Brain Research最新文献

{"title":"Harnessing anti-TNFR1 therapy has a limited impact on inflammation and motor function after stroke in obese male mice","authors":"Christine Haarslev ,&nbsp;Karen Bradshaw ,&nbsp;Silvia Corradini ,&nbsp;Stefano Raffaele ,&nbsp;Marta Fumagalli ,&nbsp;Marion S. Buckwalter ,&nbsp;Kate Lykke Lambertsen","doi":"10.1016/j.brainres.2025.149888","DOIUrl":"10.1016/j.brainres.2025.149888","url":null,"abstract":"<div><div>Obesity is a significant global health concern that exacerbates the risk and severity of ischemic stroke through chronic low-grade systemic inflammation and metabolic dysregulation. Tumor necrosis factor (TNF) signaling, particularly through its TNF receptor 1 (TNFR1), is involved in obesity-driven inflammation and adverse stroke outcomes. To assess the potential of TNFR1 blockade as a treatment strategy, we employed a diet-induced obesity model of ischemic stroke. Male C57BL/6 mice were fed a regular diet or high-fat diet for 6 weeks prior to stroke induction via photothrombosis and treated with either a TNFR1-neutralizing antibody or isotype control antibody. Outcomes were evaluated using motor function assessments, systemic inflammatory biomarker measurements, and brain tissue analysis, including evaluation of microglia, astrocytes, oligodendrocytes, myelin integrity, and stroke size. Results showed that obese mice exhibited worsened motor deficits and heightened systemic inflammation following stroke compared to non-obese controls. Treatment with anti-TNFR1 antibody did not ameliorate the increased functional deficits but did improve interleukin-6 cytokines levels after stroke in obese mice, while it had no effects on non-obese controls. Moreover, anti-TNFR1 therapy did not impact infarct size, microglial and astrocyte reactivity, or myelin integrity in both dietary groups. Overall, TNFR1-targeted therapy had a limited impact on obesity-exacerbated stroke outcomes, suggesting the need to explore broader or combination immunomodulatory approaches. These findings also emphasize the importance of considering comorbidities such as obesity in stroke, as they can influence both disease progression and treatment effectiveness.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149888"},"PeriodicalIF":2.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NF-κB signalling pathway in neurodegenerative diseases: Acupuncture as a potential therapeutic approach","authors":"Yangyang Wang ,&nbsp;Yuanfang Zhou ,&nbsp;Hao Tian ,&nbsp;Qifu Li ,&nbsp;Yan Chen ,&nbsp;Lu Wang ,&nbsp;Zihan Yin ,&nbsp;Jun Zhou ,&nbsp;Fanrong Liang","doi":"10.1016/j.brainres.2025.149893","DOIUrl":"10.1016/j.brainres.2025.149893","url":null,"abstract":"<div><div>The NF-κB signaling pathway plays a crucial role in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, particularly through its role in the regulation neuroinflammation, oxidative stress, protein misfolding, and apoptosis. Emerging evidence suggests that acupuncture modulates the NF-κB pathway, thus offering therapeutic potential by mitigating neuroinflammation, reducing oxidative stress, and protecting mitochondrial function. Specifically, acupuncture inhibits NF-κB activation, downregulates pro-inflammatory mediators like TNF-α and IL-6, and mitigates neurotoxicity and apoptosis. These effects are substantiated in animal models of Alzheimer’s and Parkinson’s diseases, with preliminary evidence in amyotrophic lateral sclerosis models. However, current studies largely rely on preclinical models with limited acupoint selection, short observation periods, and a lack of standardized protocols, posing challenges for translation to clinical settings. Future research should prioritize well-designed clinical trials, expand acupoint combinations, and explore synergistic effects with conventional therapies, aiming to maximize acupuncture’s therapeutic efficacy in neurodegenerative diseases.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149893"},"PeriodicalIF":2.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of digital addiction tendency on inhibitory control in preschoolers: An fNIRS study","authors":"Keya Ding ,&nbsp;Yining Shen ,&nbsp;Jing Gao ,&nbsp;Hui Li","doi":"10.1016/j.brainres.2025.149868","DOIUrl":"10.1016/j.brainres.2025.149868","url":null,"abstract":"<div><div>The increasing prevalence of digital devices in the lives of preschool-aged children raises concerns about their effects on early childhood development, particularly on inhibitory control, an essential cognitive function. This study investigates the relationship between digital addiction tendencies and inhibitory control using functional Near-Infrared Spectroscopy (fNIRS) to measure brain activation during a Fruit Stroop task. A sample of 71 typically developing preschoolers (29 boys, <em>M _age</em> = 60.73, <em>SD</em> = 7.79 months) was recruited, with 34 participants categorized into the high digital addiction tendency (HDAT) group (13 boys, <em>M _age</em> = 61.59, <em>SD</em> = 7.74 months) and 37 into the low digital addiction tendency (LDAT) group (16 boys, <em>M _age</em> = 59.95, SD = 7.86 months). The findings revealed that (1) accuracy of LDAT was highest under inhibition conditions while accuracy of HDAT was lowest under neutral conditions; (2)children in HDAT group exhibited significantly lower activation in the bilateral dorsolateral prefrontal Cortex and premotor Cortex compared to their counterparts in LDAT; (3) during the inhibition task, the LDAT group demonstrated substantially higher activation in the bilateral inferior frontal gyrus, while the HDAT group showed significantly lower activation in the right inferior frontal gyrus during the neutral task; and (4) a correlation was found between left prefrontal cortex activation and accuracy in the LDAT group under neutral conditions, however, no correlation between brian activation and behavioral data was found in the HDAT. These results underscore the potential negative impacts of excessive digital use on preschoolers’ inhibitory control, providing valuable insights for educators and caregivers regarding digital consumption management for young children.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149868"},"PeriodicalIF":2.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional specialization shapes abnormal cortical morphological similarity gradients in Wilson’s disease","authors":"Yuqi Song ,&nbsp;Weiqi Wang ,&nbsp;Sheng Hu ,&nbsp;Yulong Yang ,&nbsp;Chuanfu Li ,&nbsp;Kou Xu ,&nbsp;Zilong Li ,&nbsp;Taohua Wei ,&nbsp;Wenming Yang","doi":"10.1016/j.brainres.2025.149887","DOIUrl":"10.1016/j.brainres.2025.149887","url":null,"abstract":"<div><h3>Background</h3><div>Neuroimaging studies have revealed structural abnormalities in the brains of individuals with Wilson’s disease (WD), particularly within the basal ganglia, and the associated molecular mechanisms have been elucidated. However, the structural damage in the cerebral cortex, along with its underlying biological and molecular processes, remains elusive. Here, we investigated the abnormalities in cortical morphological similarity gradients associated with WD and further unraveled their underlying transcriptional specialization.</div></div><div><h3>Methods</h3><div>First, we analyzed cortical morphological features from structural magnetic resonance imaging scans from 102 WD patients and 90 healthy controls (HCs) and then computed the cortical morphological similarity (MS) connections. Subsequently, the diffusion map embedding approach was employed to investigate the cortical MS gradients. Finally, the differences in MS gradients between WD and HC were analyzed and their underlying clinical relevance and transcriptional specialization were revealed using clinical symptoms and gene expression data, respectively.</div></div><div><h3>Results</h3><div>Compared with HC, WD patients exhibited regional differences across extensive brain networks in both the first and second MS gradients. Alterations in MS gradient alterations correlated with age, neurological symptoms, liver function symptoms, and motor-related processing. Partial least squares (PLS) regression analysis results indicated a significant association between MS gradients and gene expression profiles (PLS components). Gene enrichment analysis showed that the transcriptional specialization of PLS components was enriched in biological processes such as cell projection organization, regulation of protein organization, and GPTase-mediated signal transduction, all of which are relevant to WD. The transcriptional specializations influencing the MS gradient of WD were also enriched in WD’s pathological genes associated with WD and other neuropsychiatric risks, such as dystonia and Parkinsonism.</div></div><div><h3>Conclusion</h3><div>Overall, this research offers new perspectives on the neurobiological foundations that govern the emergence of complex neural architectures and associated mental manifestations in WD.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1865 ","pages":"Article 149887"},"PeriodicalIF":2.6,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia\" [BRAIN RES, Volume 1153 (2007) 204-213].","authors":"Zhen-Xing Huang, Zhi-Min Kang, Guo-Jun Gu, Guang-Neng Peng, Liu Yun, Heng-Yi Tao, Wei-Gang Xu, Xue-Jun Sun, John H Zhang","doi":"10.1016/j.brainres.2025.149683","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149683","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149683"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Down-regulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats\" [BRAIN RES, Volume 1360 (2010) 147-158].","authors":"Tianzhu Wang, Jing Wang, Cheng Yin, Ruen Liu, John H Zhang, Xinyue Qin","doi":"10.1016/j.brainres.2025.149687","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149687","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149687"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats\" [BRAIN RES, Volume 1210 (2008) 223-229].","authors":"Jiasi Li, Wenwu Liu, Suju Ding, Weigang Xu, Yangtai Guan, John H Zhang, Xuejun Sun","doi":"10.1016/j.brainres.2025.149684","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149684","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149684"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POU2F1 facilitates the malignant phenotypes and aerobic glycolysis of pituitary adenoma by activating LDHA transcription","authors":"Huanhuan Wang,&nbsp;Fengjiao Zhang,&nbsp;Lei Li,&nbsp;Zhiqiang Kang,&nbsp;Jing Li,&nbsp;Yu Mao,&nbsp;Kai Liu,&nbsp;Lige Song,&nbsp;Shuai Shan","doi":"10.1016/j.brainres.2025.149870","DOIUrl":"10.1016/j.brainres.2025.149870","url":null,"abstract":"<div><h3>Background</h3><div>Pituitary adenoma (PA) can be benign, invasive, and metastatic, and its invasiveness and metastasis are poor prognosis factors for PA patients. Lactate dehydrogenase A (LDHA) plays a key role in glycolysis, and its overexpression can promote PA cell proliferation and invasion; however, the underlying mechanisms remain poorly understood.</div></div><div><h3>Methods</h3><div>Reverse-transcription quantitative polymerase chain reaction and western blot were used to quantify the expression of target genes. MTT, EdU, and flow cytometry assays were utilized to detect the viability, proliferation, and apoptotic rates of HP75 cells, respectively. The invasion and migration of HP75 cells were measured by invasion and wound healing assays, and the sphere formation ability of HP75 cells was analyzed by sphere formation assay. The aerobic glycolysis of HP75 cells was tested by the corresponding kits. The JASPAR, GeneCards, and PROMO databases were used to predict the potential transcription factors of LDHA. The interaction between POU domain class 2 transcription factor 1 (POU2F1) and LDHA was verified by dual-luciferase reporter and chromatin immunoprecipitation assays. A xenograft tumor model was constructed to measure the effects of the POU2F1/LDHA axis on tumor growth <em>in vivo</em>.</div></div><div><h3>Results</h3><div>LDHA was upregulated in PA tissues, and its expression levels in invasive PA tissues were higher than those in non-invasive ones. LDHA knockdown inhibited the proliferation, invasion, migration, sphere formation and aerobic glycolysis of HP75 cells and induced cell apoptosis. Mechanistically, POU2F1 activated LDHA expression to promote the proliferation, invasion, migration, sphere formation and aerobic glycolysis of HP75 cells and to inhibit cell apoptosis. Besides, LDHA overexpression could ameliorate the PI3K/AKT pathway inactivation induced by POU2F1 silence <em>in vivo</em> and <em>in vitro</em>. LDHA overexpression also alleviated the POU2F1 knockdown-induced inhibitory effect on tumor growth <em>in vivo</em>.</div></div><div><h3>Conclusion</h3><div>POU2F1-LDHA axis is up-regulated in pituitary adenomas and represents a potential therapeutic target for this disease.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149870"},"PeriodicalIF":2.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Granulocyte-colony stimulating factor inhibits apoptotic neuron loss after neonatal hypoxia-ischemia in rats\" [BRAIN RES, Volume 1145 (2007) 227-238].","authors":"Kenichiro Yata, Gerald A Matchett, Tamiji Tsubokawa, Jiping Tang, Kenji Kanamaru, John H Zhang","doi":"10.1016/j.brainres.2025.149682","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149682","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149682"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress\" [BRAIN RES, Volume 1328 (2010) 152-161].","authors":"Jian Li, Cai Wang, John H Zhang, Jian-Mei Cai, Yun-Peng Cao, Xue-Jun Sun","doi":"10.1016/j.brainres.2025.149685","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149685","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149685"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}