Biointerphases最新文献_第7页

Aerosol inhalation of inflammatory cells-targeted dendrimer-dexamethasone conjugate for efficient allergic asthma therapy. 气溶胶吸入靶向炎症细胞的树枝状聚合物-地塞米松共轭物，用于过敏性哮喘的高效治疗。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003480

Danfei Chen, Xiaobo Xuan, Yuyan Chen, Xia Fang, Liwei Liu, Guowei Wang, Jian Chen

{"title":"Aerosol inhalation of inflammatory cells-targeted dendrimer-dexamethasone conjugate for efficient allergic asthma therapy.","authors":"Danfei Chen, Xiaobo Xuan, Yuyan Chen, Xia Fang, Liwei Liu, Guowei Wang, Jian Chen","doi":"10.1116/6.0003480","DOIUrl":"10.1116/6.0003480","url":null,"abstract":"Allergic asthma (AA) is a common breathing disorder clinically characterized by the high occurrence of acute and continuous inflammation. However, the current treatment options for AA are lacking in effectiveness and diversity. In this study, we determined that the cell membrane receptor of gamma-glutamyl transferase (GGT) was highly overexpressed on the inflammatory cells that infiltrate the pulmonary tissues in AA cases. Therefore, we developed a GGT-specific dendrimer-dexamethasone conjugate (GSHDDC) that could be administered via aerosol inhalation to treat AA in a rapid and sustained manner. The GSHDDC was fabricated by the covalent attachment of 6-hydroxyhexyl acrylate-modified dexamethasone to polyamidoamine dendrimers via a carbonic ester linkage and the amino Michael addition, followed by the surface modification of the dendrimers with the GGT substrate of glutathione. After aerosol inhalation by the AA mice, the small particle-sized GSHDDC could easily diffuse into pulmonary alveoli and touch with the inflammatory cells via the glutathione ligand/GGT receptor-mediated recognition. The overexpressed GGT on the surface of inflammatory cells then triggers the gamma-glutamyl transfer reactions of glutathione to generate positively charged primary amines, thereby inducing rapid cationization-mediated cellular endocytosis into the inflammatory cells. The dexamethasone was gradually released by the intracellular enzyme hydrolysis, enabling sustained anti-inflammatory effects (e.g., reducing eosinophil infiltration, decreasing the levels of inflammatory factors) in the ovalbumin-induced AA mice. This study demonstrates the effectiveness of an inhalational and active inflammatory cells-targeted dendrimer-dexamethasone conjugate for efficient AA therapy.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered cell membrane-coated nanoparticles based cancer therapy: A robust weapon against the lethal and challenging hepatocellular carcinoma. 基于细胞膜涂层的工程纳米粒子癌症疗法：对抗致命且具有挑战性的肝细胞癌的有力武器。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003204

Jiachen Zhang, Hongjuan Yu, Gang Li

引用次数: 0

IF 1.9 4区医学

Biointerphases Pub Date : 2024-03-01 DOI: 10.1116/6.0003437

Timo Weintraut, Sven Heiles, Dennis Gerbig, Anja Henss, Johannes Junck, Rolf-Alexander Düring, Marcus Rohnke

{"title":"Lipid-related ion suppression on the herbicide atrazine in earthworm samples in ToF-SIMS and matrix-assisted laser desorption ionization mass spectrometry imaging and the role of gas-phase basicity.","authors":"Timo Weintraut, Sven Heiles, Dennis Gerbig, Anja Henss, Johannes Junck, Rolf-Alexander Düring, Marcus Rohnke","doi":"10.1116/6.0003437","DOIUrl":"10.1116/6.0003437","url":null,"abstract":"In mass spectrometry imaging (MSI), ion suppression can lead to a misinterpretation of results. Particularly phospholipids, most of which exhibit high gas-phase basicity (GB), are known to suppress the detection of metabolites and drugs. This study was initiated by the observation that the signal of an herbicide, i.e., atrazine, was suppressed in MSI investigations of earthworm tissue sections. Herbicide accumulation in earthworms was investigated by time-of-flight secondary ion mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Additionally, earthworm tissue sections without accumulation of atrazine but with a homogeneous spray deposition of the herbicide were analyzed to highlight region-specific ion suppression. Furthermore, the relationship of signal intensity and GB in binary mixtures of lipids, amino acids, and atrazine was investigated in both MSI techniques. The GB of atrazine was determined experimentally through a linear plot of the obtained intensity ratios of the binary amino acid mixtures, as well as theoretically. The GBs values for atrazine of 896 and 906 kJ/mol in ToF-SIMS and 933 and 987 kJ/mol in MALDI-MSI were determined experimentally and that of 913 kJ/mol by quantum mechanical calculations. Compared with the GB of a major lipid component, phosphatidylcholine (GBPC = 1044.7 kJ/mol), atrazine's experimentally and computationally determined GBs in this work are significantly lower, making it prone to ion suppression in biological samples containing polar lipids.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 2","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface for the Biointerphases special topic collection on polymeric biointerfaces - a collection in celebration of Nicholas D. Spencer's career. 为纪念尼古拉斯-D-斯宾塞的职业生涯而出版的《生物界面》专题集《聚合物生物界面》作序。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003375

Tobias Weidner

引用次数: 0

In situ Fourier transform infrared-attenuated total reflection spectroscopy and modeling investigation of protein adsorption: Case of expanded bovine serum albumin on titanium dioxide anatase. 蛋白质吸附的原位傅立叶变换红外全反射光谱和模型研究：二氧化钛锐钛矿上的膨胀牛血清白蛋白案例。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003020

Moustafa Tadjine, Fatima Bouzidi, Abderrezak Berbri, Hamid Nehmar, Ahmed Bouhekka

{"title":"In situ Fourier transform infrared-attenuated total reflection spectroscopy and modeling investigation of protein adsorption: Case of expanded bovine serum albumin on titanium dioxide anatase.","authors":"Moustafa Tadjine, Fatima Bouzidi, Abderrezak Berbri, Hamid Nehmar, Ahmed Bouhekka","doi":"10.1116/6.0003020","DOIUrl":"10.1116/6.0003020","url":null,"abstract":"The purpose of this experimental and modeling research is to study the pH effect and to determine the surface coverage plus the adsorption constant (Ka) of bovine serum albumin (BSA) protein adsorbed on TiO2 anatase surface, respectively. In situ Fourier transform infrared-attenuated total reflection spectroscopy in a flow-through cell was used to study the BSA adsorption on porous TiO2 anatase films. The experiments were performed in water solution, under different pH values, at a concentration of 10-6 mol/l. Theoretically, we extended the two-state model, based on a system of coupled differential equations, by adding a desorption parameter Kd2, for unfolded state. The model was solved taking into account the adsorption (Ka), desorption (Kd1,2), transformation (Kf) coefficients, and the initial solution protein concentration (C0). The findings clearly illustrated that the solution pH drastically changed the behavior of BSA adsorption, whereas the mathematical analytical solutions allowed us to determine the native state (θ1), the unfolded state (θ2), and the full one (θ) surface coverages. Finally, a good application of the approximated model on the experimental work, expanded BSA adsorbed on TiO2 anatase at pH = 1.7, indicated a value of Ka = (408.36 ± 0.996) × 102 mol-1 l min-1.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139428280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of CuO/polyaniline/multiwalled carbon nanotube composites using Macaranga indica leaves extract as hydrogen gas sensor. 利用马缨丹叶提取物合成 CuO/聚苯胺/多壁碳纳米管复合材料作为氢气传感器。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003282

Shivaprasad Chalawadi, Malatesh S Pujar, Rajashekhar F Bhajantri

{"title":"Synthesis of CuO/polyaniline/multiwalled carbon nanotube composites using Macaranga indica leaves extract as hydrogen gas sensor.","authors":"Shivaprasad Chalawadi, Malatesh S Pujar, Rajashekhar F Bhajantri","doi":"10.1116/6.0003282","DOIUrl":"10.1116/6.0003282","url":null,"abstract":"In this study, we describe the fabrication of hydrogen gas sensors in the form of nanocomposites containing metal oxides such as copper oxide (CuO), multiwalled carbon nanotubes (MWCNTs), and polyaniline (PANI) using a green synthesis method. We used Macaranga indica (M. indica) leaf extract as a reducing and stabilizing agent to prepare copper oxide nanoparticles (CuONPs). The sample was analyzed using various techniques to determine its physicochemical, morphological, and elemental composition. The XRD data showed that the sample is a CuO/PANI/MWCNT nanocomposite by the best match with the reported data. SEM images revealed a uniform distribution of MWCNTs and spherical CuO nanoparticles of 30-40 nm throughout the CNT network. EDX confirmed that the prepared sample is a pure and inline combination of Cu, O, C, and N. Due to the presence of bioactive elements and PANI, we observed 17% and 25% weight loss for CuO and CuO/PANI/MWCNTs. It was found that this combination of materials can detect H2 gas in concentrations ranging from 110 to 2 ppm at temperatures of 200 and 250 °C. As H2 concentration increased, sensitivity varied from 5% to 20%, but response and recovery times were about 290 and 500 s, respectively, for 40 ppm H2 gas. A logistic function fit to Ra/Rg versus H2 was performed using Y = A2 + (A1 - A2)/(1 + (x/x0)p). The energy bands among the CuO/PANI/MWCNT heterointerfaces were used to demonstrate enhanced H2 gas-sensing properties.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139544830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfabricated free standing, tuneable, porous microfilters from an epoxy based photoresist for effective bioseparation. 利用环氧树脂光刻胶微加工出独立的、可调节的多孔微过滤器，实现有效的生物分离。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003165

Sudeshna Sengupta, D Shyamala, Sivasundari Kannan, V T Fidal Kumar, Enakshi Bhattacharya

引用次数: 0

Fungal mycelia: From innovative materials to promising products: Insights and challenges. 真菌菌丝体：从创新材料到前景广阔的产品：见解与挑战。

IF 2.1 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003441

Wenjing Sun

引用次数: 0

Quartz crystal microbalance in soft and biological interfaces. 软界面和生物界面中的石英晶体微天平。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003312

Ilya Reviakine

引用次数: 0

Future research perspective on the interfacial physics of non-invasive glaucoma testing in pathogen transmission from the eyes. 无创青光眼检测中病原体从眼睛传播的界面物理学未来研究展望。

IF 1.9 4区医学

Biointerphases Pub Date : 2024-01-01 DOI: 10.1116/6.0003347

Durbar Roy, Saptarshi Basu

{"title":"Future research perspective on the interfacial physics of non-invasive glaucoma testing in pathogen transmission from the eyes.","authors":"Durbar Roy, Saptarshi Basu","doi":"10.1116/6.0003347","DOIUrl":"10.1116/6.0003347","url":null,"abstract":"Non-contact tonometry (NCT) is a non-invasive ophthalmologic technique to measure intraocular pressure (IOP) using an air puff for routine glaucoma testing. Although IOP measurement using NCT has been perfected over many years, various phenomenological aspects of interfacial physics, fluid structure interaction, waves on corneal surface, and pathogen transmission routes to name a few are inherently unexplored. Research investigating the interdisciplinary physics of the ocular biointerface and of the NCT procedure is sparse and hence remains to be explored in sufficient depth. In this perspective piece, we introduce NCT and propose future research prospects that can be undertaken for a better understanding of the various hydrodynamic processes that occur during NCT from a pathogen transmission viewpoint. In particular, the research directions include the characterization and measurement of the incoming air puff, understanding the complex fluid-solid interactions occurring between the air puff and the human eye for measuring IOP, investigating the various waves that form and travel; tear film breakup and subsequent droplet formation mechanisms at various spatiotemporal length scales. Further, from an ocular disease transmission perspective, the disintegration of the tear film into droplets and aerosols poses a potential pathogen transmission route during NCT for pathogens residing in nasolacrimal and nasopharynx pathways. Adequate precautions by opthalmologist and medical practioners are therefore necessary to conduct the IOP measurements in a clinically safer way to prevent the risk associated with pathogen transmission from ocular diseases like conjunctivitis, keratitis, and COVID-19 during the NCT procedure.","PeriodicalId":9053,"journal":{"name":"Biointerphases","volume":"19 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0