Brain Research最新文献

{"title":"Expression of concern: \"Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia\" [BRAIN RES, Volume 1153 (2007) 204-213].","authors":"Zhen-Xing Huang, Zhi-Min Kang, Guo-Jun Gu, Guang-Neng Peng, Liu Yun, Heng-Yi Tao, Wei-Gang Xu, Xue-Jun Sun, John H Zhang","doi":"10.1016/j.brainres.2025.149683","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149683","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149683"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Down-regulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats\" [BRAIN RES, Volume 1360 (2010) 147-158].","authors":"Tianzhu Wang, Jing Wang, Cheng Yin, Ruen Liu, John H Zhang, Xinyue Qin","doi":"10.1016/j.brainres.2025.149687","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149687","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149687"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats\" [BRAIN RES, Volume 1210 (2008) 223-229].","authors":"Jiasi Li, Wenwu Liu, Suju Ding, Weigang Xu, Yangtai Guan, John H Zhang, Xuejun Sun","doi":"10.1016/j.brainres.2025.149684","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149684","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149684"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Granulocyte-colony stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats\" [BRAIN RES, Volume 1145 (2007) 227-238].","authors":"Kenichiro Yata, Gerald A Matchett, Tamiji Tsubokawa, Jiping Tang, Kenji Kanamaru, John H Zhang","doi":"10.1016/j.brainres.2025.149682","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149682","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149682"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress\" [BRAIN RES, Volume 1328 (2010) 152-161].","authors":"Jian Li, Cai Wang, John H Zhang, Jian-Mei Cai, Yun-Peng Cao, Xue-Jun Sun","doi":"10.1016/j.brainres.2025.149685","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149685","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149685"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme\" [BRAIN RES, Volume 1343 (2010) 178-185].","authors":"Zhang Ping, Wenwu Liu, Zhimin Kang, Jianmei Cai, Qiusha Wang, Ni Cheng, Sujian Wang, Shizhong Wang, John H Zhang, Xuejun Sun","doi":"10.1016/j.brainres.2025.149686","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149686","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149686"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezo1 deletion ameliorates inflammation and functional recovery in spinal cord injury through altering microglia/macrophage phenotype","authors":"Weiwei Zheng ,&nbsp;Zeyu Han ,&nbsp;Zonghan Xu ,&nbsp;Lang Bai ,&nbsp;Yu Zhang ,&nbsp;Yixin Shen","doi":"10.1016/j.brainres.2025.149810","DOIUrl":"10.1016/j.brainres.2025.149810","url":null,"abstract":"<div><div>Disruption of their homeostasis post-spinal cord injury (SCI) triggers severe secondary inflammation. This study focuses on Piezo1, a key mediator of macrophage/microglia-driven neuroinflammation. We aimed to promulgate the effect of deleting or inhibiting macrophage/microglial Piezo1 on the neural function after SCI in vitro and vivo. Here, we used C57BL/6J mice in which Piezo1 was specifically deleted in macrophages/microglia (Piezo1-CKO, Piezo1 [flox/flox, Cx3cr1-Cre]). We investigated the expression dynamics of Piezo1 following SCI, explored the phenotypic switching of macrophages/microglia under inflammatory cytokine stimulation, and examined the changes in hindlimb motor function in Piezo1-deficient mice. Our data demonstrated that macrophages/microglia in the injured segment gathered and activated after SCI, and the number of Pierzo1 + macrophages/microglia reached the peak at the 7th day. Piezo1 leads to pro-inflammatory response of macrophages/microglia with IFNγ/LPS stimulation, while inhibition of Piezo1 can lead to anti-inflammation under IL4/IL13 stimulation. Subsequently, Piezo1-CKO mice exhibited a faster and better recovery of neural function after SCI. These findings suggested that Piezo1 deletion ameliorates inflammation and functional recovery in spinal cord injury through altering microglia/macrophage phenotype.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1864 ","pages":"Article 149810"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical activity during balance and walking tasks in stroke patients: Functional near-infrared spectroscopy neuroimaging research","authors":"Yun-Juan Xie ,&nbsp;Kai-Xuan Chen ,&nbsp;Xiao-Dan Ma ,&nbsp;Mei-Si Song ,&nbsp;Hui Xie ,&nbsp;Kui Li ,&nbsp;Hong-Mei Wen ,&nbsp;Zu-Lin Dou","doi":"10.1016/j.brainres.2025.149808","DOIUrl":"10.1016/j.brainres.2025.149808","url":null,"abstract":"<div><h3>Background</h3><div>Stroke survivors frequently suffer from balance and gait impairments, yet the cortical mechanisms underlying these functions remain unclear. This study addresses this gap by utilizing portable functional near-infrared spectroscopy (fNIRS) to map task-specific neuroplasticity.</div></div><div><h3>Objectives</h3><div>We aimed to (1) compare cortical activation patterns during balance and walking tasks, (2) analyze functional connectivity (FC) and lateralization differences, and (3) explore correlations between neuroimaging metrics and clinical outcomes.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 31 stroke patients (60 ± 11.90 years; 29 % female) completed Tetrax balance training or AlterG treadmill walking. fNIRS measured hemodynamic responses in prefrontal, premotor, motor, somatosensory, and occipital cortices. Wavelet amplitude (WA) quantified activation; wavelet phase coherence (WPCO) assessed FC.</div></div><div><h3>Results</h3><div>Bilateral premotor cortex (PMC) and contralateral primary somatosensory cortex (S1) activation significantly increased during walking (<em>P</em> &lt; 0.001).</div><div>FC strength increased between ipsilateral occipital cortex (iOC) and contralateral S1/M1 during walking (<em>P</em> &lt; 0.05) but decreased in balance tasks.</div><div>Negative correlation emerged between contralateral PMC activation and Fugl-Meyer scores during balance (<em>r</em> = −0.537, <em>P</em> = 0.039), while activities of daily living (ADL) scores positively correlated with motor/occipital activation during walking (<em>r</em> = 0.53–0.87,<!--> <em>P</em> &lt; 0.035).</div><div>No lateralization asymmetry was observed (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusions</h3><div>Enhanced S1/occipital activation highlights critical roles of sensory-visual integration in post-stroke locomotion. Contralateral recruitment compensates for ipsilateral deficits during challenging tasks, providing neurophysiological insights for targeted rehabilitation.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1864 ","pages":"Article 149808"},"PeriodicalIF":2.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calycosin improved long-term memory impairment in the very early of APP/PS1 mice","authors":"Zeyuan Ding ,&nbsp;Jiaming Wang ,&nbsp;Wancong Ding ,&nbsp;Yingying Duan ,&nbsp;Fujian Qi ,&nbsp;Junru Liu ,&nbsp;Juan Li ,&nbsp;Jiangbi Wang","doi":"10.1016/j.brainres.2025.149789","DOIUrl":"10.1016/j.brainres.2025.149789","url":null,"abstract":"<div><div>Alzheimer’s disease is a progressive syndrome characterized by cognitive dysfunction, with neuroinflammation and β-amyloid plaque deposition representing early pathological hallmarks. Activated microglia and astrocytes play pivotal roles in neuroinflammation, further exacerbating the progression of Alzheimer’s disease. Calycosin, an active ingredient derived from <em>radix astragali</em>, binds to estrogen receptors to elicit estrogen-like effects and has demonstrated efficacy in alleviating cognitive impairment. However, the impact of calycosin on memory deficits and its underlying mechanisms in the very early stages of Alzheimer’s disease remain unknown. In this study, we aimed to investigate whether calycosin can ameliorate early memory loss by inhibiting microglia and astrocyte activation in the initial stages of Alzheimer’s disease. To this end, we selected 3-month-old APP/PS1 transgenic mice and administered 20 mg/kg of calycosin daily for 90 days. Our findings revealed that calycosin administration improved long-term memory impairment, but had no significant effect on short-term learning and memory. Furthermore, calycosin reduced the number of β-amyloid plaques and alleviated neuronal loss in the cortex, although no such effect was observed in the hippocampus. Notably, calycosin did not alter the number of activated astrocytes or microglia surrounding β-amyloid plaques. Collectively, these results suggest that the improvement in long-term memory function observed with calycosin is not mediated through the inhibition of glial cell activation. These findings contribute to our understanding of the potential mechanisms underlying the beneficial effects of calycosin in Alzheimer’s disease and highlight the complexity of its actions in this disease.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1864 ","pages":"Article 149789"},"PeriodicalIF":2.7,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based ischemic stroke detection and categorization with non-invasive plantar pressure data","authors":"Zahra Atrachali ,&nbsp;Peyvand Ghaderyan","doi":"10.1016/j.brainres.2025.149807","DOIUrl":"10.1016/j.brainres.2025.149807","url":null,"abstract":"<div><h3>Purpose</h3><div>The reliable and cost-effective automatic detection of stroke is crucial for prompt treatment and rehabilitation progress. However, the current diagnosis still relies on expensive brain imagining techniques and manual assessments, resulting in a need for medical visits, experts, or human errors.</div></div><div><h3>Methods</h3><div>This study has focused on development and validation of a machine learning-based screening algorithm using cost-effective and non-invasive foot pressure signals. The signals reflect affected motor-control mechanisms and gait disturbance following stroke with high temporal resolution. A novel set of foot pressure biomarkers has been proposed based on Empirical Fourier Decomposition combining an improved Fourier spectrum segmentation and a zero-phase filter bank to characterize the affected pressure distribution pattern. Afterward, the proposed approach combines the selection power of the ReliefF ranking algorithm and the classification power of support vector machine and K-nearest neighbors in a new framework to choose the discriminative pressure components, features, plantar areas, and sensors for offering high detection performance.</div></div><div><h3>Results</h3><div>This automatic method has been evaluated using 198-foot plantar sensors recorded during walking in a sample of 82 subjects (46 healthy controls and 36 patients afflicted with stroke). It has achieved approximately perfect detection performance with an average accuracy rate of 99.19% and robust performance against clinical factors.</div></div><div><h3>Conclusion</h3><div>The proposed detection method is unique in its ability to provide robust performance against stroke sides and blood pressure status as well as to successfully detect stroke with a small number of biomarkers extracted from the toe and finger regions.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1864 ","pages":"Article 149807"},"PeriodicalIF":2.7,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}