Biomedical optics express最新文献_第3页

Oxygen-dependent functional brain haemodynamic response. 氧依赖性功能性脑血流动力学反应。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-17 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.545722

Karolina Bejm, Stanislaw Wojtkiewicz, Zanna Pastuszak, Adam Liebert

引用次数: 0

Postoperative intraocular lens tilt from preoperative full crystalline lens geometry using machine learning. 术后人工晶状体倾斜从术前全晶状体几何使用机器学习。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-13 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.551733

Eduardo Martinez-Enriquez, Gonzalo Velarde-Rodríguez, Nicolás Alejandre-Alba, Derick Ansah, Sindhu Kishore, Álvaro de la Peña, Ramya Natarajan, Pravin Vaddavalli, Yue Zhao, Joseph O Okudolo, Dylan B McBee, Ugur Celik, Mujdat Cetin, Jen-Li Dong, Yuli Lim, Li Wang, Douglas Donald Koch, Scott MacRae, Susana Marcos

{"title":"Postoperative intraocular lens tilt from preoperative full crystalline lens geometry using machine learning.","authors":"Eduardo Martinez-Enriquez, Gonzalo Velarde-Rodríguez, Nicolás Alejandre-Alba, Derick Ansah, Sindhu Kishore, Álvaro de la Peña, Ramya Natarajan, Pravin Vaddavalli, Yue Zhao, Joseph O Okudolo, Dylan B McBee, Ugur Celik, Mujdat Cetin, Jen-Li Dong, Yuli Lim, Li Wang, Douglas Donald Koch, Scott MacRae, Susana Marcos","doi":"10.1364/BOE.551733","DOIUrl":"https://doi.org/10.1364/BOE.551733","url":null,"abstract":"In cataract surgery, the opacified crystalline lens is replaced by an artificial intraocular lens (IOL), requiring precise preoperative selection of parameters to optimize postoperative visual quality. Three-dimensional customized eye models, which can be constructed using quantitative data from anterior segment optical coherence tomography, provide a robust platform for virtual surgery. These models enable simulations and predictions of the optical outcomes for specific patients and selected IOLs. A critical step in building these models is estimating the IOL's tilt and position preoperatively based on the available preoperative geometrical information (ocular parameters). In this study, we present a machine learning model that, for the first time, incorporates the full shape geometry of the crystalline lens as candidate input features to predict the postoperative IOL tilt. Furthermore, we identify the most relevant features for this prediction task. Our model demonstrates statistically significantly lower estimation errors compared to a simple linear correlation method, reducing the estimation error by approximately 6%. These findings highlight the potential of this approach to enhance the accuracy of postoperative predictions. Further work is needed to examine the potential for such postoperative predictions to improve visual outcomes in cataract patients.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1439-1456"},"PeriodicalIF":2.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation of optical properties of mouse brain using an optical clearing agent: experimental and simulation approaches. 光学清除剂对小鼠脑光学特性的影响：实验和模拟方法。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-12 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.553567

Saeed Ziaee, Mohammad Ali Ansari, Seyyede Sarvenaz Khatami, Behnam Shariati B K, Vahid Ghotbi Maleki, Samad Nejad Ebrahimi, Valery V Tuchin

{"title":"Variation of optical properties of mouse brain using an optical clearing agent: experimental and simulation approaches.","authors":"Saeed Ziaee, Mohammad Ali Ansari, Seyyede Sarvenaz Khatami, Behnam Shariati B K, Vahid Ghotbi Maleki, Samad Nejad Ebrahimi, Valery V Tuchin","doi":"10.1364/BOE.553567","DOIUrl":"https://doi.org/10.1364/BOE.553567","url":null,"abstract":"For optical diagnosis and therapy in medicine, tracking changes in tissue refractive index (RI), absorption, and scattering coefficient is important. These characteristics may be measured using a variety of techniques. Examples of simulation and experimentation techniques for determining optical parameters are inverse Monte Carlo (IMC) simulation, integrating sphere spectroscopy (ISS), and diffuse reflectance spectroscopy (DRS). The depth of optical measurements is limited by tissue light attenuation in all methods. Using optical clearing agents (OCAs) is a common method to increase optical depth and reduce light scattering in biological tissues. Thus, optical measurement techniques employing new (OCAs) can potentially achieve greater efficiency than traditional agents. This study aims to measure the optical properties of an unsliced mouse brain in the visible spectrum using an OCA composition to clear the tissue. The mouse brain model is useful for developing neuroimaging techniques and optical monitoring of brain activity. In this study, DRS, ISS, and IMC are used to analyze the changes in the RI, absorption, and scattering coefficients of the unsliced mouse brain. A fluorescence test was additionally conducted to evaluate the efficacy of the introduced OCA in comparison to glycerol. The findings and OCA described in this study may be beneficial in optical neurostimulation and brain disease treatments.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1423-1438"},"PeriodicalIF":2.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-operative monitoring of tissue perfusion in murine skin flaps using enhanced thermal imaging. 应用增强热成像技术监测小鼠皮瓣术后组织灌注。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-11 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.551057

Madeline R Kern, Cobey L McGinnis, Didier Dréau, Susan R Trammell

引用次数: 0

Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation. 空气脉冲光相干弹性学：激发角对机械波传播的影响。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-11 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.557984

Pengfei Song, Chengjin Song, Yubao Zhang, Xiao Han, Peijun Tang, Chaitanya Duvvuri, Jingjiang Xu, Yanping Huang, Jia Qin, Lin An, Michael D Twa, Gongpu Lan

{"title":"Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation.","authors":"Pengfei Song, Chengjin Song, Yubao Zhang, Xiao Han, Peijun Tang, Chaitanya Duvvuri, Jingjiang Xu, Yanping Huang, Jia Qin, Lin An, Michael D Twa, Gongpu Lan","doi":"10.1364/BOE.557984","DOIUrl":"https://doi.org/10.1364/BOE.557984","url":null,"abstract":"We evaluate the effect of excitation angles on the observation and characterization of surface wave propagations used to derive tissue's mechanical properties in optical coherence tomography (OCT)-based elastography (OCE). Air-pulse stimulation was performed at the center of the sample with excitation angles ranging from oblique (e.g., 70° or 45°) to perpendicular (0°). OCT scanning was conducted radially to record en face mechanical wave propagations in 360°, and the wave features (amplitude, attenuation, group and phase velocities) were calculated in the spatiotemporal or wavenumber-frequency domains. We conducted measurements on isotropic, homogeneous samples (1-1.6% agar phantoms), anisotropic samples (chicken breast), and samples with complex boundaries, coupling media, and stress conditions (ex vivo porcine cornea, intraocular pressure (IOP): 5-20 mmHg). Our findings indicate that mechanical wave velocities are less affected by excitation angles compared to displacement features, demonstrating the robustness of using mechanical waves for elasticity estimations. Agar and chicken breast sample measurements showed that all these metrics (particularly wave velocities) are relatively consistent when excitation angles are smaller than 45°. However, significant disparities were observed in the porcine cornea measurements across different excitation angles (even between 15° and 0°), particularly at high IOP levels (e.g., 20 mmHg). Our findings provide valuable insights for enhancing the accuracy of biomechanical assessments using air-pulse-based or other dynamic OCE approaches. This facilitates the refinement and clinical translation of the OCE technique and could ultimately improve diagnostic and therapeutic applications across various biomedical fields.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1371-1391"},"PeriodicalIF":2.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic particle pump in microfluidic systems. 微流体系统中的光动力粒子泵。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-11 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.555270

Jiahao Du, Tingting Yuan, Xiaotong Zhang, Kai Zhang, Fuyin Zhu, Wang Chen, Xuehui Tang, Changlin Xiao, Libo Yuan

{"title":"Photodynamic particle pump in microfluidic systems.","authors":"Jiahao Du, Tingting Yuan, Xiaotong Zhang, Kai Zhang, Fuyin Zhu, Wang Chen, Xuehui Tang, Changlin Xiao, Libo Yuan","doi":"10.1364/BOE.555270","DOIUrl":"https://doi.org/10.1364/BOE.555270","url":null,"abstract":"Micro-pumps are widely used in biomedical equipment such as flow cytometry. In micro-flow systems, pumps are usually the main tool and means to control the flow rate of liquid. Controlling the particle movement in micro-flow is always a difficult problem in a mixed fluid of liquid and particles. In this paper, we propose a new type of photodynamic particle pump based on annular-core hollow-center fiber. The laser is coupled into the annular core by fused tapering optical fiber and welding at the cone point. A femtosecond laser processing system is used to process microscopic holes on the side of the fiber to achieve particle injection. The laser will converge to form a conical shell light field after passing through the cone, and the speed of the particles increases after passing through the conical shell light field, thus forming a particle pump. The experimental results show that the particle velocity increases with the increase of laser power at low injection pressure. In the case of constant power, the flow rate is independent of the injection pressure, and the particle velocity in the micro-flow system is controlled. It has important value and application prospects for particle acceleration control of microfluidic chip systems and cell manipulation and sorting in the microbiological field.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1392-1405"},"PeriodicalIF":2.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal reconstruction from peripheral biometry. 外周生物测量法重建视网膜。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-11 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.549290

Iñaki Blanco-Martínez, David A Atchison, Fuensanta A Vera-Diaz, Jos J Rozema

引用次数: 0

Experimental and modeling analysis of lenses with concentric cylindrical annular refractive elements: impact on peripheral imaging. 同心圆柱环形折射元件透镜的实验与建模分析：对周边成像的影响。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-07 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.546942

Yongji Liu, Dongyu Liu, Xiaoyang Hu, Xiaoqin Chen, Hongliang Liu, Lihua Li

{"title":"Experimental and modeling analysis of lenses with concentric cylindrical annular refractive elements: impact on peripheral imaging.","authors":"Yongji Liu, Dongyu Liu, Xiaoyang Hu, Xiaoqin Chen, Hongliang Liu, Lihua Li","doi":"10.1364/BOE.546942","DOIUrl":"https://doi.org/10.1364/BOE.546942","url":null,"abstract":"The mechanism by which myopia-managing spectacle lenses slow myopia progression remains controversial. Understanding the changes these lenses introduce to peripheral imaging properties helps shed light on this controversial issue. Given the difficulty of directly measuring these changes in clinical settings, this study combined experimental and modeling approaches to evaluate changes in images at the retina induced by myopia-managing lenses. Optical characteristics that may related to the efficacy of the lenses with concentric cylindrical annular refractive elements (CARE) in myopia control were investigated. Three lenses were evaluated: MyoCare (MC), MyoCare S (MCS), and a single vision (SV) lens with a custom-built physical eye model and optical simulations for the analysis. The simulated PSFs are consistent with the measured ones. PSF analysis showed that MC and MCS lenses produce discrete curves, resulting in remarkable distortion in the simulated retina images, especially for large eccentricities. Whether they increase or decrease contrast depends on the spatial frequencies and eccentricities. These lenses also increase retinal light intensity at different eccentricities. The positive power of the CARE structure introduces myopic defocus of less than 0.25 D at only a limited range of eccentricities. The proposed approaches present relatively straightforward techniques for evaluating the optical performance of myopia-managing spectacle lenses.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1344-1358"},"PeriodicalIF":2.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PS-OCT imaging of the anterior segment under different eyeball rotations. 不同眼球旋转下前段的PS-OCT成像。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-06 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.547391

Weike Wang, Di Yang, Songwen Xu, Wenguang Chen, Wei Zhang, Yanmei Liang

{"title":"PS-OCT imaging of the anterior segment under different eyeball rotations.","authors":"Weike Wang, Di Yang, Songwen Xu, Wenguang Chen, Wei Zhang, Yanmei Liang","doi":"10.1364/BOE.547391","DOIUrl":"https://doi.org/10.1364/BOE.547391","url":null,"abstract":"Eyeball rotation potentially reflects the physiological characteristics of the anterior segment. Understanding the structural changes in the anterior segment during eyeball rotation is essential for gaining deeper insights into the biomechanical processes of eye movement and its impact on visual quality. Using a homemade swept-source polarization-sensitive optical coherence tomography (SS-PS-OCT) system, we scanned normal human eyes and examined changes in anterior segment tissues during different eyeball rotations. Our analysis of the PS-OCT images revealed the structural and polarization characteristics of the anterior segment, demonstrating that the system possesses high sensitivity in detecting changes in birefringence induced by eyeball rotation, and found that microscopic changes in the anterior segment can be identified by the polarization information. Our results demonstrated that polarization information can enhance the contrast in ophthalmic OCT diagnostics, and proved PS-OCT has significant potential in studying the characteristics of anterior segment tissues and the biomechanical behavior associated with eyeball rotation.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1330-1343"},"PeriodicalIF":2.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent breakthroughs in digital holography, 2D/3D imaging, and holographic optical elements: introduction. 数字全息、二维/三维成像和全息光学元件的最新突破：介绍。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-03-05 eCollection Date: 2025-04-01 DOI: 10.1364/BOE.559576

Pietro Ferraro, Tatiana Alieva, Pasquale Memmolo, George Nehmetallah, Yaping Zhang

引用次数: 0