Biological Trace Element Research最新文献_第10页

Elevated Serum Magnesium Levels May Delay the Loss of Residual Renal Function among Patients Receiving Peritoneal Dialysis: A Prospective Study. 血清镁水平升高可延缓腹膜透析患者残余肾功能的丧失：一项前瞻性研究

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-30 DOI: 10.1007/s12011-024-04432-w

Jing Zhao, Xuechun Lin, Jinxue Wang, Xiaolei Guo, Fan Peng, Xuezhi Zuo, Chong Tian, Chenjiang Ying

{"title":"Elevated Serum Magnesium Levels May Delay the Loss of Residual Renal Function among Patients Receiving Peritoneal Dialysis: A Prospective Study.","authors":"Jing Zhao, Xuechun Lin, Jinxue Wang, Xiaolei Guo, Fan Peng, Xuezhi Zuo, Chong Tian, Chenjiang Ying","doi":"10.1007/s12011-024-04432-w","DOIUrl":"https://doi.org/10.1007/s12011-024-04432-w","url":null,"abstract":"The association between serum magnesium and residual renal function (RRF) among peritoneal dialysis (PD) patients remains unclear. The present study examined the relationships between serum magnesium and the risk of anuria in patients receiving continuous ambulatory peritoneal dialysis (CAPD). This prospective cohort study included 261 PD patients in China. All participants received CAPD for more than 3 months between 2012 and December 2022. Loss of RRF (anuria) was characterized by a 24-h urine output below 100 ml. Cox proportional hazard regression models and competing risk models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of anuria across different serum magnesium levels. During the median follow-up of 21.3 (15.0-32.4) months, 130 individuals progressed to anuria. The mean concentration of serum magnesium was 0.9 ± 0.15 mmol/L. After multivariate adjustment, the association of serum magnesium with the risk of anuria was not significant in the entire study population. However, for PD patients with better preservation of RRF, the risk of anuria decreases significantly as serum magnesium increases (HR for per standard deviation increment 0.53, 95% CI 0.32-0.88). The protective effect of increased serum magnesium concentrations on RRF was more pronounced among PD patients with lower triglyceride glucose (TyG) index at baseline compared to those with higher TyG index (p for interaction = 0.03). Our results indicated that higher serum magnesium predicts better renal prognosis for PD patients with better preservation of RRF. Levels of TyG index may modulate the relationship.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum Levels of Trace Elements (Magnesium, Iron, Zinc, Selenium, and Strontium) are Differentially Associated with Surrogate Markers of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis. 类风湿性关节炎患者血清中微量元素（镁、铁、锌、硒和锶）水平与心血管疾病风险替代标志物之间存在差异。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-30 DOI: 10.1007/s12011-024-04434-8

Enric Vera, Joan-Carles Vallvé, Victòria Linares, Silvia Paredes, Daiana Ibarretxe, Montserrat Bellés

{"title":"Serum Levels of Trace Elements (Magnesium, Iron, Zinc, Selenium, and Strontium) are Differentially Associated with Surrogate Markers of Cardiovascular Disease Risk in Patients with Rheumatoid Arthritis.","authors":"Enric Vera, Joan-Carles Vallvé, Victòria Linares, Silvia Paredes, Daiana Ibarretxe, Montserrat Bellés","doi":"10.1007/s12011-024-04434-8","DOIUrl":"https://doi.org/10.1007/s12011-024-04434-8","url":null,"abstract":"Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD), which is attributed to inflammatory processes that accelerate atherosclerosis. Therefore, the exploration of novel biomarkers association is needed. This study investigated the associations between serum trace elements (Fe, Zn, Mg, Se, and Sr) and surrogate markers of CVD in 219 RA patients and compared them with those with metabolic disorders (MetD, n = 82) and control participants (n = 64). Surrogate markers included carotid intima-media thickness (cIMT), carotid plaque presence (cPP), pulse wave velocity (PWV), distensibility (DIST), and the augmentation index (AIx). RA patients displayed heightened inflammatory markers, increased arterial stiffness and thickness, and elevated CV risk factors. Compared with those in control participants, Se levels in RA patients were lower, regardless of sex. Women and men with RA had lower Sr and Mg levels than those with MetD, respectively. Backward regression models demonstrated inverse associations of Sr and Zn with cIMT in men with RA and those with MetD, respectively. In RA patients, Sr and Zn were predictors of an increased AIx, with sex-specific associations. Increased Fe levels were associated with an increased AIx in women with MetD. Fe and Zn were predictors of increased cIMT in control participants, with sex-specific associations. Serum trace elements are independently associated with surrogate markers of CVD in patients with RA, highlighting their potential role in CV risk assessment. Prospective studies are essential for validating these associations and establishing optimal trace element levels for managing CVD risk in patients with RA.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations Between Dietary Magnesium Consumption and Magnesium Depletion Score in Relation to Parkinson's Disease: A Population-Based Study. 帕金森病与膳食镁摄入量和镁消耗评分之间的相关性：一项基于人群的研究。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-28 DOI: 10.1007/s12011-024-04428-6

Yanmei Cen, Lu Wang, Siqi Zhang, Xiaoting Li, Yezi Xu, Zhaohao Zeng, Heng Meng

{"title":"Correlations Between Dietary Magnesium Consumption and Magnesium Depletion Score in Relation to Parkinson's Disease: A Population-Based Study.","authors":"Yanmei Cen, Lu Wang, Siqi Zhang, Xiaoting Li, Yezi Xu, Zhaohao Zeng, Heng Meng","doi":"10.1007/s12011-024-04428-6","DOIUrl":"https://doi.org/10.1007/s12011-024-04428-6","url":null,"abstract":"The purpose of the study was to examine whether magnesium (Mg) depletion score (MDS) and dietary Mg intake are associated in adults with the risk of developing Parkinson's disease (PD). In this study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES), which included 20,010 adults aged over 40 years old. To evaluate the linear association between PD and dietary intake of Mg or MDS, we conducted weighted logistic regression for univariate analysis and multivariate linear regression models. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models. A restricted cubic spline (RCS) was drawn to visualize the nonlinear relationship between MDS/dietary Mg intake and PD. In addition, we examined the variations in the relationship between MDS and PD across different confounding factors of the association using subgroup analysis. There were 240 PD cases (1.2%), and 19770 non-PD were included in the study. We found that a higher MDS was associated with an increased risk of PD after adjusting for covariates (OR per 1-unit increase, 1.47; 95% CI, 1.16-1.86). There is insufficient evidence to support a significant statistical association between Mg intake and the risk of PD. According to nonlinear regression, high MDS was associated with higher odds of PD and lower odds of PD above 250 mg/day intake of Mg. It has been shown that Mg bioavailability may be negatively associated with PD as measured by MDS. MDS is a potential method for screening the population with PD. Maintaining adequate Mg status may be important for PD prevention.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lead Toxicity and Maternal Exposure: Characterisation of Alveolar Bone Changes on Offspring Rats. 铅毒性与母体暴露：子代大鼠牙槽骨变化的特征。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-25 DOI: 10.1007/s12011-024-04412-0

Matheus Ferreira Lima Rodrigues, Deiweson Souza-Monteiro, Rayssa Maitê Farias Nazário, Walessa Alana Bragança Aragão, Victória Santos Chemelo, Luciana Eiró-Quirino, Leonardo Oliveira Bittencourt, Fabrício Mezzomo Collares, Raquel Fernanda Gerlach, Sofia Pessanha, Rafael Rodrigues Lima

{"title":"Lead Toxicity and Maternal Exposure: Characterisation of Alveolar Bone Changes on Offspring Rats.","authors":"Matheus Ferreira Lima Rodrigues, Deiweson Souza-Monteiro, Rayssa Maitê Farias Nazário, Walessa Alana Bragança Aragão, Victória Santos Chemelo, Luciana Eiró-Quirino, Leonardo Oliveira Bittencourt, Fabrício Mezzomo Collares, Raquel Fernanda Gerlach, Sofia Pessanha, Rafael Rodrigues Lima","doi":"10.1007/s12011-024-04412-0","DOIUrl":"https://doi.org/10.1007/s12011-024-04412-0","url":null,"abstract":"Lead poisoning is a global public health concern. Maternal exposure during intrauterine and lactational periods can present a higher susceptibility of harm to the offspring. Thus, pregnant female Wistar rats (Rattus norvegicus) were randomly divided in two experimental groups: control group and Lead group. The animals were exposed to 50 mg/kg of Lead Acetate daily for 42 days (21 days of gestational period + 21 days of lactational period). After the exposure period, the mandibles of the offspring were collected for lead quantification, Raman spectroscopy analysis, micro-CT, morphometric e histochemical analysis. Lead exposure altered the physical-chemical composition of alveolar bone and caused histological damage associated with a reduction in osteocyte density and collagen area fraction, increase in collagen maturity, as well as a reduction in bone volume fraction. An increase in trabecular spaces with anatomical compromise of the vertical dimensions of the bone was observed. Thus, the results suggest that developing alveolar bone is susceptible to toxic effects of lead when organisms are exposed during intrauterine and lactation periods.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Selenium Deficiency and T-2 Toxin on Zip6 Expression in Kashin-Beck Disease. 缺硒和 T-2 毒素对卡欣-贝克病 Zip6 表达的影响

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-25 DOI: 10.1007/s12011-024-04426-8

Yifan Wu, Yi Gong, Lian Liu, Lulu Bai, Yu Zhang, Shujin Li, Chaowei Wang, Yuequan Yuan, Xi Lv, Yirong Qin, Hui Wang, Yanli Liu, Feihong Chen, Sijie Chen, Feiyu Zhang, Xiong Guo, Xi Wang, Yujie Ning

{"title":"The Impact of Selenium Deficiency and T-2 Toxin on Zip6 Expression in Kashin-Beck Disease.","authors":"Yifan Wu, Yi Gong, Lian Liu, Lulu Bai, Yu Zhang, Shujin Li, Chaowei Wang, Yuequan Yuan, Xi Lv, Yirong Qin, Hui Wang, Yanli Liu, Feihong Chen, Sijie Chen, Feiyu Zhang, Xiong Guo, Xi Wang, Yujie Ning","doi":"10.1007/s12011-024-04426-8","DOIUrl":"https://doi.org/10.1007/s12011-024-04426-8","url":null,"abstract":"This study investigated the expression of Zip6, a gene predominantly located in the placenta, breast, and prostate tissues, in patients with Kashin-Beck disease (KBD). Environmental risk factor models for KBD were developed using low selenium (Se) feeding (with a Se content of 0.02 mg Se/kg in the feed) and exposure to T-2 toxin (200 ng/g*BW/D). Additionally, the study examined the alterations in Se and Zn2+ levels, along with the mRNA and protein expression levels of Zip6 and KBD related genes, including Mtf1, Mmp3, Mmp13, Adamts5, and Col2a1. Differentially expressed genes (DEGs) were examined by transcriptome sequencing to elucidate the mechanism by which Zip6 induces metabolic disorder of the extracellular matrix (ECM), subsequently leading to cartilage injury under the influence of Se deficiency and T-2 toxin. The findings indicated that the expression levels of Zip6 in adult and pediatric KBD chondrocytes were not synchronized. In the animal study, there was a notable increase in the Zn2+ level in the comprehensive exposure (CE) group. Moreover, in both the T-2 exposure (T-2) and CE groups, there was a significant decrease in the expression of Zip6 in each zone, and the expression of Adamts5 in the middle zone exhibited a significant increase (P < 0.05) correlating with varying degrees of cartilage tissue damage in each group. Sequencing results revealed that the significantly up-regulated DEGs in the CE group included Zimz2. This study suggested that Se and T-2 toxin may influence the expression of Zip6, and it investigated the role of Zn2+ in the pathogenesis of KBD, thereby providing a novel scientific foundation for understanding the pathogenesis of KBD.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Boric Acid and Calcium Fructoborate on T Helper Cell Differentiation by Influencing Foxp3 and Ror-γt in Rheumatoid Arthritis and Systemic Lupus Erythematosus. 硼酸和果酸钙通过影响类风湿关节炎和系统性红斑狼疮患者的 Foxp3 和 Ror-γt 对 T 辅助细胞分化的影响

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-24 DOI: 10.1007/s12011-024-04425-9

Rehime Yapar, Özgül Soysal Gündüz, Feyzan Özdal Kurt, Mehmet Korkmaz

{"title":"The Effect of Boric Acid and Calcium Fructoborate on T Helper Cell Differentiation by Influencing Foxp3 and Ror-γt in Rheumatoid Arthritis and Systemic Lupus Erythematosus.","authors":"Rehime Yapar, Özgül Soysal Gündüz, Feyzan Özdal Kurt, Mehmet Korkmaz","doi":"10.1007/s12011-024-04425-9","DOIUrl":"https://doi.org/10.1007/s12011-024-04425-9","url":null,"abstract":"Many animal and human studies indicate that boric acid and calcium fructoborate have effects on helper T cells in immunity. The aim of our study is to evaluate the effects of boric acid and calcium fructoborate on Treg (CD4+Foxp3+) and Th17 (CD4+Ror-γt+) cell populations and related cytokine levels in mononuclear cells isolated from peripheral blood samples of rheumatoid arthritis and systemic lupus erythematosus patients. Newly diagnosed rheumatoid arthritis (n = 10) patients, systemic lupus erythematosus (n = 5) patients, and healthy individuals (n = 9) were included in this study. Consent forms were obtained from all individuals participating the study, blood samples were taken, and peripheral blood mononuclear cells were isolated. Isolated cells were exposed to low-dose and high-dose boric acid and calcium fructoborate in cell culture. Treg and Th17 cell populations were analyzed by flow cytometry after 48 h of exposure. IL-2, IL-6, IL-17, IL-23, TNF-α, and TGF-β levels in the culture medium were tested by ELISA method. At the end of the study, in healthy controls, high-dose BA improved the Treg/Th17 population but could not display similar effects on RA and SLE group. However, both boric acid and calcium fructoborate at different doses showed an increasing effect on Ror-γt in RA and SLE group. Different doses of BA and CaF treatment found to have a variable effect on cytokine. Both BA and CaF in low doses decreased TNF-α levels in RA group which shows that these boron compounds could contribute positively to the treatment of autoimmune diseases.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotoxicity, Cytotoxicity, and Genotoxicity of Phyto-radio Synthesized Selenium Nanoparticles in Culex pipiens Complex. 植物放射性合成纳米硒粒子对喙库蚊的神经毒性、细胞毒性和遗传毒性

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-24 DOI: 10.1007/s12011-024-04418-8

H H Awad, I Abulyazid, E M S El-Kholy, H S Mohammed, H K Abdelhakim, A M Fadl

{"title":"Neurotoxicity, Cytotoxicity, and Genotoxicity of Phyto-radio Synthesized Selenium Nanoparticles in Culex pipiens Complex.","authors":"H H Awad, I Abulyazid, E M S El-Kholy, H S Mohammed, H K Abdelhakim, A M Fadl","doi":"10.1007/s12011-024-04418-8","DOIUrl":"https://doi.org/10.1007/s12011-024-04418-8","url":null,"abstract":"Effective mosquito management strategies are crucial to minimize the number of mosquito-borne diseases. Selenium nanoparticles (SeNPs) are promising in mosquito control because they are effective and eco-friendly rather than synthetic insecticides. The current study was conducted to evaluate the impact of SeNPs on the detoxification enzymes, acetylcholine esterase (AChE), glutathione S-transferase (GST), and α-carboxyl esterase (α-CarE), in larval instars of Culex pipiens complex at the LC50 concentration. In 3rd instar larvae treated with microwave-assisted selenium nanoparticles (SeNPs-MW) and gamma-assisted selenium nanoparticles (SeNPs-G), it was found that AChE activity was significantly inhibited. On the other hand, significant increases in GST and α-CarE activities were observed. Additionally, genotoxic and ultrastructure studies of midgut epithelial cells in 3rd instar larvae revealed DNA damage and cell lysis, including destruction of the cell membrane, microvilli, and nuclei. These findings suggest that SeNPs have an adverse effect on AChE gene expression, resulting in its downregulation. This downregulation can be attributed to the formation of reactive oxygen species induced by SeNPs that can modulate the host defense mechanism leading to apoptosis and subsequent larval mortality. The present study was the first to use phyto-microwave-assisted and gamma-assisted synthesis of SeNPs which provides an eco-friendly and cost-effective solution to reduce the risk of chemical insecticides. Furthermore, an integrated pest management program (IPM) using nanocides can be successfully developed for mosquito control.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Urinary Cadmium with Body Composition and Fat Distribution in US Adults: Findings from NHANES 2011-2018. 美国成年人尿镉与身体成分和脂肪分布的关系：2011-2018年NHANES调查结果。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-23 DOI: 10.1007/s12011-024-04423-x

Yue Teng, Suping Ren

{"title":"Associations of Urinary Cadmium with Body Composition and Fat Distribution in US Adults: Findings from NHANES 2011-2018.","authors":"Yue Teng, Suping Ren","doi":"10.1007/s12011-024-04423-x","DOIUrl":"https://doi.org/10.1007/s12011-024-04423-x","url":null,"abstract":"The effects of cadmium (Cd) on metabolic physiology remain controversial. Given the varying metabolic impacts associated with different body compositions, investigating the relationship between Cd exposure and body composition may facilitate further research. Here, the associations of body composition and fat distribution with urine Cd (UCd) were evaluated. This analysis included 2979 adult participants from the 2011-2018 National Health and Demographic Survey (NHANES). UCd was measured using inductively coupled plasma mass spectrometry and adjusted for urinary creatinine. Body composition and fat distribution were estimated using dual-energy x-ray absorptiometry (DXA). The study results show that UCd was negatively associated with fat mass index (FMI) and percent fat mass (p for trend < 0.001), and the negative correlation between UCd and FMI was stronger in males and smokers (all p for interaction < 0.05). In terms of abdominal fat distribution, UCd was negatively associated with abdominal subcutaneous adipose tissue (SAT) mass (p for trend < 0.001), but with abdominal visceral adipose tissue (VAT) mass only in those with low percent fat mass (< 32.3%) (p for trend = 0.026 and p for interaction < 0.05). UCd was positively related to percent VAT (p for trend < 0.001) and visceral-to-subcutaneous (VAT/SAT) ratio (p for trend = 0.003). And there was a significant negative association between UCd and android-to-gynoid (A/G) ratio (p for trend = 0.001). Meanwhile, UCd was negatively correlated with fat-free mass index (FFMI) (p for trend < 0.001). And the negative correlation between UCd and FFMI was stronger in males, smokers, and individuals with < 32.3 percent fat mass (all p for interaction < 0.05). We found the association of UCd with body composition and fat distribution, with distinct patterns observed in different demographic groups. These findings underscore the importance of considering UCd exposure in the context of body composition and fat distribution.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly. 碘过量与老年人甲状腺功能障碍有关

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-23 DOI: 10.1007/s12011-024-04420-0

Qi Jin, Zhangzhao Wang, Junjing Li, Hexi Zhang, Mengxin Liu, Chunxi Wang, Wenxing Guo, Wanqi Zhang

{"title":"Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly.","authors":"Qi Jin, Zhangzhao Wang, Junjing Li, Hexi Zhang, Mengxin Liu, Chunxi Wang, Wenxing Guo, Wanqi Zhang","doi":"10.1007/s12011-024-04420-0","DOIUrl":"https://doi.org/10.1007/s12011-024-04420-0","url":null,"abstract":"The relationship between high water iodine levels and thyroid dysfunction in the elderly remains poorly understood. This study aimed to elucidate how excessive iodine in drinking water affects iodine nutrition and thyroid function in the elderly population. This cross-sectional study was performed in the elderly in Yuncheng, Heze, Shandong. We identified a total of 385 patients with thyroid dysfunction and 385 propensity score-matched controls with euthyroid. Water, urinary, and blood samples were collected to detect the concentrations of iodine in water and urine, as well as thyroid hormones. The median (IQR) iodine concentrations in cooking water and drinking water for the total population were 294.99 (48.99, 478.14) µg/L and 172.87 (20.87, 462.13) µg/L, respectively. Among the elderly, median (IQR) urinary iodine concentration (UIC) was 394.20 (169.47, 764.41) µg/L, and 24-h urinary iodine concentration (24-h UIE) was 523.04 (277.84, 910.76) µg/day. Subjects with thyroid dysfunction reported higher intake of iodine from water (P < 0.001) and urinary iodine levels (P < 0.001) than controls. Logistic regression analysis showed thyroid dysfunction was associated with higher risks of elevated iodine concentrations in cooking water (OR 1.957, 95% CI 1.413-2.711), drinking water (OR 2.206, 95% CI 1.607-3.027), UIC (OR 3.612, 95% CI 2.494-5.230), and 24-h UIE (OR 2.568, 95% CI 1.784-3.698), indicating increased thyroid dysfunction risk among the elderly with high water iodine levels. Elevated iodine levels in water are associated with an increased risk of thyroid dysfunction among the elderly. Clinical trial registry number: Medical Ethics Committee of Tianjin Medical University; Trial registration number: NCT05716191, date of registration was December 08, 2023.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Mechanisms of Anti-tumoral Effect of Combination Therapy of Calcitriol and Sodium Pentaborate Pentahydrate on HepG2 Hepatocellular Carcinoma Cells. 探究骨化三醇与五硼酸钠联合疗法对 HepG2 肝细胞癌细胞的抗肿瘤作用机制

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2024-10-23 DOI: 10.1007/s12011-024-04416-w

Nurdan Sena Degirmenci, Gamze Padar, Fikrettin Sahin, Zehra Omeroglu Ulu

{"title":"Investigating the Mechanisms of Anti-tumoral Effect of Combination Therapy of Calcitriol and Sodium Pentaborate Pentahydrate on HepG2 Hepatocellular Carcinoma Cells.","authors":"Nurdan Sena Degirmenci, Gamze Padar, Fikrettin Sahin, Zehra Omeroglu Ulu","doi":"10.1007/s12011-024-04416-w","DOIUrl":"https://doi.org/10.1007/s12011-024-04416-w","url":null,"abstract":"Hepatocellular carcinoma (HCC) is one of the most common primary liver cancers worldwide and is often associated with poor prognosis due to drug resistance. Combination therapies demonstrate superior efficacy at lower drug dosages on cancer cells compared to single treatments, resulting in less drug resistance in the cells. This study investigates the synergistic anti-tumoral effects of calcitriol, the biologically active form of vitamin D, and sodium pentaborate pentahydrate (NaB) on HepG2 cells. We examined the cell viability of NaB, calcitriol, or the combination of NaB and calcitriol on HepG2 cells and healthy human hepatic stellate cells (HHSC) using MTS. Our findings showed that combination therapy with 3.3 mM NaB and 1 µM calcitriol has a synergistic effect and a more cytotoxic effect on HepG2 cells. This combination significantly increased apoptosis and ROS levels compared to treatment alone with NaB or calcitriol. Gene expression and proteomics analysis revealed inhibition of DNA replication and the cell cycle process, further confirming the potent anti-proliferative effects of the combination therapy. When HepG2 cells were treated with a combination of 3.3 mM NaB and 1 µM calcitriol, mRNA levels of apoptosis-related genes AKT1 and MDM2 were downregulated, while p53 was upregulated. Additionally, cell cycle-related genes CDKN1A, GADD45A, and p27 were upregulated, whereas MCM2, MCM5, and MCM7 were downregulated. Furthermore, genes associated with the vitamin D receptor (VDR), including VDR and CYP24A1, were upregulated, while CYP27B1 was downregulated. Our proteomic analysis revealed decreased MCM2 and MCM5 protein expressions which was confirmed by western blotting. In conclusion, this study highlights the potential of NaB and calcitriol as a promising therapeutic strategy for HCC.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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