion tasks.ObjectiveThis study was to develop a biomechanical model to analyze the knee joint mechanics during deep squatting while wearing various conceptually designed knee aids.MethodsThe musculoskeletal loadings in the knees were calculated using inverse dynamic modeling. Commercially available software AnyBody (version 7.2) was used for the analysis. In deep squatting, the back of the thighs will contact the calves, influencing the joint contact forces. An analytical approach to consider the effects of the thigh-calf contact interactions was derived and implemented in the AnyBody model. The knee joint loading for deep squatting tasks without knee aids was compared with those wearing knee aids of different spring stiffness levels.ResultsThe current biomechanical modeling predictions indicate that the use of typical commercial spring knee-aids helps to reduce the contact forces in the tibiofemoral (TF) and patellofemoral (PF) joints by approximately 7-8%, and that the effects of the knee aids in reducing musculoskeletal loading can be enhanced about four times by increasing the spring stiffness of the knee aids to 1-4 times of the original values.ConclusionThe current analysis provides a biomechanical basis for improving the design of commercially available knee aids, thereby reducing knee OA in workers frequently performing high knee-flexion tasks.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989261487142"},"PeriodicalIF":1.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter-2 inhibitor administration recovers peri-implant bone formation in type 2 diabetes: An experimental study using a type 2 diabetes rat model.","authors":"Tomohiro Masuzaki, Fumio Suehiro, Naohiro Komabashiri, Takaharu Shimizu, Masahiro Nishimura","doi":"10.1177/09592989261481043","DOIUrl":"https://doi.org/10.1177/09592989261481043","url":null,"abstract":"<p><p>BackgroundDiabetes mellitus is risk factors in implant treatment and maintenance, and it is necessary to consider the effects of diabetes medications.ObjectiveThis study investigates whether oral administration of sodium-glucose cotransporter 2 (SGLT2) inhibitor, affects bone formation after implant placement.MethodsA total of 44 Goto-Kakizaki rats were used as a type 2 diabetes model, divided into two groups: the drug administration group (MD) and the non-administration group (GK). A total of 22 Wistar rats were used as the control group (CO). Titanium implants were implanted into the rat tibiae.ResultsHistological and SEM images showed that the GK group had significantly less bone formation than the CO group at both 2 and 4 weeks. No significant differences were observed between groups in serum biochemistry and body weight. Mechanical strength was significantly lower in the GK group than in the CO group at 2 weeks and 4 weeks. Blood glucose levels in the MD group were significantly lower than the baseline values at both 2 weeks and 4 weeks.ConclusionIn a diabetic rat model, the SGLT2 inhibitor restored implant bone formation without side effects. Further detailed research in clinical settings is needed on the effects of diabetes medications.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989261481043"},"PeriodicalIF":1.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofunctionalized nanofibrous scaffolds for enhancing osteoblast cells proliferation.","authors":"Kiran Konain, Jieun Bae, Mariam Amir, Sajida Farid, Aiman Saeed, Muhammad Tahir Sarwar, Kyung Mi Woo, Saeed Ur Rahman","doi":"10.1177/09592989261489547","DOIUrl":"https://doi.org/10.1177/09592989261489547","url":null,"abstract":"<p><p>BackgroundBiomimetic nanofibrous scaffolds have shown promising potential in tissue engineering as a means for local drug delivery of osteoinductive small molecules and recapitulating the nanotopograpy of the extracellular matrix (ECM).ObjectiveThe current study aims at construction a cytocompatible, biodegradable, drug loaded nanofibrous scaffold to enhance osteoblast cell proliferation.MethodsHerein, we synthesized berberine (BrB)-incorporated poly(ε-caprolactone) (PCL) nanofibrous scaffold via electrospinning, and various cellular and physicochemical characterization studies were performed using MC3T3-E1 osteoblasts to determine cytocompatibility.ResultsThe results demonstrate that BrB exhibits a hormetic effect with optimal dose at 10 µg indicating an increase in osteoblast cell proliferation. Scanning electron microscopy (SEM) analysis revealed uniform, randomly aligned, beadless fibers, with greater proportion of fibers in lower nano-range with the addition of BrB. Energy-dispersive X-ray (EDX) spectroscopy confirmed the elemental composition consistent with PCL and the successful incorporation of BrB. X-ray diffraction (XRD) demonstrated preserved crystallinity of the PCL nanofibers, while Fourier transform infrared (FTIR) spectroscopy verified characteristic functional groups of BrB within the PCL matrix, substantiating its molecular integration. The scaffold exhibited controlled degradation and sustained drug release profiles with improved swelling capacity, which is favorable for tissue regeneration. Notably, PCL-BrB demonstrated biocompatibility and enhanced osteoblast cells adhesion and proliferation.ConclusionCollectively, these findings validate the BrB-loaded PCL nanofibrous scaffold as a promising biomaterial platform for guiding osteoblast cells proliferation.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989261489547"},"PeriodicalIF":1.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of corrosion behavior of Ti-based PVD coatings on 316L SS for biomedical implants.","authors":"M Shunmuga Priyan, G Godwin","doi":"10.1177/09592989261485537","DOIUrl":"https://doi.org/10.1177/09592989261485537","url":null,"abstract":"<p><p>Background316L stainless steel (SS) is widely used in biomedical implant applications because of its excellent mechanical properties, corrosion resistance, biocompatibility, and cost-effectiveness. However, its long-term performance in physiological environments is limited by localized corrosion, ion release, and inadequate surface interactions with biological tissues. Surface modification using Ti-based physical vapor deposition (PVD) coatings has emerged as a promising strategy to enhance the corrosion resistance and durability of implant materials.ObjectiveThis study aimed to investigate the effect of Ti-based PVD coatings, namely TiCoCr, TiN, and TiO₂, on the corrosion behavior of 316L SS under simulated physiological conditions.MethodsTiCoCr, TiN, and TiO₂ coatings were deposited onto 316L SS substrates using the PVD technique. The corrosion performance of the coated and uncoated samples was evaluated in phosphate-buffered saline (PBS), Hanks' solution, and Ringer's solution at 37 °C. Electrochemical corrosion parameters, including corrosion potential and corrosion current density, were analyzed to assess the effectiveness of the coatings.ResultsAll Ti-based coatings improved the corrosion resistance of 316L SS compared with the uncoated substrate. Among the investigated coatings, the TiCoCr coating deposited for 90 min exhibited the best corrosion performance. In Ringer's solution, the coating showed a corrosion potential of -0.0504 V and a corrosion current density of 4.74 × 10^-6 A/cm². In Hanks' solution, the same coating demonstrated a corrosion potential of -0.1815 V and a corrosion current density of 5.0537 × 10^-6 A/cm². The enhanced corrosion resistance was attributed to the protective and stable nature of the Ti-based coating layer.ConclusionThe TiCoCr, TiN, and TiO₂ PVD coatings significantly enhanced the corrosion resistance of 316L SS in simulated physiological environments. Among them, the TiCoCr coating demonstrated superior corrosion protection, indicating its strong potential for improving the long-term reliability and performance of biomedical implants.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989261485537"},"PeriodicalIF":1.3,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Softwood nanocellulose-silver nanoparticle membranes for burn wound healing in rabbits.","authors":"Leticia G de Gutierrez, Francine C Claro, Washington L E Magalhães, Marcelo J C de Sá, Gabriel Goetten de Lima","doi":"10.1177/09592989261453731","DOIUrl":"10.1177/09592989261453731","url":null,"abstract":"<p><p>In this study, the efficacy of pinus sp. nanocellulose membranes, with and without silver nanoparticles, was evaluated in the treatment of experimental burns in rabbits. A total of twenty animals were used, each receiving three standardized dorsal burns of equal size, treated with either a simple dressing (negative control), a nanocellulose membrane without silver, or a nanocellulose membrane containing silver. Healing was monitored through macroscopic and microscopic analyses performed on days 3, 7, 14, and 30 after the induction of the burns. The findings demonstrated that nanocellulose membranes effectively promoted tissue repair and skin regeneration, with evidence of fibroblast activity, collagen deposition, and neovascularization throughout the healing process. The incorporation of silver nanoparticles showed potential to enhance early wound contraction, although all groups achieved complete re-epithelialization by the end of the experimental period. While the addition of silver may contribute to antimicrobial protection and early tissue response, further studies are required to confirm its role in accelerating the healing process and to better elucidate its mechanisms of action. Overall, pinus sp. nanocellulose membranes represent a safe and effective alternative for the treatment of burns, supporting their potential application in clinical practice.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"191-199"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Mesenchymal stem cells derived from human adipose tissue exhibit significantly higher chondrogenic differentiation potential compared to those from rats.","authors":"Faisal Yaqoob, Muhammad Khizer Hayat, Muhammad Sharjeel Chaughtai, Sehrish Khan, Musa Bin Bashir","doi":"10.3233/BME-240062","DOIUrl":"10.3233/BME-240062","url":null,"abstract":"","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"NP2-NP14"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of substrate temperature on mechanical and electrochemical properties of flame-sprayed coatings for Titanium implants.","authors":"Trong-Linh Nguyen, Tsung-Chieh Cheng","doi":"10.1177/09592989261476170","DOIUrl":"10.1177/09592989261476170","url":null,"abstract":"<p><p>BackgroundHydroxyapatite (HA) coatings on titanium (Ti) implants are widely studied owing to their biocompatibility and osteoconductivity. However, the effect of substrate temperature during flame spraying on coating performance remains unclear.ObjectiveThis study investigated the influence of substrate temperature on the microstructure, mechanical properties, and electrochemical behavior of flame-sprayed HA coatings on Ti implants.MethodsHA coatings were deposited on commercially pure Ti Grade 2 substrates by flame spraying at room temperature (RT) and 300 °C. The coatings were characterized by XRD, FTIR, XPS, SEM, and EDS. Surface roughness, adhesion strength, abrasion resistance, potentiodynamic polarization, and electrochemical impedance spectroscopy were evaluated.ResultsSubstrate heating at 300 °C modified the crystalline phase composition and slightly increased the apparent HA crystallite size and crystalline peak index. The 300 °C coating exhibited a more compact surface morphology, higher adhesion strength, lower abrasion-induced mass loss, lower corrosion current density, and higher charge transfer resistance than the RT coating.ConclusionSubstrate heating at 300 °C improved the mechanical durability and corrosion resistance of flame-sprayed HA coatings, indicating its usefulness for enhancing Ti implant coating performance.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"229-240"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Mesenchymal stem cells derived from human adipose tissue exhibit significantly higher chondrogenic differentiation potential compared to those from rats'.","authors":"","doi":"10.1177/09592989251347678","DOIUrl":"10.1177/09592989251347678","url":null,"abstract":"","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"NP1"},"PeriodicalIF":1.3,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}