Biomedical optics express最新文献_第2页

Diffuse Optical Spectroscopy: Technology and Applications: introduction to the feature issue. 漫反射光学光谱学：技术与应用：特刊导言。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-24 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.542635

Thomas D O'Sullivan, Hamid Dehghani, Rebecca Re

引用次数: 0

Ultra-wide-angle peripheral refraction using a laser-scanning instrument. 使用激光扫描仪进行超广角周边折射。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-24 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.540051

Santiago Sager, Arturo Vicente-Jaen, Zhenghua Lin, Pedro M Prieto, Zhikuang Yang, Weizhong Lan, Pablo Artal

引用次数: 0

ATLAS: a large array, on-chip compute SPAD camera for multispeckle diffuse correlation spectroscopy. ATLAS：用于多层漫射相关光谱学的大型阵列片上计算 SPAD 相机。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-24 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.531416

Alistair Gorman, Neil Finlayson, Ahmet T Erdogan, Lars Fisher, Yining Wang, Francescopaolo Mattioli Della Rocca, Hanning Mai, Edbert J Sie, Francesco Marsili, Robert K Henderson

引用次数: 0

Fundamental limits of light-wave sensing for non-contact respiration monitoring. 用于非接触式呼吸监测的光波传感的基本限制。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-21 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.514776

Brenden Martin, Md Zobaer Islam, Carly Gotcher, Tyler Martinez, Sabit Ekin, John F O'Hara

{"title":"Fundamental limits of light-wave sensing for non-contact respiration monitoring.","authors":"Brenden Martin, Md Zobaer Islam, Carly Gotcher, Tyler Martinez, Sabit Ekin, John F O'Hara","doi":"10.1364/BOE.514776","DOIUrl":"10.1364/BOE.514776","url":null,"abstract":"An experimental testbed was constructed to rigorously assess the fundamental limits of light-wave sensing-an economic, non-contact vitals monitoring approach previously reported. We improve the testbed using lock-in amplification and demonstrate that a photodetector and a commonplace array of infrared LEDs are sufficient to detect respiratory motion and quantify respiration rate up to 2.5 meters away. We propose a novel scattering model, from which we derive the performance limits of the light-wave sensing system in terms of a theoretical range resolution limited by the dynamic range of the system. Using a robotic breathing phantom, we experimentally assess, for the first time, the range resolution of the testbed system and compare this to theoretical predictions. This work also introduces a process for generating stochastic respiration patterns, which may prove broadly useful to the designers of breathing phantoms. Holistically exploring practical challenges and analytical models, this paper serves as a unique and comprehensive tutorial for understanding and designing light-wave sensing systems.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6449-6468"},"PeriodicalIF":2.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of pupil size and corneal spherical aberrations on the performance of monofocal intraocular lenses: an experimental model. 瞳孔大小和角膜球面像差对单焦点眼内透镜性能的影响：一个实验模型。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-21 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.530708

Benjamin Stern, Damien Gatinel

引用次数: 0

DFC-Net: a dual-path frequency-domain cross-attention fusion network for retinal image quality assessment. DFC-Net：用于视网膜图像质量评估的双路频域交叉注意力融合网络。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-17 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.531292

Xiaoyan Kui, Zeru Hai, Beiji Zou, Wei Liang, Liming Chen

{"title":"DFC-Net: a dual-path frequency-domain cross-attention fusion network for retinal image quality assessment.","authors":"Xiaoyan Kui, Zeru Hai, Beiji Zou, Wei Liang, Liming Chen","doi":"10.1364/BOE.531292","DOIUrl":"10.1364/BOE.531292","url":null,"abstract":"Retinal image quality assessment (RIQA) is crucial for diagnosing various eye diseases and ensuring the accuracy of diagnostic analyses based on retinal fundus images. Traditional deep convolutional neural networks (CNNs) for RIQA face challenges such as over-reliance on RGB image brightness and difficulty in differentiating closely ranked image quality categories. To address these issues, we introduced the Dual-Path Frequency-domain Cross-attention Network (DFC-Net), which integrates RGB images and contrast-enhanced images using contrast-limited adaptive histogram equalization (CLAHE) as dual inputs. This approach improves structure detail detection and feature extraction. We also incorporated a frequency-domain attention mechanism (FDAM) to focus selectively on frequency components indicative of quality degradations and a cross-attention mechanism (CAM) to optimize the integration of dual inputs. Our experiments on the EyeQ and RIQA-RFMiD datasets demonstrated significant improvements, achieving a precision of 0.8895, recall of 0.8923, F1-score of 0.8909, and a Kappa score of 0.9191 on the EyeQ dataset. On the RIQA-RFMiD dataset, the precision was 0.702, recall 0.6729, F1-score 0.6869, and Kappa score 0.7210, outperforming current state-of-the-art approaches.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6399-6415"},"PeriodicalIF":2.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-based 3D analysis of retinal vasculature associated with retinal diseases using OCT angiography. 基于人工智能的视网膜血管三维分析，利用 OCT 血管造影技术分析与视网膜疾病相关的视网膜血管。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-17 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.534703

Yu Liu, Zhenfei Tang, Chao Li, Zhengwei Zhang, Yaqin Zhang, Xiaogang Wang, Zhao Wang

{"title":"AI-based 3D analysis of retinal vasculature associated with retinal diseases using OCT angiography.","authors":"Yu Liu, Zhenfei Tang, Chao Li, Zhengwei Zhang, Yaqin Zhang, Xiaogang Wang, Zhao Wang","doi":"10.1364/BOE.534703","DOIUrl":"10.1364/BOE.534703","url":null,"abstract":"Retinal vasculature is the only vascular system in the human body that can be observed in a non-invasive manner, with a phenotype associated with a wide range of ocular, cerebral, and cardiovascular diseases. OCT and OCT angiography (OCTA) provide powerful imaging methods to visualize the three-dimensional morphological and functional information of the retina. In this study, based on OCT and OCTA multimodal inputs, a multitask convolutional neural network model was built to realize 3D segmentation of retinal blood vessels and disease classification for different retinal diseases, overcoming the limitations of existing methods that can only perform 2D analysis of OCTA. Two hundred thirty sets of OCT and OCTA data from 109 patients, including 138,000 cross-sectional images in normal and diseased eyes (age-related macular degeneration, retinal vein occlusion, and central serous chorioretinopathy), were collected from four commercial OCT systems for model training, validation, and testing. Experimental results verified that the proposed method was able to achieve a DICE coefficient of 0.956 for 3D segmentation of blood vessels and an accuracy of 91.49% for disease classification, and further enabled us to evaluate the 3D reconstruction of retinal vessels, explore the interlayer connections of superficial and deep vasculatures, and reveal the 3D quantitative vessel characteristics in different retinal diseases.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6416-6432"},"PeriodicalIF":2.9,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proof of concept validation of bioresorbable optical fibers for diffuse correlation spectroscopy. 用于扩散相关光谱学的生物可吸收光纤的概念验证。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.540137

Jawad T Pandayil, Nadia G Boetti, Davide Janner, Turgut Durduran, Lorenzo Cortese

{"title":"Proof of concept validation of bioresorbable optical fibers for diffuse correlation spectroscopy.","authors":"Jawad T Pandayil, Nadia G Boetti, Davide Janner, Turgut Durduran, Lorenzo Cortese","doi":"10.1364/BOE.540137","DOIUrl":"10.1364/BOE.540137","url":null,"abstract":"Optical quality bioresorbable materials have been gaining interest in recent years for various interstitial biomedical/medical application. An example of this is when the implant gradually dissolves in the body, providing physiological information over extended periods of time, hence reducing the need for revision surgeries. This study reports for the first time the in-house fabrication of single mode (at 785 nm) calcium phosphate glass (CPG) based bioresorbable optical fibers and investigates their suitability for microvascular blood flow monitoring using diffuse correlation spectroscopy (DCS). Ex vivo experiments in liquid phantom and non-invasive in vivo experiments on the human forearm muscle were conducted using multimode and single mode CPG bioresorbable optical fibers. The retrieved flow index from the correlation curves acquired using CPG fibers was in good agreement with that obtained using standard silica (Si) fibers, both ex vivo and in vivo. The results demonstrate the potential of CPG optical fibers for further exploration.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6384-6398"},"PeriodicalIF":2.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-destructive viability assessment of cancer cell spheroids using dynamic optical coherence tomography with trypan blue validation. 利用动态光学相干断层扫描和胰蓝验证对癌细胞球体进行非破坏性活力评估。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-14 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.533339

Ko Hui Tan, Joel Lang Yi Ang, Alexander Si Kai Yong, Stefanie Zi En Lim, Jessica Sze Jia Kng, Kaicheng Liang

{"title":"Non-destructive viability assessment of cancer cell spheroids using dynamic optical coherence tomography with trypan blue validation.","authors":"Ko Hui Tan, Joel Lang Yi Ang, Alexander Si Kai Yong, Stefanie Zi En Lim, Jessica Sze Jia Kng, Kaicheng Liang","doi":"10.1364/BOE.533339","DOIUrl":"10.1364/BOE.533339","url":null,"abstract":"3D cell cultures are widely used in biomedical research for the recapitulation of in vivo microenvironments. Viability assessment and monitoring of these intricate conformations remain an open problem as standard cell viability protocols based on colorimetry or microscopy are not directly applicable to intact 3D samples. Optical coherence tomography (OCT) has been explored extensively for subsurface structural and quasi-functional analysis of 3D cell cultures and tissue. Recent studies of dynamic OCT as a source of cellular contrast have found qualitative associations with necrosis in cell spheroids, suggesting potential as a viability marker. We present empirical and validated evidence for dynamic OCT as a quantitative indicator of cell viability in 3D cultures. We analysed over 240 MCF-7 cancer cell spheroids with dynamic OCT and corresponding viability measurements using the trypan blue exclusion assay. Significant effects of common reagents dimethyl sulfoxide (DMSO) and phosphate-buffered saline (PBS) on OCT readouts were noted. We proposed a regression-based OCT brightness normalisation technique that removed reagent-induced OCT intensity biases and helped improve correspondence to the viability assay. These results offer a quantitative biological foundation for further advances of dynamic OCT as a novel non-invasive modality for 3D culture monitoring.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6370-6383"},"PeriodicalIF":2.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Realtime and noninvasive assessment of endotracheal tube displacement using near-infrared and visible cameras. 使用近红外和可见光摄像机对气管导管位移进行实时和无创评估。

IF 2.9 2区医学

Biomedical optics express Pub Date : 2024-10-14 eCollection Date: 2024-11-01 DOI: 10.1364/BOE.531815

Tongtong Lu, Pawjai Khampang, Ahmed Beydoun, Anna Berezovsky, Rebecca Rohde, Wenzhou Hong, Joseph E Kerschner, Bing Yu

{"title":"Realtime and noninvasive assessment of endotracheal tube displacement using near-infrared and visible cameras.","authors":"Tongtong Lu, Pawjai Khampang, Ahmed Beydoun, Anna Berezovsky, Rebecca Rohde, Wenzhou Hong, Joseph E Kerschner, Bing Yu","doi":"10.1364/BOE.531815","DOIUrl":"10.1364/BOE.531815","url":null,"abstract":"Endotracheal tube (ETT) intubation is a medical procedure routinely used for achieving mechanical ventilation in critically ill patients. Appropriate ETT placement is crucial as undetected tube migration may cause multiple complications or even fatalities. Therefore, prompt detection of unplanned movement of the ETT and immediate action to restore proper placement are essential to ensure patient safety. Despite this necessity, there is not a widely adopted tool for real-time assessment of ETT displacement. We have developed a device, a dual-camera endotracheal tube or DC-ETT, to address this unmet clinical need. This device uses a near-infrared (NIR) LED and a side-firing optical fiber embedded in the side of an ETT to light up the tracheal tissue and a visible and NIR camera module for the displacement detection. The NIR camera tracks the movement of the NIR pattern on the skin, while the visible camera is used to correct the body movements. The efficacy of the DC-ETT was assessed in two piglets with a linear displacement sensor as reference. A mean discrepancy of less than 0.5 mm between the DC-ETT and reference sensor was observed within a displacement range of ±15 mm. The results suggest that the DC-ETT can potentially provide a simple and cost-effective solution for real-time monitoring of ETT displacements in operating rooms, intensive care units, and emergency departments.","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"15 11","pages":"6355-6369"},"PeriodicalIF":2.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0