Biological Trace Element Research最新文献_第5页

Comparative Toxicity of TiO₂ and Sn-Doped TiO₂ Nanoparticles in Zebrafish After Acute and Chronic Exposure. 斑马鱼急性和慢性接触二氧化钛和掺锡二氧化钛纳米粒子后的毒性比较

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-03-12 DOI: 10.1007/s12011-024-04127-2

Maryam Mahjoubian, Akram Sadat Naeemi, Mehdi Sheykhan

{"title":"Comparative Toxicity of TiO2 and Sn-Doped TiO2 Nanoparticles in Zebrafish After Acute and Chronic Exposure.","authors":"Maryam Mahjoubian, Akram Sadat Naeemi, Mehdi Sheykhan","doi":"10.1007/s12011-024-04127-2","DOIUrl":"10.1007/s12011-024-04127-2","url":null,"abstract":"This study was conducted to assess the toxicological potential of synthesized pure and Sn-doped TiO2 NPs (Sn-TiO2 NPs) in zebrafish after acute and chronic exposure. The pure TiO2 NPs, 4%, and 8% Sn-TiO2 NPs were synthesized and characterized using X-ray diffraction, Scanning Electron Microscope, diffuse reflectance spectra, dynamic light scattering, and zeta potential analyses. The pure TiO2 NPs, 4%, and 8% Sn-TiO2 NPs were spherical with average sizes of about 40, 28, and 21 nm, respectively, indicating significant size reduction of TiO2 NPs following Sn doping. According to our results, the LC50-96h increased in the order of 8% Sn-TiO2 NPs (45 mg L-1) < 4% Sn-TiO2 NPs (80.14 mg L-1) < pure TiO2 NPs (105.47 mg L-1), respectively. Exposure of fish to Sn-TiO2 NPs after 30 days resulted in more severe histopathological alterations in gills, liver, intestine, and kidneys than pure TiO2 NPs. Furthermore, Sn-doping significantly elevated malondialdehyde levels and micronuclei frequency, indicating increased oxidative stress and genotoxicity. Expression analysis revealed altered expression of various genes, including upregulation of pro-apoptotic Bax gene and downregulation of anti-apoptotic Bcl-2 gene, suggesting potential induction of apoptosis in response to Sn-doped NPs. Additionally, antioxidant genes (Gpx, Sod, Cat, and Ucp-2) and stress response gene (Hsp70) showed altered expression, suggesting complex cellular responses to mitigate the toxic effects. Overall, this study highlights the concerning impact of Sn-doping on the toxicity of TiO2 NPs in zebrafish and emphasizes the need for further research to elucidate the exact mechanisms underlying this enhanced toxicity.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Silver Nanoparticles for the Control of Anthelmintic Resistance in Small and Large Ruminants. 纳米银颗粒在控制大小反刍动物抗药性中的作用

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-03-04 DOI: 10.1007/s12011-024-04132-5

Sahar Mustafa, Lafi M Alharbi, Mona Z Abdelraheem, Muhammad Mobashar, Warda Qamar, Amin A Al-Doaiss, Rao Zahid Abbas

{"title":"Role of Silver Nanoparticles for the Control of Anthelmintic Resistance in Small and Large Ruminants.","authors":"Sahar Mustafa, Lafi M Alharbi, Mona Z Abdelraheem, Muhammad Mobashar, Warda Qamar, Amin A Al-Doaiss, Rao Zahid Abbas","doi":"10.1007/s12011-024-04132-5","DOIUrl":"10.1007/s12011-024-04132-5","url":null,"abstract":"Helminths are considered a significant threat to the livestock industry, as they cause substantial economic losses in small and large ruminant farming. Their morbidity and mortality rates are also increasing day by day as they have zoonotic importance. Anthelmintic drugs have been used for controlling these parasites; unfortunately, due to the development of resistance of these drugs in helminths (parasites), especially in three major classes like benzimidazoles, nicotinic agonists, and macrocyclic lactones, their use is becoming very low. Although new anthelmintics are being developed, the process is time-consuming and costly. As a result, nanoparticles are being explored as an alternative to anthelmintics. Nanoparticles enhance drug effectiveness, drug delivery, and target specificity and have no resistance against parasites. Different types of nanoparticles are used, such as organic (chitosan) and inorganic (gold, silver, zinc oxide, iron oxide, and nickel oxide). One of them, silver nanoparticles (AgNPs), has unique properties in various fields, especially parasitology. AgNPs are synthesized from three primary methods: physical, chemical, and biological. Their primary mechanism of action is causing stress through the production of ROS that destroys cells, organs, proteins, and DNA parasites. The present review is about AgNPs, their mode of action, and their role in controlling anthelmintic resistance against small and large ruminants.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Blood Lead Levels and Urgency Urinary Incontinence Among Adult Females: A Retrospective Study Based on NHANES 2005-2020. 成年女性血铅水平与急迫性尿失禁之间的关系：基于 NHANES 2005-2020 的回顾性研究。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-07 DOI: 10.1007/s12011-024-04445-5

Junwei Wang, Cunming Zhang, Aiwei Zhang

{"title":"The Association Between Blood Lead Levels and Urgency Urinary Incontinence Among Adult Females: A Retrospective Study Based on NHANES 2005-2020.","authors":"Junwei Wang, Cunming Zhang, Aiwei Zhang","doi":"10.1007/s12011-024-04445-5","DOIUrl":"https://doi.org/10.1007/s12011-024-04445-5","url":null,"abstract":"The purpose of this study is to investigate whether blood lead levels influence the risk of urgency urinary incontinence (UUI) in adult females. This study utilized data from the National Health and Nutrition Examination Survey from 2005 to 2020, involving 9509 adult women aged 20 and older. The effect of blood lead levels on UUI was assessed using weighted multivariate logistic regression models. Additionally, the relationship between the two was illustrated using restricted cubic splines. Stratified analyses based on covariate categories were used to explore if factors influenced the relationship between blood lead levels and UUI. Adjusted multivariate logistic regression analysis indicated that for each unit increase in blood lead levels, the risk of UUI increased by 10% (OR = 1.10; 95% CI, 1.02-1.17; P = 0.01). After categorizing blood lead levels into weighted tertiles, compared to the first tertile, the third tertile increased the risk of UUI by 1.34 times in Model 1 (OR = 1.34; 95% CI, 1.13-1.59; P < 0.001). A restricted cubic spline analysis demonstrated a nonlinear relationship between blood lead levels and UUI (P for nonlinearity = 0.016). Stratified analysis revealed that baseline characteristics such as age, BMI, and PIR did not have an impact on the association between blood lead levels and UUI. This study demonstrated a close association between the risk of blood lead levels and UUI in adult women aged 20 and above. High blood lead levels were found to increase the risk of UUI.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Health Risk and Heavy Metal Pollution Caused by Dust Storms in Zabol City. 评估扎布尔市沙尘暴造成的健康风险和重金属污染。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-07 DOI: 10.1007/s12011-024-04415-x

Maryam Sarkhosh, Ali Asghar Najafpoor, Somayeh Rahdar

{"title":"Evaluation of Health Risk and Heavy Metal Pollution Caused by Dust Storms in Zabol City.","authors":"Maryam Sarkhosh, Ali Asghar Najafpoor, Somayeh Rahdar","doi":"10.1007/s12011-024-04415-x","DOIUrl":"https://doi.org/10.1007/s12011-024-04415-x","url":null,"abstract":"This study investigated the concentrations and compositions of specific elements in total suspended particulate (TSP) samples and the associated ecological, carcinogenic, and non-carcinogenic risks related to the inhalation, ingestion, and dermal absorption of heavy metals. The study focused on adult and pediatric populations in the highly dust-polluted city of Zabol, Iran, during 2022-2023. The samples were analyzed by using inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration of metals in milligram per kilogram (mg/kg) was as follows: Al (75053) > Ca (8206) > Fe (5439) > Mg (5323) > Zn (15.27) > Pb (3.66) > Cr (3.38) > Cd (0.011); according to the results, the highest amount of metals related to aluminum and calcium in dust particles. The calculated individual indices, including the ecological risk index (ERI), pollution factor (Cfi), and geographic accumulation index (Igeo), indicated that calcium exhibited minimal pollution, while the metal samples (Al, Mg, Fe, Cd, Cr, Pb, and Zn) were categorized as uncontaminated. The results revealed that the ecological risk factor (Er) is below 40, indicating a low level of contamination. Additionally, the pollution level determined by the ecological risk potential (RI) was less than 150, suggesting a low probability of contamination. Ingestion posed the highest average hazard quotient (HQ) values for both children and adults in terms of non-carcinogenic risk assessment, while cutaneous and inhalation exposures showed lower values. Furthermore, the hazard index (HI) for heavy metals remained below the safe threshold of 1. The risk index (RI) values for lead, cadmium, and chromium were all below 1 × 10-6 in both adult and pediatric populations. The United States Environmental Protection Agency (USEPA) guidelines suggest an acceptable level of carcinogenicity for all heavy metals, indicating a potential risk of cancer associated with the presence of these metals in suspended particles in Zabol.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc Deficiency Leads to Reproductive Impairment in Male Mice Through Imbalance of Zinc Homeostasis and Inflammatory Response. 缺锌通过锌平衡和炎症反应失衡导致雄性小鼠生殖能力受损

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-06 DOI: 10.1007/s12011-024-04441-9

Zhan Hou, Jing Ma, Huanhuan Li, Xinying Wang, Wen Li, Xuan Liu, Yanqing Tie, Shusong Wang

{"title":"Zinc Deficiency Leads to Reproductive Impairment in Male Mice Through Imbalance of Zinc Homeostasis and Inflammatory Response.","authors":"Zhan Hou, Jing Ma, Huanhuan Li, Xinying Wang, Wen Li, Xuan Liu, Yanqing Tie, Shusong Wang","doi":"10.1007/s12011-024-04441-9","DOIUrl":"https://doi.org/10.1007/s12011-024-04441-9","url":null,"abstract":"Zinc is an essential trace element crucial for growth and development and plays a significant role in male reproductive function. The aim of this study was explore the mechanism of male reproductive damage caused by different degrees of zinc deficiency. Thirty male ICR mice were randomly assigned to three groups: zinc-normal diet group (ZN, n = 10, Zn content = 30 mg/kg), low zinc-deficiency diet group (LZD, n = 10, Zn content = 15 mg/kg), and high zinc-deficiency diet group (HZD, n = 10, Zn content = 7.5 mg/kg). The mice were maintained for 8 weeks. At the end of the experiment, they were sacrificed, and their blood, testicular, and epididymal tissues were collected for further study. Zinc-deficient diet led to weight loss, testicular structural disorder, decreased semen quality, imbalance of zinc homeostasis, and inflammatory damage in mice. Semen quality, testosterone, serum Zn, testicular tissue Zn, testicular free Zn ions, Zrt-, Irt-like protein8 (ZIP8), Zrt-, Irt-like protein5 (ZIP5), and interleukin-10 (IL-10) were significantly decreased; zinc transporter 4(ZnT4), NF-κB p65, P-NF-κB p65, NLRP3, Caspase-8, and Caspase-3 were significantly increased in both LZD and HZD group mice. While compared with the LZD group, Zrt-, Irt-like protein13 (ZIP13), TNF-α, NF-κB p65, P-NF-κB p65, NLRP3, Caspase-1, and GSDMD were significantly increased in the HZD group. Both low and high zinc-deficiency diets can disrupt zinc homeostasis in mice, leading to heightened inflammatory responses, the activation of the NF-κB pathway, and increased apoptosis in testicular cells. Notably, a high zinc-deficiency diet led to an up-regulation of ZIP13 expression, exacerbated inflammation, and induced testicular pyroptosis, resulting in more severe reproductive damage in male mice.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Selenium Levels and Their Relationship with Insulin Resistance in Individuals with Polycystic Ovary Syndrome. 多囊卵巢综合征患者的血清硒水平及其与胰岛素抵抗的关系

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-06 DOI: 10.1007/s12011-024-04435-7

Mohammed Karami, Safa Almaghrabi, Omar Banasr, Khulood Hussein

{"title":"Serum Selenium Levels and Their Relationship with Insulin Resistance in Individuals with Polycystic Ovary Syndrome.","authors":"Mohammed Karami, Safa Almaghrabi, Omar Banasr, Khulood Hussein","doi":"10.1007/s12011-024-04435-7","DOIUrl":"https://doi.org/10.1007/s12011-024-04435-7","url":null,"abstract":"Growing evidence indicates a potential link between polycystic ovary syndrome (PCOS) and selenium (Se) levels. This study aims to assess Se concentrations in Saudi women with and without PCOS and to explore the relationships between Se levels, insulin resistance (IR), adiponectin, and lipid markers. We randomly recruited 197 women aged 18 to 40, both with and without PCOS, for this age-matched case-control study. The PCOS participants were categorized into three groups based on their Se levels. All participants underwent interviews, and their anthropometric measurements and blood samples were collected for further analysis of biochemical variables. There was a notable difference between the two groups studied across all biochemical variables. Specifically, fasting blood glucose, insulin, the homeostasis model assessment (HOMA-IR) index, total cholesterol, low-density lipoprotein cholesterol, and triglycerides were significantly higher in the PCOS group compared to the control group (p < 0.01). Conversely, Se, high-density lipoprotein cholesterol, and adiponectin levels were significantly lower in women with PCOS than in their age-matched controls (p < 0.01). HOMA-IR was identified as the sole independent predictor of serum Se levels, explaining 17.2% of the variability in its circulating levels (β = - 0.57; 95% CI: - 0.96 to - 0.18, p = 0.004). The findings reveal that women with PCOS have lower serum Se levels compared to the controls. Furthermore, the results confirm a correlation between Se levels and insulin resistance.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Cadmium, Lead, Chromium, and Nickel Content in Various Types of Nuts: Almonds, Cashews, Hazelnuts, Peanuts, and Walnuts - Health Risk of Polish Consumers. 评估各类坚果中的镉、铅、铬和镍含量：杏仁、腰果、榛子、花生和核桃 - 波兰消费者的健康风险。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-06 DOI: 10.1007/s12011-024-04438-4

Małgorzata Ćwieląg-Drabek, Joanna Nieć-Leśniak, Agnieszka Białek-Dratwa, Agata Piekut, Agata Kiciak, Grzegorz Dziubanek, Elżbieta Szczepańska

{"title":"Evaluation of Cadmium, Lead, Chromium, and Nickel Content in Various Types of Nuts: Almonds, Cashews, Hazelnuts, Peanuts, and Walnuts - Health Risk of Polish Consumers.","authors":"Małgorzata Ćwieląg-Drabek, Joanna Nieć-Leśniak, Agnieszka Białek-Dratwa, Agata Piekut, Agata Kiciak, Grzegorz Dziubanek, Elżbieta Szczepańska","doi":"10.1007/s12011-024-04438-4","DOIUrl":"https://doi.org/10.1007/s12011-024-04438-4","url":null,"abstract":"World production and consumption of nuts continue to rise year on year. Nuts, due to their high nutrient content, are becoming increasingly popular among consumers. A potential health risk may result from the consumption of nuts contaminated with metallic trace elements like cadmium or lead. In this research, we measured the content of Cd, Pb, Cr, and Ni in various edible nuts. All elements were detected using the electrothermal atomic absorption spectrometry analytical technique (ETAAS). The study material comprised 69 nut samples including almonds, cashews, hazelnuts, peanuts, and walnuts available on the Polish market. Indicators such as the hazard quotient (HQ) and hazard index (HI) were used to assess the health risk of consumers. The concentrations of elements in all analyzed samples of nuts were as follows: Cd: peanuts > almonds > hazelnuts > walnuts > cashews, Pb: peanuts > almonds > hazelnuts > walnuts > cashews, Ni: cashews > peanuts > walnuts > hazelnuts > almonds, Cr: almonds > cashews & hazelnuts > peanuts > walnuts. Health risk indicators estimated for consumers whose diet is rich in nuts, in which metallic trace elements were recorded, indicate that an unacceptable impact may occur, and the risk of negative health effects (non-cancer) will be moderate to high.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines. 在各种细胞株上测试铊的毒性及其对钾通路的干扰。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-01 Epub Date: 2024-02-13 DOI: 10.1007/s12011-024-04086-8

Ana Marija Marjanović Čermak, Stipe Mustać, Petra Cvjetko, Ivan Pavičić, Domagoj Kifer, Erim Bešić, Ana-Marija Domijan

{"title":"Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines.","authors":"Ana Marija Marjanović Čermak, Stipe Mustać, Petra Cvjetko, Ivan Pavičić, Domagoj Kifer, Erim Bešić, Ana-Marija Domijan","doi":"10.1007/s12011-024-04086-8","DOIUrl":"10.1007/s12011-024-04086-8","url":null,"abstract":"Thallium (Tl) is a highly toxic heavy metal whose mechanism of toxicity is still not completely understood. The aim of this study was to test Tl cytotoxicity on several cell lines of different tissue origin in order to clarify specific Tl toxicity to a particular organ. In addition, possible interference of Tl with cell potassium (K) transport was examined. Human keratinocytes (HaCaT), human hepatocellular carcinoma (HepG2), porcine kidney epithelial cells (PK15), human neuroblastoma (SH-SY5Y) and Chinese hamster lung fibroblast cells (V79) were treated with thallium (I) acetate in a wide concentration range (3.9-500 µg/mL) for 24 h, 48 and 72 h. To assess competitive interaction between Tl and K, the cells were treated with four Tl concentrations close to IC50 (15.63, 31.25, 62.50, 125 µg/mL) in combination with/or without potassium (I) acetate (500 µg/mL). The cells' morphology was monitored, and cytotoxic effect was assessed by 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test. The most sensitive to Tl exposure were SH-SY5Y cells, while HepG2 were the most resistant. The combined exposure to thallium (I) acetate and potassium (I) acetate for every cell line, except V79 cells, resulted in higher cell viability compared to thallium (I) acetate alone. The results of our study indicate that cell sensitivity to Tl treatment is largely affected by tissue culture origin, its function, and Na+/K+-ATPase activity.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis. 补锌对 2 型糖尿病患者血脂组合和身体组成的影响：GRADE评估的系统综述和剂量反应荟萃分析》。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-01 Epub Date: 2024-01-15 DOI: 10.1007/s12011-024-04059-x

Mahsa Khajeh, Shirin Hassanizadeh, Fatemeh Pourteymour Fard Tabrizi, Reza Hassanizadeh, Mahdi Vajdi, Gholamreza Askari

{"title":"Effect of Zinc Supplementation on Lipid Profile and Body Composition in Patients with Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis.","authors":"Mahsa Khajeh, Shirin Hassanizadeh, Fatemeh Pourteymour Fard Tabrizi, Reza Hassanizadeh, Mahdi Vajdi, Gholamreza Askari","doi":"10.1007/s12011-024-04059-x","DOIUrl":"10.1007/s12011-024-04059-x","url":null,"abstract":"The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to investigate the overall effects of zinc supplementation on lipid profile and body composition such as body weight (BW), body mass index (BMI), triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) in patients with type 2 diabetes mellitus (T2DM). Scopus, Web of Science, PubMed, and Embase databases were searched from inception through October, 2023. The I2 and Cochran's Q tests were used to assess heterogeneity between studies. Nineteen RCTs (n = 1357 participants) were included in the meta-analysis. Zinc supplementation significantly reduced TG (WMD = - 17.41 mg/dL; 95% CI: - 22.60, - 12.22; P < 0.001), TC (WMD: - 19.60 mg/dL; 95% CI: - 28.46, - 10.73, P < 0.001), LDL-C (WMD = - 8.80 mg/dL; 95% CI: - 14.80, - 2.81; P = 0.004), and BMI (WMD = - 0.53 kg/m2; 95% CI: - 1.05, - 0.01; P = 0.046) but not BW (WMD: - 0.51 kg, 95 % CI: - 1.99, 0.97, P = 0.498). Moreover, zinc supplementation increased HDL-C (WMD = 4.82 mg/dL; 95% CI: 0.88, 8.76; P = 0.016) in patients with T2DM. Our results propose that zinc supplementation may be an effective strategy for improving lipid profile and body composition in patients with T2DM.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis. 镉暴露通过调控 miR-494-3p/PTEN 轴诱导甲状腺细胞凋亡和坏死

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-11-01 Epub Date: 2024-01-26 DOI: 10.1007/s12011-024-04075-x

Jinghua Zhao, Huan Zeng, Chen Guo, Xue Qi, Zijiang Yang, Wei Wang

{"title":"Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis.","authors":"Jinghua Zhao, Huan Zeng, Chen Guo, Xue Qi, Zijiang Yang, Wei Wang","doi":"10.1007/s12011-024-04075-x","DOIUrl":"10.1007/s12011-024-04075-x","url":null,"abstract":"Cadmium (Cd) exposure is a persistent pollution problem, necessitating caution in using cadmium-expelling complexing agents. Currently, there is no targeted therapy to treat Cd poisoning. The thyroid gland is a major endocrine organ that directly regulates thyroid hormones involved in various physiological processes and is a target organ for Cd accumulation. Herein, the effects of Cd exposure on swine thyroid glands were investigated. Six-week-old male pigs were randomly divided into the Cd and control groups. The control group was fed a normal diet containing 0 mg Cd/kg, while the Cd group was fed a diet containing 20 mg Cd/kg (CdCl2) for 40 days. The regulation mechanism of phosphatase and tensin homolog (PTEN) microRNA-494-3p (miR-494-3p) was evaluated to determine the toxic effects of Cd exposure on free radicals' cleaner. Notably, heat shock proteins (HSPs) were triggered as defense agents against Cd. Cd exposure increased the enzyme activity of superoxide dismutase1(SOD1) and SOD2, catalase (CAT), and glutathione (GSH), and the endoplasmic reticulum stress in thyroid cells. Histopathological staining, RT-qPCR, and Western Blot assays were further employed to detect possible apoptosis and necroptosis of thyroid cells induced by Cd exposure. The assays revealed increased thyroid inflammatory injury, fibrosis, and apoptosis caused by Cd exposure. This study demonstrates the role of microRNAs in regulating Cd toxicity in pig thyroid tissue and provides evidence of Cd's negative effects. It further provides an assessment of the toxicological impact of Cd as an environmental endocrine disruptor (ED) that threatens public health and safety, which forms a basis for the development of Cd poisoning treatment therapies.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139562953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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