Effect of coamorphization on meloxicam/saccharine: Intermolecular interaction investigations using chemometrics.

IF 1 4区医学 Q4 ENGINEERING, BIOMEDICAL

Bio-medical materials and engineering Pub Date : 2025-07-21 DOI:10.1177/09592989251341175

Yuta Otsuka

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引用次数: 0

Abstract

Background: Aqueous solubility of pharmaceuticals is a factor as it is directly associated with bioavailability; accordingly, strategies to enhance solubility have been well investigated. Objectives: The purpose of this study was to determine the effects of coamorphization on meloxicam (MX) and saccharine (SA) mixtures. Methods: An equimolar mixture of MX and SA was ground for 4 h at 300 rpm. The obtained samples were evaluated using Fourier-transform mid-infrared spectroscopy, Fourier transform near-infrared spectroscopy, powder X-ray diffraction (PXRD), and thermal analysis. No molecular interactions were observed in the physical mixture sample. The ground samples showed broad peaks in the PXRD patterns and an exothermic peak at an early temperature. Results: The results suggested that the grinding process transformed MX and SA into a coamorphous phase. The attenuated total reflection - IR spectra exhibited new peaks at 1719 cm^-1 and 1398 cm^-1, and the NH peak disappeared with grinding time. Measurement data of MX and SA ground sample suggested they constructed coamorphous phase. Conclusion: It was indicated by multivariate analysis that the formation of the MX/SA coamorphous system occurred in a two-step process.

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共定型对美洛昔康/糖精的影响：利用化学计量学研究分子间相互作用。

背景：药物的水溶性是一个因素，因为它直接关系到生物利用度；因此，提高溶解度的策略已经得到了很好的研究。目的：本研究的目的是确定共定型对美洛昔康（MX）和糖精（SA）混合物的影响。方法：将MX和SA的等摩尔混合物在300 rpm下研磨4h。利用傅里叶变换中红外光谱、傅里叶变换近红外光谱、粉末x射线衍射（PXRD）和热分析对所得样品进行了评价。在物理混合样品中未观察到分子相互作用。地面样品在PXRD谱图中表现出宽峰，在早期温度处表现出放热峰。结果：研磨过程使MX和SA转变为共晶相。衰减后的全反射-红外光谱在1719 cm-1和1398 cm-1处出现新峰，NH峰随研磨时间的延长而消失。MX和SA地面样品的测量数据表明它们构成了共晶相。结论：多变量分析表明，MX/SA共晶体系的形成是一个两步法过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bio-medical materials and engineering 工程技术-材料科学：生物材料

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.