Biomedical optics express最新文献

Minimally-invasive common-path OCT system for neurosurgery applications.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-31 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.549160

Gary Evans, Jerome Gandar, Simon Thiele, David J Segar, Yoseline Rosales Cabara, Matthew Lapinski, Ivana Gantar, Thierry Campiche, Corinne Brana, Michalina J Gora, Jules Scholler

引用次数: 0

Perceptual cost and benefit of presbyopia-correcting intraocular lenses: effect of energy balance, addition, and adaptation.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-31 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.543908

Eduardo Esteban-Ibañez, Enrique Gambra, Yassine Marrakchi, Lucie Sawides, Carlos Dorronsoro

引用次数: 0

Multi-modal transport of intensity diffraction tomography microscopy with an electrically tunable lens [Invited].

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-31 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.545258

Zihao Zhou, Runnan Zhang, Ning Zhou, Qian Chen, Chao Zuo

{"title":"Multi-modal transport of intensity diffraction tomography microscopy with an electrically tunable lens [Invited].","authors":"Zihao Zhou, Runnan Zhang, Ning Zhou, Qian Chen, Chao Zuo","doi":"10.1364/BOE.545258","DOIUrl":"10.1364/BOE.545258","url":null,"abstract":"Optical diffraction tomography (ODT) is an important technique for three-dimensional (3D) imaging of semi-transparent biological samples, enabling volumetric visualization of living cells, cultures, and tissues without the need for exogenous dyes. However, ODT faces significant challenges in imaging complex biological specimens due to the limited specificity of refractive index (RI) and the coupled relationship between absorption and phase in image formation. Here, we present multi-modal transport of intensity diffraction tomography (MM-TIDT), a high-speed 3D microscopy technique that integrates an electrically tunable lens with modified illumination patterns to decouple phase and absorption information. Leveraging dual illumination schemes-circular and annular apertures-MM-TIDT acquires two intensity stacks, facilitating accurate phase and absorption decoupling. Based on an alternating direction method of multipliers (ADMM) framework with total variation (TV) and non-negativity regularization, our method reconstructs multi-modal 3D distributions of fluorescence and complex RI with high accuracy and robustness. Experimental validation with fluorescent polystyrene microspheres, Spirulina specimens, and DAPI-labeled C166 cells demonstrates the multi-modal imaging capability of MM-TIDT to resolve fine structural details across diverse sample types, providing a versatile platform for exploring dynamic biological processes and intricate cellular interactions.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 2","pages":"837-848"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-modality imaging technologies and machine learning for non-invasive, precise assessment of rabbit endometrium.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-31 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.547855

Zhaoping Tan, Yudong Tian, Xiaomeng Zha, Zihan Qin, Qiaohua Xiong, Mei Wang, Shaoyuan Xu, Yuanzhen Zhang

{"title":"Multi-modality imaging technologies and machine learning for non-invasive, precise assessment of rabbit endometrium.","authors":"Zhaoping Tan, Yudong Tian, Xiaomeng Zha, Zihan Qin, Qiaohua Xiong, Mei Wang, Shaoyuan Xu, Yuanzhen Zhang","doi":"10.1364/BOE.547855","DOIUrl":"10.1364/BOE.547855","url":null,"abstract":"Developing a minimally invasive, real-time diagnostic tool to accurately assess endometrial conditions is critical to increasing pregnancy rates in assisted reproductive technology (ART). In this research, fiberoptic bronchoscopy and optical coherence tomography (OCT) were used before and after alcohol injury and human chorionic gonadotropin (hCG)-induced pseudopregnancy to monitor changes in the rabbit endometrium. Histological analysis and electron microscopy were performed on 1 cm uterine sections while simultaneously training a conditional generative adversarial network (cGAN) to convert OCT images into virtual hematoxylin and eosin H&E stained sections. By combining these optical elements, we have managed to non-invasively observe changes in the endometrium at different stages. Traditional endoscopy assesses surface changes such as mucosal color changes, congestion, and fibrous adhesions, while OCT provides detailed views of superficial and submucosal changes and can correspond to pathological H&E sections. Machine learning improves OCT by converting images to H&E format, enabling real-time, non-invasive assessment of endometrial status and improving the accuracy of endometrial receptivity assessment.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 2","pages":"821-836"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatic dispersion based axial length estimation using retinal spectral domain optical coherence tomography.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-30 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.553735

Johannes Kübler, Jörg P Fischer, Johannes F de Boer

{"title":"Chromatic dispersion based axial length estimation using retinal spectral domain optical coherence tomography.","authors":"Johannes Kübler, Jörg P Fischer, Johannes F de Boer","doi":"10.1364/BOE.553735","DOIUrl":"10.1364/BOE.553735","url":null,"abstract":"We propose a method for extracting the axial length of the human eye from high-resolution spectral domain optical coherence tomography (SD-OCT) retinal scans. The method evaluates the chromatic dispersion introduced by the anterior segment and the vitreous of the eye. By analyzing sub-spectral scans, we quantify the axial shift caused by dispersion and relate it to the thicknesses of the media passed by the OCT beam. The method depends on accurate k-linearization and pixel-to-wavenumber calibration. First, we demonstrate the feasibility of our approach using a model eye with adjustable water chamber length. Subsequently, the method is explored for in vivo retinal OCT scans. Challenges are inter-subject variability and limited availability of exact chromatic dispersion data for ocular tissues in the relevant spectral range for OCT imaging. By interpolating the refractive indices of an established eye model from visible wavelengths to the infrared wavelengths of the OCT system using the dispersion of water and estimating refined dispersion properties of the lens, we improve the model's agreement with in vivo measurements.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 2","pages":"793-805"},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Unpaired intra-operative OCT (iOCT) video super-resolution with contrastive learning: erratum.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-30 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.555423

Charalampos Komninos, Theodoros Pissas, Blanca Flores, Edward Bloch, Tom Vercauteren, Sébastien Ourselin, Lyndon Da Cruz, Christos Bergeles

引用次数: 0

Estimation of heart rate and respiratory rate by fore-background spatiotemporal modeling of videos.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-30 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.546968

Xiujuan Zheng, Wenqin Yan, Boxiang Liu, Yue Ivan Wu, Haiyan Tu

{"title":"Estimation of heart rate and respiratory rate by fore-background spatiotemporal modeling of videos.","authors":"Xiujuan Zheng, Wenqin Yan, Boxiang Liu, Yue Ivan Wu, Haiyan Tu","doi":"10.1364/BOE.546968","DOIUrl":"10.1364/BOE.546968","url":null,"abstract":"Heart rate (HR) and respiratory rate (RR) are two critical physiological parameters that can be estimated from video recordings. However, the accuracy of remote estimation of HR and RR is affected by fluctuations in ambient illumination. To address this adverse effect, we propose a fore-background spatiotemporal (FBST) method for estimating HR and RR from videos captured by consumer-grade cameras. Initially, we identify the foreground regions of interest (ROIs) on the face and chest, as well as the background ROIs in non-body areas of the videos. Subsequently, we construct the foreground and background spatiotemporal maps based on the dichromatic reflectance model. We then introduce a lightweight network equipped with adaptive spatiotemporal layers to process the spatiotemporal maps and automatically generate a feature map of the non-illumination perturbation pulses. This feature map serves as input to a ResNet-18 network to estimate the physiological rhythm. Finally, we extract pulse signals and estimate HR and RR concurrently. Experiments conducted on three public and one private dataset demonstrate the superiority of the proposed FBST method in terms of accuracy and computational efficiency. These findings provide novel insights into non-intrusive human physiological measurements using common devices.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 2","pages":"760-777"},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of next generation low-cost OCT towards improved point-of-care retinal imaging.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-30 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.551625

Hillel B Price, Ge Song, Wan Wang, Erin O'Kane, Kechao Lu, Evan Jelly, David A Miller, Adam Wax

引用次数: 0

Optical coherence tomography guided automatic robotic craniotomy surgery platform.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-30 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.549260

Haoyuan Li, Yongchao Wang, Wei Chen, Yanjun Zhang, Xiangsen Guo, Luke Xu, Yuerong Bao, Junxiong Zhou, Heng Sun, Yuntian Bi, Huijuan Feng, Wenjin Wang, Sen Suo, Jianbo Tang

引用次数: 0

Fresnel biprism common-path low-coherence digital holography for dynamic light scattering spectroscopy of biological materials.

IF 2.9 2区医学

Biomedical optics express Pub Date : 2025-01-30 eCollection Date: 2025-02-01 DOI: 10.1364/BOE.543308

Gabriel Goodwin, Dawith Lim, Shivani Mahajan, David D Nolte

引用次数: 0