Biological Trace Element Research最新文献

{"title":"Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly.","authors":"Qi Jin, Zhangzhao Wang, Junjing Li, Hexi Zhang, Mengxin Liu, Chunxi Wang, Wenxing Guo, Wanqi Zhang","doi":"10.1007/s12011-024-04420-0","DOIUrl":"10.1007/s12011-024-04420-0","url":null,"abstract":"<p><p>The relationship between high water iodine levels and thyroid dysfunction in the elderly remains poorly understood. This study aimed to elucidate how excessive iodine in drinking water affects iodine nutrition and thyroid function in the elderly population. This cross-sectional study was performed in the elderly in Yuncheng, Heze, Shandong. We identified a total of 385 patients with thyroid dysfunction and 385 propensity score-matched controls with euthyroid. Water, urinary, and blood samples were collected to detect the concentrations of iodine in water and urine, as well as thyroid hormones. The median (IQR) iodine concentrations in cooking water and drinking water for the total population were 294.99 (48.99, 478.14) µg/L and 172.87 (20.87, 462.13) µg/L, respectively. Among the elderly, median (IQR) urinary iodine concentration (UIC) was 394.20 (169.47, 764.41) µg/L, and 24-h urinary iodine concentration (24-h UIE) was 523.04 (277.84, 910.76) µg/day. Subjects with thyroid dysfunction reported higher intake of iodine from water (P < 0.001) and urinary iodine levels (P < 0.001) than controls. Logistic regression analysis showed thyroid dysfunction was associated with higher risks of elevated iodine concentrations in cooking water (OR 1.957, 95% CI 1.413-2.711), drinking water (OR 2.206, 95% CI 1.607-3.027), UIC (OR 3.612, 95% CI 2.494-5.230), and 24-h UIE (OR 2.568, 95% CI 1.784-3.698), indicating increased thyroid dysfunction risk among the elderly with high water iodine levels. Elevated iodine levels in water are associated with an increased risk of thyroid dysfunction among the elderly. Clinical trial registry number: Medical Ethics Committee of Tianjin Medical University; Trial registration number: NCT05716191, date of registration was December 08, 2023.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3470-3478"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Serum Magnesium Levels May Delay the Loss of Residual Renal Function among Patients Receiving Peritoneal Dialysis: A Prospective Study.","authors":"Jing Zhao, Xuechun Lin, Jinxue Wang, Xiaolei Guo, Fan Peng, Xuezhi Zuo, Chong Tian, Chenjiang Ying","doi":"10.1007/s12011-024-04432-w","DOIUrl":"10.1007/s12011-024-04432-w","url":null,"abstract":"<p><p>The association between serum magnesium and residual renal function (RRF) among peritoneal dialysis (PD) patients remains unclear. The present study examined the relationships between serum magnesium and the risk of anuria in patients receiving continuous ambulatory peritoneal dialysis (CAPD). This prospective cohort study included 261 PD patients in China. All participants received CAPD for more than 3 months between 2012 and December 2022. Loss of RRF (anuria) was characterized by a 24-h urine output below 100 ml. Cox proportional hazard regression models and competing risk models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of anuria across different serum magnesium levels. During the median follow-up of 21.3 (15.0-32.4) months, 130 individuals progressed to anuria. The mean concentration of serum magnesium was 0.9 ± 0.15 mmol/L. After multivariate adjustment, the association of serum magnesium with the risk of anuria was not significant in the entire study population. However, for PD patients with better preservation of RRF, the risk of anuria decreases significantly as serum magnesium increases (HR for per standard deviation increment 0.53, 95% CI 0.32-0.88). The protective effect of increased serum magnesium concentrations on RRF was more pronounced among PD patients with lower triglyceride glucose (TyG) index at baseline compared to those with higher TyG index (p for interaction = 0.03). Our results indicated that higher serum magnesium predicts better renal prognosis for PD patients with better preservation of RRF. Levels of TyG index may modulate the relationship.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3559-3569"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Arsenic Exposure on AS3MT Protein Levels in Serum of Type 2 Diabetic Patients Compared to Non-diabetics.","authors":"Saima Shokat, Riffat Iqbal, Muhammad Ahmed Ali, Atif Yaqub, Shaista Aslam, Samreen Riaz","doi":"10.1007/s12011-024-04448-2","DOIUrl":"10.1007/s12011-024-04448-2","url":null,"abstract":"<p><p>This research explores the impact of arsenic exposure on serum protein profiles in type 2 diabetes patients, with an emphasis on the AS3MT protein as a biomarker. Utilizing Bradford protein assay, SDS-PAGE, HPLC, and mass spectrometry, we quantified and analyzed variations in serum protein levels, focusing on differences between control groups (82.94 ± 8.03 µg/mL) and diabetic patients (96.95 ± 5.02 µg/mL) of high arsenic exposed in areas Kasur and Lahore, Punjab, Pakistan. The study revealed a significant increase in total serum proteins and specifically identified elevated levels of AS3MT in the diabetic group compared to controls. By using 15% gel, proteins were separated, and bands were visible at 42KD. Further investigations using HPLC provided a detailed chromatographic profile of AS3MT, isolating this protein effectively and displaying its heightened abundance through a marked peak within the sample chromatograms. Additionally, intact mass and tryptic digestion profiles analyzed by mass spectrometry (molecular weight of 41,747.79 D) further corroborated the identity and modification of AS3MT in the context of arsenic exposure. ELISA was used for the quantification of AS3MT protein concentration, and a 260% increase was confirmed in the diabetic group exposed to arsenic. These findings suggested that arsenic exposure significantly alters AS3MT protein and serum protein levels in diabetic patients, supporting the hypothesis that AS3MT can serve as a biomarker for arsenic-induced diabetic conditions.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3640-3657"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Serum Iodine Concentrations in Early Pregnancy Exhibited Well Diagnostic Ability for Thyroid Dysfunction, Inverse Associations with Gestational Weight Gain, and Birth Size: Longitudinal Analyses Based on Huizhou Mother-Infant Cohort.","authors":"Zhao-Min Liu, Huan-Huan Long, Dan Li, Ai-Ping Fang, Chao-Gang Chen, Cheng Wang, Min-Min Li, Yi Wu, Su-Juan Zhang, Wen-Jing Pan","doi":"10.1007/s12011-024-04443-7","DOIUrl":"10.1007/s12011-024-04443-7","url":null,"abstract":"<p><p>The study aims to explore the associations of maternal serum iodine concentrations (SIC) with thyroid function, obstetric, and birth outcomes. This was a prospective study embedded in the Huizhou Mother-Infant Cohort. Singleton mothers aged 18-45 years were enrolled at their first antenatal visits. Maternal SIC and thyroid markers were tested by inductively coupled plasma mass spectrometry and electronic chemiluminescent assay, respectively. Obstetric and birth outcomes were retrieved from the Hospital Information System. Two nested 1:1 age and body mass index-matched case-control studies were embedded in the cohort including 224 pairs of mothers with gestational diabetes mellitus (GDM) and 302 paired of newborns with small for gestational age (SGA) and their respective healthy controls. Multivariable linear and conditional logistic regression models were applied to explore the relationship of maternal SIC with obstetric complications and birth outcomes. A total of 1558 mothers were included for analysis. Receiver operating characteristic curve (ROC) analysis showed that maternal SIC in the 1st trimester (T1) had well diagnostic ability for clinical and subclinical hyperthyroidism, clinical hypothyroidism, and hypothyroxinemia with the areas under the curve of 0.907, 0.734, 0.867, and 0.927, respectively (all p < 0.05). Mothers in the highest quartile of SIC at T1 had an increased risk of SGA (OR = 2.043, 95% CI: 1.198-3.483, p = 0.009) but not for GDM risk. Maternal SIC were significantly and inversely associated with gestational weight gain (GWG), birth weight, and Ponderal index (all p < 0.05). SIC at T1 had well diagnostic values for thyroid dysfunction. High gestational SIC during early pregnancy were associated with lowered GWG, birth size, and increased risk of SGA. Study registration no: NCT03922087 at Clinicaltrial.gov.com.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3618-3629"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Zinc Oxide Improves Growth Rate, Carcass Traits, Meat Chemical Composition, Serum and Tissue Mineral Profiles, Mineral Retention, and Intestinal Morphology in Broiler Chickens Compared to Inorganic and Organic Zinc.","authors":"Hamada S Saber, Heba A Alian","doi":"10.1007/s12011-025-04716-9","DOIUrl":"https://doi.org/10.1007/s12011-025-04716-9","url":null,"abstract":"<p><p>This study aimed to compare the impact of inorganic, organic, and nano zinc sources on growth rate, carcass traits, meat composition, mineral profiles and retention, and intestinal morphology of the broilers. A 1-day \"Cobb\" broiler chick (n = 192) was randomly distributed into six groups with four replicates. The groups were set up as follows: G1: G3 received a basal diet with 100 mg Zn/kg from inorganic zinc oxide, inorganic zinc sulfate monohydrate, and organic zinc methionine. Groups G4: G6 received a basal diet supplemented with nano zinc oxide at 20, 10, and 5 mg Zn/kg diet, respectively. The results revealed that the nano zinc oxide (NZnO) in G6 significantly increased the growth rate and improved carcass quantity and quality, as proved by a reduction in abdominal fat percentage. It was observed that nano zinc oxide achieved the highest crude protein and the lowest crude fat percentages in meat. The highest significant calcium (Ca), phosphorus (P), and zinc deposition in serum and breast, and thigh were observed in G5 and G6. Interestingly, a 20 mg NZnO/kg diet considerably raised Ca and P content in the tibia while having no significant difference in G2 or G3. A significant elevation in zinc (Zn) retention (%) was recorded in G6, followed by G4 and G5. The intestinal absorption surface area (ASA) in G5 and G6 showed a significant maximum value. The current study indicated that the lower levels of NZnO (10 and 5 mg/kg diet) showed promising results with no detrimental effect on health status, so it can safely be used in mineral premixes of broilers.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exchangeable Copper Excess and Zinc Deficiency in the Serum of Patients with Colorectal Cancer.","authors":"Rosanna Squitti, Amit Pal, Anastasia De Luca, Gianluca Rizzo, Mauro Rongioletti, Vincenzo Tondolo","doi":"10.1007/s12011-024-04431-x","DOIUrl":"10.1007/s12011-024-04431-x","url":null,"abstract":"<p><p>Copper (Cu) and Zinc (Zn) are altered in colorectal cancer (CRC) but their association with the clinical classification of the tumor has not been fully explored. To examine the association of Cu and Zn homeostasis in the onset and severity of CRC, we performed an exploratory case-control study comparing the serum levels for Cu, the exchangeable component of Cu in serum (CuExc), Zn, the ratio between them (CuExc:Zn), ceruloplasmin [Cp, concentration (iCp) and its activity (eCp), Cp specific activity (eCp:iCp)], and the Cu:Cp, assessed in 31 consecutive CRC patients before surgical resection to those obtained from 37 healthy controls (CTRL). Additionally, we correlated the analyte levels with the indices of the pathological tumor, node, and metastasis (TNM) staging, namely tumor (T), node (N), and metastasis (M), evaluated at the histopathological examination. We found that Cu, CuExc, CuExc:Zn, iCp, eCp, eCp:iCp, and Cu:Cp ratios increased while Zn decreased in CRC patients. In addition, correlation analyses showed that CuExc and Zn levels confirmed the CRC diagnosis. Specifically, CuExc:Zn further increased the discrimination between the individuals of the two groups, providing an area under the curve (ROC AUC) = 0.94. Elevated CuExc was the strongest factor associated with CRC resulting in 15-fold increased odds. These data were confirmed through a multivariable regression model revealing an effect of Zn and CuExc on the CRC risk, with the CuExc resulting in 11-fold increased odds of having the disease. We also found that most of the Cu biological variables analyzed were associated with T, while the CuExc was associated with M. The current pilot study demonstrates that excess labile Cu pool, Zn deficiency, and even further their combination in the CuExc:Zn provide information about CRC in terms of diagnosis, risk of having CRC, and CRC disease stage.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3548-3558"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Dietary Zinc Promotes its Optimal Absorption Through Modulation of Key Transporter Genes, SOD1, and HSP70 Expression in Heat-stressed Rats.","authors":"Eranna Lokesha, Sunil Ekanath Jadhav, Ganesh Narayanrao Aderao, Pramod Chaudhary, Sanjay Kumar Gupta, Narayan Dutta, Gyanendra Singh","doi":"10.1007/s12011-024-04447-3","DOIUrl":"10.1007/s12011-024-04447-3","url":null,"abstract":"<p><p>Global warming causes heat stress (HS) in animals, impacting nutrient absorption and metabolism. Antioxidant nutrients are crucial for combating HS. This study assessed the impact of increased dietary Zn on nutrient utilization, mineral absorption, and expression of Zn homeostasis regulators, superoxide dismutase-1 (SOD1), and heat shock protein-70 (HSP70) genes in rats under HS. Seventy-two four-week-old Wistar rats were assigned to six groups in a 3×2 factorial design, with three dietary Zn levels (14.6, 32.7, and 48.9 ppm) and two environments, thermo-neutral (TN) and HS, for 42 days, including 14 days of HS exposure. Results showed that HS reduced nutrient intake across Zn levels, though ether extract digestibility increased at 32.7 and 48.9 ppm Zn. Intake, excretion, and apparent daily absorption of Ca, P, Zn, Cu, Mn, and Fe were lower in HS than in TN groups. Hepatic metallothionein-1 (MT1) mRNA expression was downregulated in rats fed 14.6 and 32.7 ppm Zn compared to 48.9 ppm Zn under both environmental conditions. Duodenal Zinc transporter-1 (ZnT1) and Zrt- and Irt-like protein-1 (ZIP1) mRNA expression increased with dietary Zn under TN and HS conditions, respectively. Hepatic SOD1 mRNA expression was significantly downregulated in HS groups, while hepatic HSP70 mRNA expression was significantly upregulated at 48.9 ppm Zn under HS. Present study suggests that, under HS conditions in rats, a higher dietary Zn level of 48.9 ppm may be optimal for improving Zn absorption, enhancing ZIP1, MT1, and HSP70 gene expression, and alleviating the negative effects of HS.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3779-3792"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activating PPARβ/δ-Mediated Fatty Acid β-Oxidation Mitigates Mitochondrial Dysfunction Co-induced by Environmentally Relevant Levels of Molybdenum and Cadmium in Duck Kidneys.","authors":"Jiamei Zhu, Gaohui Nie, Xueyan Dai, Dianyun Wang, ShanXin Li, Caiying Zhang","doi":"10.1007/s12011-024-04450-8","DOIUrl":"10.1007/s12011-024-04450-8","url":null,"abstract":"<p><p>Cadmium (Cd) and high molybdenum (Mo) pose deleterious effects on health. Prior studies have indicated that exposure to Mo and Cd leads to damage in duck kidneys, but limited studies have explored this damage from the perspective of fatty acid metabolism. In this study, 40 healthy 8-day-old ducks were randomly assigned to four groups and fed a basic diet containing Cd (4 mg/kg Cd) or Mo (100 mg/kg Mo) or both. Kidney tissues were harvested on the 16th week. Results demonstrated that Cd and/or Mo inhibited mitochondrial fatty acid β-oxidation and disrupted mitochondrial dynamics, along with significant suppression of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) protein in duck kidneys. In vitro study, duck renal tubular epithelial cells were exposed for 12 h to either Mo (480 μM Mo), Cd (2.5 μM Cd), and GW0742 (0.3 μM, a potent agonist of PPARβ/δ) alone or in combination. The results demonstrated that Cd and/or Mo led to marked fatty acid oxidation deficiency and mitochondrial dysfunction and that PPARβ/δ protein was involved in the process. Altogether, this study found that activating PPARβ/δ-mediated fatty acid β-oxidation mitigates mitochondrial dysfunction co-induced by Mo and Cd in duck kidneys.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3870-3883"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Nanoparticles as Safer Alternatives for Gastric Ulcers: An Update on Green Synthesis Methods, Toxicity, and Their Efficacy in Controlling Inflammation.","authors":"Susmita Yadav, Suraj N Mali, Anima Pandey","doi":"10.1007/s12011-024-04446-4","DOIUrl":"10.1007/s12011-024-04446-4","url":null,"abstract":"<p><p>Peptic ulcers, affecting approximately 10% of the global population, can result from factors such as stress, alcohol use, smoking, NSAIDs, Helicobacter pylori infection, and genetic predisposition. Plant-based medicines are gaining recognition for their therapeutic potential, including in the treatment of peptic ulcers. Green chemistry methods for the biological synthesis of nanoparticles (NPs) provide a sustainable alternative to traditional chemical techniques. These nanoparticles, particularly metallic NPs and metal oxides synthesized from plant extracts, offer promising anti-ulcer properties. This review highlights research from 2000 to 2024 on the use of green-synthesized nanoparticles and their role in peptic ulcer treatment, focusing on their therapeutic mechanisms and potential benefits. For this purpose, an electronic search of published research and review articles was conducted in PubMed, Scopus, Science Direct, Cochrane databases, and Google Scholar.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3967-3986"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Levels of Trace Elements (Magnesium, Iron, Zinc, Selenium, and Strontium) are Differentially Associated with Surrogate Markers of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis.","authors":"Enric Vera, Joan-Carles Vallvé, Victòria Linares, Silvia Paredes, Daiana Ibarretxe, Montserrat Bellés","doi":"10.1007/s12011-024-04434-8","DOIUrl":"10.1007/s12011-024-04434-8","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD), which is attributed to inflammatory processes that accelerate atherosclerosis. Therefore, the exploration of novel biomarkers association is needed. This study investigated the associations between serum trace elements (Fe, Zn, Mg, Se, and Sr) and surrogate markers of CVD in 219 RA patients and compared them with those with metabolic disorders (MetD, n = 82) and control participants (n = 64). Surrogate markers included carotid intima-media thickness (cIMT), carotid plaque presence (cPP), pulse wave velocity (PWV), distensibility (DIST), and the augmentation index (AIx). RA patients displayed heightened inflammatory markers, increased arterial stiffness and thickness, and elevated CV risk factors. Compared with those in control participants, Se levels in RA patients were lower, regardless of sex. Women and men with RA had lower Sr and Mg levels than those with MetD, respectively. Backward regression models demonstrated inverse associations of Sr and Zn with cIMT in men with RA and those with MetD, respectively. In RA patients, Sr and Zn were predictors of an increased AIx, with sex-specific associations. Increased Fe levels were associated with an increased AIx in women with MetD. Fe and Zn were predictors of increased cIMT in control participants, with sex-specific associations. Serum trace elements are independently associated with surrogate markers of CVD in patients with RA, highlighting their potential role in CV risk assessment. Prospective studies are essential for validating these associations and establishing optimal trace element levels for managing CVD risk in patients with RA.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3570-3584"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}