Brain Research最新文献

Expression of concern: "Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia" [BRAIN RES, Volume 1153 (2007) 204-213]. 关注的表达：“在内皮素-1诱导的局灶性脑缺血大鼠模型中高压氧的治疗效果”[BRAIN RES, vol . 1153(2007) 204-213]。

IF 2.7 4区医学

Brain Research Pub Date : 2025-08-15 Epub Date: 2025-05-20 DOI: 10.1016/j.brainres.2025.149683

Zhen-Xing Huang, Zhi-Min Kang, Guo-Jun Gu, Guang-Neng Peng, Liu Yun, Heng-Yi Tao, Wei-Gang Xu, Xue-Jun Sun, John H Zhang

引用次数: 0

Expression of concern: "Down-regulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats" [BRAIN RES, Volume 1360 (2010) 147-158]. 关注的表达：“Nogo受体的下调通过增强大鼠脑卒中后轴突连通性促进功能恢复”[BRAIN RES, vol . 60(2010) 147-158]。

IF 2.7 4区医学

Brain Research Pub Date : 2025-08-15 Epub Date: 2025-05-20 DOI: 10.1016/j.brainres.2025.149687

Tianzhu Wang, Jing Wang, Cheng Yin, Ruen Liu, John H Zhang, Xinyue Qin

引用次数: 0

Expression of concern: "Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats" [BRAIN RES, Volume 1210 (2008) 223-229]. 关注的表达：“高压氧预处理通过上调大鼠的抗氧化酶诱导对脑缺血再灌注损伤的耐受性”[brain RES, vol . 1210(2008) 223-229]。

IF 2.7 4区医学

Brain Research Pub Date : 2025-08-15 Epub Date: 2025-05-19 DOI: 10.1016/j.brainres.2025.149684

Jiasi Li, Wenwu Liu, Suju Ding, Weigang Xu, Yangtai Guan, John H Zhang, Xuejun Sun

引用次数: 0

Expression of concern: "Granulocyte-colony stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats" [BRAIN RES, Volume 1145 (2007) 227-238]. 关注的表达：“粒细胞集落刺激因子抑制新生儿缺氧缺血后大鼠的凋亡神经元损失”[BRAIN RES, vol . 145(2007) 227-238]。

IF 2.7 4区医学

Brain Research Pub Date : 2025-08-15 Epub Date: 2025-05-19 DOI: 10.1016/j.brainres.2025.149682

Kenichiro Yata, Gerald A Matchett, Tamiji Tsubokawa, Jiping Tang, Kenji Kanamaru, John H Zhang

引用次数: 0

Expression of concern: "Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress" [BRAIN RES, Volume 1328 (2010) 152-161]. 关注的表达：“富氢盐水通过减少氧化应激改善淀粉样β诱导的阿尔茨海默病大鼠模型的记忆功能”[BRAIN RES, vol . 1328(2010) 152-161]。

IF 2.7 4区医学

Brain Research Pub Date : 2025-08-15 Epub Date: 2025-05-19 DOI: 10.1016/j.brainres.2025.149685

Jian Li, Cai Wang, John H Zhang, Jian-Mei Cai, Yun-Peng Cao, Xue-Jun Sun

引用次数: 0

Expression of concern: "Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme" [BRAIN RES, Volume 1343 (2010) 178-185]. 关注的表达：“萝卜硫素通过诱导nrf2依赖性2期酶保护大脑免受缺氧缺血性损伤”[BRAIN RES, vol . 43(2010) 178-185]。

IF 2.7 4区医学

Brain Research Pub Date : 2025-08-15 Epub Date: 2025-05-08 DOI: 10.1016/j.brainres.2025.149686

Zhang Ping, Wenwu Liu, Zhimin Kang, Jianmei Cai, Qiusha Wang, Ni Cheng, Sujian Wang, Shizhong Wang, John H Zhang, Xuejun Sun

引用次数: 0

Corrigendum to “Neuroprotective effect of Cyclosporin A on the development of early brain injury in a subarachnoid hemorrhage model: a pilot study” [Brain Res. 1472 (2012) 113–123. doi: 10.1016/j.brainres.2012.06.053. PMID: 22796593] “环孢素A对蛛网膜下腔出血模型早期脑损伤发展的神经保护作用：一项初步研究”[脑杂志]. 1472(2012)113-123。doi: 10.1016 / j.brainres.2012.06.053。PMID: 22796593)

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-16 DOI: 10.1016/j.brainres.2025.149764

Zongyi Xie , Bo Lei , Qin Huang , Jinmu Deng , Mingjun Wu , Weiwei Shen , Yuan Cheng

引用次数: 0

Regulation of LRRK2 activity by metabolic stress and heavy metal exposure 代谢应激和重金属暴露对LRRK2活性的调节

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-14 DOI: 10.1016/j.brainres.2025.149785

Michalis Kentros , Jordan Follett , Nitya Subrahmanian , Aravindraja Chairmandurai , Katerina Melachroinou , Diane B. Re , Rafael de Cabo , Ruth Chia , Jillian H. Kluss , Alexandra Beilina , Heather Mortiboys , Matthew J. LaVoie , Hardy J. Rideout , Mark R. Cookson , Adamantios Mamais

{"title":"Regulation of LRRK2 activity by metabolic stress and heavy metal exposure","authors":"Michalis Kentros , Jordan Follett , Nitya Subrahmanian , Aravindraja Chairmandurai , Katerina Melachroinou , Diane B. Re , Rafael de Cabo , Ruth Chia , Jillian H. Kluss , Alexandra Beilina , Heather Mortiboys , Matthew J. LaVoie , Hardy J. Rideout , Mark R. Cookson , Adamantios Mamais","doi":"10.1016/j.brainres.2025.149785","DOIUrl":"10.1016/j.brainres.2025.149785","url":null,"abstract":"<div><div>Genetic variability in the gene encoding leucine-rich repeat kinase 2 (LRRK2) is associated with both familial and sporadic Parkinson’s disease (PD). While LRRK2 is known to modulate vesicular trafficking and stress signaling through its phosphorylation and kinase activity, how it responds to metabolic and environmental stressors remains poorly understood. Here, we show that acute inhibition of glycolysis and oxidative phosphorylation triggers rapid, reversible dephosphorylation of LRRK2 at constitutive sites in cells, <em>ex vivo</em> brain slices, and primary astrocytes. In contrast, glucose deprivation modestly increases LRRK2 kinase activity and Rab substrate phosphorylation. <em>In vivo</em>, chronic 2-deoxyglucose treatment reduces S935 phosphorylation in kidney tissue, linking energy stress to LRRK2 modulation in peripheral organs. Strikingly, manganese (Mn), a PD-relevant environmental toxicant, robustly activates LRRK2, inducing pS1292 autophosphorylation and phosphorylation of Rab8a, Rab10 and Rab12, while suppressing S935 phosphorylation after a 24 hrs exposure. Time-resolved analysis revealed distinct temporal substrate regulation, with rapid Rab12 phosphorylation and pRab10 levels gradually increasing and peaking only after 24 h. Phosphorylated Rab10 remains closely associated with both lysosomal and centrosomal membranes under Mn stress. Mn impaired mitochondrial respiration and increased ROS, and antioxidant treatment rescued Rab10 phosphorylation, establishing a redox-dependent mechanism of LRRK2 activation. Together, these findings reveal stressor-specific modes of LRRK2 regulation and suggest that LRRK2 integrates metabolic and environmental signals via redox-sensitive pathways relevant to PD pathogenesis.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1863 ","pages":"Article 149785"},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the complexity of glioblastoma microenvironment: A comparative study of 3D and 2D cultures in response to combination drug therapy. 揭示胶质母细胞瘤微环境的复杂性：3D和2D培养对联合药物治疗反应的比较研究。

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-14 DOI: 10.1016/j.brainres.2025.149783

Rasoul Rashidi, Mahmoudreza Hadjighassem, Babak Negahdari

{"title":"Unraveling the complexity of glioblastoma microenvironment: A comparative study of 3D and 2D cultures in response to combination drug therapy.","authors":"Rasoul Rashidi, Mahmoudreza Hadjighassem, Babak Negahdari","doi":"10.1016/j.brainres.2025.149783","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149783","url":null,"abstract":"<p><p>Glioblastoma multiforme (GBM) represents one of the most prevalent and treatment-resistant forms of brain cancer. This investigation explored the therapeutic potential of a combined Erlotinib and Imatinib regimen through experimental studies conducted in both two-dimensional and three-dimensional cell culture systems. Cellular viability and apoptotic responses were evaluated 24- and 48-hours post-treatment utilizing MTT assays and flow cytometry, while gene expression analysis of Bcl-2 and VEGF was performed using qRT-PCR. Furthermore, the scratch assay was employed to assess the impact of drug treatment on cellular migration. Notably, lower drug concentrations were required in 3D cultures due to enhanced cell-cell interactions, resulting in greater cytotoxicity and a marked inhibition of tumor cell proliferation. Significant downregulation of Bcl-2 and VEGF expression was observed, particularly a pronounced reduction in Bcl-2, which correlated with elevated apoptosis rates after 48 h. Furthermore, the apoptotic effect of combination therapy was confirmed, with an increase in death percentage in 48 h-3D treated groups, as expected (*P < 0.05 for monotherapy and ***P < 0.001 for combination). The 3D culture model provided a physiologically relevant context for evaluating oncolytic therapies. These findings support the need for continued investigation through advanced preclinical models and eventual clinical validation.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149783"},"PeriodicalIF":2.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic modulation of cGAS-STING pathway in neurodegeneration. 神经退行性变中cGAS-STING通路的治疗调节。

IF 2.7 4区医学

Brain Research Pub Date : 2025-06-13 DOI: 10.1016/j.brainres.2025.149784

Veerta Sharma, Reet Verma, Prateek Sharma, Thakur Gurjeet Singh

{"title":"Therapeutic modulation of cGAS-STING pathway in neurodegeneration.","authors":"Veerta Sharma, Reet Verma, Prateek Sharma, Thakur Gurjeet Singh","doi":"10.1016/j.brainres.2025.149784","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149784","url":null,"abstract":"<p><p>Neurodegenerative diseases are characterized by progressive loss of neurons and chronic neuroinflammation. Emerging evidence highlights the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) plays a pivotal role in the innate immune system by detecting cytosolic DNA and initiating type-1 interferons and pro-inflammatory responses. In NDDs, the accumulation of misfolded or mutant proteins compromises mitochondrial function, leading to the release of mitochondrial or nuclear deoxyribose nucleic acid (DNA) into the cytosol. This aberrant DNA sensing activates the cGAS-STING pathway, triggering sustained neuroinflammatory cascades and contributing to neuronal dysfunction and disease progression. Therefore, this review highlights the role of cGAS-STING pathway as a promising therapeutic target, with pharmacological inhibitors demonstrating the potential to attenuate disease pathology in animal models. Future directions should focus on translating cGAS-STING modulators into clinical applications, optimizing their specificity and safety, and integrating biomarker-based strategies to enable patient stratification and monitor therapeutic efficacy. Modulating this pathway offers a novel and exciting avenue for intervention in currently intractable neurodegenerative conditions.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149784"},"PeriodicalIF":2.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0