{"title":"采用增强多层螺旋ct结合磁共振成像技术对结肠癌患者进行分期及术前评估。","authors":"Cong Liang, Ying Wu, Limei Wang, Junfang Bai, Dan Wang, Fei Zhao","doi":"10.1177/09592989251335125","DOIUrl":null,"url":null,"abstract":"<p><p>BackgroundColon cancer (CC) refers to malignant tumor of the digestive tract worldwide and is also among the cancers with high mortality rates.ObjectiveThe aim of this work was to evaluate the diagnostic performance of multislice spiral CT (MSCT), magnetic resonance imaging (MRI), and MSCT + MRI in different stages of colon cancer (CC) (T1-T2, T3, T4). This work compared the differences in sensitivity (<i>Sen</i>), specificity (<i>Spe</i>), accuracy (Acc), and area under the curve (AUC) values among these methods and explored the optimal diagnostic strategy.MethodsA total of 120 patients with CC confirmed by pathological biopsy and 30 individuals suspected of CC but without detected tumors (as controls) were selected. All subjects underwent MSCT, MRI, and combined MSCT + MRI examinations. Statistical analyses of <i>Sen</i>, <i>Spe</i>, <i>Acc</i>, and AUC values were performed.ResultsIn the T1-T2 stage, MSCT had a <i>Sen</i> of 85.2%, <i>Acc</i> of 86.8%, and an AUC value of 0.878; MRI had a <i>Spe</i> of 91.0%, <i>Sen</i> of 81.6%, and an AUC value of 0.865; the combined MSCT + MRI examination had a <i>Sen</i> of 90.6% and an AUC of 0.903. In the T3 stage, MRI had a significantly higher <i>Sen</i> (91.7%) than MSCT (80.0%), with an AUC of 0.887, while the combined MSCT + MRI examination had a <i>Sen</i> of 98.3% and an AUC of 0.942. In the T4 stage, the combined MSCT + MRI examination performed the best, with a <i>Sen</i> of 100% and an AUC of 0.933, and compared with MSCT or MRI alone, the differences were statistically significant (<i>P </i>< 0.05).ConclusionMSCT and MRI each have their own advantages in the diagnosis of different stages of CC. MSCT is suitable for initial screening in the T1-T2 stage, while MRI is more effective in assessing tumor invasiveness in the T3 and higher stages. The combined MSCT + MRI examination can provide more comprehensive diagnostic information, especially in the T4 stage, where it shows the highest <i>Sen</i> and <i>Acc</i>. Selecting the appropriate examination method based on the patient's specific condition and staging needs is of great significance in improving the diagnostic <i>Acc</i> of CC.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":"9592989251335125"},"PeriodicalIF":1.0000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adoption of enhanced multislice spiral computed tomography combined with magnetic resonance imaging in staging and preoperative assessment of colon cancer patients.\",\"authors\":\"Cong Liang, Ying Wu, Limei Wang, Junfang Bai, Dan Wang, Fei Zhao\",\"doi\":\"10.1177/09592989251335125\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BackgroundColon cancer (CC) refers to malignant tumor of the digestive tract worldwide and is also among the cancers with high mortality rates.ObjectiveThe aim of this work was to evaluate the diagnostic performance of multislice spiral CT (MSCT), magnetic resonance imaging (MRI), and MSCT + MRI in different stages of colon cancer (CC) (T1-T2, T3, T4). This work compared the differences in sensitivity (<i>Sen</i>), specificity (<i>Spe</i>), accuracy (Acc), and area under the curve (AUC) values among these methods and explored the optimal diagnostic strategy.MethodsA total of 120 patients with CC confirmed by pathological biopsy and 30 individuals suspected of CC but without detected tumors (as controls) were selected. All subjects underwent MSCT, MRI, and combined MSCT + MRI examinations. Statistical analyses of <i>Sen</i>, <i>Spe</i>, <i>Acc</i>, and AUC values were performed.ResultsIn the T1-T2 stage, MSCT had a <i>Sen</i> of 85.2%, <i>Acc</i> of 86.8%, and an AUC value of 0.878; MRI had a <i>Spe</i> of 91.0%, <i>Sen</i> of 81.6%, and an AUC value of 0.865; the combined MSCT + MRI examination had a <i>Sen</i> of 90.6% and an AUC of 0.903. In the T3 stage, MRI had a significantly higher <i>Sen</i> (91.7%) than MSCT (80.0%), with an AUC of 0.887, while the combined MSCT + MRI examination had a <i>Sen</i> of 98.3% and an AUC of 0.942. In the T4 stage, the combined MSCT + MRI examination performed the best, with a <i>Sen</i> of 100% and an AUC of 0.933, and compared with MSCT or MRI alone, the differences were statistically significant (<i>P </i>< 0.05).ConclusionMSCT and MRI each have their own advantages in the diagnosis of different stages of CC. MSCT is suitable for initial screening in the T1-T2 stage, while MRI is more effective in assessing tumor invasiveness in the T3 and higher stages. The combined MSCT + MRI examination can provide more comprehensive diagnostic information, especially in the T4 stage, where it shows the highest <i>Sen</i> and <i>Acc</i>. Selecting the appropriate examination method based on the patient's specific condition and staging needs is of great significance in improving the diagnostic <i>Acc</i> of CC.</p>\",\"PeriodicalId\":9109,\"journal\":{\"name\":\"Bio-medical materials and engineering\",\"volume\":\" \",\"pages\":\"9592989251335125\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-04-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bio-medical materials and engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/09592989251335125\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bio-medical materials and engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/09592989251335125","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Adoption of enhanced multislice spiral computed tomography combined with magnetic resonance imaging in staging and preoperative assessment of colon cancer patients.
BackgroundColon cancer (CC) refers to malignant tumor of the digestive tract worldwide and is also among the cancers with high mortality rates.ObjectiveThe aim of this work was to evaluate the diagnostic performance of multislice spiral CT (MSCT), magnetic resonance imaging (MRI), and MSCT + MRI in different stages of colon cancer (CC) (T1-T2, T3, T4). This work compared the differences in sensitivity (Sen), specificity (Spe), accuracy (Acc), and area under the curve (AUC) values among these methods and explored the optimal diagnostic strategy.MethodsA total of 120 patients with CC confirmed by pathological biopsy and 30 individuals suspected of CC but without detected tumors (as controls) were selected. All subjects underwent MSCT, MRI, and combined MSCT + MRI examinations. Statistical analyses of Sen, Spe, Acc, and AUC values were performed.ResultsIn the T1-T2 stage, MSCT had a Sen of 85.2%, Acc of 86.8%, and an AUC value of 0.878; MRI had a Spe of 91.0%, Sen of 81.6%, and an AUC value of 0.865; the combined MSCT + MRI examination had a Sen of 90.6% and an AUC of 0.903. In the T3 stage, MRI had a significantly higher Sen (91.7%) than MSCT (80.0%), with an AUC of 0.887, while the combined MSCT + MRI examination had a Sen of 98.3% and an AUC of 0.942. In the T4 stage, the combined MSCT + MRI examination performed the best, with a Sen of 100% and an AUC of 0.933, and compared with MSCT or MRI alone, the differences were statistically significant (P < 0.05).ConclusionMSCT and MRI each have their own advantages in the diagnosis of different stages of CC. MSCT is suitable for initial screening in the T1-T2 stage, while MRI is more effective in assessing tumor invasiveness in the T3 and higher stages. The combined MSCT + MRI examination can provide more comprehensive diagnostic information, especially in the T4 stage, where it shows the highest Sen and Acc. Selecting the appropriate examination method based on the patient's specific condition and staging needs is of great significance in improving the diagnostic Acc of CC.
期刊介绍：
The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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