Biomedical optics express最新文献_第4页

In-situ, real-time monitoring of thermo-mechanical properties of biological tissues undergoing laser heating and ablation. 原位实时监测正在接受激光加热和烧蚀的生物组织的热机械特性。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-04 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.537374

Bayan Kurbanova, Shakhrizat Alisherov, Zhannat Ashikbayeva, Zhanerke Katrenova, Akbota Sametova, Abduzhappar Gaipov, Carlo Molardi, Wilfried Blanc, Daniele Tosi, Zhandos Utegulov

{"title":"In-situ, real-time monitoring of thermo-mechanical properties of biological tissues undergoing laser heating and ablation.","authors":"Bayan Kurbanova, Shakhrizat Alisherov, Zhannat Ashikbayeva, Zhanerke Katrenova, Akbota Sametova, Abduzhappar Gaipov, Carlo Molardi, Wilfried Blanc, Daniele Tosi, Zhandos Utegulov","doi":"10.1364/BOE.537374","DOIUrl":"10.1364/BOE.537374","url":null,"abstract":"In this work, Brillouin light-scattering spectroscopy and optical backscattering reflectometry (OBR) using Mg-silica-NP-doped distributed sensing fibers were employed for monitoring local GHz visco-elastic properties and surface temperature, respectively, during laser driven heating and ablation of chicken tissues. The spatial temperature distribution measured by OBR at various infrared laser heating powers and times was used to validate spatio-temporal local temperature variations modeled by the finite element method via solving Pennes' bioheat conduction equation. The reduction of viscosity and stiffness in chicken skin during its laser heating was attributed to water loss, protein denaturation and change in lipid phase behavior. These findings open avenues for the simultaneous real-time hybrid optical sensing of both viscoelasticity and local temperature in biological tissues undergoing denaturation and gelation during thermal ablation in clinical settings.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6198-6210"},"PeriodicalIF":2.9,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Affordable ultra-widefield smartphone PedCam for comprehensive pediatric retinal examination. 经济实惠的超宽视场智能手机 PedCam，用于全面的儿科视网膜检查。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-02 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.537633

Alfa Rossi, Devrim Toslak, Muhammet Kazim Erol, Mojtaba Rahimi, Taeyoon Son, R V Paul Chan, Xincheng Yao

{"title":"Affordable ultra-widefield smartphone PedCam for comprehensive pediatric retinal examination.","authors":"Alfa Rossi, Devrim Toslak, Muhammet Kazim Erol, Mojtaba Rahimi, Taeyoon Son, R V Paul Chan, Xincheng Yao","doi":"10.1364/BOE.537633","DOIUrl":"10.1364/BOE.537633","url":null,"abstract":"Widefield fundus photography is critical for the detection, documentation, and management of pediatric eye diseases. Existing clinical pediatric fundus cameras offer a limited field of view (FOV) and suboptimal image contrast, hindering comprehensive peripheral retina examination. Additionally, the high cost and lack of portability of commercial devices restrict their use in resource-limited settings. We introduce a cost-effective smartphone-based pediatric camera (PedCam) that provides a 180° eye angle (126° visual angle) snapshot FOV. Utilizing trans-pars planar illumination, the device enables nonmydriatic imaging by allocating the pupil exclusively for imaging, eliminating the need for pharmacological pupillary dilation. By adjusting the optical axis of the PedCam relative to the ocular axis, the effective FOV can be expanded up to 240° eye angle (180° visual angle), enabling complete retinal evaluation. This innovative smartphone PedCam represents a significant advancement in affordable telemedicine for the screening, monitoring, and management of retinopathy of prematurity and other pediatric eye conditions.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6171-6182"},"PeriodicalIF":2.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving cone identification using merged non-confocal quadrant-detection adaptive optics scanning light ophthalmoscope images. 利用合并的非聚焦象限检测自适应光学扫描光眼底镜图像改进锥体识别。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-02 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.539001

Toco Y P Chui, Justin V Migacz, Luis Muncharaz Duran, Affan Haq, Oscar Otero-Marquez, Alfredo Dubra, Richard B Rosen

引用次数: 0

Attenuation coefficient as a tool to detect changes in the white matter of the rat brain caused by different types of gliomas and irradiation. 用衰减系数检测不同类型胶质瘤和照射引起的大鼠脑白质变化。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-02 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.533903

Ksenia A Achkasova, Elena B Kiseleva, Arseniy L Potapov, Liudmila S Kukhnina, Alexander A Moiseev, Konstantin S Yashin, Anastasia V Polozova, Anastasia D Komarova, Natalia D Gladkova

{"title":"Attenuation coefficient as a tool to detect changes in the white matter of the rat brain caused by different types of gliomas and irradiation.","authors":"Ksenia A Achkasova, Elena B Kiseleva, Arseniy L Potapov, Liudmila S Kukhnina, Alexander A Moiseev, Konstantin S Yashin, Anastasia V Polozova, Anastasia D Komarova, Natalia D Gladkova","doi":"10.1364/BOE.533903","DOIUrl":"10.1364/BOE.533903","url":null,"abstract":"In the present work, we carried out a comparative study of the attenuation coefficient of the white matter of the rat brain during the growth of glial tumors characterized by different degrees of malignancy (glioblastoma 101/8, astrocytoma 10-17-2, glioma C6) and during irradiation. We demonstrated that some tumor models cause a pronounced decrease in white matter attenuation coefficient values due to infiltration of tumor cells, myelinated fiber destruction, and edema. In contrast, other tumors cause compression of the myelinated fibers of the corpus callosum without their ruptures and prominent invasion of tumor cells, which preserved the attenuation coefficient values changeless. In addition, for the first time, the possibility of using the attenuation coefficient to detect late radiation-induced changes in white matter characterized by focal development of edema, disruption of the integrity of myelinated fibers, and a decrease in the amount of oligodendrocytes and differentiation of these areas from tumor tissue and healthy white matter has been demonstrated. The results indicate the promise of using the attenuation coefficient estimated from OCT data for in vivo assessment of the degree of destruction of peritumoral white matter or its compression, which makes this method useful not only in primary resections but also in repeated surgical interventions for recurrent tumors.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6136-6155"},"PeriodicalIF":2.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HyFormer: a hybrid transformer-CNN architecture for retinal OCT image segmentation. HyFormer：用于视网膜 OCT 图像分割的混合变换器-CNN 架构。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-02 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.538959

Qingxin Jiang, Ying Fan, Menghan Li, Sheng Fang, Weifang Zhu, Dehui Xiang, Tao Peng, Xinjian Chen, Xun Xu, Fei Shi

{"title":"HyFormer: a hybrid transformer-CNN architecture for retinal OCT image segmentation.","authors":"Qingxin Jiang, Ying Fan, Menghan Li, Sheng Fang, Weifang Zhu, Dehui Xiang, Tao Peng, Xinjian Chen, Xun Xu, Fei Shi","doi":"10.1364/BOE.538959","DOIUrl":"10.1364/BOE.538959","url":null,"abstract":"Optical coherence tomography (OCT) has become the leading imaging technique in diagnosing and treatment planning for retinal diseases. Retinal OCT image segmentation involves extracting lesions and/or tissue structures to aid in the decisions of ophthalmologists, and multi-class segmentation is commonly needed. As the target regions often spread widely inside the retina, and the intensities and locations of different categories can be close, good segmentation networks must possess both global modeling capabilities and the ability to capture fine details. To address the challenge in capturing both global and local features simultaneously, we propose HyFormer, an efficient, lightweight, and robust hybrid network architecture. The proposed architecture features parallel Transformer and convolutional encoders for independent feature capture. A multi-scale gated attention block and a group positional embedding block are introduced within the Transformer encoder to enhance feature extraction. Feature integration is achieved in the decoder composed of the proposed three-path fusion modules. A class activation map-based cross-entropy loss function is also proposed to improve segmentation results. Evaluations are performed on a private dataset with myopic traction maculopathy lesions and the public AROI dataset for retinal layer and lesion segmentation with age-related degeneration. The results demonstrate HyFormer's superior segmentation performance and robustness compared to existing methods, showing promise for accurate and efficient OCT image segmentation. .","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6156-6170"},"PeriodicalIF":2.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor. 利用金字塔波前传感器改进用于视网膜前部成像的自适应光学 OCT 的速度、稳定性和视野。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI: 10.1364/BOE.533451

Elisabeth Brunner, Laura Kunze, Victoria Laidlaw, Daniel Jodlbauer, Wolfgang Drexler, Ronny Ramlau, Andreas Pollreisz, Michael Pircher

{"title":"Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.","authors":"Elisabeth Brunner, Laura Kunze, Victoria Laidlaw, Daniel Jodlbauer, Wolfgang Drexler, Ronny Ramlau, Andreas Pollreisz, Michael Pircher","doi":"10.1364/BOE.533451","DOIUrl":"https://doi.org/10.1364/BOE.533451","url":null,"abstract":"We present improvements on the adaptive optics (AO) correction method using a pyramid wavefront sensor (P-WFS) and introduce a novel approach for closed-loop focus shifting in retinal imaging. The method's efficacy is validated through in vivo adaptive optics optical coherence tomography (AO-OCT) imaging in both, healthy individuals and patients with diabetic retinopathy. In both study groups, a stable focusing on the anterior retinal layers is achieved. We further report on an improvement in AO loop speed that can be used to expand the imaging area of AO-OCT in the slow scanning direction, largely independent of the eye's isoplanatic patch. Our representative AO-OCT data reveal microstructural details of the neurosensory retina such as vessel walls and microglia cells that are visualized in single volume data and over an extended field of view. The excellent performance of the P-WFS based AO-OCT imaging in patients suggests good clinical applicability of this technology.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 10","pages":"6098-6116"},"PeriodicalIF":2.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser device. 使用便携式斑点对比光学光谱激光设备，将中风风险与非侵入性脑血管灌注动态相关联。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-09-30 eCollection Date: 2024-10-01 DOI: 10.1364/BOE.534796

Yu Xi Huang, Simon Mahler, Aidin Abedi, Julian Michael Tyszka, Yu Tung Lo, Patrick D Lyden, Jonathan Russin, Charles Liu, Changhuei Yang

{"title":"Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser device.","authors":"Yu Xi Huang, Simon Mahler, Aidin Abedi, Julian Michael Tyszka, Yu Tung Lo, Patrick D Lyden, Jonathan Russin, Charles Liu, Changhuei Yang","doi":"10.1364/BOE.534796","DOIUrl":"10.1364/BOE.534796","url":null,"abstract":"Stroke poses a significant global health threat, with millions affected annually, leading to substantial morbidity and mortality. Current stroke risk assessment for the general population relies on markers such as demographics, blood tests, and comorbidities. A minimally invasive, clinically scalable, and cost-effective way to directly measure cerebral blood flow presents an opportunity. This opportunity has the potential to positively impact effective stroke risk assessment prevention and intervention. Physiological changes in the cerebrovascular system, particularly in response to hypercapnia and hypoxia during voluntary breath-holding can offer insights into stroke risk assessment. However, existing methods for measuring cerebral perfusion reserves, such as blood flow and blood volume changes, are limited by either invasiveness or impracticality. Herein we propose a non-invasive transcranial approach using speckle contrast optical spectroscopy (SCOS) to non-invasively monitor regional changes in brain blood flow and volume during breath-holding. Our study, conducted on 50 individuals classified into two groups (low-risk and higher-risk for stroke), shows significant differences in blood dynamic changes during breath-holding between the two groups, providing physiological insights for stroke risk assessment using a non-invasive quantification paradigm. Given its cost-effectiveness, scalability, portability, and simplicity, this laser-centric tool has significant potential for early diagnosis and treatment of stroke in the general population.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 10","pages":"6083-6097"},"PeriodicalIF":2.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic opening of the blood-brain barrier affects meningeal lymphatics and the brain's drainage in healthy male mice. 光动力打开血脑屏障会影响健康雄性小鼠的脑膜淋巴管和大脑引流。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1364/BOE.527892

Inna Blokhina, Andrey Terskov, Arina Evsiukova, Alexander Dubrovsky, Viktoria Adushkina, Daria Zlatogorskaya, Alexander Dmitrenko, Matvey Tuzhilkin, Maria Manzhaeva, Valeria Krupnova, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Maria Tzoy, Alexander Shirokov, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya

引用次数: 0

Stand-alone segmentation of blood flow pulsatility measured with diffuse correlation spectroscopy. 利用弥散相关光谱学测量血流脉动性的独立分割。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1364/BOE.533916

Srinidhi Bharadwaj, Tara M Urner, Kyle R Cowdrick, Rowan O Brothers, Tisha Boodooram, Hongting Zhao, Vidisha Goyal, Eashani Sathialingam, Yueh-Chi Wu, Ayesha Quadri, Katherine Turrentine, Mariam M Akbar, Sydney E Triplett, Shasha Bai, Erin M Buckley

引用次数: 0

Light-adapted flicker-optoretinography based on raster-scan optical coherence tomography towards clinical translation. 基于光栅扫描光学相干断层扫描的光适配闪烁视网膜成像技术走向临床转化。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-09-26 eCollection Date: 2024-10-01 DOI: 10.1364/BOE.538481

Zhaoyu Gong, Yaping Shi, Jian Liu, Ramkumar Sabesan, Ruikang K Wang

{"title":"Light-adapted flicker-optoretinography based on raster-scan optical coherence tomography towards clinical translation.","authors":"Zhaoyu Gong, Yaping Shi, Jian Liu, Ramkumar Sabesan, Ruikang K Wang","doi":"10.1364/BOE.538481","DOIUrl":"https://doi.org/10.1364/BOE.538481","url":null,"abstract":"Optoretinography (ORG) is a promising non-invasive and objective technique for assessing retinal function by measuring its response to light stimulation. Optical coherence tomography (OCT) has emerged as a promising tool for implementing ORG due to its three-dimensional imaging capabilities, high sensitivity to nanometer-scale changes induced by light stimulation, and clinical availability. Although ORG has proven feasible in laboratory settings, research-grade OCT systems lack satisfactory usability and cost-effectiveness to be clinically viable. Standard clinical raster-scan OCT systems, with their limited imaging speed, fall short of the requirements for measuring rapid ORG responses. To bridge this gap, we introduce a flicker-ORG modality based on a raster-scan OCT system that resembles standard clinical OCT. This system overcomes speed limitations through an innovative two-stage scanning protocol coupled with a 600 kHz swept source, enabling repeated volume imaging and precise retinal activity measurements over a finite area. Additionally, the light-adapted ORG strategy eliminates the need for dark adaptation, allowing examinations under photopic conditions and thus improving patient compliance. We tested this new ORG method by measuring flicker-induced photoreceptor responses in five healthy subjects. The results demonstrated high repeatability and revealed dependencies of the ORG response on flicker frequency and retinal eccentricity. These findings, combined with the system's utility, cost-effectiveness, and ease of integration into existing technologies, underscore its substantial potential for clinical application.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 10","pages":"6036-6051"},"PeriodicalIF":2.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11482172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0