Biological Trace Element Research最新文献

{"title":"Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.","authors":"Junwang Gu, Huishen Huang, Jun Liang, Qian Liao, Peng Tang, Ying Tang, Jinghua Long, Jiehua Chen, Dongping Huang, Dongxiang Pan, Xiaoyun Zeng, Xiaoqiang Qiu","doi":"10.1007/s12011-025-04561-w","DOIUrl":"https://doi.org/10.1007/s12011-025-04561-w","url":null,"abstract":"<p><p>Prospective studies examining early maternal exposure to trace metal (TM) mixtures and their effects on offspring remain limited. We analyzed data regarding maternal plasma trace metal concentrations and bone mineral density (BMD) for 220 children aged 3-6 years from the Guangxi Zhuang Birth Cohort. Inductively coupled plasma-mass spectrometry was used to measure 22 trace metal concentrations-Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, Sb, Cs, Ba, W, Tl, Pb, and U-in maternal plasma samples collected before 13 weeks of gestation. BMD Z-scores in children were assessed using quantitative ultrasound. Generalized linear models, restricted cubic spline (RCS) models, principal component analysis, Bayesian kernel machine regression, and quantile-based g-computation (qgcomp) were used to evaluate the associations between maternal plasma metal levels and BMD Z-scores in the child. Higher maternal Fe concentration was correlated with lower child BMD Z-scores (β [95% confidence interval]: - 1.374 [- 2.426 to - 0.323], p = 0.011). Increased Pb exposure was correlated with higher Z-scores (β [95% CI]: 1.035 [0.150-1.920], p = 0.023), corroborated by the RCS model (p = 0.031). Ti levels exceeding the median were associated with increased BMD Z-scores (p = 0.027). Increased BMD in children was associated with higher levels of metal mixtures, including Mn, V, Ti, U, Ni, Zn, Sr, Pb, W, and Co. Pb appears to play a primary role in this effect. TM exposure during early pregnancy is associated with BMD in children; however, additional longitudinal and experimental studies are required to confirm this conclusion.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Long-Term Dietary Cobalt Supplementation on Lactation Performance and Reproductive Efficiency in Maghrabi She-Camels.","authors":"Mohamed S Ayyat, Usama M Abdel Monem, Tarek H Mostafa, Rafiq M Thabet, Khaled M Abd El-Latif, Adham A Al-Sagheer","doi":"10.1007/s12011-025-04551-y","DOIUrl":"https://doi.org/10.1007/s12011-025-04551-y","url":null,"abstract":"<p><p>This study examined the effects of cobalt supplementation, given from three months prepartum to nine months postpartum, on lactation performance, reproductive efficiency, blood biochemistry, colostrum immunoglobulin levels, and hormonal profiles in she-camels, along with the growth of their calves. Twenty Maghrabi she-camels, weighing 489 ± 2.31 kg and aged 6-9 years, were used in this study. The camels were divided into four groups: one control group fed only the basal diet, and three treatment groups receiving 0.16, 0.32, and 0.48 mg of cobalt per kg of feed as cobalt glucoheptonate. Results indicated that cobalt supplementation significantly increased colostrum immunoglobulin concentrations (IgG, IgM, and IgA), as well as monthly milk yield and lactation period. Milk contents of total solids, protein, and lactose also improved in the supplemented groups, particularly at 0.32 mg/kg cobalt. Additionally, pre- and post-partum serum cobalt, vitamin B₁₂, T3, T4, progesterone, and estradiol levels were higher in the cobalt-treated groups. Enhanced reproductive outcomes included shorter postpartum intervals to first estrus, reduced services per conception, and improved weaning weights and average daily gains of calves in all cobalt-supplemented groups. In conclusion, dietary cobalt supplementation at a level of 0.32 mg/kg from three months prepartum to nine months postpartum significantly enhanced the lactation and reproductive performance of Maghrabi she-camels, increased colostrum immunoglobulin levels, and positively affected the growth performance of their calves.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercury Levels in Selected Medicines and Dietary Supplements in Poland.","authors":"Barbara Brodziak-Dopierała, Agnieszka Fischer, Bożena Ahnert","doi":"10.1007/s12011-024-04269-3","DOIUrl":"10.1007/s12011-024-04269-3","url":null,"abstract":"<p><p>Current trends are promoting youth, beauty, health, and fitness. Individuals often seek out remedies, such as medicines or dietary supplements (DS), to achieve these goals. However, highly processed foods, chronic stress, and environmental pollution contribute to the development of civilization diseases. The aim of this study was to evaluate the mercury (Hg) content in medicines and DS that are available in Poland. A total of 139 preparations were tested (75 drugs, 64 DS). The medicines contained preparations belonging to antibacterial, antiviral, antifungal; analgesic, antipyretic, and anti-inflammatory; heart and blood vessel disease preventatives; respiratory tract infections treatment; diuretics; aiding digestion; supplements; antidiarrhoeals; anti-allergics; anti-rheumatics; antibiotics; and others. The tested dietary supplements had an effect on the following: improve the condition of skin, hair, and nails; vitamins; minerals; probiotics; weight loss; special for women; and others. The Hg content of the samples was determined using atomic absorption spectrometry (AAS). The Hg content of all the preparations varied widely (0.1-57.4 µg/kg), with a median Hg concentration of 1.2 µg/kg. The median Hg concentration for medicines was 0.8 µg/kg, prescription medicines having higher Hg concentrations (0.9 µg/kg) than over-the-counter (OTC) drugs (0.5 µg/kg). For DS, the Hg content was found to be higher than for drugs, at 2.0 µg/kg. The herbal preparations showed the highest Hg content among the individual DS groups (3.4 µg/kg). The Hg concentrations in the tested drug and DS samples did not exceed acceptable standards. However, if multiple pharmaceutical preparations are taken simultaneously over a long period of time, and there is existing environmental exposure, there is a possibility of Hg concentration accumulation and adverse health effects.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1685-1700"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141455039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Heavy Metal and Specific Trace Elements Levels Among Fast-Food Workers and Their Susceptibility to Atherosclerosis.","authors":"Falah S Al-Fartusie, Muntaha A Mohammed, Mohammed Z Thani, Safaa Kader, Roaa M Khadim","doi":"10.1007/s12011-024-04262-w","DOIUrl":"10.1007/s12011-024-04262-w","url":null,"abstract":"<p><p>Fast-food workers in Iraq face significant health risks due to exposure to heavy metals from fumes and dust during cooking activities. Heavy metals, such as lead (Pb), cadmium (Cd), and nickel (Ni), are toxic to cells even at low concentrations and can cause health risks, including atherosclerosis, due to oxidative stress and reduced antioxidant activity. To the best of our knowledge, this is the first study assess the levels of heavy metals in fast-food workers and investigate their potential link to atherosclerosis development by monitoring the levels of copper (Cu), zinc (Zn), magnesium (Mg), manganese (Mn), and iron (Fe). A total of 120 male participants aged between 20 and 40 years were included in the study, with 40 fast-food workers, 40 patients with atherosclerosis, and 40 healthy individuals evaluated. The levels of Pb, Cd, Ni, Cu, Zn, Mg, Mn, and Fe in all blood samples were determined using atomic absorption spectrometry. Results showed that the fast-food worker group had significantly higher levels of Pb, Cd, Cu, and Fe compared to the healthy control group, with increases of 57%, 75%, 30%, and 55%, respectively. Conversely, their levels of Zn and Mg were significantly lower, decreasing by 15% and 16%, respectively. On the other hand, the atherosclerosis patients' group had significantly higher levels of Pb, Cd, Cu, and Fe, with increases of 47%, 74%, 34%, and 28%, respectively, as well as significantly lower levels of Zn and Mg, decreasing by 17% and 21%, respectively, compared to the control group. These findings suggest that fast-food workers are at risk of developing atherosclerosis due to exposure to high levels of heavy metals and imbalances in essential trace elements. The results showed a significant increase in the levels of Pb and Cd in the sera of these workers, which was expected because of the long duration and high intensity of exposure to toxic heavy metals. This is a serious indicator that must be considered, as it has been previously established that increased levels of Pb and Cd in the body are linked to the risk of atherosclerosis. Additionally, an association between Pb and Cd levels and an imbalance in trace element levels (Cu, Zn, Mg, and Fe) were observed. The Implementation of stricter regulations and guidelines for maintaining cleanliness and safety in fast-food restaurants may be crucial for protecting workers and preventing long-term health complications.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1317-1326"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141327200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adequate Levels of Zinc and Copper on Turkey Poult Performance, Immunological Response, and Skeletal Health.","authors":"Jayanti L Agashe, Chandra Deo, Avishek Biswas, Divya Sharma, Mukesh T Nampalle, Ashok Kumar Tiwari","doi":"10.1007/s12011-024-04257-7","DOIUrl":"10.1007/s12011-024-04257-7","url":null,"abstract":"<p><p>In this study, the impact of varying dietary zinc (Zn) and copper (Cu) levels on the growth, immunological response, and skeletal health of developing turkey poults was investigated. For 0-4 and 5-8 weeks of age, respectively, three Zn levels of 50, 70, and 90 mg/kg and 45, 65, and 85 mg/kg were employed. Three Cu levels, namely 8, 12, and 16 mg/kg for 0-8 weeks of age, were also utilized. There were 288 (9 × 4 × 8) day-old turkey poults with equal body weight that were randomly assigned to 9 treatments, each consisting of 4 replicates and 8 poults per replicate. In comparison to other dietary combinations, there was a significant (P ≤ 0.05) increase in body weight gain observed in the 90 and 85 mg Zn/kg with 16 mg Cu/kg diet during 0-4 and 0-8 weeks of age, respectively, and the 70 and 65 mg Zn with 16 mg Cu /kg diet during 0-4 and 0-8 weeks of age, respectively. When compared to low levels of zinc in the diet at 5-8 and 0-8 weeks of age, respectively, feed conversion ratio was shown to be significantly (P ≤ 0.01) better with 90 and 85 mg Zn/kg diet. In a similar pattern, feed utilization efficiency was considerably (P ≤ 0.01) higher at 16 mg Cu/kg diet than it was at lower Cu levels in the diets given to the animals over the 0-4 week period. Compared to other dietary combinations, there was a substantial (P ≤ 0.01) improvement in cell-mediated immune response (foot web index to PHAP) and humoral immune response (HA titer to SRBC) when 85 mg zinc and 16 mg copper/kg diet was consumed at 0-4 and 5-8 weeks of age. At greater dietary Zn and Cu levels than its lower values, the weight of the spleen and thymus was considerably (P ≤ 0.05) higher. In a dietary combination of 90 mg Zn with 16 mg Cu/kg during 0-4 and 85 mg Zn with 16 mg Cu/kg diet during 5-8 weeks of age, respectively, there were significantly (P ≤ 0.05) greater bone width (proximal and distal), tibia bone ash, calcium, and phosphorus detected respectively. Significantly (P ≤ 0.01) greater Zn and Fe contents were found in the tibia bone at 90 and 85 mg Zn/kg diet, respectively, compared to values obtained at other Zn levels in the diet throughout 0-4 and 5-8 weeks of age. During the first 8 weeks of life, a diet containing 12 mg of copper per kilogram was shown to have a significantly (P ≤ 0.05) increased Zn and Fe content in the tibia bone compared to other levels. It is possible to draw the conclusion from the data that, for growing turkey poults, dietary combinations of 90 mg Zn/kg with 16 mg Cu/kg diet and 85 mg Zn with 16 mg Cu/kg diet between 0 and 4 and 5-8 weeks of age, respectively, were sufficient for optimum development, immunity, and skeletal health indices.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1609-1617"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141309865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of Plant-Based Nanotechnology in Cancer Immunotherapy: Benefits, Limitations, and Future Perspectives.","authors":"Ashish Pandey, Ines Karmous","doi":"10.1007/s12011-024-04266-6","DOIUrl":"10.1007/s12011-024-04266-6","url":null,"abstract":"<p><p>Reconceptualizing cancer immunotherapy can be improved if combined with plant production systems and nanotechnology. This review aims to contribute to the knowledge of plant use in nanomedicine and cancer immunotherapy. In the foreground, we outlined each of these approaches; nanomedicine, green synthesis, and immunotherapy. The benefits of plant-based nanoparticles in mending the immune systems were subsequently analyzed, with reference to the literature. The combining effects of biological and therapeutic properties of some phytochemicals and their derivatives, with targeted nanoparticles and selective immunotherapy, can enhance the delivery of drugs and antibodies, and induce antitumor immune responses, via activation of functions of neutrophils, lymphocyte cells, and natural killer cells, and macrophages, resulting in induced apoptosis and phagocytosis of tumor cells, which can improve designing immunotherapeutic strategies targeting cancer, with a larger spectrum compared to the current cytotoxic anticancer drugs commonly used in clinics. This study uncovers the mechanistic drivers of cancer immunoengineering in cancer therapy using plant-based nanomaterials, enhancing therapeutic benefits while minimizing toxic and side effects.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1746-1763"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Hair Toxic and Essential Trace Element and Mineral Profiles of Patients with Chronic Gout.","authors":"Anatoly V Skalny, Tatiana V Korobeinikova, Tatiana I Sotnikova, Serafima Ia Tazina, Galina D Morozova, Xiong Guo, Feng Zhang, Sergey V Nekhoroshev, Yujie Ning, Alexey A Tinkov","doi":"10.1007/s12011-024-04273-7","DOIUrl":"10.1007/s12011-024-04273-7","url":null,"abstract":"<p><p>The objective of the present study was to evaluate hair levels of toxic and essential trace elements and minerals in male and female patients with chronic gout. A total of 223 examinees aged from 27 to 82 years old including 116 healthy controls (64 women and 52 men) and 107 patients with gout (56 women and 51 men) were enrolled in the current cross-sectional study. Analysis of hair toxic and essential trace element and mineral content was performed using inductively-coupled plasma mass-spectrometry. The obtained data demonstrate that hair B, Fe, I, and Mo levels in gout patients were 67%, 8%, 46%, and 21% higher in comparison to the respective control values. Hair Cr and V content in patients was more than twofold higher than in the controls. Hair Mg and Zn levels were found to be 34% and 11% lower when compared to the respective control values. Hair toxic metal and metalloid content was also significantly affected in gout patients. Specifically, hair Al, As, and Pb levels were 24%, 43%, and 33% higher in gout patients than in healthy controls, respectively. Analysis of covariance demonstrated that sex also had a significant influence on hair trace element and mineral levels in gout patients. Specifically, gout-associated overaccumulation of hair trace elements including was more profound in male than in female patients. It is assumed that trace element dysregulation may contribute to gout development and progression, especially in men. However, further studies are required to elucidate this association and the underlying molecular mechanisms.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1351-1361"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Cadmium and Lead Co-exposure on Sleep Status in Rural Areas Northwestern China.","authors":"Min Huang, Honglong Zhang, Haiping Wang, Jingping Niu, Bin Luo, Gang Wu, Xun Li, Jun Yan","doi":"10.1007/s12011-024-04243-z","DOIUrl":"10.1007/s12011-024-04243-z","url":null,"abstract":"<p><p>In this study, we explored how cadmium and lead co-exposure affects sleep status among residents of a polluted area and nature reserve in rural northwestern China. Cadmium and lead levels were measured using blood samples, and sleep status was evaluated using sleep questionnaires, with the main sleep indicators including sleep duration, sleep quality, bedtime, and staying up. Furthermore, cadmium-lead co-exposure levels were divided into three groups: high exposure, medium exposure, and low exposure. Subjects in the contaminated area had significantly higher exposure levels (p < 0.001) and more negative sleep indicators (p < 0.01). Significant differences were found for all four sleep indicators in the high exposure group compared to the low exposure group (p < 0.01). Moreover, the overall evaluation of sleep status with high cadmium-lead co-exposure had a negative impact. Our data suggest that cadmium-lead co-exposure has a negative effect on sleep status and may have a synergistic effect on sleep.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1241-1250"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Using Selenium-enriched Mutated Probiotics as Enhancer for Fertility Parameters in Mice.","authors":"Ahmed Mohamed Darwish, Abdulrahman A Almehiza, Abd El-Nasser Khattab, Hafiza A Sharaf, Ahmed M Naglah, Mashooq A Bhat, Amer Alhag Zen, Atef Kalmouch","doi":"10.1007/s12011-024-04252-y","DOIUrl":"10.1007/s12011-024-04252-y","url":null,"abstract":"","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1786"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141183865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Serum Zinc and Non-Alcoholic Fatty Liver Disease and Advanced Liver Fibrosis: NHANES 2011-2016.","authors":"Miaomin Ye, Yijia He, Yin Xia, Ziyi Zhong, Xiaocen Kong, Yunting Zhou, Wenqing Xia, Weiping Wang, Huan Fan, Lu Chen, Xiaohui Wu, Qian Li","doi":"10.1007/s12011-024-04261-x","DOIUrl":"10.1007/s12011-024-04261-x","url":null,"abstract":"<p><p>Limited and inconclusive evidence exists regarding the correlation between serum zinc levels and non-alcoholic fatty liver disease (NAFLD) and advanced fibrosis. The objective of this cross-sectional study was to investigate the association between serum zinc concentration and both NAFLD and advanced liver fibrosis among the United States (US) adults. 3398 subjects from National Health and Nutrition Examination Survey (NHANES) 2011-2016 were included. Serum zinc concentration was measured by inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS). NAFLD was diagnosed with Hepatic Steatosis Index (HSI), and advanced fibrosis risk was assessed by NAFLD Fibrosis Score (NFS). Weighted logistic regression and restricted cubic splines (RCS) were used to examine the association between serum zinc concentration and NAFLD and advanced fibrosis. Linear trend tests were conducted by incorporating the median of serum zinc quartiles as a continuous variable in the models. We employed sensitivity analysis and subgroup analysis to enhance the robustness of our results. The results from the RCS regression revealed no evident nonlinear relationship between serum zinc concentration and the presence of NAFLD and advanced fibrosis (p-nonlinear > 0.05). Compared with those in the lowest quartile (Q1) of serum zinc concentrations, the odds ratios (95% confidence intervals) of NAFLD were 1.49 (0.89,2.49) in Q2, 0.99 (0.68,1.45) in Q3, and 2.00 (1.40,2.86) in Q4 (p-trend = 0.002). Similarly, the odds ratios (95% confidence intervals) for advanced fibrosis in Q2-4 compared to Q1 were 0.86 (0.50,1.47), 0.60 (0.26,1.39), and 0.41 (0.21,0.77), respectively (p-trend = 0.006). Subgroup analyses and sensitivity analyses reinforce the same conclusion. The investigation revealed a positive linear relationship between serum zinc concentrations and the probability of developing NAFLD. Conversely, an inverse correlation was observed between serum zinc concentrations and the incidence of advanced liver fibrosis among individuals diagnosed with NAFLD.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1305-1316"},"PeriodicalIF":3.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141299921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}