Brain Research最新文献

{"title":"Transcriptomic and network analysis identifies shared pathways across Alzheimer's disease and vascular dementia.","authors":"Cengceng Zheng, Yejing Zhao, Chaoying Hu, Li Zhang, Gengkuo Li, Cuicui Yang","doi":"10.1016/j.brainres.2025.149548","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149548","url":null,"abstract":"<p><p>Alzheimer's disease (AD) and vascular dementia (VaD) are often accompanied, but there are no effective differential diagnosis and treatment for VaD. The search for common pathogenic targets or pathways connecting the two diseases is helpful to the drug development and treatment of the disease. In this study, we used gene expression array data from the GEO database to analyze common differentially expressed genes (DEGs) in the temporal cortex of patients with AD and VaD. AD and VaD shared 143 DEGs. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that the biological function of common DEGs was mainly related to chemical synaptic transmission, neuroactive ligand-receptor, and cytokine-cytokine receptor interaction pathway. The protein-protein interaction (PPI) analysis showed the interaction of down- and up-regulated DEGs. The mRNA expression levels of key proteins in neuroactive ligand-receptor and cytokine-cytokine receptor interaction pathway were verified in AD and VaD mice. The real-time quantitative polymerase chain reaction (RT-qPCR) test was used to detect the expression of DEGs. Data of RT-qPCR showed the mRNA level of γ-aminobutyric acid type B receptor subunit 1 (GABBR1) was decreased in both AD and VaD. In addition, the mRNA of interleukin-17 receptor A (IL-17RA), IL-17 and IL-18 were increased. In conclusion, the shared genes in AD and VaD were verified in our study. We identified the critical genes to offer a theoretical basis for understanding the linkage of AD and VaD, which provided potential drug targets against AD and VaD.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149548"},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative effect of stress on decisional exploration-to-exploitation switch assessed through a gambling task in female mice","authors":"Stéphanie Cramoisy ,&nbsp;Lidia Cabeza ,&nbsp;Bahrie Ramadan ,&nbsp;Christophe Houdayer ,&nbsp;Emmanuel Haffen ,&nbsp;David Belin ,&nbsp;Yvan Peterschmitt ,&nbsp;Fanchon Bourasset","doi":"10.1016/j.brainres.2025.149546","DOIUrl":"10.1016/j.brainres.2025.149546","url":null,"abstract":"<div><div>Survival and well-being hinge on an organism’s ability to evaluate options, weighing costs and benefits to make adaptive decisions. It has long been shown that stress influences cognition and reward-related behaviour, the nature of which depends on the stressor’s type and duration as well as gene x environment interactions. However, how stress influence decision-making in females has not been completely elucidated. Here, we have developed a new mouse gambling task (mGT) adapted to assess decision-making under uncertainty and risk. Adult female C57BL/6JRj mice administered with corticosterone (CORT) for 5 or 8 weeks reached similar final performance in the mGT as vehicle-treated controls. All groups tended to learn to maximize gain as the task progressed. Our results revealed that individual choice kinetics is impacted by chronic exposure to CORT, showing an accentuated sensitivity to penalties in female mice. These results confirm the suitability of our new mGT to assess decision-making under uncertainty and risk and are in line with previous reports of the effect of chronic CORT treatment on decision-making in male mice. Thereby this study provides new insights into the influence of sex and stress on decision-making.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1854 ","pages":"Article 149546"},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of the role of Caspases in glioma.","authors":"Heming Wang, Qunfang Mei, Pengying Mei","doi":"10.1016/j.brainres.2025.149529","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149529","url":null,"abstract":"<p><p>Caspases (CASPs) are attractive targets for cancer therapy. Many prognostic models based on gene signatures include genes from the CASPs family in diffuse glioma. CASP3, CASP4 and CASP6 in glioma have been studied individually. However, specialized comprehensive analysis of the roles CASPs family in glioma is lacking. Therefore, this study utilized bioinformatics methods to investigate this issue. CASP1-10 expressions were significantly up-regulated in LGG and GBM and glioma, and varied significantly across different clinical subgroups of glioma and LGG and various cell types, and most of CASP1-10 showed significant differences in recurrence status of LGG. 10 signatures (CASP1-10) were associated with poor overall survival (OS) in glioma and LGG and GBM. However, pan-cancer survival analysis showed that CASP1-10 were associated with the prognosis of LGG, but not GBM. CASP1-10 were related to poor prognosis of glioma and LGG, except for CASP9, which was the opposite of a protective factor. CASP1-10 were independent prognostic factors for OS in glioma and LGG, except for CASP5, and also for recurrence-free survival (RFS) in LGG. Most of CASP1-10 were also independent prognostic factors for disease-specific survival (DSS) and progression-free interval (PFI) and had diagnostic value in glioma and LGG. Genetic alterations of CASP1-10 genes set were associated with poor prognosis in LGG. CASP1-10 were involved in immune infiltration and programmed cell death in glioma and LGG and GBM, and might promote the apoptosis of immune cells. Compared to GBM, CASP1-10 had a more significant impact on the prognosis, cancer-related pathways, and immune infiltration in LGG, indicating that CASP1-10 might play important roles in the recurrence and progression of LGG, and might be promising therapeutic targets for LGG. Therefore, it is speculated that natural caspase inhibitor p35 may be a promising drug for the treatment of glioma, especially for LGG.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149529"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol impairs learning and timing of conditioned eyeblink responses","authors":"Fredrik Johansson ,&nbsp;Vincent Rydberg ,&nbsp;Nils-Erik Arn ,&nbsp;Johannes Lundin ,&nbsp;Artem Gornov ,&nbsp;Robert Winton ,&nbsp;Guy Madison ,&nbsp;Germund Hesslow ,&nbsp;Anders Rasmussen","doi":"10.1016/j.brainres.2025.149545","DOIUrl":"10.1016/j.brainres.2025.149545","url":null,"abstract":"<div><div>Alcohol impairs motor performance, but it remains unclear precisely why this is the case. Here, we examine the effects of alcohol intoxication on conditioned eyeblink responses, a form of classical conditioning dependent on the cerebellum. In experiment 1, the conditioned responses of 18 students before and after alcohol consumption up to 1 ‰ were compared against the performance of 26 non-drinking controls. In experiment 2, 17 students were tested repeatedly at increasing blood alcohol levels up to 1 ‰. The results reveal a gradual decrease in both the percentage and timing of conditioned responses following alcohol consumption, with pronounced impairments emerging at blood alcohol content levels exceeding 0.5 ‰. These findings are consistent with the idea that the motor deficits associated with alcohol consumption are linked to effects on the cerebellum.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1854 ","pages":"Article 149545"},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avocado (Persea americana Mill.) consumption during pregnancy and lactation induces anxiogenic-like behavior, cerebral oxidative stress and compromises fecal microbiota in rat offspring.","authors":"Marília Ferreira Frazão Tavares de Melo, Renally de Lima Moura, Elisiane Beatriz da Silva, Diego Elias Pereira, Maciel da Costa Alves, Larissa Maria Gomes Dutra, Daline Fernandes de Araújo, Gerlane Coelho Bernardo Guerra, Maria Manuela Estevez Pintado, Gustavo Felipe Correia Sales, Celso José Bruno de Oliveira, Juliana Késsia Barbosa Soares","doi":"10.1016/j.brainres.2025.149544","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149544","url":null,"abstract":"<p><p>This study aimed to evaluate the impact of consumption of avocado oil (AO) and pulp (AP) on anxiety-like behavior, cerebral oxidative stress and alteration of the fecal microbiota in the mother and male Wistar rats offspring treated during gestation and lactation. Anxiety-like behavior was measured through the elevated plus maze (EPM) and open field test (OFT) tests. Cerebral malondialdehyde (MDA) and glutathione (GLUT) levels were measured in mothers and offspring. The fatty acid profile was determined for maternal milk and brain. Data showed a shorter time spent on the open arms of EPM in mothers and offspring for those fed AO and AP (P < 0.001). Moreover, the AO offspring adolescent and adult spent less time in the central area (P < 0.05). Furthermore, offspring adults from the AO moved about less and offspring from the AP ambulated more (P < 0.001). MDA was increased in mothers and decreased in the offspring in AO and AP and GLUT was lower in mothers and higher in adolescent and adult offspring in AP (P < 0.05). Polyunsaturated fatty acids in the brain and breast milk in AO and AP were decreased (P < 0.05). Furthermore, there was an increase in the abundance of intestinal bacteria related to the production of inflammatory metabolites that compromised brain function in offspring treated with avocado. These results suggest that avocado induces anxiogenic-like behavior and increases cerebral oxidative stress in mothers and offspring of rats treated during pregnancy and lactation, negatively altering the fecal microbiota of the offspring. So, we report for the first time how the consumption of avocado oil and pulp interferes with a developing organism when consumed in the early stages of life in rats.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149544"},"PeriodicalIF":2.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of an efficient and economical method for primary oligodendrocyte progenitor cell culture from neonatal mouse brain","authors":"Hong Liu ,&nbsp;Yimin Yuan ,&nbsp;Jiali Li ,&nbsp;Zhida Lan ,&nbsp;Ziwei Dai ,&nbsp;Guanyu Li ,&nbsp;Kouwei Xiao ,&nbsp;Yingyan Pu ,&nbsp;Cheng He ,&nbsp;Shangyao Qin ,&nbsp;Zhida Su","doi":"10.1016/j.brainres.2025.149519","DOIUrl":"10.1016/j.brainres.2025.149519","url":null,"abstract":"<div><div>The primary culture of oligodendrocyte progenitor cells (OPCs) provides an indispensable tool for characterizing their biological properties and myelin repair potential. However, the current OPC preparation methods are mainly limited to rat tissues, and it remains a substantial challenge for replicating the primary culture from mouse tissues to generate large quantities of high-quality OPCs. Here, we describe a protocol to successfully establish highly enriched OPC cultures from the cerebral cortex of mice at the age of neonatal 3 days. OPCs were isolated and purified from the bed layer of astrocytes by shaking for 6 h at 250 rpm. Using this protocol, mouse OPCs can be easily produced in bulk and economically without the need for specific cell-surface antibodies and equipment. These mouse OPC cultures were identified by immunocytochemical, immunobloting and RNA-seq analysis. Furthermore, they could be expanded <em>in vitro</em> and differentiate into mature oligodendrocytes. We propose this method as a viable and affordable protocol to obtain mouse OPC culture, which should significantly facilitate studies on OPC lineage progression and their application in myelin-related disease modeling and regenerative medicine.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1853 ","pages":"Article 149519"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143526556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treadmill exercise mitigates rotenone-induced neuroinflammation and α-synuclein level in a mouse model of Parkinson’s disease","authors":"Deepak Kumar ,&nbsp;Rohith Kumar ,&nbsp;Sushmita Janrao ,&nbsp;Vaishnavi Sharma ,&nbsp;Nusrat Begum ,&nbsp;Valencia Fernandes ,&nbsp;Dharmendra Kumar Khatri","doi":"10.1016/j.brainres.2025.149540","DOIUrl":"10.1016/j.brainres.2025.149540","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting 7–10 million people globally. It presents with motor symptoms like bradykinesia, tremors, rigidity, and postural instability, along with non-motor issues such as anxiety and mood fluctuations. PD is characterized by the progressive loss of nigrostriatal neurons, α-synuclein protein aggregation, reduced tyrosine hydroxylase level, and impaired dopamine signaling. Neuroinflammation plays a key role in PD progression, with elevated pro-inflammatory cytokines promoting M1 microglial activation, which exacerbates neurodegeneration. Conversely, anti-inflammatory cytokines such as IL-10 and IL-4 help shift microglia to the neuroprotective M2 phenotype, reducing inflammation. Animal models show an imbalance with increased M1 and reduced M2 microglia. This study explored the neuroprotective effects of treadmill exercise in a rotenone-induced PD mouse model. After 21 days of exercise, behavioral impairments improved, as shown by open field tests, Rota-rod, and footprint analysis. Exercise also reduced pro-inflammatory cytokines; TNF-α, and IL-1β levels while increasing anti-inflammatory cytokines; IL-10, and IL-4. This shift correlated with decreased α-synuclein levels and increased tyrosine hydroxylase expression, indicating reduced neurodegeneration. These findings suggest that treadmill exercise can mitigate PD symptoms and pathology by modulating neuroinflammation and restoring dopaminergic function.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1854 ","pages":"Article 149540"},"PeriodicalIF":2.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal resting-state brain networks and their relationship with cognitive reappraisal preferences in depressive tendencies","authors":"Yan Sun,&nbsp;Xinge Mao,&nbsp;Peiyu Hou","doi":"10.1016/j.brainres.2025.149522","DOIUrl":"10.1016/j.brainres.2025.149522","url":null,"abstract":"<div><h3>Objective</h3><div>Currently, the neural mechanisms underlying the topological changes in the brains of individuals with depressive tendencies and the decline in their emotion regulation abilities remain largely unknown. Therefore, this study investigates resting-state brain network characteristics in college students with depressive tendencies (DT) and their preference to cognitive reappraisal strategies.</div></div><div><h3>Method</h3><div>A group of 38 DT students and 41 healthy controls (HCs) were assessed using questionnaires on cognitive reappraisal sub-strategies, followed by alpha and beta frequency band EEG feature extraction.</div></div><div><h3>Results</h3><div>Through complex network analysis, DT participants showed significantly reduced preferences for positive reappraisal and detached reappraisal compared to HCs, while exhibiting higher preferences for involved reappraisal and negative reappraisal. Additionally, abnormalities in brain network centrality were observed, particularly in the frontal and limbic lobes across various frequency bands. A significant correlation was found between the preference for cognitive reappraisal sub-strategies in DT participants and significant changes in graph indices.</div></div><div><h3>Conclusions</h3><div>The findings highlight substantial alterations in the resting-state brain networks of DT individuals, closely associated with cognitive reappraisal strategy preferences. These alterations may affect emotion regulation strategy choices, offering insights into the neural mechanisms of emotional regulation difficulties in DT.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1854 ","pages":"Article 149522"},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passiflora incarnate extract attenuates neuronal loss and memory impairment in stressed rats","authors":"Mohammad Amin Dehghani ,&nbsp;Gholam Hossein Meftahi ,&nbsp;Elham Moghtadaei Khorasgani","doi":"10.1016/j.brainres.2025.149520","DOIUrl":"10.1016/j.brainres.2025.149520","url":null,"abstract":"<div><div>The present study investigated the protective effects of hydroalcoholic <em>Passiflora incarnate</em> extract on memory, anxiety-like behaviors, inflammatory factors, and cell density in the brain following stress. This study randomly divided 40 adult Wistar rats into 5 groups: control, normal saline, stress, stress + <em>Passiflora incarnata</em>, and <em>Passiflora incarnata</em> groups. For 21 consecutive days, the stress group and the <em>Passiflora inca</em>rnata + stress group were exposed to immobilizing stress for 2 h each day. The <em>Passiflora incarnata</em> and the stress + <em>Passiflora incarnata</em> groups were gavaged with <em>Passiflora incarnata</em> extract half an hour before stress for 21 days. One day after the last stress, the Barnes and elevated plus maze were used to measure learning, memory, and anxiety-like behavior, respectively. Additionally, the MDA (malondialdehyde), TNF-α, IL-1, and gamma-glutamyl transferase (GGT) factors in the serum, as well as the cell density in the hippocampus, amygdala, and prefrontal regions, were investigated. The results of the Barnes maze showed that immobility stress increases the number of errors and the distance traveled to reach the target hole. Administering <em>Passiflora incarnata</em> extract prior to stress led to fewer errors and a shorter distance covered to reach the target hole. The use of <em>Passiflora incarnata</em> before stress in the elevated plus maze reduced anxiety-like behaviours (less frequent entries into the open arm, reduced duration of time in the open arm) compared to the stress group. The stress group caused a significant enhance in MDA, TNF-α, and IL-1 and a decrease in GGT, while treatment with <em>Passiflora incarnata</em> significantly improved these factors than the stress group. The immobility stress caused a significant decrease in cell density in the hippocampus, amygdala, and prefrontal region, and treatment with <em>Passiflora incarnata</em> increased cell density in these areas than the stress animals. In conclusion, <em>Passiflora incarnata</em> improves learning and memory impairment, anxiety-like behaviors, inflammatory factors, and damage caused by stress in the hippocampus, amygdala, and prefrontal areas.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1853 ","pages":"Article 149520"},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIMI-ONET: Multi-Modal image augmentation via Butterfly Optimized neural network for Huntington DiseaseDetection.","authors":"S Amudaria, S Joseph Jawhar","doi":"10.1016/j.brainres.2025.149530","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149530","url":null,"abstract":"<p><p>Huntington's disease (HD) is a chronic neurodegenerative ailment that affects cognitive decline, motor impairment, and psychiatric symptoms. However, the existing HD detection methods are struggle with limited annotated datasets that restricts their generalization performance. This research work proposes a novel MIMI-ONET for primary detection of HD using augmented multi-modal brain MRI images. The two-dimensional stationary wavelet transform (2DSWT) decomposes the MRI images into different frequency wavelet sub-bands. These sub-bands are enhanced with Contract Stretching Adaptive Histogram Equalization (CSAHE) and Multi-scale Adaptive Retinex (MSAR) by reducing the irrelevant distortions. The proposed MIMI-ONET introduces a Hepta Generative Adversarial Network (Hepta-GAN) to generates different noise-free HD images based on hepta azimuth angles (45°, 90°, 135°, 180°, 225°, 270°, 315°). Hepta-GAN incorporates Affine Estimation Module (AEM) to extract the multi-scale features using dilated convolutional layers for efficient HD image generation. Moreover, Hepta-GAN is normalized with Butterfly Optimization (BO) algorithm for enhancing augmentation performance by balancing the parameters. Finally, the generated images are given to Deep neural network (DNN) for the classification of normal control (NC), Adult-Onset HD (AHD) and Juvenile HD (JHD) cases. The ability of the proposed MIMI-ONET is evaluated with precision, specificity, f1 score, recall, and accuracy, PSNR and MSE. From the experimental results, the proposed MIMI-ONET attains the accuracy of 98.85% and reaches PSNR value of 48.05 based on the gathered Image-HD dataset. The proposed MIMI-ONET increases the overall accuracy of 9.96%, 1.85%, 5.91%, 13.80% and 13.5% for 3DCNN, KNN, FCN, RNN and ML framework respectively.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149530"},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}