Brain Research最新文献

{"title":"Phyllanthus niruri L. Administration during pregnancy and breastfeeding: Maternal evaluation and effects on initial development and adult behavior of male rat offspring.","authors":"Maciel da Costa Alves, Diego Elias Pereira, Rita de Cássia de Araújo Bidô, Camila Maria Sousa de Andrade, Juliano Carlo Rufino Freitas, Camila Carolina de Menezes Santos Bertozzo, Daline Fernandes de Souza Araújo, Gerlane Coelho Bernardo Guerra, Juliana Késsia Barbosa Soares","doi":"10.1016/j.brainres.2024.149402","DOIUrl":"10.1016/j.brainres.2024.149402","url":null,"abstract":"<p><p>The leaves of Phyllanthus niruri L. are used in folk medicine in many countries to treat various diseases. However, despite the enormous therapeutic potential, use of the plant is contraindicated during pregnancy and breastfeeding. Reports on the impacts of exposure to this plant on the development of the offspring of rats are still scarce and controversial. The aim of this study is to evaluate the effects of the administration of P. niruri aqueous extract, during pregnancy and lactation, on maternal toxicity, on postnatal physical development, and on behavioral aspects in adult male offspring. Pregnant rats were divided into three experimental groups (n = 8/group) and treated daily during pregnancy and lactation, (gavage), with vehicle and doses of 75 and 150 mg/kg of aqueous extract of P. niruri. To assess maternal toxicity; weight gain, feed intake, reproductive outcomes, and biochemical profiles were analyzed. The male pups were evaluated for physical development through the end of lactation and submitted to tests evaluating their behavior in adulthood. Treatment with the aqueous extract of P. niruri (AEPN) did not cause significant changes in the maternal and reproductive parameters analyzed. However, changes in the biochemical markers of liver function were observed. In the male offspring, the extract did not alter postnatal physical growth, but caused early opening of the ear canal and eyes. In the evaluation of adult male offspring, it was found that the groups exposed to AEPN presented behavioral changes predictive of anxiolytic effect. Brain malondialdehyde levels of male offspring whose mothers were treated with AEPN were significantly reduced. Our results demonstrate that exposure to P. niruri extract did not induce significant changes sufficiently to indicate occurrence of maternal or postnatal toxicity. In addition, in the male offspring exposed to the extract, anticipation of physical maturation parameters and anxiolytic-like behavior was observed.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149402"},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of ACE inhibitors and ARBs in preserving cognitive function via hypertension Management: A critical Update.","authors":"Sabina Yasmin, Sumel Ashique, Tahreen Taj, Ashish Garg, Joy Das, Eman Shorog, Utpal Bhui, Radheshyam Pal, Samy Selim, Uttam Prasad Panigrahy, Naseem Begum, Anas Islam, Mohammad Yousuf Ansari","doi":"10.1016/j.brainres.2024.149400","DOIUrl":"10.1016/j.brainres.2024.149400","url":null,"abstract":"<p><p>Hypertension poses a significant risk to cognition-related disorders like dementia. As the global population ages, age-related neurological illnesses such as Alzheimer's disease are becoming increasingly prevalent. The primary hypertension treatments, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors, exhibit neuroprotective properties. However, observational studies suggest that they may independently contribute to cognitive decline and dementia. Some of these medications have shown promise in reducing cognitive impairment and amyloid buildup in Alzheimer's models. While direct comparisons between the two drug classes are limited, angiotensin receptor blockers have been associated with less brain shrinkage, lower dementia incidence, and slower cognitive decline compared to angiotensin-converting enzyme inhibitors. Both types of medications can influence cognition by passing the blood-brain barrier, with angiotensin receptor blockers potentially offering superior neuroprotective effects due to their selective blockade of the angiotensin type 1 receptor.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149400"},"PeriodicalIF":2.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal characteristics in disorders of consciousness: A resting-state functional magnetic resonance imaging study.","authors":"Hui Li, Linghui Dong, Jiajie Liu, Xiaonian Zhang, Hao Zhang","doi":"10.1016/j.brainres.2024.149401","DOIUrl":"10.1016/j.brainres.2024.149401","url":null,"abstract":"<p><strong>Aims: </strong>To explore the functional brain imaging characteristics of patients with disorders of consciousness (DoC).</p><p><strong>Methods: </strong>This prospective cohort study consecutively enrolled 27 patients in minimally conscious state (MCS), 23 in vegetative state (VS), and 25 age-matched healthy controls (HC). Resting-state functional magnetic resonance imaging (rs-fMRI) was employed to evaluate the amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC). Sliding windows approach was conducted to construct dynamic FC (dFC) matrices. Moreover, receiver operating characteristic analysis and Pearson correlation were used to distinguish these altered characteristics in DoC.</p><p><strong>Results: </strong>Both MCS and VS exhibited lower ALFF, ReHo, and DC values, along with reduced FC in multiple brain regions compared with HC. Furthermore, the values in certain regions of VS were lower than those in MCS. The primary differences in brain function between patients with varying levels of consciousness were evident in the cortico-striatopallidal-thalamo-cortical mesocircuit. Significant differences in the temporal properties of dFC (including frequency, mean dwell time, number of transitions, and transition probability) were also noted among the three groups. Moreover, these multimodal alterations demonstrated high classificatory accuracy (AUC > 0.8) and were correlated with the Coma Recovery Scale-Revised (CRS-R).</p><p><strong>Conclusion: </strong>Patients with DoC displayed abnormal patterns in local and global dynamic and static brain functions. These alterations in rs-fMRI were closely related to the level of consciousness.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149401"},"PeriodicalIF":2.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-regulatory cells and extracellular vesicles in Alzheimer's disease: New therapeutic concepts and hypotheses.","authors":"Ricardo Augusto Leoni De Sousa, Bruno Ferreira Mendes","doi":"10.1016/j.brainres.2024.149393","DOIUrl":"10.1016/j.brainres.2024.149393","url":null,"abstract":"<p><p>Cell-based treatment has experienced exponential expansion in recent years in terms of clinical application and market share among pharmaceutical companies. When malignant cells in a healthy individual produce antigenic peptides derived from mutant or improperly synthesized proteins, the immune system attacks and kills the transforming cells. This process is carried out continuously by immune cells scanning the body for altered cells that could cause some harm. T-regulatory cells (Tregs), which preserve immunological tolerance and can exert neuroprotective benefits in numerous disorders, including animal models of Alzheimer's disease (AD), have demonstrated considerable therapeutic potential. Evidence also suggests that not only Tregs, but extracellular vesicles (EVs) are involved in a wide range of diseases, such as cellular homoeostasis, infection propagation, cancer development and heart disease, and have become a promisor cell-based therapeutic field too. Nevertheless, despite significant recent clinical and commercial breakthroughs, cell-based medicines still confront numerous challenges that hinder their general translation and commercialization. These challenges include, but are not limited to, choosing the best cell source, and creating a product that is safe, adequately viable, and fits the needs of individual patients and diseases. Here, we summarize what we know about Tregs and EVs and their potential therapeutic usage in AD.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149393"},"PeriodicalIF":2.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise alleviates cognitive decline of natural aging rats by upregulating Notch-mediated autophagy signaling.","authors":"Dandan Chen, Yuan Guo, Meng Zhang, Xingran Liu, Baowen Zhang, Xianjuan Kou","doi":"10.1016/j.brainres.2024.149398","DOIUrl":"10.1016/j.brainres.2024.149398","url":null,"abstract":"<p><p>Notch signaling, a classical signaling pathway of neurogenesis, is downregulated during the aging and age-related neurodegenerative diseases. Exercise has been proposed as an effective lifestyle intervention for delaying cognitive decline. However, it remains unclear whether exercise intervention could alleviate cognitive decline by modulating neurogenesis in naturally aging rats. In this study, 21-month-old natural aging rats were used to study brain aging. The natural aging rats underwent different forms of exercise training (aerobic exercise or strength training or comprehensive exercise with aerobic exercise and strength training) for 12 consecutive weeks. The cognitive function of natural aging rats was determined by Morris Water Maze. Notch signaling, autophagy-related proteins and hippocampal neurogenesis were examined by immunofluorescence, qRT-PCR and Western blot. Results showed that natural aging rats exhibited cognitive decline, accumulation of AD pathological proteins (APP and Aβ), and decreased neurogenesis (decreased DCX, Ki67 and GFAP), compared with the young control rats. Moreover, a significant decline in Notch signaling and autophagy was found in the hippocampus of natural aging rats. However, different forms of exercise upregulated Notch signaling and its downstream target genes, as well as autophagy-related proteins, including LC3, Beclin1, and p62. In summary, our data suggest that different forms of exercise can mitigate brain aging by upregulating Notch signaling and autophagy, thereby increasing hippocampal neurogenesis and improves spatial learning and memory abilities.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149398"},"PeriodicalIF":2.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Astaxanthin reduces matrix metalloproteinase-9 expression and activity in the brain after experimental subarachnoid hemorrhage in rats\" [Brain Res. 1624 (2015) 113-124].","authors":"Xiang-Sheng Zhang, Xin Zhang, Qing-Rong Zhang, Qi Wu, Wei Li, Tian-Wei Jiang, Chun-Hua Hang","doi":"10.1016/j.brainres.2024.149390","DOIUrl":"https://doi.org/10.1016/j.brainres.2024.149390","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1850 ","pages":"149390"},"PeriodicalIF":2.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanism of SiJunZi decoction in the treatment of Parkinson's disease.","authors":"Baoquan Wen, Xiuzhi Li, Jiafu Xu, Yuqin He, Xiaofeng Lin, Xiujuan Wu, Chaoyin Wu","doi":"10.1016/j.brainres.2024.149397","DOIUrl":"10.1016/j.brainres.2024.149397","url":null,"abstract":"<p><p>Parkinson's disease (PD) is the second most common neurodegenerative disease, but treatment options for PD are limited, and drug development has reached a bottleneck. With the progress of the aging population, the number of PD patients in China is increasing day by day, imposing a heavy burden on patients and society. Therefore, it is urgent to explore targeted medicine based on the pathogenesis of PD and disease targets. Ancient physicians have used the traditional Chinese medicine formula SiJunZi decoction (SJZD) to treat PD. However, it is less commonly used clinically now, and its pharmacological mechanism still needs to be further elucidated. In this study, based on network pharmacology research and molecular docking technology, the mechanism of SJZD in treating PD was revealed, showing that the extract of SJZD acts on cell microdomain membranes and lipid rafts, affecting ubiquitin-protein ligase binding and ubiquitin-like protein ligase binding processes, and plays a role in neurogenesis. Molecular docking results showed that Ellipticine and Hederagenin in SJZD exhibited significant effects on targets: CASP3, BCL2, and PTGS2. The effect of SJZD reversing MPP⁺-induced SH-SY5Y cells injury was verified by experiments, concentrations ranging from 5ug/mL to 0.1ug/mL showed significant cell protection at 24 h.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149397"},"PeriodicalIF":2.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyes-open and eyes-closed EEG of older adults with subjective cognitive impairment versus healthy controls: A frequency principal components analysis study.","authors":"Adele E Cave, Frances M De Blasio, Dennis H Chang, Gerald W Münch, Genevieve Z Steiner-Lim","doi":"10.1016/j.brainres.2024.149399","DOIUrl":"10.1016/j.brainres.2024.149399","url":null,"abstract":"<p><p>Subjective Cognitive Impairment (SCI) is a self-perceived worsening of cognitive decline, carrying an increased risk of developing Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD). Due to the self-report nature of SCI, an understanding of the biological mechanisms that contribute to an increased dementia risk is needed. This study aims to assess the differences in resting state electroencephalography (EEG) (eyes-open, eyes-closed; EO, EC) between older adults with SCI and healthy controls (HCs) utilising frequency principal components analysis (fPCA), a novel data driven approach. Participants (n = 14 per group: SCI, HCs) were matched on age, sex, years of education, mood, cognition, and pre-morbid function. Continuous resting EEG was recorded during 2-minute conditions (EO, EC) and were submitted to 4 separate fPCAs (each condition, group). Corresponding components were assessed between groups and conditions, correlated with demographics, mood, and cognition variables; multivariate logistic regression was also carried out. Component amplitudes were larger in HCs for delta-theta and alpha-beta, while theta-alpha was larger for SCI. DASS anxiety scores contributed to higher amplitudes for HCs in EO delta-theta and alpha-beta, while male sex and depressive symptoms contributed to higher amplitudes for the SCI group in EO and EC theta-alpha. Findings demonstrate a distinct divergent signature of neurological activity in older people with SCI, despite normal objective cognitive function. This is the first fPCA study to investigate neuronal differences between HCs and older adults with SCI at rest. Novel confounders and effect modifiers were identified that should be controlled in future studies.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149399"},"PeriodicalIF":2.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects and possible mechanisms of whole-body vibration on cognitive function: A narrative review.","authors":"Huan Yang, Jie Gao, Hai-Yan Wang, Xin-Mei Ma, Bing-Yao Liu, Qian-Zhong Song, Hui Cheng, Sen Li, Zai-Yun Long, Xiu-Min Lu, Yong-Tang Wang","doi":"10.1016/j.brainres.2024.149392","DOIUrl":"10.1016/j.brainres.2024.149392","url":null,"abstract":"<p><p>Whole-body vibration (WBV) is a physical stimulation method that transmits mechanical oscillations to the entire body through a vibration platform or device. Biokinetic and epidemiologic studies have shown that prolonged exposure to high-intensity WBV increases health risks, primarily to the lumbar spine and the nervous system connected to it. There is currently insufficient evidence to demonstrate a quantitative relationship between vibration exposure and risk of health effects. The positive effects of WBV on increasing muscle strength and improving balance and flexibility are well known, but its effects on cognitive function are more complex, with mixed findings, largely related to vibration conditions, including frequency, amplitude, and duration. Studies have shown that short-term low-frequency WBV may have a positive impact on cognitive function, demonstrates potential rehabilitation benefits in enhancing learning and memory, possibly by promoting neuromuscular coordination and enhancing neural plasticity. However, long term exposure to vibration may lead to chronic stress in nerve tissue, affecting nerve conduction efficiency and potentially interfering with neuroprotective mechanisms, thereby having a negative impact on cognitive ability, even causes symptoms such as cognitive decline, mental fatigue, decreased attention, and drowsiness. This literature review aimed to explore the effects of WBV on cognitive function and further to analyze the possible mechanisms. Based on the analysis of literatures, we came to the conclusion that the impact of WBV on cognitive function depends mainly on the frequency and duration of vibration, short-term low-frequency WBV may have a positive impact on cognitive function, while long term exposure to WBV may lead to cognitive decline, and the mechanisms may be involved in neuroinflammation, oxidative stress, synaptic plasticity, and neurotransmitter changes. This review may provide some theoretical foundations and guidance for the prevention and treatment of WBV induced cognitive impairment.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149392"},"PeriodicalIF":2.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRMP2 regulates mossy fiber sprouting and modulates microtubule dynamics in a pilocarpine induced rat model of epilepsy.","authors":"Zhongqian Su, Yuxiang Li, Fangchao Tong, Yiying Cai, Yuanfang Li, Jing Ding, Qiang Wang, Xin Wang","doi":"10.1016/j.brainres.2024.149395","DOIUrl":"10.1016/j.brainres.2024.149395","url":null,"abstract":"<p><strong>Objective: </strong>Our study aimed to investigate the role of CRMP2 in mossy fiber sprouting (MFS) using a pilocarpine-induced rat model of epilepsy.</p><p><strong>Methods: </strong>First, the rats were sacrificed on the 1, 7, 14 and 28 day after pilocarpine injection. Quantitative Real-time PCR (qPCR) and Western blot (WB) were performed to assess mRNA and protein levels in the hippocampus and cortex. Next, shCRMP2 AAV was injected into the dentate gyrus of hippocampus to knock down CRMP2 expression. Two weeks later, the epileptic rat model was induced by pilocarpine injection. On the day of status epilepticus (SE) induction, animals in the shCtrl + EP + LCM and shCRMP2 + EP + LCM group received twice-daily intragastric administration of Lacosamide (LCM). The rats were video monitored from day 7 to 28, and were sacrificed on day 28 after pilocarpine injection for subsequent experiment.</p><p><strong>Results: </strong>In the present study, we observed downregulation of phosphorylated CRMP2 in the hippocampus of epileptic rats. Additionally, LCM treatment reduces the expression level of CRMP2 protein in the hippocampus of these rats. Both CRMP2 knockdown and LCM treatment were found to decrease mossy fiber sprouting (MFS) in the dentate gyrus and shorten the duration of seizures in epileptic rats. Furthermore, we discovered that microtubule dynamics are reduced in the hippocampus of epileptic rats. Both CRMP2 Knockdown and LCM treatment were shown to increase the microtubule dynamics in the hippocampus of rats with epilepsy.</p><p><strong>Conclusion: </strong>In conclusion, we demonstrated convincingly that CRMP2 regulates mossy fiber sprouting and modulates microtubule dynamics in a pilocarpine induced rat model of epilepsy.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149395"},"PeriodicalIF":2.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}