Brain Research最新文献_第6页

Whole-brain mapping of afferent and efferent connections of lateral hypothalamic orexinergic neurons in mice 小鼠下丘脑外侧食欲能神经元传入和传出连接的全脑作图。

IF 2.6 4区医学

Brain Research Pub Date : 2025-09-01 DOI: 10.1016/j.brainres.2025.149921

Jinjiang Du, Zean Du, Yichen Che, Danlei Liu, Yuanyuan Xu, Jifeng Zhang, Xuefeng Zheng, Guoqing Guo

{"title":"Whole-brain mapping of afferent and efferent connections of lateral hypothalamic orexinergic neurons in mice","authors":"Jinjiang Du, Zean Du, Yichen Che, Danlei Liu, Yuanyuan Xu, Jifeng Zhang, Xuefeng Zheng, Guoqing Guo","doi":"10.1016/j.brainres.2025.149921","DOIUrl":"10.1016/j.brainres.2025.149921","url":null,"abstract":"<div><div>Orexin (Orx) is a vital peptide neurotransmitter essential for regulating feeding, sleep-wake cycles, and reward-seeking behavior. Orexinergic neurons are predominantly located in the lateral hypothalamus (LH). However, the precise neural connectivity of these neurons across the brain remains insufficiently characterized. In this study, we used cell-specific anterograde and retrograde viral tracers to map the afferent and efferent connections of LH orexinergic neurons. Our results revealed that LH orexinergic neurons received extensive afferent inputs from cortical regions, including the primary motor cortex (M1) and secondary motor cortex (M2), the basal ganglia, including the caudate putamen (CPu), the diencephalon, such as the zona incerta (ZI) and reticular nucleus (Rt), and brainstem nuclei, including the ventral tegmental area (VTA) and locus coeruleus (LC). Simultaneously, the orexinergic neurons projected primarily to the telencephalon, including the bed nucleus of the stria terminalis (BNST) and lateral septum (LS), the diencephalon, including the medial preoptic nucleus (MPA) and lateral preoptic area (LPO), and the brainstem, such as the periaqueductal gray (PAG) and superior colliculus (SC). Among these, BNST, LS, MPA, and PAG were the primary projection targets of LH orexinergic neurons, whereas ZI, VTA, M1, and LC serve as their major input sources. Additionally, significant bidirectional projections were observed between LH orexinergic neurons and regions such as ZI and VTA, suggesting their potential roles in signal integration. These findings provide a detailed framework for the neural connectivity of LH orexinergic neurons, highlighting their potential involvement in mediating complex brain functions and neuropsychiatric disorders.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149921"},"PeriodicalIF":2.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional connectivity linking the hippocampus, retrosplenial, and orbitofrontal cortex correlates with increased seizure severity in temporal lobe epilepsy 连接海马、脾后和眶额皮质的功能连通性与颞叶癫痫发作严重程度增加相关

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-30 DOI: 10.1016/j.brainres.2025.149915

Tamara Bustamante , José L. Valdés

{"title":"Functional connectivity linking the hippocampus, retrosplenial, and orbitofrontal cortex correlates with increased seizure severity in temporal lobe epilepsy","authors":"Tamara Bustamante , José L. Valdés","doi":"10.1016/j.brainres.2025.149915","DOIUrl":"10.1016/j.brainres.2025.149915","url":null,"abstract":"<div><div>Temporal lobe epilepsy (TLE) is a highly prevalent neurological disorder characterized by severe seizures and altered consciousness. Seizures in TLE often originate in the hippocampus (HIP) but can spread to widespread brain regions, including the retrosplenial cortex (RSC) and orbitofrontal cortex (ORB). The RSC is a highly interconnected cortical region implicated in seizure onset and propagation, yet its role in epilepsy remains poorly understood. We induced seizures (n = 48) in behaving adult male Sprague-Dawley rats (n = 5) via unilateral electrical stimulation of the right ventral hippocampus (targeting the dentate gyrus) using square biphasic pulses (1 ms per phase) at 60 Hz for 2 s. Stimulation began at 50 μA and was increased in 25 μA steps if no seizure was evoked, up to a maximum of 500 μA or until the animals exhibited up to five seizure episodes, to investigate the dynamic changes in the RSC during seizures of varying severity and their temporal coordination with other brain regions.</div><div>Seizures were categorized based on the presence of fast poly-spike activity (7–15 Hz) and slow-wave activity (1–2 Hz) and their spread to the HIP and ORB. Spectral power density changes across the three regions correlated with seizure severity. Coherence patterns transitioned from adaptive (flexible and localized), RSC-ORB and HIP-RSC coupling to maladaptive, persistent hypersynchronization involving the HIP-RSC and HIP-ORB hypersynchronization as severity increased.</div><div>The RSC acts as a key hub for integrating and transmitting information between distant brain regions, particularly during low-severity seizures. In contrast, it predominantly receives input from both upstream and downstream sources during high-severity seizures. Our findings provide critical insights into the relationship between seizure severity and brain network dynamics, highlighting the RSC as a potential therapeutic target for epilepsy.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149915"},"PeriodicalIF":2.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymoquinone ameliorates cognitive impairment and neuroinflammation in an amyloid-beta-induced rat model of Alzheimer’s disease 百里醌改善淀粉样蛋白诱导的阿尔茨海默病大鼠模型的认知障碍和神经炎症

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-30 DOI: 10.1016/j.brainres.2025.149918

Saliha Ayşenur Çam Özünlü , Fatma Uysal , Hayriye Tatlı Doğan , Ali Parlar , Ayhan Çetinkaya , Seyfullah Oktay Arslan

{"title":"Thymoquinone ameliorates cognitive impairment and neuroinflammation in an amyloid-beta-induced rat model of Alzheimer’s disease","authors":"Saliha Ayşenur Çam Özünlü , Fatma Uysal , Hayriye Tatlı Doğan , Ali Parlar , Ayhan Çetinkaya , Seyfullah Oktay Arslan","doi":"10.1016/j.brainres.2025.149918","DOIUrl":"10.1016/j.brainres.2025.149918","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. Amyloid-beta (Aβ) peptide accumulation is one of the most important chatacteristics of AD that cause neuronal damage and neuroinflammation. Thymoquinone (TQ), a bioactive compound derived from <em>Nigella sativa</em>, has shown neuroprotective properties in previous studies. This study aimed to evaluate the ameliorative effects of TQ in an Aβ1-42-induced AD rat model. Male Wistar-Albino rats were divided into four groups: Control, AD, TQ-10 (10 mg/kg TQ), and TQ-30 (30 mg/kg TQ). TQ was administered orally for 7 days before and 10 days after Aβ1-42 injection into the hippocampus. Cognitive functions were assessed using the Passive Avoidance (PA) and Morris Water Maze (MWM) tests. After behavioral experiments, hippocampal cytokine (tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β)) levels, as well as astrocyte and microglial activation, are evaluated. TQ treatment reversed memory impairements in the AD group. Hippocampal TNF-α and IL-1β levels were elevated in the AD and reduced in TQ-treated groups. Immunohistochemical analysis revealed that the increased reactivity of glial fibrillary acidic protein (GFAP) and ionized calcium-binding adapter molecule 1 (Iba1) in the AD group was significantly attenuated by TQ treatment. Both 10 mg/kg and 30 mg/kg doses of TQ administration improved cognitive performance, reduced neuroinflammation, and mitigated glial activation in an Aβ-induced AD rat model. These findings suggest that TQ may serve as a promising neuroprotective agent for AD. Further studies are required to elucidate its molecular mechanisms and therapeutic potential in clinical settings.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149918"},"PeriodicalIF":2.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The SIRT1 activator SRT2104 mitigates hypoxia-induced white matter injury in neonatal mice SIRT1激活剂SRT2104减轻新生小鼠缺氧诱导的白质损伤

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-30 DOI: 10.1016/j.brainres.2025.149917

Xinyu Wei , Shan Chen , Dong Liu , Junrong Li , Qian Deng , Yantang Wang , Yan Zhou

{"title":"The SIRT1 activator SRT2104 mitigates hypoxia-induced white matter injury in neonatal mice","authors":"Xinyu Wei , Shan Chen , Dong Liu , Junrong Li , Qian Deng , Yantang Wang , Yan Zhou","doi":"10.1016/j.brainres.2025.149917","DOIUrl":"10.1016/j.brainres.2025.149917","url":null,"abstract":"<div><div>This study investigated the effects of the Sirtuin 1 (SIRT1) activator SRT2104 on hypoxia-induced white matter injury (WMI) in neonatal mice. A mouse model of neonatal WMI was established by exposing C57BL/6 mice to chronic hypoxia from postnatal Day 3 to Day 11. SRT2104 was administered intraperitoneally at doses of 2 mg/kg or 4 mg/kg from Day 11 for 5 days. Assessments included brain histology, myelination markers, oligodendrocyte differentiation, and behavioral tests. The results demonstrated SRT2104 at 4 mg/kg significantly reduced histological damage, promoted myelination by enhancing myelin basic protein and myelin-associated glycoprotein expression, and decreased oligodendrocyte apoptosis by reducing cleaved caspase-3 levels. Behavioral improvements were observed in locomotor activity, motor coordination, and cognitive function in treated mice. In summary, SRT2104 demonstrates protective effects against hypoxia-induced WMI by promoting oligodendrocyte survival and myelination, suggesting its potential as a therapeutic agent for WMI in neonatal hypoxia.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149917"},"PeriodicalIF":2.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigating habitation effect through a cognitive approach: the impact of motor inhibition training on the motor interference effect of dangerous objects 从认知角度缓解居住效应：运动抑制训练对危险物体运动干扰效应的影响

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-29 DOI: 10.1016/j.brainres.2025.149903

Peng Liu

{"title":"Mitigating habitation effect through a cognitive approach: the impact of motor inhibition training on the motor interference effect of dangerous objects","authors":"Peng Liu","doi":"10.1016/j.brainres.2025.149903","DOIUrl":"10.1016/j.brainres.2025.149903","url":null,"abstract":"<div><div>The processing of dangerous objects slows an individual’s prepared motor responses, a phenomenon referred to as the motor interference effect. This self-protective mechanism reduces the likelihood of accidental interactions with dangerous objects. However, habituation can diminish the motor interference effect over time, potentially increasing the risk of unsafe behaviors. To address this issue, the present study introduces a motor inhibition training protocol designed to counteract habituation effects by targeting specific stimuli. A prime-target grasping consistency judgment task was used as both a pre-test and post-test to evaluate the effectiveness of a 10-session Go/No-Go training program. The training used target stimuli identical to those in the judgment task, with the goal of enhancing individuals’ ability to inhibit responses to specific dangerous stimuli. The results demonstrated that the training not only mitigated the impact of habituation but also significantly prolonged reaction times to dangerous stimuli, indicating a dehabituation effect. Furthermore, Event-Related Potential analyses revealed that although the training exclusively employed dangerous stimuli as the No-Go condition to enhance inhibition of dangerous objects, the post-test results showed enhanced conflict monitoring and motor inhibition processing for both dangerous and safe stimuli within the experimental group. From a practical perspective, the dangerous (No-Go) stimuli used in the training task could be replaced with real-world dangerous objects relevant to specific work environments to strengthen the motor interference effect. This approach may offer a promising motor inhibition training strategy for reducing unsafe behaviors in real-world settings.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149903"},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of age, education, and vocabulary size on the speed of word recognition across the lifespan 年龄、教育程度和词汇量对整个生命周期中单词识别速度的影响

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-29 DOI: 10.1016/j.brainres.2025.149891

Péter Rácz , Ágnes Lukács

{"title":"The effect of age, education, and vocabulary size on the speed of word recognition across the lifespan","authors":"Péter Rácz , Ágnes Lukács","doi":"10.1016/j.brainres.2025.149891","DOIUrl":"10.1016/j.brainres.2025.149891","url":null,"abstract":"<div><div>Age and language experience both shape the speed of visual word recognition for children and adults. There is a considerable debate in the literature regarding whether these effects are primarily facilitating or impeding and whether the influences of age and language experience can be distinct and delineated. In order to address these questions, we collected data from Hungarian participants, analyzing data from 80 children (ages 9–17) and 387 adults (ages 18–90), on 250 words in an online visual lexical decision task. We used a pre-calibrated word list, based on prior familiarity ratings, to assess the participants’ vocabulary size and compared the effects of vocabulary size, age, and years spent in education on response speed in correct lexical decision trials over real words (as opposed to filler non-words). We found that vocabulary size and education facilitate, while age impedes word recognition speed in the task, and that vocabulary size effects are mediated by both age and education. These age-related trends were observed across a broad age range, although conclusions regarding the oldest participants (70+) must remain tentative due to their limited representation in our sample.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149891"},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive function and synaptic plasticity in the hippocampus exposed to stress respond similarly to different probiotic mixtures 应激下海马体的认知和突触可塑性对不同益生菌混合物的反应相似。

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-29 DOI: 10.1016/j.brainres.2025.149916

Zahra Taleblou, Sayyed Alireza Talaei, Mahmoud Salami

{"title":"Cognitive function and synaptic plasticity in the hippocampus exposed to stress respond similarly to different probiotic mixtures","authors":"Zahra Taleblou, Sayyed Alireza Talaei, Mahmoud Salami","doi":"10.1016/j.brainres.2025.149916","DOIUrl":"10.1016/j.brainres.2025.149916","url":null,"abstract":"<div><div>It has been proven that while stressors change the quantity and quality of gut microbes, probiotic bacteria repair the intestinal flora. We evaluated the effect of different probiotic mixtures on cognitive function, synaptic plasticity, and some biochemical factors in a rat model of chronic unpredictable mild stress (CUMS). Animal groups included the control rats (CON), rats exposed to CUMS (STS), and three groups of stressed animals with different probiotic regimens. Cognitive behavior, hippocampal synaptic plasticity, and serum oxidant/antioxidant factors were evaluated. Whereas the CUMS disrupted the spatial learning and memory, the probiotic administration improved behavioral functions. While the CON rats displayed a robust plasticity, their STS counterparts did not. The probiotics restored the synaptic plasticity in all stressed groups. CUMS also led to a decrease in antioxidants and an increase in oxidants, but probiotic treatment improved these changes. It appears that the various probiotic cocktails have a similar effect on hippocampus-dependent cognition and synaptic plasticity, as well as on oxidant/antioxidant factors.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149916"},"PeriodicalIF":2.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FaithfulNet: An explainable deep learning framework for autism diagnosis using structural MRI faithnet：一个可解释的深度学习框架，用于使用结构MRI进行自闭症诊断

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-27 DOI: 10.1016/j.brainres.2025.149904

D. Swainson Sujana, D. Peter Augustine

{"title":"FaithfulNet: An explainable deep learning framework for autism diagnosis using structural MRI","authors":"D. Swainson Sujana, D. Peter Augustine","doi":"10.1016/j.brainres.2025.149904","DOIUrl":"10.1016/j.brainres.2025.149904","url":null,"abstract":"<div><div>Explainable Artificial Intelligence (XAI) can decode the ‘black box’ models, enhancing trust in clinical decision-making. XAI makes the predictions of deep learning models interpretable, transparent, and trustworthy. This study employed XAI techniques to explain the predictions made by a deep learning-based model for diagnosing autism and identifying the memory regions responsible for children’s academic performance. This study utilized publicly available sMRI data from the ABIDE-II repository. First, a deep learning model, FaithfulNet, was developed to aid in the diagnosis of autism. Next, gradient-based class activation maps and the SHAP gradient explainer were employed to generate explanations for the model’s predictions. These explanations were integrated to develop a novel and faithful visual explanation, Faith_CAM. Finally, this faithful explanation was quantified using the pointing game score and analyzed with cortical and subcortical structure masks to identify the impaired brain regions in the autistic brain. This study achieved a classification accuracy of 99.74% with an AUC value of 1. In addition to facilitating autism diagnosis, this study assesses the degree of impairment in memory regions responsible for the children’s academic performance, thus contributing to the development of personalized treatment plans.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149904"},"PeriodicalIF":2.6,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep brain stimulation of the olfactory bulb alleviates depressive-like behaviors and alters prefrontal cortex hippocampal coherence 对嗅球的深部脑刺激可减轻抑郁样行为并改变前额皮质海马的一致性

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-26 DOI: 10.1016/j.brainres.2025.149902

Mahta Bastani , Mohammad Reza Raoufy , Behrooz Khakpour-Taleghani , Mohammad Rostampour , Adele Jafari , Kambiz Rohampour

{"title":"Deep brain stimulation of the olfactory bulb alleviates depressive-like behaviors and alters prefrontal cortex hippocampal coherence","authors":"Mahta Bastani , Mohammad Reza Raoufy , Behrooz Khakpour-Taleghani , Mohammad Rostampour , Adele Jafari , Kambiz Rohampour","doi":"10.1016/j.brainres.2025.149902","DOIUrl":"10.1016/j.brainres.2025.149902","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD), marked by persistent depressive symptoms unresponsive to standard treatments, presents a significant challenge in psychiatry. Deep brain stimulation (DBS) has emerged as a novel intervention for TRD. This study examined the impact of DBS in the olfactory bulb (OB) on depressive symptoms, local field potentials (LFPs), and the medial prefrontal cortex (mPFC)-ventral hippocampus (vHPC) connectivity.</div><div>Thirty-six male Wistar rats were assigned to four groups: control, chronic mild stress (CMS), CMS + DBS, and DBS. Stereotactic surgery was performed to implant electrodes in the OB, mPFC, and vHPC. The CMS protocol was administered for 3 weeks to induce depression. Behavioral assessments included the sucrose preference test (SPT), forced swim test (FST), and open field test (OFT). During the final 4 days of CMS induction, the DBS groups received OB stimulation for one hour daily. On day 22, LFPs were recorded from the mPFC and vHPC and analyzed using MATLAB. Data were evaluated using ANOVA, with <em>P</em>-values ≤ 0.05 considered significant.</div><div>Results indicated that three weeks of CMS reduced low-frequency gamma power in the mPFC and overall gamma power in the vHPC, along with decreased delta and theta band coherence between these regions. CMS also increased delta, theta, and alpha band power during exploration. OB-DBS improved depressive-like behaviors, enhanced low-frequency gamma power in both mPFC and vHPC, and increased delta and theta coherence.</div><div>These findings suggest that depression’s pathogenesis involves alterations in the mPFC-vHPC neural network, and that OB-DBS may counteract these changes, offering a potential therapeutic target for TRD.</div></div>","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1866 ","pages":"Article 149902"},"PeriodicalIF":2.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality and social attention: Trait-driven differences in neural engagement 人格和社会注意：神经参与的特质驱动差异

IF 2.6 4区医学

Brain Research Pub Date : 2025-08-26 DOI: 10.1016/j.brainres.2025.149905

Yuzhan Hang , Wei Wu , Satoshi Shioiri , Xiaosong He

引用次数: 0