Systematic review of optimizing brain-targeted vitamin D delivery: Novel approaches to enhance mental illness therapeutics

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-04-24 DOI:10.1016/j.brainres.2025.149656

Jinghu He , Zhiyuan Gao , Xilian Li , Long Zhao , Xue Tian , Biao Gao

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引用次数: 0

Abstract

Background

Vitamin D is increasingly recognized for its neuroprotective, anti-inflammatory, and immunomodulatory roles in mental health. However, its delivery to the central nervous system remains constrained by various factors.

Objective

This systematic review evaluates strategies for optimizing brain-targeted vitamin D delivery, highlighting molecular, physiological, and technological approaches to enhance its efficacy in mental disorders.

Methods

Following PRISMA guidelines, a comprehensive search across PubMed, Web of Science, Scopus, Embase, and PsycINFO was conducted. Relevant studies were assessed thematically, focusing on BBB transport mechanisms, nanocarriers, structural modifications, and transporter-mediated delivery.

Results

Strategies including nanotechnology, biotin-based transporter targeting (e.g., SMVT/SLC5A6), DBP–Megalin/Cubilin-mediated transcytosis, and intranasal administration show promise in enhancing vitamin D brain uptake. Differences between serum and brain vitamin D concentrations, genomic and non-genomic VDR pathways, and psychiatric disorder-specific associations (e.g., depression, schizophrenia, ASD) were also examined.

Conclusions

Although limited by the scarcity of large-scale clinical data, emerging strategies demonstrate significant potential in enhancing brain-targeted vitamin D delivery. These findings lay a foundation for future translational research aimed at precision mental health interventions.

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优化脑靶向维生素D递送的系统综述：加强精神疾病治疗的新方法

维生素D因其在精神健康中的神经保护、抗炎和免疫调节作用而越来越被人们所认识。然而，其向中枢神经系统的输送仍然受到各种因素的限制。目的本系统综述了优化脑靶向维生素D递送的策略，强调了分子、生理和技术途径，以提高其对精神障碍的疗效。方法遵循PRISMA指南，在PubMed、Web of Science、Scopus、Embase和PsycINFO中进行综合检索。对相关研究进行了主题评估，重点是血脑屏障的转运机制、纳米载体、结构修饰和转运体介导的递送。包括纳米技术、基于生物素的转运体靶向（如SMVT/SLC5A6）、dbp - meggalin / cubilin介导的胞吞作用和鼻内给药在内的策略显示出增强维生素D脑摄取的希望。还研究了血清和脑维生素D浓度、基因组和非基因组VDR途径以及精神疾病特异性关联（如抑郁症、精神分裂症、ASD）之间的差异。尽管受到大规模临床数据缺乏的限制，新兴策略在增强脑靶向维生素D递送方面显示出巨大的潜力。这些发现为未来旨在精确心理健康干预的转化研究奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.