BMJ Paediatrics Open最新文献

{"title":"Examining the effect of newborn feeding method on postnatal length of stay and healthcare utilisation among Neonates With In-utero SSRI Exposure (NeoWISE): a retrospective cohort study.","authors":"Christina Cantin, Wenbin Li, Erna Snelgrove-Clarke, Daniel Corsi, Cindy-Lee Dennis, Amanda Ross-White, Susan Brogly, Laura Gaudet","doi":"10.1136/bmjpo-2026-004689","DOIUrl":"10.1136/bmjpo-2026-004689","url":null,"abstract":"<p><strong>Introduction: </strong>Up to 30% of in-utero selective serotonin reuptake inhibitor (SSRI)-exposed newborns experience withdrawal and up to 60% experience behavioural impacts. Breastfeeding may offer benefits from skin-to-skin contact and transfer of SSRIs through breastmilk. Limited data are available on healthcare utilisation of these newborns beyond neonatal intensive care unit admission. We aimed to identify whether newborn feeding method affected healthcare utilisation in the first 30 days of postnatal life among <i>Neo</i>nates <i>W</i>ith <i>I</i>n-utero <i>S</i>SRI <i>E</i>xposure (NeoWISE).</p><p><strong>Methods: </strong>This retrospective cohort study included newborns born in Ontario hospitals between 1 April 2012 and 31 March 2020 to beneficiaries of the Ontario Drug Benefit Program who filled at least one SSRI prenatal prescription. Administrative health and birth registry data were used. Newborn feeding methods were available from birth to hospital discharge. Outcomes were postnatal length of stay (LOS), emergency department visit(s) and hospital readmission within the first 30 days of life. Adjusted linear regression models using inverse probability of treatment weights for feeding method were conducted.</p><p><strong>Results: </strong>The cohort included a total of 5079 NeoWISE participants, with 3321 (65.4%) exclusively breastfed. Formula-fed infants were more likely to have older mothers with an urban residence, lower income quintile, prior live birth, who smoked at delivery and to be born via caesarean delivery; these imbalances were balanced after propensity score weighting. Exclusively breastfed newborns were significantly less likely to have postnatal LOS ≥3 days (11.6% vs 16.3%) (adjusted relative risk (adjRR) 0.84, 95% CI 0.72 to 0.97), but more likely to have emergency department visit (adjRR 1.42, 95% CI 1.03 to 1.97) and hospital readmission (adjRR 1.78, 95% CI 1.21 to 2.62) compared with formula-fed newborns, primarily due to jaundice.</p><p><strong>Conclusion: </strong>Women taking SSRI medication during pregnancy should receive anticipatory guidance about newborn feeding effectiveness, signs of jaundice and when to seek healthcare after birth. In-hospital feeding method was associated with emergency department visits and hospital readmission among NeoWISE. Breastfeeding cessation was not measured and could have affected estimated associations.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evidence for assessing early childhood development in Brazil: the Child Development Diagnostic Form in the Criança Feliz Program.","authors":"Ellayne Souza Cerqueira, Michael E Reichenheim, Ana Angélica Rodrigues Alves, Ricardo Rodrigues Dutra, Claudia Leite Moraes, Priscila Ribas de Farias Costa, Rita de Cássia Ribeiro-Silva, Mauricio L Barreto","doi":"10.1136/bmjpo-2025-004362","DOIUrl":"10.1136/bmjpo-2025-004362","url":null,"abstract":"<p><strong>Introduction: </strong>Child development is a multidimensional process influenced by socioeconomic conditions. The Programa Criança Feliz (PCF), Brazil's largest home-visiting initiative, uses the Formulário de Observação Inicial do Desenvolvimento Infantil (FOIDI) to monitor developmental milestones. Despite being widely implemented, the FOIDI had not previously undergone formal validation. This study evaluated configural and metric validity of FOIDI in a representative sample of Brazilian children aged 0-36 months.</p><p><strong>Methods: </strong>A total of 183 974 assessments from 82 797 children in PCF (2020-2023) were analysed. Cohorts for seven age groups were divided into three independent partitions. Initially, Horn's parallel analysis determined the number of underlying factors. Confirmatory factor analyses followed, using weighted least-squares mean and variance adjusted estimator and polychoric correlation matrices. Model fit was evaluated using root mean square error of approximation, comparative fit index and Tucker-Lewis index. Items with factor loadings<0.40 were considered unreliable. Modification indices (MIs; univariate Lagrange multiplier) and expected parameter changes were used to identify potential cross-loadings and residual correlations. Convergent validity was estimated using average variance extracted (AVE≥0.50); discriminant validity was assessed by comparing the square root of AVE with factor correlations.</p><p><strong>Results: </strong>Modules exhibited unidimensional (M3-M7) or bidimensional structures (M1-M2), with factor loadings ranging from 0.519 to 0.903. AVE was≥0.50 for all factors evaluated, supporting convergent validity. Discriminant validity was confirmed within the bidimensional modules. The removal of redundant items increased model parsimony without compromising informativeness.</p><p><strong>Conclusion: </strong>The FOIDI demonstrated robust configural and metric validity, capturing core aspects of child development across different age groups in contexts of socioeconomic vulnerability. The refined instrument proved suitable for home-visiting programmes, offering a practical, reliable and scalable tool for developmental surveillance and the support of public policies.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight status is associated with puberty timing in girls in Isfahan province, Iran.","authors":"Maryam Esmaeili, Mohammad Reza Maracy, Roya Kelishadi, Nafiseh Mozafarian, Mahin Hashemipour","doi":"10.1136/bmjpo-2026-004972","DOIUrl":"10.1136/bmjpo-2026-004972","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine how Body Mass Index (BMI) influences the timing of puberty in girls.</p><p><strong>Methods: </strong>This cross-sectional study included students from urban and rural areas of Isfahan Province, Iran. Breast development was assessed by visual inspection and palpation and pubic hair development was evaluated using Tanner's Sexual Maturation Scale. Participants reported the month and year of menarche. Median ages for each pubertal stage were estimated using probit modelling, and analyses were performed separately by BMI category (underweight, normal weight, overweight and obese).</p><p><strong>Results: </strong>A total of 13 886 girls aged 6-18 years participated. According to WHO cut-offs, 61.9% were normal weight, 9.5% underweight, 13.1% overweight, 15.5% obese and 50.2% had experienced menarche. The onset of breast development (≥B2) occurred earliest in overweight (9.59 years) and obese (9.68 years) girls, followed by normal-weight (9.87 years) and underweight (10.61 years) participants. A similar trend was observed across subsequent Tanner stages and pubic hair development. Median age at menarche was 11.62 years in obese girls, 11.76 years in overweight, 12.04 years in normal-weight and 13.15 years in underweight participants. Overall, girls with higher BMI reached pubertal milestones and menarche earlier than their normal-weight and underweight peers.</p><p><strong>Conclusions: </strong>Higher BMI in girls is associated with earlier onset of puberty and menarche. These findings highlight the impact of childhood overweight and obesity on pubertal development and underscore the importance of monitoring growth and weight status to anticipate and manage potential health consequences.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let us stop admiring the problem: we need social prescribing for children with disability now.","authors":"Anna Purna Basu, Tim Rapley, Mackenzie Woodbury, Arvin Garg, Michelle Phoenix, Katarina Ostojic, Iona Novak, Susan Woolfenden","doi":"10.1136/bmjpo-2026-004946","DOIUrl":"10.1136/bmjpo-2026-004946","url":null,"abstract":"","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High levels of parenting stress and trauma despite age-appropriate developmental outcomes following perinatal asphyxia: a cross-sectional observational study.","authors":"Angela Sutterer-Verrelli, Anna Katharina Georg, Anja Riecker, Veronique B Weiss, Alexandra F Puchwein-Schwepcke, Claudia Nussbaum","doi":"10.1136/bmjpo-2026-004976","DOIUrl":"10.1136/bmjpo-2026-004976","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association of perinatal asphyxia across mild to moderate hypoxic-ischaemic encephalopathy (HIE) severity levels and therapeutic hypothermia (TH) with child developmental outcomes and parenting stress and to explore parental trauma and psychosocial support.</p><p><strong>Design: </strong>Multicentre, cross-sectional, comparative observational study.</p><p><strong>Setting: </strong>Two university medical centres in Germany.</p><p><strong>Participants: </strong>Parents of children aged 1-5.5 years with a history of perinatal asphyxia treated with TH (n=58) or without TH (n=77), and unexposed control children (n=179).</p><p><strong>Outcome measures: </strong>Parents completed the Ages & Stages Questionnaire, Third Edition, and the Parenting Stress Index (PSI) for the primary outcome, and reported on birth-related trauma, psychosocial support and family planning decisions as exploratory secondary outcomes.</p><p><strong>Results: </strong>Most children showed age-appropriate developmental outcomes across all groups. In contrast, parents in both asphyxia groups reported elevated stress levels, with higher PSI scores in the TH group, particularly in the health, competence and attachment domains. Postnatal trauma was highly prevalent, affecting 88% of parents in the TH group, 73% in the non-TH group and 15% in controls. Psychosocial support was perceived as sufficient by only 20% of parents in the non-TH group, compared with 39% in the TH group. Birth-related trauma was a significant predictor of parental stress.</p><p><strong>Conclusions: </strong>Despite mostly age-appropriate development on screening, parental stress and trauma were highly prevalent regardless of HIE severity, and psychosocial support was markedly insufficient, particularly for families whose infants did not receive TH. These findings highlight the need for structured, accessible psychosocial support for all patient-families affected by perinatal asphyxia.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absence of digital intervention: exploring the motivations behind self-harm adolescents' avoidance of psychological support techniques.","authors":"Haohuan Ye, Minghui Ye","doi":"10.1136/bmjpo-2026-004699","DOIUrl":"10.1136/bmjpo-2026-004699","url":null,"abstract":"<p><strong>Background: </strong>From the perspective of behavioural psychology and adolescent psychopathology, non-suicidal self-harm (NSSI) among adolescents is a multidetermined behaviour shaped by biological, psychological and social factors. Digital mental health interventions are vital for adolescent self-harm support, yet their acceptance among self-harming adolescents is low with significant avoidance tendencies. Existing research focuses on technical attributes of these tools but rarely explores the psychological motivations and contextual factors driving avoidance in this group, and few studies interpret such avoidance behaviour under a unified biopsychosocial framework.</p><p><strong>Methods: </strong>A grounded theory approach was adopted, complying with the COREQ criteria. Semi-structured interviews were conducted with 21 emotionally stable adolescents aged 12-18 years who had engaged in NSSI in the past year, recruited from a tertiary hospital emergency department. Data were analysed via open, axial and selective coding with ethical approval obtained.</p><p><strong>Results: </strong>Guided by the biopsychosocial behavioural framework, this study identified that adolescents' avoidance of digital psychological interventions is a comprehensive outcome of interactions among biological traits, psychological mechanisms and social contextual factors. Three core psychological pathways driving avoidance were extracted: emotional avoidance, trust deficit and feelings of ineffectiveness and frustration. Physiological stress responses linked to shame and anxiety (biological dimension) amplified these psychological barriers, while situational social factors moderated the entire behavioural process.</p><p><strong>Conclusions: </strong>Adolescents' avoidance of digital interventions is a layered, dynamic, multidetermined behavioural phenomenon embedded in the Chinese cultural context, which can be systematically interpreted via the biopsychosocial behavioural framework covering biological traits, individual psychology, interpersonal and ecological social factors. Future digital tools require trauma-informed, context-adaptive design to reduce emotional triggers, enhance user control, strengthen privacy protection and rebuild trust, thereby improving acceptability and effectiveness.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What works in educational interventions for teams caring for children and young people admitted to general acute paediatric wards for mental health? A systematic review.","authors":"Olatokunbo Sanwo, Antonia Rich, Isabelle Pomfret, James Downs, Sophie Davis, James Dearden, Mark Buchanan, Lee Omer, Ann Griffin, Lee D Hudson","doi":"10.1136/bmjpo-2026-004809","DOIUrl":"10.1136/bmjpo-2026-004809","url":null,"abstract":"<p><strong>Objective: </strong>To systematically review educational interventions for staff working on acute paediatric wards aimed at improving the care of children and young people (CYP) admitted for mental health support.</p><p><strong>Design: </strong>We conducted a systematic search of PubMed, The Education Resources Information Centre, PsychInfo and Web of Science from 2000 to March 2026 using terms related to healthcare professionals, training/education, mental health and children/young people. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Interventions were classified using the Kirkpatrick model and the Behavioural Change Technique Taxonomy (BCT V.1) to identify mechanisms underpinning effective change.</p><p><strong>Results: </strong>We found nine studies meeting inclusion criteria, across a range of teaching methodologies and settings. Most interventions were designed and applied for nurses. Overall quality of evidence was poor. Although no single intervention could be recommended, analysis identified potentially useful components tailored to different learner needs, mapped through the Kirkpatrick and BCT frameworks. A notable gap was a lack of codesign with CYP and carers with lived experience and the absence of strategies to engage ambivalent or reluctant learners who might not attend educational interventions voluntarily.</p><p><strong>Conclusions: </strong>Existing educational interventions contain elements that may support behavioural and practice change among staff caring for CYP with mental health needs. However, future research should prioritise high-quality, framework-based evaluations developed through codesign with CYP and carers. Interventions should also address how to engage learners who may be reluctant to participate in training for this area of clinical practice.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enablers and challenges of family-centred care for preterm infants in a tertiary health facility in Northern Nigeria: perspective of parents and health workers - a qualitative study.","authors":"Yasangra Rabo Adeniji, Tolu Adeniji, Otobo Ujah, Kamiludeen Shina Hassan, Mercy Poksireni Raymond","doi":"10.1136/bmjpo-2026-004470","DOIUrl":"10.1136/bmjpo-2026-004470","url":null,"abstract":"<p><strong>Background: </strong>The family-centred care (FCC) is a model that emphasises the active participation of family members in patient care decisions, fostering collaboration and recognising families as vital partners in the healthcare journey, with evidence linking it to improved neonatal outcomes and parental satisfaction. In Nigeria, where neonatal mortality remains among the highest globally, evidence on FCC integration, particularly from the perspectives of both parents and health workers, is scarce.</p><p><strong>Objective: </strong>To explore the enablers and challenges of FCC for preterm newborns in a tertiary neonatal unit in Northern Nigeria, drawing on the lived experiences of parents and nurses.</p><p><strong>Methods: </strong>We conducted a qualitative study in the neonatal intensive care unit of Federal Teaching Hospital Gombe, Nigeria, between April 2023 and April 2024. Purposive sampling recruited parents of preterm infants who had been discharged and neonatal nurses. Three focus group discussions (FGDs) with 20 parents and one FGD with 14 nurses were held. Sessions were conducted in English and Hausa, transcribed, translated where necessary and analysed thematically using Braun and Clarke's framework with NVivo V.10 software.</p><p><strong>Results: </strong>Parents identified enablers such as the intrinsic value they derived, supportive structure and confidence/readiness to care for the baby. Challenges included the burden and stress associated with FCC, culture and attitude as well as role negotiation within the unit. Nurses highlighted enablers including job satisfaction and reduced workload, but expressed concerns over parental interference and resistance to change. The findings underscore the dynamic interplay of facility, staff and family factors in shaping FCC implementation.</p><p><strong>Conclusion: </strong>FCC is acceptable and valued by parents in our neonatal setting, with important implications for neonatal policy and service delivery. Implementation of FCC is strongly influenced by the interaction of individual, institutional and community-level factors that shape parental engagement and experience.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing a parent-mediated intervention for toddlers with ASD within the Chinese child healthcare system: a real-world study.","authors":"Huiping Li, Xiang Long, Xiuqing Huang, Shu Liu, Zhuhong Yang, Chun Chen, Qing Lou, Xiubin Tong, Xiu Xu","doi":"10.1136/bmjpo-2025-004387","DOIUrl":"10.1136/bmjpo-2025-004387","url":null,"abstract":"<p><strong>Background: </strong>Behavioural interventions remain the cornerstone of evidence-based practice for addressing the core symptoms of autism spectrum disorder (ASD). The Skill Training Program for Parents with ASD Children (STPAC) is a group intervention programme for parents and the first parent-mediated intervention programme developed by Chinese clinical practitioners. This study was conducted to evaluate the feasibility and effectiveness of STPAC within the context of routine child healthcare services in China.</p><p><strong>Methods: </strong>This is a real-world, multi-site implementation study employed a single-arm, pre-post design. Between July 2023 and June 2025, 128 families of toddlers (aged 18-54 months) with suspected or diagnosed ASD were enrolled from two child healthcare settings. Participants received the 8-week, group-based parent training programme, which integrated didactic lessons, video modelling and individualised coaching. Outcomes were assessed at baseline and post-intervention using parent-reported measures: the Knowledge of Autism Intervention Questionnaire (KAIQ), the Communication and Symbolic Behavior Scales Developmental Profile (CSBS DP) and the Parenting Stress Index-Short Form (PSI-SF). Statistical analysis included paired-samples t-tests to evaluate within-group changes, with effect sizes (Cohen's d) calculated to quantify the magnitude of improvement.</p><p><strong>Results: </strong>Parental knowledge of autism intervention strategies increased substantially (mean improvement=6.26 points, p<0.001; d=1.17). Child communication and symbolic skills also improved, with the CSBS DP total score rising from 35.30 to 40.88 (p<0.001; d=0.99), representing an overall improvement rate of 85.7%. Furthermore, parenting stress decreased from clinically significant to normal levels (mean reduction=3.70 points, p=0.005). The intervention was equally effective across diverse family demographics, and baseline child communication ability was the strongest predictor of post-intervention gains.</p><p><strong>Conclusions: </strong>Despite an attrition rate of approximately 30%, STPAC demonstrated feasibility as a parent-mediated intervention delivered by trained local clinicians within routine child healthcare settings. Participation in the programme was associated with improvements in parental knowledge, child social communication and parenting stress. These findings provide preliminary evidence supporting the potential of STPAC to expand access to early ASD intervention, though confirmation in a randomised controlled trial is warranted.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procalcitonin-platelet ratio as a predictor of severity of necrotising enterocolitis in preterm infants.","authors":"Adhariana Kaddas, Andi Dwi Bahagia Febriani, Ema Alasiry, Besse Sarmila","doi":"10.1136/bmjpo-2026-004499","DOIUrl":"10.1136/bmjpo-2026-004499","url":null,"abstract":"<p><p>A retrospective cohort study included preterm infants (<37 weeks of gestation, <2500 g) diagnosed with necrotising enterocolitis (NEC) admitted to Wahidin Sudirohusodo Hospital's neonatal intensive care unit from January 2023 to December 2024. Forty-seven infants were analysed; procalcitonin (PCT) levels were significantly higher, and platelet (PLT) counts were significantly lower in the severe group compared with the mild-moderate group (p<0.05). The procalcitonin-to-platelet (PCT/PLT) ratio was notably elevated in severe NEC cases (p<0.05). Receiver operating characteristic analysis indicated area under the curve (AUC) values of 0.786 for PCT, 0.126 for PLT and 0.916 for the PCT/PLT ratio. The sensitivity and specificity of the PCT/PLT ratio are 0.862 and 0.833, respectively.</p>","PeriodicalId":9069,"journal":{"name":"BMJ Paediatrics Open","volume":"10 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13423148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}