Biomedical optics express最新文献_第9页

Optical phantom for resolution evaluation of non-contact corneal microscopy techniques. 非接触式角膜显微技术分辨率评价的光学模体。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-10 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.604912

Kenneth Marcelino, Jason Datta, Momoka Sugimura, Carmella Ocaya, Rafael Romero, Yongjun Kim, Mac Rodriguez, Milind Rajadhyaksha, Jaya D Chidambaram, Dongkyun Kang

引用次数: 0

Joint feature issue in Optics Express, Applied Optics, and Biomedical Optics Express: Computational Optical Sensing and Imaging 2025. 《光学快报》、《应用光学》和《生物医学光学快报：计算光学传感与成像》联合特刊2025。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-08 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.604894

Liang Gao, Ana Doblas, Seung Ah Lee, Ofer Levi, Yuan Luo, Guoan Zheng

{"title":"Joint feature issue in Optics Express, Applied Optics, and Biomedical Optics Express: Computational Optical Sensing and Imaging 2025.","authors":"Liang Gao, Ana Doblas, Seung Ah Lee, Ofer Levi, Yuan Luo, Guoan Zheng","doi":"10.1364/BOE.604894","DOIUrl":"https://doi.org/10.1364/BOE.604894","url":null,"abstract":"This joint feature issue of Optics Express, Applied Optics, and Biomedical Optics Express showcases recent work from the Computational Optical Sensing and Imaging community. The issue reflects the continuing expansion of computational optical sensing and imaging, where optical design, detection, calibration, physical optical system modeling, signal processing, and machine learning to acquire task-relevant information. The selected papers span computational microscopy and biomedical imaging, adaptive optics, wavefront sensing, holography, phase retrieval, single-pixel and ghost imaging, hyperspectral and polarization imaging, non-line-of-sight imaging, LiDAR, photon-efficient sensing, optical-system co-design, and emerging applications in medicine, remote sensing, manufacturing, and environmental metrology. Together, these contributions illustrate how computationally co-designed optical systems are moving from algorithmic demonstrations toward robust, application-specific imaging and sensing platforms.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 8","pages":"4097-4102"},"PeriodicalIF":3.2,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unambiguous polarimetric reconstruction in single-input polarization-sensitive OCT via spectral polarization spreading. 基于光谱偏振扩展的单输入偏振敏感OCT的无二义偏振重建。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-06 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.597600

Georgia L Jones, Maxina Sheft, Jiachen Wan, Po-Yi Lee, Hui Wang, Brett E Bouma, Martin Villiger

{"title":"Unambiguous polarimetric reconstruction in single-input polarization-sensitive OCT via spectral polarization spreading.","authors":"Georgia L Jones, Maxina Sheft, Jiachen Wan, Po-Yi Lee, Hui Wang, Brett E Bouma, Martin Villiger","doi":"10.1364/BOE.597600","DOIUrl":"https://doi.org/10.1364/BOE.597600","url":null,"abstract":"Polarization-sensitive optical coherence tomography (PS-OCT) systems employing a single polarized input state are widely used due to their simple system architecture and commercial availability. However, such configurations are inherently susceptible to polarization ambiguities that can lead to inaccurate polarimetric reconstruction, particularly when estimating depth-resolved birefringence. Our previous work demonstrated that these artifacts can be mitigated by illumination exhibiting spectral polarization spread (SPS), arising from polarization mode dispersion present in some imaging systems. SPS effectively provides additional polarization diversity across the source spectrum, reducing ambiguity in the measured retardance signals. In this work, we introduce a compact waveplate stack module that introduces controlled, intentional SPS in arbitrary single-input PS-OCT systems. We demonstrate the approach by integrating the module into the round-trip portion of the sample arm of a commercially available PS-OCT platform, enabling robust and unambiguous depth-resolved polarimetric reconstruction. The minimal hardware modification and simple calibration procedure allow straightforward retrofitting of existing single-input PS-OCT systems, facilitating broader adoption of reliable, depth-resolved birefringence imaging.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 8","pages":"4083-4096"},"PeriodicalIF":3.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative comparison of different mounting media for transmissive DUV imaging of label-free biological specimens. 不同安装介质对无标记生物标本透射DUV成像的定量比较。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-06 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.605787

Jiabin Chen, Ruilin You, Marina Miller, Yihan Wang, Gulnur Bayramli, Marco Contreras, Haijiang Cai, Anthony Burtman, Rachel Lynn Darché, Bofan Song, Rongguang Liang

{"title":"Quantitative comparison of different mounting media for transmissive DUV imaging of label-free biological specimens.","authors":"Jiabin Chen, Ruilin You, Marina Miller, Yihan Wang, Gulnur Bayramli, Marco Contreras, Haijiang Cai, Anthony Burtman, Rachel Lynn Darché, Bofan Song, Rongguang Liang","doi":"10.1364/BOE.605787","DOIUrl":"https://doi.org/10.1364/BOE.605787","url":null,"abstract":"Deep ultraviolet has emerged as a robust imaging method for label-free histopathology and cytology. This study quantitatively evaluates various mounting media to optimize transmissive DUV imaging. We identified glycerol as the optimal candidate, achieving an internal transmittance of 99.15% at 265 nm and providing a refractive index (n ≈ 1.53) that matches biological specimens and fused silica substrates. While alcohol offers high transparency, its volatility prevents extended imaging; conversely, traditional xylene-based media exhibit near total DUV extinction. Quantitative validation using local entropy, Tenengrad sharpness, and speckle contrast confirms that glycerol suppresses interfacial scattering and improves nuclear visualization across cervical cells and various murine and human tissues. These results establish glycerol as a robust, high-performance medium for enhancing diagnostic fidelity in label-free deep ultraviolet microscopy.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 8","pages":"4068-4082"},"PeriodicalIF":3.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artifact-suppressed dual-modality OCT-fluorescence endoscopic imaging of colitis in murine models. 伪影抑制的双模oct -荧光内镜下结肠炎小鼠模型成像。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-02 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.606192

Songzhi Wu, Shuo Wang, Baihan Li, Zhonglie Piao, Chong He, Fang Lu, Zhao Wang

{"title":"Artifact-suppressed dual-modality OCT-fluorescence endoscopic imaging of colitis in murine models.","authors":"Songzhi Wu, Shuo Wang, Baihan Li, Zhonglie Piao, Chong He, Fang Lu, Zhao Wang","doi":"10.1364/BOE.606192","DOIUrl":"https://doi.org/10.1364/BOE.606192","url":null,"abstract":"Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder that requires objective and repeatable assessment of both tissue structure and disease activity for proper management of the disease. Multimodal endoscopy combining optical coherence tomography (OCT) and fluorescence imaging offers complementary structural and functional contrast for this purpose. However, conventional double-clad fiber catheters often suffer from multipath interference artifacts that degrade structural image fidelity. Here, we present a fully integrated dual-modality endoscopic system enabling artifact-suppressed OCT alongside high-sensitivity fluorescence imaging. We utilized this system to longitudinally monitor the progression of dextran sulfate sodium (DSS)-induced colitis in mice in vivo. The imaging results revealed distinct stage-specific biomarkers, where acute inflammation was characterized by profound vascular permeability, while the chronic phase was distinguished by persistent thickening of the muscularis layer. An exploratory random forest classifier trained on these extracted features achieved a diagnostic accuracy of 96.7% in distinguishing different colitis states, with feature importance analysis confirming the synergistic value of combining both the structural and fluorescence information. This work establishes a robust multimodal endoscopic platform for non-invasive, longitudinal quantification of inflammatory burden in preclinical models, with potential applications in diagnostic imaging and treatment monitoring of gastrointestinal diseases.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 8","pages":"4050-4067"},"PeriodicalIF":3.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-color high-definition whole-brain imaging: simultaneous analysis of multiple anatomical structures with colocalized cytoarchitectural information. 三色高清晰度全脑成像：同时分析多个解剖结构与共定位细胞结构信息。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-02 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.604080

Tao Jiang, Miao Ren, Xueyan Jia, Jing Yuan, Xiangning Li, Qingming Luo, Hui Gong

{"title":"Three-color high-definition whole-brain imaging: simultaneous analysis of multiple anatomical structures with colocalized cytoarchitectural information.","authors":"Tao Jiang, Miao Ren, Xueyan Jia, Jing Yuan, Xiangning Li, Qingming Luo, Hui Gong","doi":"10.1364/BOE.604080","DOIUrl":"https://doi.org/10.1364/BOE.604080","url":null,"abstract":"Simultaneous multicolor whole-brain imaging with cytoarchitectural reference is critical for neural circuit mapping, but sequential scanning prolongs acquisition and complicates inter-channel registration. We developed a three-color high-definition fluorescent micro-optical sectioning tomography (HD-fMOST) system for three-channel high-throughput imaging of the whole mouse brain. We corrected chromatic aberration in the 405 nm illumination path and designed a precision 6-axis stage for pixel-level registration of three channels. Real-time DAPI counterstaining provides cytoarchitectural landmarks while preserving green/red fluorescence excitation. The system achieves sub-micron voxel resolution (0.32 × 0.32 × 1 μm3) and a high signal-to-background ratio. Validation on dual-color-labeled mouse brain demonstrates high-precision whole-brain imaging, accurate structural colocalization, and quantitative single-neuron morphological reconstruction.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 8","pages":"4017-4035"},"PeriodicalIF":3.2,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal changes in retinal image quality in school-aged children. 学龄儿童视网膜图像质量的纵向变化。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-07-02 eCollection Date: 2026-08-01 DOI: 10.1364/BOE.587977

Augusto Arias, Susanna P Clement, Siegfried Wahl, Fuensanta A Vera-Diaz

引用次数: 0

Computational validation of optical adaptive depth steering for continuous-wave fNIRS. 连续波近红外光谱自适应深度转向的计算验证。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-30 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.604286

Murad Althobaiti

{"title":"Computational validation of optical adaptive depth steering for continuous-wave fNIRS.","authors":"Murad Althobaiti","doi":"10.1364/BOE.604286","DOIUrl":"10.1364/BOE.604286","url":null,"abstract":"Continuous-wave functional near-infrared spectroscopy (CW-fNIRS) traditionally utilizes fixed-geometry optode configurations, which introduce significant anatomical bias due to inter-subject variations in skull thickness and phenotypic barriers such as dense hair. To address these limitations, we propose an Optical Adaptive Depth Steering (O-ADS) framework that mathematically synthesizes a \"Virtual Optode\" using a high-density multi-distance array (8-32 mm) and a linearly constrained minimum variance (LCMV) spatial beamformer. We computationally validated this framework using high-fidelity Monte Carlo simulations on layered cranial slabs and a 3D anatomical atlas (Colin27). Results demonstrate that O-ADS exhibits high computational resilience to anatomical bias, achieving up to a 39-fold improvement in relative brain sensitivity for thick-skull morphologies compared to traditional 32 mm static sensors. Furthermore, under realistic spatiotemporal noise conditions involving heterogeneous scalp hemodynamics and simulated phenotypic barriers (8 mm reference channel failure), O-ADS maintained a significantly higher mean signal recovery purity (38.3% ± 22.1%) than standard Multi-Distance Regression (MDR) (21.8% ± 15.4%). This software-defined approach provides a scalable solution for optical neuroimaging, reducing the dependence of sensor performance on individual anatomical and phenotypic variance to facilitate more inclusive cerebral monitoring under challenging physical constraints.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"17 7","pages":"3972-3983"},"PeriodicalIF":3.2,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-orientation non-confocal retinal imaging in an AOSLO using a Dove prism. 多方向非共聚焦视网膜成像在aoso使用鸽棱镜。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-30 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.600104

Ruth E Woehlke, Robert F Cooper

引用次数: 0

First-order field autocorrelation function analysis-based dynamic OCT for tissue viability assessment. 基于一阶场自相关函数分析的动态OCT用于组织活力评估。

IF 3.2 2区医学

Biomedical optics express Pub Date : 2026-06-30 eCollection Date: 2026-07-01 DOI: 10.1364/BOE.589704

Wei Chen, Jinze Zhang, Lingxuan Meng, Xiuhua Zheng, Yongchao Wang, Fen Yang, Shuaibin Chang, Peng Xiao, Jianbo Tang

引用次数: 0