Brain Research最新文献

{"title":"Expression of concern: \"Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia\" [BRAIN RES, Volume 1153 (2007) 204-213].","authors":"Zhen-Xing Huang, Zhi-Min Kang, Guo-Jun Gu, Guang-Neng Peng, Liu Yun, Heng-Yi Tao, Wei-Gang Xu, Xue-Jun Sun, John H Zhang","doi":"10.1016/j.brainres.2025.149683","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149683","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149683"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Down-regulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats\" [BRAIN RES, Volume 1360 (2010) 147-158].","authors":"Tianzhu Wang, Jing Wang, Cheng Yin, Ruen Liu, John H Zhang, Xinyue Qin","doi":"10.1016/j.brainres.2025.149687","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149687","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149687"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats\" [BRAIN RES, Volume 1210 (2008) 223-229].","authors":"Jiasi Li, Wenwu Liu, Suju Ding, Weigang Xu, Yangtai Guan, John H Zhang, Xuejun Sun","doi":"10.1016/j.brainres.2025.149684","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149684","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149684"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Granulocyte-colony stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats\" [BRAIN RES, Volume 1145 (2007) 227-238].","authors":"Kenichiro Yata, Gerald A Matchett, Tamiji Tsubokawa, Jiping Tang, Kenji Kanamaru, John H Zhang","doi":"10.1016/j.brainres.2025.149682","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149682","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149682"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress\" [BRAIN RES, Volume 1328 (2010) 152-161].","authors":"Jian Li, Cai Wang, John H Zhang, Jian-Mei Cai, Yun-Peng Cao, Xue-Jun Sun","doi":"10.1016/j.brainres.2025.149685","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149685","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149685"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme\" [BRAIN RES, Volume 1343 (2010) 178-185].","authors":"Zhang Ping, Wenwu Liu, Zhimin Kang, Jianmei Cai, Qiusha Wang, Ni Cheng, Sujian Wang, Shizhong Wang, John H Zhang, Xuejun Sun","doi":"10.1016/j.brainres.2025.149686","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149686","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149686"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal famine exposure and late-life functional brain network connectivity: A longitudinal study.","authors":"Amber Boots, Jessica S Damoiseaux, Youjin Jung, Aline Marileen Wiegersma, Anouk Schrantee, Daphne E Boucherie, Tessa J Roseboom, Susanne R de Rooij","doi":"10.1016/j.brainres.2025.149859","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149859","url":null,"abstract":"<p><p>The effects of the prenatal environment on resting-state functional connectivity in the brain can be detected up into older adulthood. We previously identified differences in resting-state functional connectivity of the default mode network (DMN), salience network (SN), and central executive network (CEN) at age 68 between men and women in the Dutch famine birth cohort who had been exposed or unexposed to famine in early gestation. Here, we investigated longitudinal changes in resting-state functional connectivity of the DMN, SN and CEN between ages 68 (n = 115) and 74 (n = 80) in the same cohort. Within- and between-network functional connectivity of the DMN, SN and CEN was compared between individuals unexposed (born before or conceived after) or exposed to famine in early gestation using a latent change score modeling approach with full information maximum likelihood estimation. No group differences were observed in baseline within-network functional connectivity (intercept; Δχ² = 1.41; p = 0.70) or rate of change (slope; Δχ² = 0.20; p = 0.98) of the DMN, SN and CEN between individuals exposed or unexposed to famine in early gestation. Given the poor fit of the between-network model including group status, differences between exposed and unexposed groups could not be explored. Across both groups, there was a significant increase in DMN connectivity over time and an increased negative functional connectivity between the DMN and SN. This study did not reveal more pronounced aging-related alterations in network connectivity among individuals exposed to famine in early gestation compared to unexposed individuals. Thereby, this study does not provide evidence for accelerated brain aging-related patterns of resting-state functional connectivity after prenatal famine exposure.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149859"},"PeriodicalIF":2.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does parental diet alter the neurobehaviour and the reflex and somatic parameters of the offspring?","authors":"Rafael Oliveira Pinheiro, Juliana Késsia Barbosa Soares, Anne Caroline Alves Vieira, Maria Luiza Rolim Bezerra, Geyse Araújo Costa, Mariany Bernardino da Silva Barbalho, Artur D' Angelo da Silva Andrade, Angela Maria Tribuzy de Magalhães Cordeiro, Adriano Francisco Alves, Alana Natalícia Vasconcelos de Araújo, Jailane de Souza Aquino","doi":"10.1016/j.brainres.2025.149860","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149860","url":null,"abstract":"<p><strong>Background: </strong>The early-life nutritional environment plays crucial role in shaping offspring development. While most studies have assessed maternal or paternal high-fat diet (HFD) exposure independently, the combined impact of both remains poorly understood across developmental, metabolic, and behavioural parameters. This study evaluated the effects of maternal and paternal HFD consumption on offspring metabolism, neurodevelopment, and anxiety-like behaviour.</p><p><strong>Methods: </strong>Male and female Wistar rats were randomised into four dietary groups (n = 10/group): NF/NF (both sexes received a normal-fat diet, NFD), HF/NF (only males received an HFD), NF/HF (only females received an HFD), and HF/HF (both sexes received an HFD). Offspring were assessed for physical growth, somatic maturation, reflex ontogeny (postnatal days 0-21), anxiety-like behaviours (open field and elevated plus maze tests), lipid profile, brain fatty acid composition, and prefrontal cortex histology.</p><p><strong>Results: </strong>NF/HF and HF/HF groups showed delayed somatic growth and altered physical development. Reflex maturation was impaired in HF/NF and NF/HF offspring. Anxiety-like behaviours were more evident in NF/HF and HF/HF groups. The HF/HF group exhibited elevated total cholesterol (439.28 ± 71.88 mg/dL), higher LDL (151.11 ± 28.72 mg/dL), reduced HDL (36.84 ± 18.93 mg/dL), reduced neuronal cell body size, and lower levels of brain polyunsaturated fatty acids.</p><p><strong>Conclusion: </strong>Combined maternal and paternal HFD intake exerts cumulative adverse effects on offspring, impairing physical development, reflex maturation, behaviour, and brain lipid composition. These findings provide novel evidence that parental nutritional status prior to conception jointly influences offspring neurobiological and metabolic trajectories, underscoring the importance of considering both maternal and paternal diets in early-life health strategies.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149860"},"PeriodicalIF":2.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer’s disease: a jigsaw puzzle comprised of different types of programmed cell death pieces","authors":"Yu Wang ,&nbsp;Dan Mu ,&nbsp;Ying Li ,&nbsp;Chang Liu ,&nbsp;Jianan Feng ,&nbsp;Yong Lai ,&nbsp;Guanhua Lou","doi":"10.1016/j.brainres.2025.149861","DOIUrl":"10.1016/j.brainres.2025.149861","url":null,"abstract":"<div><div>Alzheimer’s disease (AD), a prevalent neurodegenerative disorder among elderly populations, arises from complex interactions between genetic and environmental risk factors. Currently affecting over 55 million elderly individuals globally, AD cases are projected to reach approximately 150 million by 2050 due to demographic aging trends. AD is characterized by extracellular accumulated amyloid plaques (Aβ plaques), intracellular aggregated neurofibrillary tangles (NFTs), and extensive neurodegeneration caused by neuronal and neural cell death. Many investigations have proven assorted types of programmed cell death (PCD) contribute to the neurodegenerative process of AD, and many review articles have summarized the role of PCD in AD pathogenesis. While numerous experimental studies have demonstrated the involvement of various programmed cell death (PCD) pathways in Alzheimer’s disease (AD) pathogenesis, existing review articles lack comprehensive mechanistic integration. This review systematically evaluates all PCD-AD associations, including apoptosis, autophagy, necroptosis, parthanatos, phagoptosis, pyroptosis, NETosis, ferroptosis, and cuproptosis. Different from other existing reviews, this paper emphasizes that the pathogenesis of AD results from the combined involvement of multiple types of PCD (programmed cell death), rather than isolated pathways. Additionally, the roles of valence-variable metal ions in the pathogenesis of AD are also discussed.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149861"},"PeriodicalIF":2.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the role and mechanism of intermittent theta burst stimulation (iTBS) induced N-acetylaspartylglutamate (NAAG) in suppressing ferroptosis in ischemic stroke","authors":"Hanqing Zhao ,&nbsp;Yingli Bi ,&nbsp;Shiyan Wang ,&nbsp;Yuan Yin ,&nbsp;Linyan Huang ,&nbsp;Wan Wang ,&nbsp;Xiang Wang ,&nbsp;Suhua Qi ,&nbsp;Zunke Gong","doi":"10.1016/j.brainres.2025.149830","DOIUrl":"10.1016/j.brainres.2025.149830","url":null,"abstract":"<div><div>This study investigates the mechanism through which intermittent theta burst stimulation (iTBS) inhibits ferroptosis in ischemic stroke by inducing N-acetylaspartylglutamate (NAAG). In SD rats subjected to middle cerebral artery occlusion (MCAO), iTBS treatment significantly decreased ischemia–reperfusion (I/R) injury, improving motor, coordination, spatial memory abilities and Cognitive Impairment by enhancing synaptic function and neuronal repair. Western blot analysis showed that in MCAO rats treated with iTBS, GPX4 protein expression increased, while ACSL4, TFRC, and DMT1 protein levels decreased. Furthermore, malondialdehyde (MDA), a product of lipid peroxidation, was significantly reduced. The antioxidant levels of SOD and GSH were notably elevated, while the content of iron ions decreased. These results indicate that iTBS effectively inhibits ferroptosis by reducing oxidative stress and iron accumulation. Metabolomic analysis has revealed a novel finding that iTBS increases the levels of NAAG and inhibits its rate-limiting enzyme FOLH1 (GCP-II), thereby decreasing excitatory glutamate production, improving glutathione metabolism, and subsequently suppressing ferroptosis. In vitro experiments demonstrated that NAAG and 2-PMPA (a FOLH1 inhibitor) improved cell survival and antioxidant capacity in an oxygen-glucose deprivation/reperfusion (OGD/R) model, suppressing ferroptosis. In conclusion, iTBS exerts a neuroprotective effect by regulating the synthesis and metabolism of NAAG, enhancing antioxidant capacity and iron metabolism, and delaying ferroptosis. This research provides new insights into potential treatments for Post-Stroke Cognitive Impairment.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149830"},"PeriodicalIF":2.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}