Bio-medical materials and engineering最新文献

{"title":"Influence of different ligation methods on force and moment generation in a simulated condition of the maxillary crowded anterior dentition with linguo-version and rotation.","authors":"Sunmin Kim, I. Yonemitsu, H. Takemura, Kunio Shimoda, K. Suga, K. Soga, T. Ono, M. Uo","doi":"10.3233/bme-211288","DOIUrl":"https://doi.org/10.3233/bme-211288","url":null,"abstract":"BACKGROUND\u0000Most orthodontic cases consist of varying degrees of crowding. To manage crowded dentitions, nickel-titanium archwires with various ligation methods are often used.\u0000\u0000\u0000OBJECTIVE\u0000We aimed to investigate the effect of different ligation methods with respect to force and moment and suggest the efficient ligation method for treating rotation and displacement simultaneously.\u0000\u0000\u0000METHODS\u0000We built a model that simulated the three anterior teeth of the maxilla. The teeth on the two ends were fixed, and the middle tooth was set in several different positions by manipulating the amount of displacement in bucco-lingual direction and rotation angle. The measurements were taken with three different ligation methods of self-ligation (SL), elastomeric o-ring ligation on both side wings (EB), and on one side wings (EO).\u0000\u0000\u0000RESULTS\u0000The magnitude of linguo-buccal force exceeded the standard optimal force in each condition examined and was significantly larger in EB than in other ligation methods. Moreover, the magnitude of moment generation with SL was suitable in the 0.0 mm linguo-version, whereas it was suitable with EO in the linguo-version ranging 1.0-3.0 mm.\u0000\u0000\u0000CONCLUSIONS\u0000The ligation method significantly affected the force and moment. SL and EO are recommended in dentitions with light and deep lingual displacements, respectively.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44882906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis of femoral component sagittal alignment in mobile-bearing total knee arthroplasty.","authors":"Y. Koh, Jin-Ah Lee, Hwa-Yong Lee, D. Suh, Joon-Hee Park, K. Kang","doi":"10.3233/BME-211280","DOIUrl":"https://doi.org/10.3233/BME-211280","url":null,"abstract":"BACKGROUND\u0000Recently, there has been an increasing interest in mobile-bearing total knee arthroplasty (TKA). However, changes in biomechanics for femoral component alignment in mobile-bearing TKA have not been explored in depth.\u0000\u0000\u0000OBJECTIVE\u0000This study aims to evaluate the biomechanical effect of sagittal alignment of the femoral component in mobile-bearing TKA.\u0000\u0000\u0000METHODS\u0000We developed femoral sagittal alignment models with -3°, 0°, 3°, 5°, and 7° flexion. We also examine the kinematics of the tibiofemoral (TF) joint, contact point on the TF joint, contact stress on the patellofemoral (PF) joint, collateral ligament force, and quadriceps force using a validated computational model under a deep-knee-bend condition.\u0000\u0000\u0000RESULTS\u0000Posterior kinematics of the TF joint increases as the femoral component flexes. The contact stress on the PF joint, collateral ligament force, and the quadriceps force decreases as the femoral component flexes.\u0000\u0000\u0000CONCLUSIONS\u0000Our results show that a slight, approximately 0°∼3°, flexion of the implantation could be an effective substitute technique. However, excessive flexion should be avoided because of the potential loosening of the TF joint.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"33 3 1","pages":"195-207"},"PeriodicalIF":1.0,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44839562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular matrix hydrogel derived from bovine bone is biocompatible in vitro and in vivo.","authors":"A. Ayala-Ham, M. Aguilar-Medina, J. León‐Félix, J. Romero-Quintana, M. Bermúdez, J. López-Gutiérrez, G. Jiménez-Gastélum, Mariana Avendaño-Félix, Erik Lizarraga-Verdugo, H. Castillo-Ureta, C. López-Camarillo, R. Ramos-Payán","doi":"10.3233/bme-211387","DOIUrl":"https://doi.org/10.3233/bme-211387","url":null,"abstract":"BACKGROUND\u0000Nowadays, biomaterials used as a scaffold must be easy to deliver in the bone defect area. Extracellular matrix (ECM) hydrogels are highly hydrated polymers that can fill irregular shapes and act as bioactive materials.\u0000\u0000\u0000OBJECTIVE\u0000This work aims to show the effects of ECM hydrogels derived from bovine bone (bECMh) on proliferation, cytotoxicity and expression of pro-inflammatory cytokines in three cells types involved in tissue regeneration, as well as biocompatibility in vivo.\u0000\u0000\u0000METHODS\u0000In vitro, we used an extract of bECMh to test it on macrophages, fibroblasts, and adipose-derived mesenchymal stem cells (AD-MCSs). Cell proliferation was measured using the MTT assay, cytotoxicity was measured by quantifying lactate dehydrogenase release and the Live/Dead Cell Imaging assays. Concentrations of IL-6, IL-10, IL-12p70, MCP-1 and TNF-α were quantified in the supernatants using a microsphere-based cytometric bead array. For in vivo analysis, Wistar rats were inoculated into the dorsal sub-dermis with bECMh, taking as reference the midline of the back. The specimens were sacrificed at 24 h for histological study.\u0000\u0000\u0000RESULTS\u0000In vitro, this hydrogel behaves as a dynamic biomaterial that increases fibroblast proliferation, induces the production of pro-inflammatory cytokines in macrophages, among which MCP-1 and TNF-α stand out. In vivo, bECMh allows the colonization of host fibroblast-like and polymorphonuclear cells, without tissue damage or inflammation.\u0000\u0000\u0000CONCLUSIONS\u0000The results indicate that bECMh is a biocompatible material that could be used as a scaffold, alone or in conjunction with cells or functional biomolecules, enhancing proliferation and allowing the filling of bone defects to its further regeneration.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41631581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic analysis of a curved artery based on microcirculation boundary.","authors":"F. He, Xinyu Wang, L. Hua, Tingting Guo","doi":"10.3233/bme-211275","DOIUrl":"https://doi.org/10.3233/bme-211275","url":null,"abstract":"BACKGROUND\u0000Microcirculation plays a key role in regulating blood flow but is not considered in previous research of hemodynamics.\u0000\u0000\u0000OBJECTIVE\u0000 A curved artery model is established to study its hemodynamic characteristics based on microcirculation boundary.\u0000\u0000\u0000METHODS\u0000The hemodynamic model of a curved artery is constructed and simulated by computational fluid dynamics. The curved artery model is simulated by fluid-structure interaction. At the same time, a porous medium is used to simulate microcirculation as the outlet boundary.\u0000\u0000\u0000RESULTS\u0000The distribution characteristics of the blood flow velocity, the pressure and the wall shear stress in different sections at different time of the cardiac cycle are obtained. The results show that the velocities in curved arteries decrease and the pressures gradually increase. The blood flow velocity waveform and value are affected and they are sensitive to the microcirculation boundary. However, the pressure value is only affected by the microcirculation function.\u0000\u0000\u0000CONCLUSIONS\u0000 This work is useful for researchers to deeply understand the hemodynamic characteristics of curved arteries. There is important clinical significance to analyze the pathogenesis of cardiovascular disease considering microcirculation function and its coupling effect.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41528510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of leader cells by filopodia in collective cell migration using computer vision.","authors":"Mun Kit Lai, Baasansuren Otgon, T. Ohashi","doi":"10.3233/bme-221397","DOIUrl":"https://doi.org/10.3233/bme-221397","url":null,"abstract":"BACKGROUND\u0000Imaging of cells and cellular organelles has been of great interest among researchers and medical staff because it can provide useful information on cell physiology and pathology. Many researches related to collective cell migration have been established and leader cells seem to be the ones that regulate the migration, however, the identification of leader cells is very time-consuming.\u0000\u0000\u0000OBJECTIVE\u0000This study utilized computer vision with deep learning to segment cell shape and to identify leader cells through filopodia.\u0000\u0000\u0000METHODS\u0000Healthy Madin-Darby Canine Kidney (MDCK) cells cultured in a Polydimethylsiloxane (PDMS) microchannel device allowed collective cell migration as well as the formation of leader cells. The cells were stained, and cell images were captured to train the computer using UNet++ together with their corresponding masks created using Photoshop for automated cell segmentation. Lastly, cell shape and filopodia were filtered out using Filopodyan and FiloQuant were detected.\u0000\u0000\u0000RESULTS\u0000The segmentation of cell shape and the identification of filopodia were successful and produced accurate results in less than one second per image.\u0000\u0000\u0000CONCLUSIONS\u0000The proposed approach of image analysis would be a great help in the field of cell science, engineering, and diagnosis.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46376584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of knee collateral ligament stiffness by strain ultrasound elastography","authors":"S. Wadugodapitiya, M. Sakamoto, Masaei Tanaka, Yuta Sakagami, Yusuke Morise, Koichi Kobayashi","doi":"10.3233/BME-211282","DOIUrl":"https://doi.org/10.3233/BME-211282","url":null,"abstract":"BACKGROUND: Knowledge of the biomechanics of the normal collateral ligaments is important to secure optimal stability of the knee following injury. Various in vitro methods have been described in evaluating the biomechanics of these ligaments. However, a method of direct evaluation has not been reported. OBJECTIVE: To determine the stiffness characteristics of the collateral ligaments of the knee using strain ultrasound elastography. METHODS: Strain ultrasound elastography was performed on different components of the collateral ligaments in various angles of knee flexion in 18 healthy males (36 ligaments). We measured relative stiffness of the ligaments using strain ratio (SR = target tissue strain/reference strain). A lower strain ratio indicates higher relative stiffness. RESULTS: There was moderate to excellent intra- and inter-rater agreement for strain ratio measurements in all ligament portions. Strain ratios were lowest at 0° in all three ligaments, indicating high relative stiffness. In the superficial and deep medial collateral ligaments, the strain ratio increased with increasing knee flexion, whereas in the lateral collateral ligament, stiffness showed a tendency to fluctuate. CONCLUSION: Strain ultrasound elastography is a reliable tool for monitoring relative stiffness of the collateral ligaments of the knee and is easily applied to the routine clinical setting.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"33 1","pages":"337 - 349"},"PeriodicalIF":1.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41854723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of the anastomosis angle of arteriovenous fistula in hemodialysis to standardize the surgical technique.","authors":"Suraj Shembekar, D. Zodpe, P. Padole","doi":"10.3233/BME-211389","DOIUrl":"https://doi.org/10.3233/BME-211389","url":null,"abstract":"BACKGROUND\u0000Arteriovenous fistula (AVF) is the preferred route of vascular access in hemodialysis. The primary reason of fistula failure is Intimal hyperplasia (IH), which leads to stenosis. Wall shear stress (WSS) and disturbed flow are the critical parameters in the formation of IH.\u0000\u0000\u0000OBJECTIVE\u0000The primary goal of this study is to explore the influence of anastomosis angle on WSS and venous outflow rate, as well as to find the ideal angle of anastomosis for AVF to standardize surgical technique.\u0000\u0000\u0000METHODS\u0000Three-dimensional idealized geometries of end-to-side type AVF for the five various angles of anastomosis are considered in this study. The WSS, blood flow rate at the venous outlet for non-Newtonian, pulsatile blood flow are calculated using a numerical simulation technique.\u0000\u0000\u0000RESULTS\u0000The WSS is higher at 75° compared to other angles and least at 45° for pulsating arterial inflows. The WSS is moderate at 30°, 60° and 90°. On the arterial bed and outer wall of the vein, immediately after the anastomosis, the recirculation zone is observed. At an angle of 45° and 90° anastomosis, the outflow rate is greater at distal venous end.\u0000\u0000\u0000CONCLUSIONS\u0000If one believes that high wall shear stress causes IH within the AVF, the results suggest that the AVF should be formed at a 45° angle to avoid IH. However, if one believes that low wall shear stress causes IH within the AVF, the results suggest that AVF should be formed at either 30° or 75° to avoid IH. The findings spotlight the importance of anastomosis angle in determining AVF hemodynamics.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45700940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of casein phosphopeptide amorphous calcium fluoride phosphate and calcium glycerophosphate on incisors with molar-incisor hypomineralization: A cross-over, randomized clinical trial.","authors":"B. Sezer, Nihan Tuğcu, C. Çalışkan, B. Durmuş, Tatiana Kupets, N. Beki̇roğlu, B. Kargül, D. Bourgeois","doi":"10.3233/bme-211371","DOIUrl":"https://doi.org/10.3233/bme-211371","url":null,"abstract":"BACKGROUND\u0000Within the scope of minimally invasive dentistry, the use of different biocompatible remineralization agents on incisors affected by molar-incisor hypomineralization (MIH) gains importance.\u0000\u0000\u0000OBJECTIVE\u0000To evaluate the effect of casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) and calcium glycerophosphate (CaGP) in mineral density (MD) of white/creamy and yellow/brown demarcated opacities on incisors affected by MIH by means laser fluorescence (LF).\u0000\u0000\u0000METHODS\u0000As a cross-over, randomized trial, twenty-two children with 167 incisors affected by MIH were recruited and randomly assigned to one of the two different agents and crossed over to other agents with two weeks washout in between. Incisors were examined by using LF at all before and after three months periods.\u0000\u0000\u0000RESULTS\u0000The results of the paired t-tests for determining the period effect between the baseline findings showed significant difference in white/creamy and yellow/brown demarcated opacities of LF values for both groups (p < 0.05). The difference between both groups according to after categorization of 20% increasing in MD in the percent of change before and after application on LF values; was not found statistically significant in white/creamy (p = 0.970) and yellow/brown (p = 0.948) opacities.\u0000\u0000\u0000CONCLUSIONS\u0000The primary outcome was CPP-ACFP and CaGP had a positive effect in decreasing hypomineralization on MIH-affected enamel for three months period.","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44194124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on co-culture of DiI labeled rat bone marrow mesenchymal stem cells and polycaprolactone film in vitro to make a cell patch.","authors":"Zhang Zichang,&nbsp;Zhou Fan,&nbsp;Zheng Jianwei,&nbsp;Mu Junsheng,&nbsp;Bo Ping,&nbsp;You Bin","doi":"10.3233/BME-211312","DOIUrl":"https://doi.org/10.3233/BME-211312","url":null,"abstract":"<p><strong>Background: </strong>In stem cell therapy, due to the lack of an effective carrier, a large number of transplanted stem cells are lost and die. Therefore, finding a suitable carrier has become a further direction of stem cell therapy.</p><p><strong>Objective: </strong>In research on the co-culture of polycaprolactone (PCL) with 1,1'-Dioctadecyl-3,3,3',3'- tetramethylindocarbocyanine perchlorate (DiI) labeled bone marrow mesenchymal stem cells (BMSCs), we observe the effect of materials on the growth and proliferation of DiI labeled stem cells, and the effect of DiI labeling on patch preparation, so as to find a kind of biomaterial suitable for the growth and proliferation of BMSCs, and find a suitable cell carrier for stem cell therapy of myocardial infarction and in vivo tracing.</p><p><strong>Methods: </strong>Clean grade Sprague Dawley rats were selected as experimental objects, BMSCs were isolated and cultured, and the surface markers were identified by flow cytometry. After the BMSCs were cultured for 3 passages, the BMSCs were stained with DiI dye, and the BMSCs DiI and PCL biomaterial film were co-cultured. After 24 hours, the cell growth was observed under fluorescence microscope, and fixed for scanning under electron microscope. The cell proliferation was detected by CCK-8 at 1, 4, 7, 10 days of culture. The measurement data conforming to normal distribution are expressed in the form of mean ± standard deviation (X¯± s). One way ANOVA was used for comparison among groups, LSD analysis was used for pairwise comparison. The difference was statistically significant (P < 0.05).</p><p><strong>Results: </strong>BMSCs were strongly positive for CD90, CD44H, but negative for CD11b/c, CD45. Under fluorescence microscope, BMSCs DiI showed red light, fusiform or polygonal. Under the scanning electron microscope, the cell patch formed by co-culture of PCL film and DiI-BMSCs had a large number of cells on the surface and normal cell state. CCK-8 assay showed that the OD value on the first day was 0.330 ± 0.025; The OD value was 0.620 ± 0.012 on the 4th day, 1.033 ± 0.144 on the 7th day and 1.223 ± 0.133 on the 10th day. There was significant difference among the time points (P < 0.05).</p><p><strong>Conclusions: </strong>The cell patch made of PCL film and DiI labeled BMSCs can survive and proliferate on the surface, so it can be used as a scaffold material for stem cell therapy in vivo.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"33 4","pages":"269-277"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavior of implant and abutment sets of three different connections during the non-axial load application: An in vitro experimental study using a radiographic method.","authors":"Sergio Alexandre Gehrke,&nbsp;Berenice Anina Dedavid,&nbsp;José Manuel Granero Marín,&nbsp;Luigi Canullo","doi":"10.3233/BME-211221","DOIUrl":"https://doi.org/10.3233/BME-211221","url":null,"abstract":"<p><strong>Background: </strong>During the masticatory cycle, loads of different intensities and directions are received by the dental structures and/or implants, which can cause micromovements at the junction between the abutment and implant.</p><p><strong>Objective: </strong>The objective of this in vitro study was to evaluate the behavior of three different implant connections subjected to different load values using a digital radiography system. Additionally, the torque values for removing the abutment screws were also measured and compared.</p><p><strong>Methods: </strong>Ninety sets of implant and abutment (IA) were used, divided into three groups according to the type of connection (n = 30 per group): EH group, external hexagon type connection; IH group, internal hexagon connection; and, MT group, Morse taper connection.</p><p><strong>Results: </strong>MT group showed the better vertical misfit behavior at the three intensity of load applied, in comparison with EH and IH groups. In the analysis of torque maintenance (detorque test), MT group showed higher values of detorque when compared with the measured values of EH and IH groups (p < 0.001).</p><p><strong>Conclusions: </strong>The IA sets of EH and IH groups showed a microgap in all levels of applied loads, unlike the MT group this event was not observed. In the detorque test, MT group increase in the torque values when compared to the initial torque applied, unlike EH and IH groups showed a decrease in the initially torque applied in all conditions tested. A positive correlation was detected between the misfit and detorque values.</p>","PeriodicalId":9109,"journal":{"name":"Bio-medical materials and engineering","volume":"33 2","pages":"101-112"},"PeriodicalIF":1.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39407741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}