Brain Research最新文献_第9页

Psychophysiological indices of late-life depression: A systematic review 老年抑郁症的心理生理指标：系统综述。

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-27 DOI: 10.1016/j.brainres.2024.149361

Laura Catalano, Francesco Panico, Luigi Trojano, Laura Sagliano

{"title":"Psychophysiological indices of late-life depression: A systematic review","authors":"Laura Catalano, Francesco Panico, Luigi Trojano, Laura Sagliano","doi":"10.1016/j.brainres.2024.149361","DOIUrl":"10.1016/j.brainres.2024.149361","url":null,"abstract":"<div><h3>Background</h3><div>Major depression in the older population has a profound impact on patients’ quality of life and is associated with an increased risk of developing several medical illnesses. Psychophysiological methods, such as electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and eye-tracking, have provided evidence of physiological changes associated with depression in adult life. However, these aspects have not been thoroughly investigated during late-life (over 60 years of age).</div></div><div><h3>Methods</h3><div>A systematic review of the scientific literature covering the studies published between 1990 and 2022 was performed to describe the current evidence on easily attainable psychophysiological factors (detected by EEG, fNIRS and eye-tracking) associated with depression in late-life.</div></div><div><h3>Results</h3><div>Twelve studies were included in the systematic review. The included studies showed some consistent physiological patterns associated with late-life depression, such as brain hypoactivation in frontal and temporal areas and attentional biases toward emotional stimuli. No reliable patterns in EEG asymmetry and power spectrum were found, in contrast to studies on early-life depression.</div></div><div><h3>Limitations</h3><div>The small number of available studies, together with the heterogeneity in the techniques and methods used, highlight the need for further research to reliably identify the psychophysiological aspects of depression in late-life.</div></div><div><h3>Conclusions</h3><div>Physiological indices of late-life depression, as assessed by EEG, fNIRS and eye-tracking, may differ from those of early-life. The study of these indices could better clarify the physiological mechanisms underlying late-life depression with possible clinical and research implications. Recommendations for future research are also discussed.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149361"},"PeriodicalIF":2.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral transcranial direct-current stimulation confers neuroprotection through suppression of PKM2 after mouse cerebral ischemia injury 双侧经颅直流电刺激通过抑制小鼠脑缺血损伤后的 PKM2 发挥神经保护作用

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-26 DOI: 10.1016/j.brainres.2024.149353

Jinyang Ren , Jingchen Gao , Xujin Yao , Xiyuran Wang , Xiangyi Kong , Tao Lin , Hui Wang , Wenlong Ma , Oleg O. Glebov , Qi Wan

{"title":"Bilateral transcranial direct-current stimulation confers neuroprotection through suppression of PKM2 after mouse cerebral ischemia injury","authors":"Jinyang Ren , Jingchen Gao , Xujin Yao , Xiyuran Wang , Xiangyi Kong , Tao Lin , Hui Wang , Wenlong Ma , Oleg O. Glebov , Qi Wan","doi":"10.1016/j.brainres.2024.149353","DOIUrl":"10.1016/j.brainres.2024.149353","url":null,"abstract":"<div><h3>Background</h3><div>In its tetrameric form, pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays a key role in the metabolic reprogramming via regulating the signaling of pentose phosphate pathway (PPP). But the role of PKM2 in cerebral ischemia–reperfusion (I/R) injury remains unknown.</div></div><div><h3>Methods</h3><div>Mice model of middle cerebral artery occlusion (MCAO) and model of oxygen-glucose deprivation (OGD) injury in cultured neurons were established. PKM2 activator or inhibitor were used to test the effects of PKM2 in wild-type and PKM2 (−/-) mice after I/R injury. Biochemical and molecular approach were used to detect the level of PKM2 tetramers and PPP metabolites.</div></div><div><h3>Results</h3><div>We showed for the first time that ischemia-induced increase of PKM2 activity promoted neuronal death via the suppression of PPP-dependent antioxidant capacity. To identify therapeutic approach that suppresses ischemia-induced increase of PKM2 activity, we tested the effect of bilateral transcranial direct-current stimulation (BtDCS), a newly established BtDCS approach by us, on PKM2 activity after mouse I/R. Our data demonstrated that BtDCS inhibited PKM2 activity in the ischemic neurons. BtDCS also reduced the cerebral infarct volume and the neurological deficits in stroke mice. We found that BtDCS-induced neuroprotection was mediated through the suppression of PKM2 activity after I/R.</div></div><div><h3>Conclusions</h3><div>Together, this study provided novel evidence that supported PKM2 as a crucial regulator of neuronal metabolism after cerebral I/R injury, and revealed the molecular mechanism by which BtDCS protects against mouse cerebral I/R injury through regulating PKM2-mediated metabolic reprogramming.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149353"},"PeriodicalIF":2.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

“Nattokinase as a potential therapeutic agent for preventing blood-brain barrier dysfunction in neurodegenerative disorders” "纳豆激酶是预防神经退行性疾病血脑屏障功能障碍的潜在治疗药物

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-26 DOI: 10.1016/j.brainres.2024.149352

Nivedita Mahakalakar , Gunjan Mohariya , Brijesh Taksande , Nandkishor Kotagale , Milind Umekar , Madhura Vinchurney

{"title":"“Nattokinase as a potential therapeutic agent for preventing blood-brain barrier dysfunction in neurodegenerative disorders”","authors":"Nivedita Mahakalakar , Gunjan Mohariya , Brijesh Taksande , Nandkishor Kotagale , Milind Umekar , Madhura Vinchurney","doi":"10.1016/j.brainres.2024.149352","DOIUrl":"10.1016/j.brainres.2024.149352","url":null,"abstract":"<div><div>Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by progressive destruction of neurons and cognitive impairment, and thorough studies have provided evidence that these pathologies have a close relationship to the failure of the blood–brain barrier (BBB). Nattokinase (NK), a protease found in fermented soybeans, has been extensively studied because it displays powerful neuroprotective abilities, which is why current research was reviewed in the present article. It was concluded that there is enough evidence in preclinical studies using experimental animals that NK supplementation can alleviate the condition related to BBB dysfunction, reduce brain inflammation, and improve cognitive ability. Furthermore, the study of NK on the cardiovascular system leads to certain assumptions, which include the impact on vasculature function and the ability to manage blood flow, which is the key feature of BBB integrity. Such assumed mechanisms are fibrinolytic action, anti-inflammatory and antioxidant action, and endothelium function modulation. There are many positive research findings, and it seems that NK may serve as an effective opponent for BBB breakdown; however, a new research level should be taken to disclose the application and therapeutic use of NK in brain neurodegenerative disease.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149352"},"PeriodicalIF":2.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response of parvalbumin interneurons and perineuronal nets in rat medial prefrontal cortex and lateral amygdala to stressor controllability 大鼠内侧前额叶皮层和外侧杏仁核中的副斑块中间神经元和神经元周围网对压力源可控性的反应

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-26 DOI: 10.1016/j.brainres.2024.149351

Brittani Wallsten , Abigail H. Gligor , Angela E. Gonzalez , Jonathan D. Ramos , Michael V. Baratta , Barbara A. Sorg

{"title":"Response of parvalbumin interneurons and perineuronal nets in rat medial prefrontal cortex and lateral amygdala to stressor controllability","authors":"Brittani Wallsten , Abigail H. Gligor , Angela E. Gonzalez , Jonathan D. Ramos , Michael V. Baratta , Barbara A. Sorg","doi":"10.1016/j.brainres.2024.149351","DOIUrl":"10.1016/j.brainres.2024.149351","url":null,"abstract":"<div><div>Behavioral control over a stressor limits the impact of the stressor being experienced and produces enduring changes that reduce the effects of future stressors. In rats, these stress-buffering effects of control (escapable stress, ES) require activation of the medial prefrontal cortex (mPFC) and prevent the typical amygdala-dependent behavioral outcomes of uncontrollable stress (inescapable stress, IS). Parvalbumin (PV) interneurons regulate output of excitatory neurons, and most mPFC PV neurons are surrounded by perineuronal nets (PNNs), which regulate firing. We exposed male rats to a single session of ES, IS, or no stress and measured c-Fos expression within PV/PNN-containing cells in mPFC subregions (prelimbic, PL; infralimbic, IL) and in the lateral amygdala. We also measured the number and intensity of PNNs. Within PL and IL PV/PNN cells, both ES and IS increased c-Fos intensity in PV/PNN, non-PV, and non-PNN cells. Within the IL, only ES increased the number of c-Fos-expressing PV/PNN-labeled cells. In the lateral amygdala, only ES increased c-Fos intensity within PV cells and PV/PNN cells. Thus, PV neurons in the IL and lateral amygdala may represent an important substrate by which behavioral control buffers against the amygdala-dependent behavioral outcomes typically observed after uncontrollable stress.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1848 ","pages":"Article 149351"},"PeriodicalIF":2.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-fat diet during lactation, as opposed to during adolescence or gestation, programs cardiometabolic and autonomic dysfunctions in adult offspring 与青春期或妊娠期相比，哺乳期的高脂肪饮食会导致成年后代的心脏代谢和自律神经功能紊乱。

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-26 DOI: 10.1016/j.brainres.2024.149354

Annie Araújo Alves dos Santos , Rosana Torrezan , Willian do Nascimento de Souza Rodrigues, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Maria Natália Chimirri Peres, Lucas Paulo Jacinto Saavedra, Scarlett Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta , Paulo Cezar de Freitas Mathias

{"title":"High-fat diet during lactation, as opposed to during adolescence or gestation, programs cardiometabolic and autonomic dysfunctions in adult offspring","authors":"Annie Araújo Alves dos Santos , Rosana Torrezan , Willian do Nascimento de Souza Rodrigues, Maiara Vanusa Guedes Ribeiro, Anna Rebeka Oliveira Ferreira, Maria Natália Chimirri Peres, Lucas Paulo Jacinto Saavedra, Scarlett Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta , Paulo Cezar de Freitas Mathias","doi":"10.1016/j.brainres.2024.149354","DOIUrl":"10.1016/j.brainres.2024.149354","url":null,"abstract":"<div><div>The Developmental Origins of Health and Disease (DOHaD) concept has been established for three decades. Many studies have shown that, besides pregnancy, other plastic phases (mainly preconception, lactation, and infancy–adolescence) are also sensitive to environmental changes, including nutritional conditions, that can program health or disease later in life. This study compared the susceptibility of the gestation, lactation and adolescence to a high-fat diet (HFD) intervention to program rats into autonomic nervous system imbalance and cardiometabolic dysfunction in adulthood. Four groups of rats were studied: offspring from mothers exposed to a HFD (35% fat) or a standard chow diet (4.5% fat) during gestation (GEST and CONT groups, respectively), offspring from mothers exposed to the HFD during lactation (LAC), and adolescent rats exposed to the HFD (ADOL). Mothers treated during pregnancy exhibited a higher body mass, but nursing mothers presented the highest food energy intake and higher adiposity. Compared to the other groups, the LAC rats showed increased body mass gain, food energy intake, body fat, glucose intolerance and blood pressure. LAC group also showed increased parasympathetic activity. In contrast, LAC sympathetic nerve activity decreased compared with the other groups. The ADOL group exhibited mostly similar responses but of a smaller magnitude. This suggests that the lactation phase is the most sensitive to HFD programming for cardiometabolic dysfunction in adulthood and that early overnutrition may affect neural connections by altering the autonomic nervous system balance.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149354"},"PeriodicalIF":2.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying and reporting the precision of transcranial magnetic stimulation targeting 量化和报告经颅磁刺激定位的精确性。

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-24 DOI: 10.1016/j.brainres.2024.149350

Madison R. Burns, Molly S. Hermiller

{"title":"Quantifying and reporting the precision of transcranial magnetic stimulation targeting","authors":"Madison R. Burns, Molly S. Hermiller","doi":"10.1016/j.brainres.2024.149350","DOIUrl":"10.1016/j.brainres.2024.149350","url":null,"abstract":"<div><div>The precise positioning of the transcranial magnetic stimulation (TMS) coil on a person’s head is crucial for the efficacy and reliability of the delivered stimulation protocol. Sophisticated techniques have been developed to define subject-specific stimulation targets, and advancements in the use of MRI-guided neuronavigation allows for real-time monitoring of the coil location during the TMS session. However, there is a need for TMS users to objectively quantify and report the accuracy of their targeting. Here, we share our technique (open-source scripts) that extracts the location of each TMS pulse delivered in a session from an MRI-guided neuronavigation system and outputs measures of targeting precision. Such measures include the variance in coil location over the duration of a session, detection of ‘off-target’ pulses, and the distance error relative to the intended cortical target. Reporting these metrics in publications may aid in the replicability of methodology and reproducibility of results of TMS research and clinical treatments. Furthermore, these measures can be used in training TMS operators. We encourage others to adapt our technique to their system(s) and specific needs and to report their targeting precision.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149350"},"PeriodicalIF":2.7,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced oxygen supply to the prefrontal cortex during the Stroop task in migraine patients with aura: A preliminary functional near-infrared spectroscopy study 有先兆的偏头痛患者在进行 Stroop 任务时前额叶皮层供氧减少：一项初步的功能性近红外光谱研究。

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-23 DOI: 10.1016/j.brainres.2024.149344

Nilüfer Zengin , Çağdaş Güdücü , Irmak Çağlayanel , Vesile Öztürk

{"title":"Reduced oxygen supply to the prefrontal cortex during the Stroop task in migraine patients with aura: A preliminary functional near-infrared spectroscopy study","authors":"Nilüfer Zengin , Çağdaş Güdücü , Irmak Çağlayanel , Vesile Öztürk","doi":"10.1016/j.brainres.2024.149344","DOIUrl":"10.1016/j.brainres.2024.149344","url":null,"abstract":"<div><div>The role of the cerebrovascular system in migraine pathogenesis is critical. Several studies have demonstrated alterations in the regional cerebral blood flow that persist during headache-free intervals. In the present study, we aimed to measure the prefrontal hemodynamic responses to the cognitive task in interictal episodic migraineurs. We enrolled eight migraine patients with aura (mean age 25.75 ± 4.39 years), twelve migraine patients without aura (mean age 28.25 ± 6.59 years), and eleven age- and education-matched healthy subjects. We employed the Victoria Stroop task to assess executive functions, specifically selective attention and inhibitory control. The mean changes in the oxy-Hb, deoxy-Hb and total Hb concentrations during the Stroop interference (incongruent minus neutral) were recorded by functional near-infrared spectroscopy (fNIRS). Our preliminary results indicated that migraine patients with aura had higher reaction time (<em>p</em> = 0.033) and lower prefrontal oxy-Hb activity (<em>p</em> = 0.036) during the Stroop interference compared to healthy subjects. For the left lateral prefrontal cortex, migraine with aura group showed lower oxy-Hb activity than the healthy subjects during the Stroop interference (<em>p</em> = 0.009). However, there were no such differences in the right lateral prefrontal cortex. Additionally we found a relationship between prefrontal oxygenation and the severity of headaches, the frequency of attacks, and the number of monthly migraine days. We noticed a decrease in prefrontal blood flow in migraine patients with aura, even during the interictal periods. This may indicate that migraine with aura could be a persistent neurovascular uncoupling disorder. Moreover, the reduced oxygen supply to the prefrontal cortex may be associated with impaired frontal lobe functions.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149344"},"PeriodicalIF":2.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential protective effects and mechanisms of fasting on neurodegenerative disorders: A narrative review 禁食对神经退行性疾病的潜在保护作用和机制：叙述性综述。

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-23 DOI: 10.1016/j.brainres.2024.149348

Sahar Golpour-Hamedani , Gholamreza Askari , Fariborz Khorvash , Prashant Kesharwani , Mohammad Bagherniya , Amirhossein Sahebkar

{"title":"The potential protective effects and mechanisms of fasting on neurodegenerative disorders: A narrative review","authors":"Sahar Golpour-Hamedani , Gholamreza Askari , Fariborz Khorvash , Prashant Kesharwani , Mohammad Bagherniya , Amirhossein Sahebkar","doi":"10.1016/j.brainres.2024.149348","DOIUrl":"10.1016/j.brainres.2024.149348","url":null,"abstract":"<div><div>This study aimed to review the potential neuroprotective effects and underlying mechanisms of fasting in neurodegenerative disorders by synthesizing the existing literature. Research indicates that fasting may induce substantial modifications in both brain structure and function through diverse metabolic and cellular pathways. Preclinical studies utilizing animal models have elucidated several key mechanisms mediating these effects. The other significant proposed mechanism involves the modulation of gut microbiota during fasting periods. The intestinal microbiome functions as a crucial intermediary in the complex interplay between feeding patterns, circadian rhythms, and immune responses. These microbiome alterations may subsequently exert considerable influence on central nervous system functionality. Moreover, by reducing glucose availability, fasting has been shown to enhance the survival and resistance of healthy cells to adjuvant treatments in central nervous system tumors. Fasting presents a promising non-pharmacological intervention for neurodegenerative disorders, potentially offering both preventive and therapeutic benefits. However, the current evidence base remains preliminary, warranting extensive further investigation to validate these initial findings and establish robust clinical protocols for both efficacy and safety.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149348"},"PeriodicalIF":2.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ferritinophagy and ferroptosis in Alzheimer's disease. 铁蛋白吞噬和铁蛋白沉积在阿尔茨海默病中的作用

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-23 DOI: 10.1016/j.brainres.2024.149340

Ziwen Chen, Nan Zheng, Fuwei Wang, Qiong Zhou, Zihao Chen, Lihua Xie, Qiang Sun, Li Li, Baohong Li

{"title":"The role of ferritinophagy and ferroptosis in Alzheimer's disease.","authors":"Ziwen Chen, Nan Zheng, Fuwei Wang, Qiong Zhou, Zihao Chen, Lihua Xie, Qiang Sun, Li Li, Baohong Li","doi":"10.1016/j.brainres.2024.149340","DOIUrl":"10.1016/j.brainres.2024.149340","url":null,"abstract":"<p><p>Iron is a crucial mineral element within human cells, serving as a pivotal cofactor for diverse biological enzymes. Ferritin plays a crucial role in maintaining iron homeostasis within the body through its ability to sequester and release iron. Ferritinophagy is a selective autophagic process in cells that specifically facilitates the degradation of ferritin and subsequent release of free iron, thereby regulating intracellular iron homeostasis. The nuclear receptor coactivator 4 (NCOA4) serves as a pivotal regulator in the entire process of ferritinophagy, facilitating its binding to ferritin and subsequent delivering to lysosomes for degradation, thereby enabling the release of free iron. The free iron ions within the cell undergo catalysis through the Fenton reaction, resulting in a substantial generation of reactive oxygen species (ROS). This process induces lipid peroxidation, thereby stimulating a cascade leading to cellular tissue damage and subsequent initiation of ferroptosis. Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive deterioration of emotional memory and cognitive function, accompanied by mental and behavioral aberrations. The pathology of the disease is characterized by aberrant deposition of amyloid β-protein (Aβ) and hyperphosphorylated tau protein. It has been observed that evident iron metabolism disorders and accumulation of lipid peroxides occur in AD, indicating a significant impact of ferritinophagy and ferroptosis on the pathogenesis and progression of AD. This article elucidates the process and mechanism of ferritinophagy and ferroptosis, investigating their implications in AD to identify novel targets for therapeutic intervention.</p>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":" ","pages":"149340"},"PeriodicalIF":2.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells MAZ 可调节少突胶质前体细胞的铁凋亡、凋亡和分化。

IF 2.7 4区医学

Brain Research Pub Date : 2024-11-23 DOI: 10.1016/j.brainres.2024.149349

Fangkun Jing, Quancai Wang, Yangxi Xu, Jingyu Dong, Haitao Huang, Yanfeng Li

{"title":"MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells","authors":"Fangkun Jing, Quancai Wang, Yangxi Xu, Jingyu Dong, Haitao Huang, Yanfeng Li","doi":"10.1016/j.brainres.2024.149349","DOIUrl":"10.1016/j.brainres.2024.149349","url":null,"abstract":"<div><div>Oligodendrocyte precursor cells (OPCs) respond rapidly to demyelination injury. However, the rescuing effects may be hindered by cell death of OPCs, leading to incomplete remyelination. This study aimed to explore the expression of MYC-associated zinc finger protein (MAZ) in demyelinated mice and the effects of MAZ on cell death form and differentiation of OPCs. Mice received demyelinating agent (cuprizone, CZ) for 5 weeks. Histological staining demonstrated that CZ feeding triggered demyelination in the corpus callosum (CC). Detection of iron content and ferroptosis markers indicated that ferroptosis was inducted in the CC of CZ-treated mice. Notably, we found CZ feeding resulted in a reduction of MAZ expression within the CC. Using CCK-8 assay, detection of iron content, MDA level, GSH level, and ferroptosis markers, lipid ROS detection, and immunofluorescence staining for 4-HNE, we found that knockdown of MAZ facilitated OPC ferroptosis. We also evaluated the susceptibility of MAZ-overexpressing OPCs to ferroptosis inducer, erastin, and demonstrated that MAZ-overexpressing OPCs were resistant to erastin-induced ferroptosis. TUNEL staining and western blot analysis indicated that MAZ knockdown promoted apoptosis of OPCs by inhibiting PI3K/Akt activation. Immunofluorescence staining of MBP indicated that knockdown of MAZ inhibited OPC differentiation. Moreover, we elucidate the mechanism responsible for MAZ’s protective effects on OPC death and differentiation, which may be achieved through transcriptional activation of SOX2. Our findings introduced MAZ as a beneficial modulator of OPC survival and differentiation, and it could serve as a potential therapeutic target for demyelination diseases.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1849 ","pages":"Article 149349"},"PeriodicalIF":2.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0