Biological Trace Element Research最新文献

{"title":"Rare Earth Element and Yttrium Fingerprints in Human Kidney Stones: Tracing Environmental Exposure and Pathological Mineralization Pathway.","authors":"Di Wang, Guilin Han, Chaochun Fu, Wenqian Sun, Ziyang Ding, Haibo Li","doi":"10.1007/s12011-026-05278-0","DOIUrl":"https://doi.org/10.1007/s12011-026-05278-0","url":null,"abstract":"<p><p>Rare earth elements and yttrium (REE + Y) are increasingly mobilized in modern environments, affecting human physiological processes through multiple exposure pathways. Pathological biominerals, such as kidney stones, may provide valuable records of long-term elemental deposition. However, it remains unclear whether REE + Y directly inherit environmental signals or are reshaped by physiological and mineralogical processes. This study analyzed kidney stones from a high-incidence karst region in eastern Yunnan, China. The results indicate that regional hydrogeochemical background and the mineralogical pathways jointly control the REE + Y distribution of kidney stones. Fourier transform infrared spectroscopy combined with non-negative matrix factorization identified the dominant spectral components and their relative proportions in the stones. The total REE + Y load was mainly controlled by the dominant mineral phase, with the median in uric acid stones (36.4 ng/g) remaining significantly lower than in calcium-bearing stones (up to 218.2 ng/g). This study further found that increasing phosphate proportions were significantly correlated with weaker Yb anomalies and higher Lu concentrations, whereas total REE concentrations showed no significant change. Unsupervised and supervised model analyses demonstrated that REE + Y distribution patterns can reliably distinguish stones with different dominant mineral types. These results indicate that REE + Y are sensitive to biomineralization processes in kidney stones and may serve as potential tracers for apatite incorporation in calcium-bearing stones. Moreover, although human metabolism and biomineralization filter most environmental signals, the light REE-enriched patterns in calcium-bearing stones are broadly compatible with the karst hydrogeochemical background. Overall, this study reveals the REE + Y fingerprints support precise subtyping of kidney stones, serving as composite geochemical archives reflecting both environmental signals and pathological biomineralization.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Lead Levels and Mortality Risk in Cancer Patients: A Prospective Cohort Study with Mediation and Pan-Cancer Pathway Analysis.","authors":"Jiukang Sun, Wenyuan Gan, Jing Zhou, Wenlou Liu, Zhengxiang Han","doi":"10.1007/s12011-026-05270-8","DOIUrl":"https://doi.org/10.1007/s12011-026-05270-8","url":null,"abstract":"<p><p>Blood lead levels were associated with increased mortality in cancer patients, with mediation analyses suggesting a partial role of oxidative stress and inflammation, and heterogeneity across cancer types linked to Hallmark pathway activity. We analyzed 2,689 cancer patients from NHANES (1999-2016) using Cox regression, restricted cubic spline, and mediation analyses. Over 22,151.5 person-years, 983 deaths occurred. Compared with the lowest quartile, the highest blood lead quartile was associated with increased all-cause mortality (HR = 2.44; 95% CI: 1.79-3.34) and cancer mortality (HR = 2.34; 95% CI: 1.20-4.46). Lipid-adjusted inflammation indicators-including uric acid-to-high-density lipoprotein ratio (UHR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory response index (SIRI)-mediated 4.51-5.72% of the association, supporting partial mediation through oxidative stress and inflammation. The effect varied by cancer type and correlated with TCGA Hallmark pathway activities, including KRAS signaling (ρ = -0.95) and xenobiotic metabolism (ρ = 0.79), suggesting that molecular context modulates lead toxicity.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brewing Time and Lemon Juice as Factors Affecting the Elemental Composition in Commercial Tea Infusions.","authors":"Magdalena Sęk, Urszula Cięciel, Michał Halagarda","doi":"10.1007/s12011-026-05299-9","DOIUrl":"https://doi.org/10.1007/s12011-026-05299-9","url":null,"abstract":"<p><p>Tea is one of the most widely consumed beverages worldwide and can contribute to dietary exposure to both essential and potentially toxic elements. This study investigated the effects of brewing time and lemon juice addition on the concentrations and multivariate relationships among selected metals in commercial black tea infusions. Brewing time significantly affected the concentrations of Pb, Cd, Mn, and Al, whereas acidification through lemon juice addition influenced Pb, Cr, Zn, Cu, Mn, and Al. Prolonged brewing increased Mn and Al concentrations but reduced Pb and Cd levels. Lemon juice addition enhanced the concentrations of Al, Mn, Zn, and Cr while decreasing Cu concentration in the infusions. Principal component analysis demonstrated that acidification was the primary factor shaping the elemental profile of tea infusions, exerting a greater influence than brewing time. The strongest responses to both experimental factors were observed for Mn and Al, whose concentrations increased markedly under acidic conditions and with extended brewing time. Despite these changes, the contribution of Ni, Al, Zn, Cu, Pb, Cd, and Cr to dietary intake or exposure remained low across all brewing variants. In contrast, tea infusions represented a substantial source of Mn, providing approximately 30-60% of the adequate intake, depending on preparation conditions. These findings indicate that common brewing practices can significantly modify the elemental composition of black tea infusions, with acidification having a stronger effect than extraction time. Nevertheless, consumption of the investigated teas is unlikely to pose a significant health risk and may contribute beneficially to manganese intake.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Pattern, Food Selenium and Environmental Stress Regulating the Urinary Selenium in Tibetan Population.","authors":"Li Wang, Feifei Li, Chang Kong, Hairong Li, Lijuan Gu, Hongqiang Gong, Linsheng Yang, Binggan Wei, Cangjue Nima, Yangzong Deji, Shengcheng Zhao, Min Guo, Zongji Gesang, Rujun Li","doi":"10.1007/s12011-026-05293-1","DOIUrl":"https://doi.org/10.1007/s12011-026-05293-1","url":null,"abstract":"<p><p>Tibetan Plateau, which was once a severe endemic area of Kashin-Beck disease (KBD), was low with selenium in the soil geochemical background and with harsh environment, thus resulting in selenium deficiency in local foods while high environmental-derived oxidative stress and inflammatory responses in human body. Diet was the major selenium source for humans, while external environment conditions could influence selenium consumption and disturb the selenium metabolism. This study explored the influence on urinary selenium of Tibetan population from the pespevtive of selenium intake, represented by food patterns and selenium concentration, and from the perspective of selenium metabolism caused by environmental stress. From 2019 to 2022, 572 food consumption questionnaires of Tibetan residents, matched urine samples, staple food samples, and local agricultural soil and water samples were collected. Environmental stressors, including absolute oxygen concentration, temperature-humidity index and ultraviolet radiation intensity were considered. Statistical analysis and Random Forest (RF) were used to explore the association, contribution importance and interactive effect of the factors above on urinary selenium concentrations. Urinary selenium concentrations of Tibetan residents were still generally low, declined with age whereas no difference was found between genders. In terms of food consumption patterns, dietary diversity score (DDS) and non-local food intake, poultry consumption frequency in particular were positively associated with urinary selenium, exerted a pro-linear relationship. Highland barley and wheat flour selenium concentrations showed positive impact on the urinary selenium concentrations, and the magnitude of impact was more obvious when the highland barley selenium concentration exceeded 0.04 µg/g, and the wheat flour selenium concentration was lower than 0.051 µg/g. The soil and water selenium concentrations also positively influenced the urinary selenium concentrations. Environmental stressors exerted distinct influencing curves on urinary selenium concentrations, with higher ultraviolet radiation intensity (UVRI) and lower environmental comfort induced by cold and dry conditions positively regulating urinary selenium concentrations, while oxygen concentration exhibited a marginal effect only when it reached a certain threshold. Food diversity, non-local food intake, staple food selenium concentrations and local agricultural selenium concentrations were all important factors for elevating the selenium status among Tibetan residents. Environmental stressors regulated the urinary selenium concentrations differently due to the divergent action pathways on the selenium depletion and metabolism. Correspondingly, increasing the food diversity through introducing non-local food, increasing the selenium level of local food and elevating the human selenium reference standards were suggested.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Serum Zinc Levels, Conventional and Novel Anthropometric Indices in Postmenopausal Women in Montenegro - a Cross-Sectional Study.","authors":"Aleksandra Klisic, Dijana Djurovic, Nevena Cupara, Paschalis Karakasis, Ana Ninić","doi":"10.1007/s12011-026-05295-z","DOIUrl":"https://doi.org/10.1007/s12011-026-05295-z","url":null,"abstract":"<p><p>Hormonal disturbances that women in postmenopause face favor increased redistribution of fat into visceral compartments, leading to central obesity and related disorders. The mechanisms underlying dysregulated zinc (Zn) metabolism in individuals with obesity and related disorders remain unresolved. This study aimed to investigate the association between serum Zn levels and conventional and novel anthropometric parameters in the cohort of postmenopausal women in Montenegro. A cohort of 94 postmenopausal women (mean age 64.55 ± 8.71 years) was consecutively included. Zn determination was performed using inductively coupled plasma optical emission spectrometry. Multivariable ordinal logistic regression analysis was used to estimate associations of demographic data, obesity-related scores, and laboratory markers with Zn tertile levels. Serum Zn levels were negatively correlated with conventional [body mass index (BMI) and waist-to-height ratio (WHtR)] and novel [body adiposity index (BAI), body roundness index (BRI), and cardiometabolic index (CMI)] anthropometric parameters in postmenopausal women. Although no difference in hip circumference and height across Zn tertiles was found, the BAI, as a composite index of both parameters, showed an association with serum Zn levels. Similarly, despite no difference in waist circumference across Zn tertiles, the BRI as a composite index of waist circumference and height was correlated with Zn levels. Serum Zn concentrations were positively associated with HDL-C levels, but not with other lipid parameters. The measurement of new anthropometric parameters, in addition to traditional ones, may add a contribution to the relationship between adiposity indices and serum Zn levels in postmenopausal women.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Ameliorating Nickel-Induced Stress in Hypophthalmichthys molitrix (Silver Carp) Through Piper nigrum Extract Supplementation.","authors":"Syed Muhammad Farhan Ali Shah, Syed Makhdoom Hussain, Shafaqat Ali, Pallab K Sarker, Khalid A Al-Ghanim, Sunakbaeva Dilara","doi":"10.1007/s12011-026-05281-5","DOIUrl":"https://doi.org/10.1007/s12011-026-05281-5","url":null,"abstract":"","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Sodium Hypochlorite Washing on Eggshell Membrane Integrity, Microbial Decontamination, and Trace Element-Related Dietary Risk in Poultry and Duck Eggs.","authors":"Mahfuzur Rahman, Claudia Ionita, Mohammad Amirul Islam, Kay Cooksey, Omer Sadak","doi":"10.1007/s12011-026-05274-4","DOIUrl":"https://doi.org/10.1007/s12011-026-05274-4","url":null,"abstract":"<p><p>This study examined baseline trace element exposure in poultry and duck eggs consumed in Bangladesh and assessed the impact of sodium hypochlorite (NaOCl) washing on microbial decontamination and eggshell membrane integrity. Fifteen elements were measured in yolk, albumen, and whole egg samples using instrumental neutron activation analysis (INAA) and atomic absorption spectrometry (AAS). Most elements were below maximum allowable concentrations; however, Pb and Cr exceeded permissible limits in some whole egg samples. Despite this, exposure-related risks, including estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and target carcinogenic risk (TCR), remained within acceptable limits for both adults and children. Multivariate analyses, such as principal component analysis (PCA) and hierarchical cluster analysis (HCA), revealed distinct clustering patterns and relationships among elements across different egg parts and species. In addition, eggs were treated with 0-200 ppm NaOCl to evaluate microbial reduction and structural effects on the eggshell membrane. NaOCl treatment significantly reduced total bacterial and fungal loads, with 150 and 200 ppm reducing cultivable microorganisms to below the detection limit (10 CFU g⁻¹). Moderate NaOCl levels effectively enhanced microbial safety, while higher concentrations caused oxidative modifications and structural deterioration of the eggshell membrane.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manganese Gluconate as a Safe Trace Element Supplement Enhances Immune Function and Resistance to Staphylococcus aureus Infection in Broilers.","authors":"Changquan Liu, Shuyu Wei, Ming Xu, Mingyang Tao, Youxi Fu, Kexin Liu, Siqi Wang, Simiao Yu, Beiyan Wang, Liquan Yu, Baifen Song, Jinzhu Ma","doi":"10.1007/s12011-026-05291-3","DOIUrl":"https://doi.org/10.1007/s12011-026-05291-3","url":null,"abstract":"<p><p>Manganese is an essential trace element with known immunomodulatory properties, yet the effects of organic manganese supplementation on disease resistance in poultry remain poorly understood. This study evaluated the safety and immunoprotective efficacy of orally administered manganese gluconate in yellow-feathered broilers. A total of 120 seven-day-old broilers were randomly allocated to four groups and orally administered either vehicle control or manganese gluconate at 1, 5, or 10 mg/kg body weight for 14 consecutive days. No adverse health responses were observed across all treatment groups, confirming the safety of manganese gluconate within this dosage range. At the optimal dosage, manganese gluconate significantly promoted splenic lymphocyte proliferation (CCK-8 assay), upregulated the expression of key cytokines (IL-2, IL-4, IL-10, TNF-α), improved serum antioxidant status (T-AOC, T-SOD, GSH-PX, MDA), enhanced specific anti-S. aureus IgG production, and strengthened peritoneal macrophage-mediated phagocytosis of S. aureus. Following intraperitoneal challenge with S. aureus Newman strain (1 × 10¹⁰ CFU/bird), manganese gluconate effectively reduced bacterial colonization in the liver, spleen, and kidney, and improved the survival rate of infected broilers. These findings demonstrate that manganese gluconate is a safe and effective nutritional supplement that enhances immune function and increases resistance to bacterial infection in broiler production.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium Nanoparticles Alleviate Intestinal Epithelial Barrier Dysfunction by Coordinating Mitochondria-lysosome Communication under Dual Organelle Stress.","authors":"Jiajing Chang, Xiaonan Zeng, Runan Zhang, Tiantian Li, Qianqian Gao, Xina Dou, Chunlan Xu","doi":"10.1007/s12011-026-05287-z","DOIUrl":"https://doi.org/10.1007/s12011-026-05287-z","url":null,"abstract":"<p><p>Intestinal barrier homeostasis is closely associated with coordinated signaling between mitochondria and lysosomes. Although our previous studies demonstrated the barrier-protective effects of biogenic selenium nanoparticles (SeNPs), the inter-organelle signaling mechanisms underlying this protection under dual-organelle stress remain unclear. In the present study, we established a targeted dual-injury model in IPEC-J2 cells using chloroquine (CQ) and 2,4-dinitrophenol (DNP) to investigate the signaling events governing mitochondria-lysosome communication. Combined exposure to CQ and DNP profoundly disrupted organelle homeostasis, as evidenced by severe adenosine triphosphate (ATP) depletion, elevated intracellular reactive oxygen species (ROS) and mitochondrial superoxide production, impaired lysosomal acidification, and altered autophagy-related processes. These synergistic insults ultimately promoted apoptosis, induced tight junction disassembly, and increased epithelial permeability. Notably, SeNPs pretreatment significantly upregulated the mRNA expression of key selenoproteins, including SELENOF, SELENOS, and SELENOP, and restored the activities of the selenium-dependent antioxidant enzymes glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). This restoration of antioxidant capacity attenuated intracellular ROS and mitochondrial superoxide accumulation and restored the bioenergetic support required for autophagy-related processes and lysosomal acidification. Mechanistically, restoration of intracellular redox homeostasis by SeNPs prevented oxidative stress-induced dissociation of the TBC1D15/Rab7/Fis1 complex, a key tethering axis involved in mitochondria-lysosome communication. Stabilization of this complex was accompanied by improved autophagy-lysosome homeostasis and preservation of intestinal epithelial barrier integrity. Collectively, these findings demonstrate that biogenic SeNPs preserve intestinal epithelial barrier integrity under dual-organelle stress by enhancing selenoprotein-mediated antioxidant defense, thereby stabilizing mitochondria-lysosome tethering and restoring inter-organelle communication.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Deficiency in Athletes.","authors":"Takako Fujii","doi":"10.1007/s12011-026-05289-x","DOIUrl":"https://doi.org/10.1007/s12011-026-05289-x","url":null,"abstract":"<p><p>Iron, although present in trace amounts, is a crucial micronutrient in the human body. It plays a significant role in essential bodily functions such as oxygen transport and energy metabolism. For athletes, particularly those engaged in endurance activities with high oxygen demands, iron is an indispensable nutrient. Despite its importance, a notable number of athletes experience iron deficiency. Research has suggested a connection between exercise performance and iron regulation, leading to increased focus on how these two factors interact. The aim of this study was to investigate how various types of exercise affect the body's iron reserves, the specific iron needs associated with different forms of physical activity, and the prevalence of iron deficiency linked to chronic inflammation.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}