Biomedical optics express最新文献_第10页

In vitro optical characterization of the RayOne Galaxy spiral extended depth-of-focus intraocular lens using high-resolution Mach-Zehnder interferometry. 利用高分辨率马赫-曾德干涉法对RayOne Galaxy螺旋形扩展焦深人工晶体进行体外光学表征。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-30 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.596696

Damien Gatinel, Amy Entin, Benjamin Stern

引用次数: 0

Advances in Technology and Applications of Optical Sensing and Imaging for Biomedicine: introduction. 生物医学光学传感与成像技术及其应用进展。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-29 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.609129

Wu Yuan, Guanghan Meng, Timothy M Baran

引用次数: 0

Developing a fiber-based diffuse reflectance spectroscopy setup for tissue optical property estimation. 开发一种基于光纤漫反射光谱的组织光学特性估计装置。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-29 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.596022

Akuroma Tolvanen, Mahdi Qaryan, Nithin Sadeesh, Ervin Nippolainen, Ari-Petteri Ronkainen, Iman Kafian-Attari, Isaac O Afara

{"title":"Developing a fiber-based diffuse reflectance spectroscopy setup for tissue optical property estimation.","authors":"Akuroma Tolvanen, Mahdi Qaryan, Nithin Sadeesh, Ervin Nippolainen, Ari-Petteri Ronkainen, Iman Kafian-Attari, Isaac O Afara","doi":"10.1364/BOE.596022","DOIUrl":"10.1364/BOE.596022","url":null,"abstract":"Our study demonstrates that a compact, low-cost, phantom-calibrated diffuse reflectance spectroscopy system can provide realistic estimates of tissue optical properties, supporting its progression toward in situ cartilage diagnostics. We developed and validated a fiber-based DRS system capable of quantitative estimation of absorption coefficient (µa) and reduced scattering coefficient (µs') in cartilage using a phantom-derived calibration model at wavelengths of 660, 780, and 850 nm. Diffuse reflectance spectra were acquired using a custom-built multi-distance probe, corrected using wavelength-specific calibration coefficients derived from optical phantoms, and fitted using diffusion theory with extrapolated boundary correction to recover µa and µs'. Our system was validated using phantoms with known optical properties, calibrated to correct system response, and applied to articular cartilage. Theoretical and measured reflectance showed an excellent agreement (bias ∼0, 95% limits of agreement ±0.0114). After calibration, µa and µs' were extracted from bovine patellar cartilage at the same wavelengths. The estimated µa values (0.07-0.24 cm-1) were characteristic of weakly absorbing, hydrated soft tissue, while µs' values (9.7-15.8 cm-1) showed the expected consistent decrease with wavelength. We found our estimated optical properties were consistent with literature trends, especially µs' values, which were between the range reported for µs' values from integrating-sphere and Monte Carlo-based analysis for bovine cartilage. Phantom-calibrated DRS enables accurate, reproducible estimation of cartilage optical properties, providing a validated framework for future translation toward arthroscopic optical assessment of joint health.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3944-3958"},"PeriodicalIF":3.2,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal drug response assessment of tumor organoids based on optical attenuation coefficient and multi-dimensional morphological characterization. 基于光学衰减系数和多维形态表征的肿瘤类器官纵向药物反应评价。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-26 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.604536

Shanshan Yang, Jing Guo, Wanli Wang, Zhe Feng, Ling Wang, Mingen Xu

{"title":"Longitudinal drug response assessment of tumor organoids based on optical attenuation coefficient and multi-dimensional morphological characterization.","authors":"Shanshan Yang, Jing Guo, Wanli Wang, Zhe Feng, Ling Wang, Mingen Xu","doi":"10.1364/BOE.604536","DOIUrl":"10.1364/BOE.604536","url":null,"abstract":"Patient-derived tumor organoids (PDTOs) are vital for precision oncology, but standard drug screening methods, including adenosine triphosphate (ATP) assays, are destructive and prevent longitudinal monitoring. Optical coherence tomography (OCT) offers non-destructive 3D imaging, capturing morphological features and tissue attenuation characteristics via the optical attenuation coefficient (OAC). Here, we propose a non-destructive evaluation framework for tumor organoids that fuses OAC and multi-dimensional morphological features. Using intrahepatic cholangiocarcinoma (iCCA) PDTOs treated with icaritin, we found that OAC exhibited a significant dose-dependent increase (up to 32.8% at 80 μM compared to control), accompanied by a morphological transition of cystic organoids into solid phenotypes. By integrating these features via K-means++ clustering and principal component analysis, we constructed a relative growth score. This fusion score correlated strongly with the ATP gold standard (Pearson correlation coefficient r = 0.938), outperforming a morphology-only model (r = 0.906). Furthermore, independent experiments with first-line chemotherapeutics (e.g., 5-Fluorouracil, Gemcitabine) and combinatorial regimens indicated the model's potential generalizability (r = 0.887). This method overcomes the limitations of destructive, single-metric evaluations, providing a quantitative and non-destructive platform for high-throughput drug screening and personalized treatment decision-making.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3922-3943"},"PeriodicalIF":3.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double Stokes polarimetry of birefringent structures. 双折射结构的双斯托克斯偏振法。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-26 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.603139

Viktoras Mazeika, Mykolas Maciulis, Kamdin Mirsanaye, Serguei Krouglov, Mehdi Alizadeh, Lukas Kontenis, Virginijus Barzda

引用次数: 0

Real-time monitoring and quantitative analysis of PAG-mediated chemical cochleostomy using 1.06-µm swept-source optical coherence tomography. 1.06-µm扫描源光学相干断层扫描实时监测和定量分析pag介导的化学耳蜗造口术。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-26 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.603374

You-Nan Tsai, Chuan-Bor Chueh, Ting-Hao Tsai, Ting-Yen Tsai, Ting-Hao Chen, Hsin-Chien Chen, Chih-Hung Wang, Hsiang-Chieh Lee

{"title":"Real-time monitoring and quantitative analysis of PAG-mediated chemical cochleostomy using 1.06-µm swept-source optical coherence tomography.","authors":"You-Nan Tsai, Chuan-Bor Chueh, Ting-Hao Tsai, Ting-Yen Tsai, Ting-Hao Chen, Hsin-Chien Chen, Chih-Hung Wang, Hsiang-Chieh Lee","doi":"10.1364/BOE.603374","DOIUrl":"10.1364/BOE.603374","url":null,"abstract":"Traditional cochleostomy relies on mechanical drilling, which carries inherent risks of acoustic and thermal trauma. In this study, we performed a quantitative analysis of phosphoric acid gel (PAG)-mediated chemical cochleostomy in ex vivo mouse cochleae using a 1.06-µm swept-source optical coherence tomography (SS-OCT) system. The imaging results demonstrated that 1.06-µm OCT provides high contrast for visualizing internal anatomic features, such as the organ of Corti, and changes in cochlear architecture during the chemical etching process. Quantitative evaluation revealed a reduction in bony wall thickness and enhanced visibility of intracochlear conduits post-PAG-application. Notably, the PAG-mediated thinning mitigates signal attenuation by reducing scattering from the dense bony wall, thereby improving OCT imaging contrast of internal structures. Real-time M-mode OCT imaging successfully captured dynamic reaction kinetics, providing a reliable feedback mechanism for identifying the etching endpoint. These findings suggest that 1.06-µm SS-OCT is a feasible guidance tool for precise, hearing-preservation cochlear interventions.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3909-3921"},"PeriodicalIF":3.2,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo assessment of melanoma based on photoacoustic absorption and viscoelasticity imaging. 基于光声吸收和粘弹性成像的黑色素瘤体内评估。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-25 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.603217

Yiting Tan, Ao Jiang, Yuxuan Liang, Heng Zhang, Yeling Ma, Liang Dong, Pingping Wang

{"title":"In vivo assessment of melanoma based on photoacoustic absorption and viscoelasticity imaging.","authors":"Yiting Tan, Ao Jiang, Yuxuan Liang, Heng Zhang, Yeling Ma, Liang Dong, Pingping Wang","doi":"10.1364/BOE.603217","DOIUrl":"10.1364/BOE.603217","url":null,"abstract":"Malignant melanoma tends to metastasize early, and its prognosis is extremely poor and life-threatening in advanced stages. Tumor size and lesion thickness are the most common imaging parameters used to detect melanoma. While changes in mechanical properties during the disease process are closely related to the tumor's basic composition and cellular activity, and are directly linked to its invasiveness and metastatic potential. Here, we present a dual-modality imaging system that combines photoacoustic absorption imaging (PAI) and photoacoustic viscoelasticity imaging (PAVEI) for the staging biopsies of melanoma. The tumor size and thickness can be accurately evaluated by PAI, and PAVEI helps to characterize the tumor viscoelasticity through the phase delay of photoacoustic signals. Experimental results demonstrate that the PAI-PAVEI system can comprehensively characterize the absorption characteristics and mechanical properties of tumor lesions, thereby providing essential reference for the early diagnosis, staging assessment, and efficacy prediction of melanoma.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3877-3891"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hadamard-encoded scattered light imaging for faster, signal-enhanced mapping of brain fiber orientations. 哈达玛编码散射光成像，更快，信号增强映射大脑纤维方向。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-25 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.596576

Dennis Scheidt, Felix Matuschke, Katrin Amunts, Miriam Menzel, Markus Axer

{"title":"Hadamard-encoded scattered light imaging for faster, signal-enhanced mapping of brain fiber orientations.","authors":"Dennis Scheidt, Felix Matuschke, Katrin Amunts, Miriam Menzel, Markus Axer","doi":"10.1364/BOE.596576","DOIUrl":"10.1364/BOE.596576","url":null,"abstract":"A deeper understanding of brain function requires resolving the intricate networks formed by neurons at the microscopic scale. Imaging the connecting nerve fibers remains a significant challenge, particularly due to the difficulty of resolving crossing fibers using conventional optical imaging techniques. Computational Scattered Light Imaging (ComSLI) addresses this by using obliquely incident light to reconstruct the in-plane orientations of nerve fibers based on their scattering profiles, enabling the resolution of fiber crossings. One approach is to use an LED display as a light source, which allows for illuminating the sample by arbitrary patterns and measuring full scattering patterns as well as angular scattering profiles. However, when using an LED display instead of a high-intensity LED spot, ComSLI is limited by a low signal and acquisition times of several seconds per image. To overcome these limitations, this work introduces Hadamard basis sampling for the angular illumination patterns, allowing an increase in illumination intensity and a corresponding reduction in measurement time. Compared to standard sampling approaches, this method yields significantly sharper defined scattering peaks, resulting in enhanced angular resolution of the scattering profiles. The Hadamard-based illumination enhances the reconstruction of cortical fiber organization, overcoming a key limitation in challenging ComSLI applications and neuroscience.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3854-3876"},"PeriodicalIF":3.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Missed isochromatic cardiac pulsation in remote photoplethysmography: detection, impact, and removal. 远距光容积脉搏图遗漏的等色心脏搏动：检测、影响和去除。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-24 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.599752

Gurnoor Kaur, Vasudevan Lakshminarayanan, Simarjeet Singh Saini

{"title":"Missed isochromatic cardiac pulsation in remote photoplethysmography: detection, impact, and removal.","authors":"Gurnoor Kaur, Vasudevan Lakshminarayanan, Simarjeet Singh Saini","doi":"10.1364/BOE.599752","DOIUrl":"10.1364/BOE.599752","url":null,"abstract":"Remote photoplethysmography (rPPG) extracts the cardiac pulse from facial video by isolating chromatic variation due to wavelength-dependent hemoglobin absorption. We report that this signal model is incomplete. A second cardiac-frequency signal is present in skin video: an isochromatic pulsation along the skin's mean reflectance direction, arising from ballistocardiographic modulation of skin surface geometry and changes in the effective scattering cross-section of the dermal vascular bed. This isochromatic component is conflated with the chromatic signal by every rPPG method we evaluated, including chrominance-based methods (POS, CHROM) and other projection or decomposition methods (OMIT, LGI, PBV, ICA). The two signals share the cardiac frequency but differ in phase and signal fidelity, and their relative directions vary with skin tone, lighting, and recording conditions. To assess whether the isochromatic component contributes significant error to rPPG, we constructed chrominance Phase-Aware Cardiac Eigenprojection (cPACE), a method that removes the isochromatic direction via a subject-adaptive projection orthogonal to the measured skin reflectance before extracting the cardiac signal through eigen-vector projection. Across UBFC-Phys (rest and speech) and the CMU-rPPG India and Sierra Leone cohorts, cross-ROI phase-locking values of the recovered signal are systematically higher under cPACE than under any other method evaluated, indicating cleaner waveform recovery. The resulting heart rate estimates achieve mean absolute error of 1.7, 3.7, 1.7, and 1.1 BPM, respectively, on these cohorts, compared to 2.8, 9.5, 16.8, and 17.8 BPM for POS with homodyne envelope correction applied for parity. Together, these results show that the isochromatic component is a major source of error in existing rPPG methods, and future methods should explicitly account for it.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3832-3853"},"PeriodicalIF":3.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromatic differential confocal matrix-based 3D topography and hyperspectral imaging with deep learning for osteoarthritis grading. 基于色差共焦矩阵的三维地形和高光谱成像与深度学习的骨关节炎分级。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-23 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.596126

Xiaer Zou, Jiajing Ye, Dawei Gong, Xinhua Zhu, Junbo Liang, Sailing He

{"title":"Chromatic differential confocal matrix-based 3D topography and hyperspectral imaging with deep learning for osteoarthritis grading.","authors":"Xiaer Zou, Jiajing Ye, Dawei Gong, Xinhua Zhu, Junbo Liang, Sailing He","doi":"10.1364/BOE.596126","DOIUrl":"10.1364/BOE.596126","url":null,"abstract":"Accurate assessment of knee osteoarthritis (KOA) is limited by the current arthroscopy's reliance on subjective visual inspection. We propose a 3D spatio-spectral automatic grading framework combining deep learning with chromatic differential confocal matrix-based 3D topography and hyperspectral imaging (CDCM-THI). Our digital micromirror device-based system simultaneously captures high-resolution 3D micro-topography and hyperspectral cartilage signatures (lateral: 3.91 µm, axial: 1.96 µm, spectral: ∼15 nm). To analyze this multi-modal data, we developed an improved ResNet50 late fusion network optimized with a consistency-enhanced loss function. Evaluated on ex vivo clinical samples, our framework achieved an average cross-validation accuracy of 94.83%, significantly outperforming single-modal baselines. This non-destructive approach bridges the gap between topographical assessment and broadband optical analysis, providing a powerful quantitative tool for future deep learning-assisted arthroscopic integration.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3794-3815"},"PeriodicalIF":3.2,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0