Biological Trace Element Research最新文献

{"title":"Effect of NiCl2 Intake Through Respiratory Tract on Antioxidant Capacity, Lung, and Trace Element Content in Mice.","authors":"Aifei Du, Shaohua Feng, Xuan Zhou, Yiyin Li, Shangqing Lu, Bangyuan Wu","doi":"10.1007/s12011-025-04630-0","DOIUrl":"https://doi.org/10.1007/s12011-025-04630-0","url":null,"abstract":"<p><p>This study examined the acute respiratory toxicity of NiCl₂ in mice, focusing on oxidative stress, tissue damage, and trace element dysregulation. Forty male KM mice were allocated to a saline control group and three NiCl₂ exposure groups (20, 60, 115 mg/kg; n = 10/group). Serum analysis assessed oxidative stress (MDA, GSH, SOD), liver (AST, ALT), kidney (Cr, BUN) function, and TP. Lung and tracheal tissues were examined for histopathological/ultrastructural pathological changes and apoptosis. Tissue levels of Ni, Zn, Cu, Fe, Ca, Mg, and Mn were measured using spectrophotometry. Results revealed dose-responsive elevations in serum AST, ALT, BUN, Cr, and MDA, accompanied by diminished GSH, TP, and T-SOD (P < 0.05). Nickel exposure caused tracheal pseudostratified columnar epithelium detachment, alveolar structural wall thickening and widened septa, capillary congestion, mitochondrial swelling in alveolar type-II cells, and increased pulmonary apoptosis (P < 0.05). Ni accumulated predominantly in the liver, lung, and kidney, with concurrent Zn upregulation and Cu/Fe depletion (P < 0.05), while Ca, Mg, and Mn levels remained stable. These findings demonstrate that acute NiCl₂ inhalation induces oxidative stress, impairs liver/kidney function, and provokes pulmonary apoptosis and mitochondrial damage. Ni disrupted Cu/Zn/Fe homeostasis but exhibited negligible effects on Ca, Mg, or Mn metabolism.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Investigation on the Effects of Metal Oxides in Hydroxyapatite Biocomposite Implants for Improving Bone Regeneration.","authors":"Mostafa Mabrouk, Hanan H Beherei, Omar H Abd-Elkader, Fariborz Sharifianjazi, Diganta B Das","doi":"10.1007/s12011-025-04651-9","DOIUrl":"https://doi.org/10.1007/s12011-025-04651-9","url":null,"abstract":"<p><p>Incorporating biocompatible nanomaterials in bone implants continues to pose a significant challenge in biomedical engineering. In addressing this issue, this study examines the critical role of the interactions of nanoscale metal oxides, specifically Al₂O₃, TiO₂, and SiO₂, with hydroxyapatite while developing novel multiphase biocomposites. The study also investigates how animal models respond to these new implants while focusing on improving the physicochemical properties, microstructure and osteoconductivity of calcium phosphate ceramics. Blood antioxidant enzymes and bone turnover markers were examined, and the effects on vital organs like the kidneys and liver were investigated. The results demonstrated that hydroxyapatite/SiO₂/TiO₂ (SHT) composite significantly impacted the liver and kidney functions during the study periods. However, the hydroxyapatite/SiO₂/Al₂O₃ (SHA) composite had no measurable effect at 2 days, while there was a significant effect at 20 days. Overall, it is concluded that the SHT composite ceramic has more osteoconductive effects and relatively high toxicity on the liver and kidney. SHA is found to be moderately toxic, and hydroxyapatite/SiO₂ (SH) composite displayed lesser or no toxicity. The results, which showed a significant depletion of blood GPX and SOD, indicate that oxidative stress mediates the cytotoxicity of the SHT and SHA composites.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired Synthesis, Characterization, and Biomedical Applications of Optimized Ceiba pentandra Silver Nanoparticles.","authors":"Loick Pradel Kojom Foko, Joseph Hawadak, Philippe Belle Ebanda Kedi, Veena Pande, Vineeta Singh","doi":"10.1007/s12011-025-04652-8","DOIUrl":"https://doi.org/10.1007/s12011-025-04652-8","url":null,"abstract":"<p><p>Green nanotechnology can provide new avenues for drug and insecticide discovery. This study aimed at synthesizing and evaluating the potential of silver nanoparticles, using an innovative plant-driven synthesis approach, with the potential to be used as an endectocide. Optimized silver nanoparticles using Ceiba pentandra (CP-AgNPs) were evaluated for their hemotoxic and killing activities against the deadliest malaria parasite Plasmodium falciparum (Pf) and three mosquito species (Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti) of medical importance. Optimized CP-AgNPs were predominantly spheroidal, stable, polycrystalline, and coated with several phytochemical compounds, including terpenoids, alkaloids, and phenols. CP-AgNPs exhibited good hemocompatibility and high lethal activity on Pf 3D7 and RKL9 strains, with respective IC₅₀ values of 9.71 µg/mL and 15.57 µg/mL. Likewise, LC₅₀ values were < 20 µg/mL in the three mosquito species after 24-h exposure, and the CP-AgNPs were most toxic against An. stephensi (LC₅₀ = 13.48 µg/mL). Green AgNPs could be an interesting tool for discovering and developing eco-friendly and effective antimalarial drugs and insecticides.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empagliflozin Inhibits Cadmium-Induced Hepatic Cell Apoptosis Through Endoplasmic Reticulum Stress and Autophagy Pathways.","authors":"Naeem F Qusty, Bayan T Bokhari, Medhat Taha, Mohammad Ahmad Alobaidy, Abdullah G Al-Kushi, Hatem A Sembawa, Omer Abdelbagi, Tourki A S Baokbah, Rami Obaid, Halah Tariq Albar, Omar Babateen, Naief Dahran","doi":"10.1007/s12011-025-04631-z","DOIUrl":"https://doi.org/10.1007/s12011-025-04631-z","url":null,"abstract":"<p><p>Cadmium (Cd), a well-known toxic heavy metal, adversely affects multiple organs. The SGLT-2 inhibitor empagliflozin (EMPA) exhibits significant antioxidant properties and hypoglycemic potential. This study aimed to investigate the hepatoprotective effect of EMPA against Cd-induced liver injury and elucidate its molecular mechanisms. Thirty-two male rats were allocated into four groups of eight rats each: group I (control group), group II (EMPA group), group III (Cd group), and group IV (Cd + EMPA group). Cd intake disrupted liver enzymes (ALT, AST, and ALP) and impaired hepatic histological architecture. Cd induced hepatic oxidative stress, as evidenced by increased MDA levels and reduced antioxidant enzymes, including SOD, GPx, and CAT. It downregulated the Nrf2/HO-1 pathway and elevated proinflammatory mediators IL-1β, IL-6, and TNF-α. Furthermore, Cd increased ER stress markers GRP78 and CHOP, along with apoptotic markers Bax and caspase-3 while decreasing anti-apoptotic Bcl-2 and reducing the autophagic indicator Beclin-1. Interestingly, EMPA administration in the Cd + EMPA group attenuated Cd-induced hepatic deterioration, improving hepatocyte structure. This beneficial effect was driven by the downregulation of hepatic oxidative stress, inflammation, ER stress, and apoptosis, alongside the upregulation of the autophagy process. In conclusion, this study highlights the hepatoprotective effect of EMPA against Cd-induced liver injury, elucidating its underlying molecular mechanisms.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syzygium cumini Fruit Extract and Quercetin Ameliorate Cadmium-Induced Ovarian Apoptosis in Rats Via miRNA- 204 - 5p-Mediated Bcl- 2 Upregulation and Bax/Caspase 9/Caspase 3 Downregulation.","authors":"Walaa I E Abdel-Badeea, Ahmed Abdel-Wahab, Ahmed A Mahmoud, Abdel-Razik H Abdel-Razik, Eman Z Attia, Usama R Abdelmohsen, Kamel M A Hassanin","doi":"10.1007/s12011-025-04632-y","DOIUrl":"https://doi.org/10.1007/s12011-025-04632-y","url":null,"abstract":"<p><p>The correlation between exposure to environmental pollutants and adverse impacts on fertility has been documented. Cadmium (Cd) is one of the most toxic elements that impairs female reproductive capacity. Syzygium cumini is a plant that contains polyphenols with strong antioxidant properties. Our study aimed to investigate the possible protective effects of Syzygium cumini fruit extract (SCFE) and quercetin (QU) against Cd-induced ovarian toxicity and apoptosis in rats assisted by measuring oxidative stress markers, hormonal profile, intrinsic apoptotic pathway, miRNA-204-5p, and histopathology. For that, 45 adult female rats were divided randomly into five groups; control, cadmium chloride (CdCl₂), CdCl₂ + QU, CdCl₂ + SCFE200, and CdCl₂ + SCFE400, and the experiment lasted 35 days. Cadmium exposure induced irregular estrus cycle, and oxidative challenges, as evidenced by increased malondialdehyde and decreased antioxidant indicators that include superoxide dismutase, catalase and reduced glutathione, and hormonal imbalances, including reduced follicle-stimulating hormone, luteinizing hormone, anti-mullarian hormone, estrogen, and progesterone levels. Additionally, Cd triggered ovarian apoptosis through upregulating miRNA- 204 - 5p expression that in turn downregulated Bcl- 2 and upregulated the members of intrinsic mitochondrial apoptotic pathway including Bax and caspases 3, 9. The histopathological findings, morphometric and lesion scoring in ovarian, and uterine tissues confirmed the negative impacts of Cd. Interestingly, treatment with QU or SCFE, especially at the higher dose (400 mg/kg), significantly ameliorated these Cd-induced adverse effects, suggesting their potential as protective agents against ovarian toxicity.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Cytotoxicity of Nano-titanium Dioxide and Phthalocyanine on HepG2 Cells via Sonophotodynamic Therapy.","authors":"Adem Yavaş, Ömer Kesmez, Feride Demir, Mehran Aksel","doi":"10.1007/s12011-025-04660-8","DOIUrl":"https://doi.org/10.1007/s12011-025-04660-8","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) presents a significant therapeutic challenge, necessitating novel approaches beyond conventional treatments. This study investigates the combined cytotoxic effects of nano-titanium dioxide (nano-TiO₂), copper (II) phthalocyanine (CuPc), and copper (II) phthalocyanine-modified nano-TiO₂-(nano-TiO₂/Pc) on HepG2 hepatocellular carcinoma cells using sonodynamic therapy (SDT), photodynamic therapy (PDT), and sonophotodynamic therapy (SPDT). The results show that individual treatments with nano-TiO₂ or CuPc alone did not induce significant cytotoxicity. However, when combined with SDT or PDT, a noticeable decrease in cell viability was observed. Strikingly, SPDT combined with nano-TiO₂/Pc demonstrated the most significant cytotoxic effect, achieving up to 83.80% apoptosis in HepG2 cells. This was associated with a marked reduction in Bcl-2 protein levels and an increase in cleaved caspase-3, cleaved caspase-9, cytochrome-c (cyt-c), and Bax indicating the activation of both intrinsic and extrinsic apoptotic pathways. Furthermore, SPDT-nano-TiO₂/Pc significantly increased oxidative stress, as evidenced by decreased levels of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), along with elevated levels of malondialdehyde (MDA). These findings suggest that phthalocyanine-mediated SPDT effectively enhances mitochondrial apoptosis and disrupts the tumor cytoplasmic membrane, highlighting the potential of combining SDT and PDT with nano-TiO₂/Pc as a promising strategy for cancer treatment.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes or Spirulina Platensis: Enhancing Sheep Thermo-Tolerance Through Physio-Metabolic, Immune, and Antioxidant Pathways.","authors":"Ahmed I M Alfaraj, Hemat K Mahmoud, Fayiz M Reda, Usama M Abdel Monem, Layla A Almutairi, Eman A Al-Shahari, Rabah N Alsulami, Sameh A Abdelnour","doi":"10.1007/s12011-025-04656-4","DOIUrl":"https://doi.org/10.1007/s12011-025-04656-4","url":null,"abstract":"<p><p>This study evaluated the potential of supplementing sheep diets with cobalt (CoNPs), iron (FeNPs) nanoparticles, or Spirulina platensis (SP) to tackle the adverse impacts of heat stress by assessing growth performance, oxidative status, metabolic pathways, immune parameters, gene expression, and hormone levels in sheep exposed to hot environmental conditions. A total of 32 Rahmani male lambs were randomly divided into four equal groups (n = 8). The CON group was fed the control diet or supplemented with 2 mg/kg of CoNPs (CoNPs group), 50 mg/kg of FeNPs (FeNPs group), or 1 g of SP/kg (SP group) diet for 3 months. The average size of nanozymes CoNPs and FeNPs were 41 and 44 nm, respectively. The temperature humidity index (THI) was 81.99 overall the study period. All nanozyme or SP treatments significantly (P < 0.05) enhanced growth performance, including final and average body weight, and dry matter intake. Nanozyme treatments also achieved the best results regarding hematocrit (P < 0.01) and platelets (P < 0.01). All supplemented groups exhibited lower WBC and lymphocyte counts, and higher globulin levels in comparison to stressed sheep. Total protein levels were significantly (P < 0.001) elevated in the FeNPs and SP groups compared to the remaining groups. Rams fed CoNPs or SP had notably (P < 0.001) higher TC and TG levels, while the FeNPs group showed the lowest TC levels (P < 0.05), as well as the lowest VLDL and LDL levels (P < 0.05). The levels of blood immune markers, specifically lysozyme, IgG, and IgM, were significantly (P < 0.05) elevated in all supplemented groups in comparison to the untreated group. Furthermore, rams receiving FeNPs demonstrated higher (P < 0.05) values for TAC, CAT, SOD, and GPX, and lower MDA levels than the other groups. Additionally, the supplemented group exhibited greater (P < 0.05) leptin and testosterone levels than the stressed group. Further, serum concentrations of zinc, selenium, and iron were significantly (P < 0.05) greater in the nano-feed additives and SP groups compared to the HS group. Dietary supplementation with nanozymes or SP notably (P < 0.05) upregulated GPX1 and HSP70 expression and downregulated TNF-alpha mRNA levels (P < 0.05). In summary, dietary supplementation with nanozymes or microalgae robustly bolstered sheep's immune-antioxidant capacity, improved growth performance, and promoted health under heat stress conditions relevant to global warming.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Tumor Necrosis Factor Alpha Gene Polymorphism (TNF-α 308 G/A) with Enhanced Severity of Metal-Induced Chronic Kidney Disease via Upregulation of Transmembrane Protein Expression.","authors":"Mohammed S El-Gedamy, Sherouk S Elnagar, El-Shaimaa E Shabana, Safaa A Derbala","doi":"10.1007/s12011-025-04650-w","DOIUrl":"https://doi.org/10.1007/s12011-025-04650-w","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a progressive disorder often aggravated by environmental exposure to waterborne metal pollutants, such as lead (Pb), cobalt (Co), copper (Cu), and zinc (Zn).These metals induce renal injury predominantly through oxidative stress and inflammatory pathways, with tumor necrosis factor-alpha (TNF-α) serving as a key mediator. The study aimed to investigate the association of the TNF-α -308 G/A (rs1800629) gene polymorphism and transmembrane(Tm)-TNF-α expression with the risk and severity of metal-induced CKD. A case-control study was conducted, including 80 patients with CKD (40 with early-stage and 40 with late-stage disease) and 40 age- and sex-matched healthy controls, selected according to stringent inclusion criteria. Metal concentrations were quantified using inductively coupled plasma mass spectrometry (ICP-MS), TNF-α genotyping was performed via amplification refractory mutation system-polymerase chain reaction (ARMS-PCR), and Tm-TNF-α levels were assessed by flow cytometry. The findings revealed that the A allele was significantly associated with increased CKD risk across dominant, recessive, and allelic genetic models. In a co-dominant model, the AA genotype conferred a fourfold and 15-fold higher risk for early- and late-stage CKD, respectively, compared to those with the GG genotype. Moreover, elevated Tm-TNF-α expression was significantly associated with the GA and AA genotypes and was most pronounced in late-stage CKD patients (p < 0.001). These findings suggest that the TNF-α -308 G/A polymorphism markedly enhances susceptibility to metal-induced CKD, driven by increased Tm-TNF-α expression. Understanding this genetic variation elucidates the pathogenesis of metal-induced nephropathy and offers new opportunities for early diagnosis and targeted therapeutic development.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Selenium as a Key Regulator in Thyroid Health.","authors":"Iqra Bano, Mohammad Farooque Hassan, Marek Kieliszek","doi":"10.1007/s12011-025-04653-7","DOIUrl":"https://doi.org/10.1007/s12011-025-04653-7","url":null,"abstract":"<p><p>Selenium (Se) is an essential trace element crucial for thyroid function, participating in the production and metabolism of thyroid hormones and the immune system. It engages in synthesizing selenoproteins, which are essential for antioxidant defense and regulating thyroid hormone levels. It is crucial to convert thyroxine (T4) into the active thyroid hormone triiodothyronine (T3) via deiodinase activity and safeguard thyroid cells from oxidative damage. Therefore, thyroid dysfunction, including abnormalities in thyroid hormone synthesis and the emergence of autoimmune thyroid conditions such as Graves' disease and Hashimoto's thyroiditis, has been linked to Se deficiency. When evaluating the benefits of Se supplementation, it is crucial to recognize that excessive mineral intake may be detrimental and result in adverse consequences, including gastrointestinal disturbances and neurological problems. The effectiveness of Se-based therapies is influenced by individual characteristics, including hereditary anomalies in thyroid function and Se metabolism. Further research should be performed on personalized Se supplementation approaches using genetics and nanotechnology to optimize the bioavailability and efficacy of the supplements. This study aims to thoroughly examine Se's role in thyroid health and how its therapeutic use in thyroid-related diseases may be optimized via appropriate dosing.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mercury Level in Worldwide Poultry Food Products: a Systematic Review.","authors":"Ana Clara Nogueira Alves, Adriene Núzia de Almeida Santos, Suelen Miranda Dos Santos, Junior Ribeiro Carvalho, João Paulo Ferreira Rufino, Adriano Teixeira de Oliveira","doi":"10.1007/s12011-025-04659-1","DOIUrl":"https://doi.org/10.1007/s12011-025-04659-1","url":null,"abstract":"<p><p>Mercury is a metal known for its toxic effects on environmental, animal and human health. The presence of Hg in poultry and its potential impact on food safety still need to be explored, especially considering that poultry is the most consumed source of protein in the global population. This study aimed to systematically review mercury and methylmercury levels in poultry meat and eggs worldwide. The searches were conducted in the Web of Science, PubMed, and Scopus databases, resulting in 123 studies, of which only 30 were deemed suitable. Studies were found across sixteen countries: India, Thailand, Malaysia, China, Poland, Egypt, Ghana, Nigeria, Bangladesh, Iran, USA, Italy, Colombia, Romania, Tanzania, Algeria, and Saudi Arabia. Five poultry species were reported, with chicken being the most recorded species in 16 countries. Among biological samples, eggs and liver were the most used for measuring mercury and methylmercury levels. Levels above those permitted by regulatory organizations such as the United States Department of Agriculture (USDA), China's National Health Commission (NHC), and Thailand's Ministry of Public Health - set at 0.05, 0.05, and 0.02 mg.kg^-1 respectively - were observed in 12 of the 17 countries, with the highest concentrations detected in chicken eggs from Colombia. Therefore, poultry production is not Hg-free and contamination by this metal must be monitored.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}