Biological Trace Element Research最新文献

{"title":"New Insights into Trace Element Accumulation in Kernels of Two Algerian Populations of Argan (Argania spinosa (L.) Skeels): An Endangered Endemic Tree.","authors":"Bouzid Nedjimi","doi":"10.1007/s12011-024-04310-5","DOIUrl":"10.1007/s12011-024-04310-5","url":null,"abstract":"<p><p>Argan is one of the valuable oilseed trees in the Northwest Africa area, with important ecological and socioeconomic benefits; however, information underlying its elemental status remains absent . The current work was performed for the first time to quantify the mineral status of Argania spinosa kernels collected from two different geographic Algerian regions (Mostaganem and Tindouf). Elemental investigation (As, Br, Ca, Ce, Co, Cr, Fe, K, La, Na, Rb, Sb, Sc, Sm, Th, and Zn) was performed using neutron activation analysis (NAA). Two standard reference materials from the National Research Center for certified reference materials (China), namely, CRM-GBW 07605 (GSV-4 tea leaves), and the National Institute of Standards and Technology (USA), namely, NIST (SRM 1573a, tomato leaves), were used to ensure precision and validation of NAA measurements. A computational calculation of data including principal component analysis (PCA) and Pearson correlation coefficient (r) was applied. The extents of essential elements in Mostaganem kernels were found to be in the order of K (7185 μg g^-1) > Ca (2079 μg g^-1) > Na (205 μg g^-1) > Fe (84.33 μg g^-1) > Zn (73.41 μg g^-1) > Cr (0.66 μg g^-1) > Co (0.035 μg g^-1), whereas the overall order of these elements in Tindouf kernels was K (7206 μg g^-1) > Ca (3725 μg g^-1) > Fe (114.69 μg g^-1) > Zn (67.37 μg g^-1) > Na (56.29 μg g^-1) > Cr (0.54 μg g^-1) > Co (0.11 μg g^-1). PCA results revealed that Tindouf population was highly loaded with Br, Cr, Cu, Mn, Sr, V, and Zn, while Mostaganem population was associated only with Ce and Sm contents. These findings can be useful for making new formulations for cosmetic and culinary usage and contribute to the nutritional database and food safety.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1808-1816"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy Metal Accumulation in Fish, Sediment and Water from Three Riverine Ecosystems in the South-western Bangladesh and Nexus to Human Health.","authors":"Sadman Sakib, Goutam Kumar Kundu, Md Samrat Mohay Menul Islam, Rahma Akhter, Mohammad Moniruzzaman, Badhan Saha, Md Asadur Rahman, Md Aftab Ali Shaikh, Md Monirul Islam","doi":"10.1007/s12011-024-04321-2","DOIUrl":"10.1007/s12011-024-04321-2","url":null,"abstract":"<p><p>This study investigated heavy metal accumulations in fish, water and sediment from three rivers around a major urban area in Bangladesh, namely the Rupsha, the Atai, and the Bhairab with a view to assessing the ecological and human health risks. Samples were collected from 10 stations over two seasons (summer and winter) and concentrations of 11 metals (As, Se, Pb, Be, Cd, Co, Cr, Cu, Mn, Ni, V) were measured using ICP-MS. Heavy metals in water of these rivers were above the WHO higher thresholds. The Rupsha River, which runs close to industrially dense areas and the downstream part of the three-river network, demonstrated the highest As, Cu, and V concentrations during both seasons. On the other hand, As, Mn and Cr were highest in the Bhairab which is the upstream to the Rupsha and connected to several industrial setups which differ from Bhairab. The less anthropogenically connected Atai River only showed elevated concentrations of Cu and Se. Ecological risk indices indicated low pollution in the rivers during both seasons. In all three rivers and in nearly all fish species, the contamination was higher in winter than summer. Benthic and carnivorous fish species such as, Cynoglossus lingua, Glossogobius giuris, Pseudapocryptes elongatus showed higher metal accumulation compared to other species. Health risk indices like the target hazard quotient (THQ) and carcinogenic risk (CR) suggested low risks but pointed potential risks to human health. The outcomes of this research reports insights into metal contamination pattern in interconnected river systems.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1839-1858"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Antioxidant, Cytotoxicity, and Anti-human Lung Cancer Properties of Silver Nanoparticles Green-Formulated by Foeniculum vulgare Extract Combined with Radiotherapy.","authors":"Qian Wu, Zifu Qin, Pei Sun, Fang Liu, Yin Ge, Pengbo Wang","doi":"10.1007/s12011-024-04332-z","DOIUrl":"10.1007/s12011-024-04332-z","url":null,"abstract":"<p><p>The current investigation involved the silver nanoparticles green synthesis utilizing the aqueous extract derived from the Foeniculum vulgare leaves (AgNPs@FV). The effectiveness of these newly developed nanoparticles in conjunction with radiotherapy was evaluated on lung cancer cells. The synthesized AgNPs@FV underwent characterization through various analytical techniques such as energy dispersive X-ray (EDX), field emission-scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and ultraviolet-visible (UV-Vis) spectrophotometry. The efficacy of AgNPs@FV in conjunction with radiotherapy against human lung cancer was assessed through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The AgNPs@FV exhibited a spherical morphology ranging in size from 10.16 to 42.74 nm. The EDX diagram of nanoparticles shows energy signals at 3.02 and 2.64 keV, which are attributed to Ag Lβ and Ag Lα, respectively. During the antioxidant evaluation, AgNPs@FV and butylated hydroxytoluene (BHT) displayed IC₅₀ values of 166 and 59 µg/mL, respectively. The cells treated with AgNPs@FV in conjunction with radiotherapy were evaluated using the MTT assay over 48 h to determine cytotoxicity and anti-human lung cancer characteristics on normal (human umbilical vein endothelial cell (HUVEC)) and lung cancer cells and exhibited IC₅₀ values of 211, 166, and 296 µg/mL against NCI-H2126, NCI-H1299, and NCI-H1437, respectively. Furthermore, the malignant lung cell viability decreased when treated with a combination of AgNPs@FV and radiotherapy. Based on the aforementioned findings, it is possible that the newly developed AgNPs@FV could serve as a novel chemotherapeutic medication or adjunct for addressing lung cancer following the completion of clinical trials involving human subjects.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2139-2148"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Essential and Toxic Element Levels in the Toenails of Children with Autism Spectrum Disorder.","authors":"Mariam Ouisselsat, Amal El Maouaki, Sana Maidoumi, Yannick François, Alain Pineau, Azeddine Sedki","doi":"10.1007/s12011-024-04319-w","DOIUrl":"10.1007/s12011-024-04319-w","url":null,"abstract":"<p><p>Autism spectrum disorder (ASD) has become a global public health concern, impacting the quality of life. The question of gene-environment interaction in the emergence of ASD remains a subject of ongoing debate, and exploring its pathophysiology is thoroughly related to metals as a risk factor. Therefore, this study aims to assess the levels of toxic (Al, Cd, Hg, and Pb) and essential (Cr, Mn, Fe, Ni, Cu, Zn, and Se) elements in toenail samples collected in children with ASD and neurotypical children, by ICP-MS. Parallelly, we will discuss the use of toenails as an exposure indicator. The study involved 208 children aged 3 to 14 from Marrakech, Morocco. One hundred two were diagnosed with ASD and 106 were neurotypical children. Significant statistical differences in the concentration of Cr, Mn, and Fe were documented between the two groups. Higher levels of Pb in toenails compared to reference values have been reported. No association was established between concentrations of elements and age. Spearman correlation coefficients revealed a significantly different pattern of mutual dependence for toxic and essential elements between the two groups. The strongest positive correlations were found in the neurotypical group (Fe-Mn (ρ = 0.750), and Se-Zn (ρ = 0.800)). These results provide additional, although inconclusive, evidence on the probable role of element disturbance in the pathogenesis of ASD. Further studies should be performed to explore other nutritional, cultural, sociodemographic, environmental, and methodological factors that may impact the levels of these elements in the nails and their possible correlation with the incidence of ASD.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2394-2408"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Replacing Inorganic Source of Zinc with Zinc Hydroxy Chloride: Effects on Health Status, Hemato-biochemical Attributes, Antioxidant Status, and Immune Responses in Pre-ruminant Crossbred Calves.","authors":"Ravi Prakash Pal, Veena Mani, Shahid Hassan Mir, Amit Sharma, Srobana Sarkar","doi":"10.1007/s12011-024-04317-y","DOIUrl":"10.1007/s12011-024-04317-y","url":null,"abstract":"<p><p>The current research aimed to assess the feasibility of using Zn hydroxy chloride (ZnOHCl) as an alternative to ZnSO₄ in pre-ruminant crossbred calves. Twenty-four male crossbred calves (Tharparkar × Holstein Friesian) were categorized into four groups according to body weight and age (body weight 31 kg; age 10 days). Experimental calves were kept on a similar feeding regimen except that different groups were supplemented with either 0 mg Zn/kg DMI (Zn-0), 80 mg Zn/kg DMI as ZnSO₄ (ZnS-80), 40 mg Zn/kg DMI as ZnOHCl (ZnH-40), or 80 mg Zn/kg DMI as ZnOHCl (ZnH-80). All the calves were fed for 90 days as per ICAR (2013) feeding standard to fulfill their nutrient requirements for growth rate of 500 g/day. The study observed the influence of different sources and varying levels of Zn supplementation over a 90-day experimental period on health status, hemato-biochemical attributes, antioxidant status, immune responses, and plasma minerals and erythrocyte Zn concentrations. The data was examined using a randomized complete block design (RCBD) with fixed effects of treatment, period, and their interaction. The results indicated that irrespective of the sources and levels of Zn, supplementation did not lead to significant changes in health status as assessed by fecal score, nasal score, ear score, and eye score. Hematological parameters remained unchanged following supplementation with different sources and levels of Zn. Zn-supplemented groups showed higher levels of total protein, globulin, and alkaline phosphates (ALP) compared to the non-supplemented group. However, no significant variations were detected within the Zn-supplemented groups. Zinc supplementation significantly increased total antioxidant capacity (TAC), antioxidant enzyme activity, total immunoglobulin (Ig), immunoglobulin G (IgG), cell-mediated immunity (CMI), and humoral immunity (HI); however, no significant variations were detected among Zn-supplemented groups. Zn supplementation enhanced plasma and RBC Zn concentration without affecting the plasma concentration of other minerals. However, among the Zn-supplemented groups, 80 mg Zn/kg DMI as ZnOHCl resulted in the highest RBC Zn concentration. The study results demonstrate that Zn supplementation enhanced biomarkers of zinc status, antioxidant levels, and immune responses in pre-ruminant crossbred calves. Nevertheless, no significant variations were observed between the different Zn sources (ZnSO₄ and ZnOHCl) utilized in this study. Research suggests that ZnOHCl could be a feasible alternative to ZnSO₄ in the diet of pre-ruminant crossbred calves.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2001-2012"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Elemental Deficiency of Crossbred Dairy Cows and Mineral Composition in Natural Feed and Nutritional Supplements in the Northern and Northwestern Provinces in Sri Lanka.","authors":"Joseph W Clarkson, Neil I Ward, Joaquín M Prada, David Tisdall, Mónica Felipe-Sotelo, J K Vidanarachchi, Mike Christian, Mark Andrew Chambers","doi":"10.1007/s12011-024-04299-x","DOIUrl":"10.1007/s12011-024-04299-x","url":null,"abstract":"<p><p>This study assessed the elemental status of cross-bred dairy cows in small holder farms in Sri Lanka, with the aim to establish the elemental baseline and identify possible deficiencies. For this purpose, 458 milk, hair, serum and whole blood samples were collected from 120 cows in four regions of Northern and Northwestern Sri Lanka, (namely Vavaniya, Mannar, Jaffna and Kurunegala). Farmers also provided a total of 257 samples of feed, which included local fodder as well as 79 supplement materials. The concentrations of As, Ca, Cd, Co, Cr, Cu, Fe, I, K, Mg, Mn, Mo, Na, Ni, Pb, Se, V and Zn were determined by inductively coupled plasma mass spectrometry (ICP-MS). Evaluation of the data revealed that all cows in this study could be considered deficient in I and Co (18.6-78.5 µg L^-1 I and 0.06-0.65 µg L^-1 Co, in blood serum) when compared with deficiency upper boundary levels of 0.70 µg L^-1 Co and 50 µg L^-1 I. Poor correlations were found between the composition of milk or blood with hair, which suggests that hair is not a good indicator of mineral status. Most local fodders meet dietary requirements, with Sarana grass offering the greatest nutritional profile. Principal component analysis (PCA) was used to assess differences in the elemental composition of the diverse types of feed, as well as regional variability, revealing clear differences between forage, concentrates and nutritional supplements, with the latter showing higher concentrations of non-essential or even toxic elements, such as Cd and Pb.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2029-2040"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin Treatment Ameliorates Hepatic Insulin Resistance Induced by Sub-chronic Oral Exposure to Cadmium LOAEL Dose via NF-κB and Nrf2 Pathways.","authors":"Victor Enrique Sarmiento-Ortega, Diana Moroni-González, Alfonso Diaz, Eduardo Brambila, Samuel Treviño","doi":"10.1007/s12011-024-04314-1","DOIUrl":"10.1007/s12011-024-04314-1","url":null,"abstract":"<p><p>Cadmium (Cd) is a global pollutant, and its accumulation in the liver causes oxidative stress, inflammation, insulin resistance (IR), and metabolic complications. This study investigated whether curcumin treatment could alleviate hepatic IR in Wistar rats exposed to sub-chronic cadmium and explored the underlying molecular pathways. Male Wistar rats were divided into a control group (standard normocaloric diet + cadmium-free water) and a cadmium group (standard normocaloric diet + drinking water with 32.5 ppm CdCl₂) for 30 days. Oral glucose tolerance, insulin response, and IR were assessed using mathematical models. Liver tissue was analyzed for markers of oxidative stress, inflammation, and key regulatory pathways, including NF-κB, Nrf2, MAPKs (JNK and p38), and the IRS1-Akt pathway. We established an effective curcumin dose of 250 mg/kg for 5 days orally. Results demonstrated that after 30 days of exposure, cadmium accumulated in the liver, inducing an oxidative and inflammatory state. This was characterized by increased expression of NF-κB, JNK, and p38, along with diminished Nrf2 expression, hepatic IR, hyperglycemia, and hyperinsulinemia. Curcumin treatment effectively alleviated these metabolic disorders by restoring the balance between NF-κB and Nrf2 in the liver, modulating the MAPK pathway, and, consequently, improving oxidative and inflammatory balance. In conclusion, this study suggests that cadmium induces hepatic IR through an imbalance between NF-κB and Nrf2 signaling pathways. Curcumin treatment appears to improve these pathways, thereby ameliorating hepatic IR.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2382-2393"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metallic Makos: Metal and Metalloid Levels and Human Health Risks Arising from the Consumption of Shortfin Makos (Isurus oxyrinchus) from Southeastern Brazil.","authors":"Júlia Vianna de Pinho, Isabel Quental Willmer, Amanda Pontes Lopes, Regina Fonsêca, Tatiana Dillenburg Saint'Pierre, Patricia Charvet, Acácio Ribeiro Gomes Tomas, Rachel Ann Hauser-Davis","doi":"10.1007/s12011-025-04572-7","DOIUrl":"https://doi.org/10.1007/s12011-025-04572-7","url":null,"abstract":"<p><p>Sharks are among the most threatened vertebrate groups, facing pressures from overfishing, habitat loss, and pollution, with the latter posing risks not only to marine ecosystems but also to human health due to the global consumption of shark meat. This study assessed the concentrations of essential, potentially toxic, and toxic metals in the muscle tissue of 61 shortfin makos (Isurus oxyrinchus), an endothermic pelagic species, caught by industrial fleets off the coast of São Paulo, Southeastern Brazil. Several elements, including Co, Ni, V, Rb, and Ti, are reported herein for the first time in this species, expanding the understanding of metal bioaccumulation in pelagic sharks. High levels of toxic elements such as As, Cd, Cr, Hg, and Pb, along with potentially toxic elements like Ti, were detected, with concentrations of As and Hg exceeding food-safety thresholds, raising significant public health concerns. Shortfin makos may present partial physiological resilience to environmental stressors due to endothermy; although, the elevated concentrations of neurotoxic metals like Hg and significant levels of Cu and Ti detected herein highlight its vulnerability to contamination. Moderate positive correlations between metallothionein (MT) and Ti and Rb, and a moderate negative correlation with Co, suggest selective detoxification pathways; although, the limited correlation with other elements points to restricted MT-mediated protective mechanisms in muscle tissue. The relatively high MT levels observed may reflect an adaptive response to chronic exposure rather than effective detoxification. An elevated hazard index indicates that even when individual contaminants are within acceptable limits, their combined effects pose considerable health risks. Given species-specific variability in metal accumulation and the absence of toxicological thresholds for elasmobranchs, future research should aim to define these limits to guide both conservation strategies and public health policies. Ecotoxicological assessments can serve as indirect conservation tools by highlighting human health risks associated with the consumption of threatened species, potentially discouraging their exploitation.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combined Effect Between SEPS1 Genetic Polymorphisms and Exposure to Metals on the Risk of Gestational Diabetes Mellitus.","authors":"Weiwei Wu, Yulin Li, Weixuan Hu, Jing Zhao, Bole Zhang, Yongliang Feng, Yawei Zhang, Suping Wang","doi":"10.1007/s12011-025-04597-y","DOIUrl":"https://doi.org/10.1007/s12011-025-04597-y","url":null,"abstract":"<p><p>Environmental metal exposure is a key risk factor for gestational diabetes mellitus (GDM), but the mechanisms remain unclear. The traditional view holds that excessive accumulation of metals directly damages the islets to induce GDM. Recent studies suggest that supplementing with trace elements can alleviate insulin resistance by reducing endoplasmic reticulum stress, indicating that endoplasmic reticulum stress might have a comparable impact in metal-induced GDM. Selenoprotein S (SEPS1), a key regulator of endoplasmic reticulum function, may play a role. This study aims to investigate the interaction between the genetic predisposition of the SEPS1 gene and exposure to metals on GDM from the perspective of endoplasmic reticulum stress. A total of 278 pregnant women with GDM and 278 matched pregnant women without GDM were recruited. Maternal blood samples were collected before delivery to genotype the SEPS1 gene and measure metal levels. We found that rs28533324 and rs894317 were associated with the risk of GDM. The level of chromium (Cr) Q3 in maternal blood increased the risk of GDM, and the level of nickel (Ni) Q4 decreased the risk of GDM. Furthermore, the Q3 and Q4 Cr exhibit a multiplicative interaction with rs894317 in both the codominant and dominant models, and a multiplicative interaction between the Cr Q3 and rs894317 is also observed in the allele model. We found a novel link between SEPS1 gene variation and GDM, with these associations potentially being modified by Cr exposure. Our findings provide new etiological insights into GDM induced by Cr through endoplasmic reticulum stress.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Higher Intakes of Dietary Zinc with Higher Ferritin or Hemoglobin: a Cross-sectional Study from NHANES (2017-2020).","authors":"Hanieh Abdi, Mohammad Safargar, Mihnea-Alexandru Găman, Camellia Akhgarjand, Kousalya Prabahar, Haniye Zarezadeh, Xin Ying Chan, Parsa Jamilian, Hamed Kord-Varkaneh","doi":"10.1007/s12011-025-04589-y","DOIUrl":"https://doi.org/10.1007/s12011-025-04589-y","url":null,"abstract":"<p><p>Zinc is an essential trace element that plays a critical role in numerous physiological processes, including immune function, cell growth, and particularly iron metabolism. This study aimed to explore the association between dietary zinc intake and key biomarkers of iron status, specifically serum ferritin and hemoglobin levels, in a representative sample of the US population. A cross-sectional analysis was conducted using data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES), which included 15,560 participants. Dietary zinc intake was assessed through 24-h dietary recall, and serum ferritin and hemoglobin levels were measured through laboratory tests. Participants were grouped into quartiles based on their zinc intake. Multivariable linear regression models were applied to evaluate the relationship between dietary zinc intake and ferritin and hemoglobin levels, adjusting for potential confounders such as age, sex, body mass index (BMI), waist circumference, energy intake, macronutrients, and micronutrients. These adjustments ensured a more accurate analysis of the associations between zinc intake and iron markers. Our findings demonstrate that higher dietary zinc intake is significantly associated with elevated serum ferritin (B = 6.17, p = 0.027) and hemoglobin (B = 0.048, p = 0.019) levels, independent of other factors. Participants in the highest zinc intake quartile also showed higher hematocrit and mean corpuscular volume (MCV) levels compared to those in the lowest quartile. These results suggest that adequate dietary zinc intake may play a crucial role in improving iron status and reducing the risk of iron-deficiency anemia, particularly in populations at risk. Future research is necessary to further elucidate the mechanisms behind this relationship and to inform public health nutritional guidelines.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}