Multi-spectral optoacoustic microscopy driven by gas-filled hollow-core fiber laser pulses.

IF 3.2 2区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Biomedical optics express Pub Date : 2025-07-22 eCollection Date: 2025-08-01 DOI:10.1364/BOE.567845
Cuiling Zhang, Marcello Meneghetti, J E Antonio-Lopez, Rodrigo Amezcua-Correa, Yazhou Wang, Christos Markos
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引用次数: 0

Abstract

Multi-spectral optoacoustic microscopy (MS-OAM) requires high-performance light sources capable of delivering multiple intense spectral lines precisely matched to the absorption characteristics of selected biomolecules. We present a gas-filled anti-resonant hollow-core fiber (ARHCF) laser source optimized for near-infrared (NIR) MS-OAM. The hydrogen (H2)-filled ARHCF laser emits multiple spectral lines with high pulse energy and narrow linewidths (<0.1 nm) across a broad spectral range (∼1100 nm to ∼2200 nm). Several Raman laser lines were generated to overlap with key biomolecular absorption bands, including lipids (1210 nm and 1700nm), collagen (∼1540 nm), and water (∼1400 nm and ∼1900 nm). We demonstrate the system's performance by mapping absorbers in the first and second overtone regions of hair, pig tissue, and collagen samples. This work aims to bring the gas-filled fiber technology into MS-OAM applications and paves the way for high-resolution, label-free bio-imaging across extended infrared and ultraviolet regimes.

充气空心光纤激光脉冲驱动的多光谱光声显微镜。
多光谱光声显微镜(MS-OAM)需要能够提供与所选生物分子的吸收特性精确匹配的多条强谱线的高性能光源。提出了一种针对近红外(NIR) MS-OAM进行优化的充气抗谐振空心芯光纤(ARHCF)激光源。充满氢(H2)的ARHCF激光器发射出脉冲能量高、线宽窄的多谱线(
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来源期刊
Biomedical optics express
Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS
CiteScore
6.80
自引率
11.80%
发文量
633
审稿时长
1 months
期刊介绍: The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.
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