Engineered cell membrane-coated nanoparticles based cancer therapy: A robust weapon against the lethal and challenging hepatocellular carcinoma.

IF 1.6 4区医学 Q4 BIOPHYSICS

Biointerphases Pub Date : 2024-03-01 DOI:10.1116/6.0003204

Jiachen Zhang, Hongjuan Yu, Gang Li

引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) has become an important public health problem, and there are still challenges to overcome in clinical treatment. The nanodrug delivery system (NDDS) has developed tremendously in recent years, and many researchers have explored NDDS for the treatment of HCC. Engineered cell membrane-coated nanoparticles (ECNPs) have emerged, combining the unique functions of cell membranes with the engineering versatility of synthetic nanoparticles (NPs) to effectively deliver therapeutic drugs. It is designed to have the capabilities: specific active targeting, immune evasion, prolonging the circulation blood time, controlled drug release delivery, and reducing drugs systematic toxicity. Thus, ECNPs are a promising bionic tool in the treatment of HCC and have operability to achieve combination and integrated therapy. This review focuses on the mechanism and strategy of ECNPs for the treatment of HCC and summarizes its research progress in the treatment of HCC in recent years.

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基于细胞膜涂层的工程纳米粒子癌症疗法：对抗致命且具有挑战性的肝细胞癌的有力武器。

肝细胞癌（HCC）已成为一个重要的公共卫生问题，临床治疗中仍有许多难题需要克服。近年来，纳米给药系统（NDDS）得到了长足的发展，许多研究人员都对 NDDS 治疗 HCC 进行了探索。工程细胞膜包被纳米颗粒（ECNPs）应运而生，它结合了细胞膜的独特功能和合成纳米颗粒（NPs）的工程多功能性，能有效地递送治疗药物。其设计具有以下功能：特异性活性靶向、免疫避避、延长血液循环时间、控释给药、降低药物的系统毒性。因此，ECNPs 是治疗 HCC 的一种前景广阔的仿生工具，具有实现联合和综合治疗的可操作性。本综述重点探讨了ECNPs治疗HCC的机制和策略，并总结了近年来ECNPs在治疗HCC方面的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biointerphases 生物-材料科学：生物材料

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期刊介绍： Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.