Biological Trace Element Research最新文献

{"title":"Long-Term Impact of Cr(VI) Exposure in Swiss Albino Mice: ROS-Driven Modulation of Autophagy and Cellular Fate.","authors":"Shehnaz Islam, Olivia Sarkar, Sunanda Mukherjee, Ansuman Chattopadhyay","doi":"10.1007/s12011-025-04599-w","DOIUrl":"https://doi.org/10.1007/s12011-025-04599-w","url":null,"abstract":"<p><p>Hexavalent chromium [Cr(VI)], due to its high solubility and permeability, is significantly more toxic than trivalent chromium [Cr(III)] as it generates reactive oxygen species (ROS) during cellular reduction. Industrial discharges have led to increasing Cr(VI) contamination in surface and groundwater, posing serious environmental and public health concerns. In our previous study, we demonstrated that exposure to 5 ppm Cr(VI) for 4 and 8 months adversely affected body weight, water consumption, and liver function in Swiss albino mice. Histological analyses revealed tissue alterations, disrupted DNA repair gene expression in liver tissue, and a marked increase in apoptotic gene expression after 8 months of exposure. Building on these findings, we employed the same Cr(VI) concentration (5 ppm via drinking water) over 4 and 8 months in the present study. Our results showed a significant increase in ROS generation in the liver, brain, and kidney tissues at both time intervals. Additionally, the presence of autophagolysosomes was markedly elevated after chronic Cr(VI) exposure in each tissue. We also observed altered expression patterns of key autophagy-related genes (Atg5, Beclin1, and Lc3) and mTor in these tissues. Immunohistochemical analysis further confirmed a significant increase in LC3B expression after 4 months of exposure. Our findings suggest that heightened intracellular oxidative stress triggers a protective autophagy response, mediated via mTOR signaling, to maintain cellular integrity. However, prolonged toxic insult and ROS accumulation may eventually shift pro-survival autophagy toward apoptotic cell death in the liver and brain tissues.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Dietary Copper Supplementation on Fish Growth: A Meta-Analysis.","authors":"Xingzhong Wang, Haixia Sun, Ying Zheng, Xianping Shao, Jinyun Ye","doi":"10.1007/s12011-025-04606-0","DOIUrl":"https://doi.org/10.1007/s12011-025-04606-0","url":null,"abstract":"<p><p>Copper is an essential trace element for fish, yet defining its optimal dietary levels remains a challenge in aquaculture nutrition. This meta-analysis quantitatively evaluated the effects of dietary copper supplementation on fish growth performance, superoxide dismutase activity, tissue copper levels, and body composition. Significant benefits in terms of fish survival, weight gain, hepatic Cu-Zn superoxide dismutase activity, and copper concentrations in the whole body, liver, and intestine were observed following supplementation with varying levels of copper, while excessive copper intake (> 25 mg/Kg) led to trade-offs in feed conversion, protein efficiency, and condition factor. Meta-regression identified that dietary copper levels, source of copper, feeding duration, and main protein content in the diet significantly moderated effect sizes of weight gain. Piecewise regression showed that the optimal dietary copper concentration determined to be 5.7 mg/kg. Structural equation models revealed that increased dietary protein and feeding duration enhance effect sizes of weight gain through elevated copper and crude protein levels in the body. This study provides a nuanced understanding of dietary copper supplementation effects on fish physiology, offering valuable insights for formulating diets that enhance aquaculture productivity while maintaining fish health.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Toxicological Implications Ascribed to Morphology and Size-Based Platinum Nanoparticles and Its Modulation by Naringin in Wistar Rats.","authors":"Saliha Manzoor, Mobin A Siddiqui, Dar Junaid Bashir, Nidhi, Mohd Sarfaraj, Shweta Rastogi, Indu Arora, Mohammed Samim","doi":"10.1007/s12011-025-04590-5","DOIUrl":"https://doi.org/10.1007/s12011-025-04590-5","url":null,"abstract":"<p><p>Automotive catalytic converters have been used for many years to reduce the amount of harmful substances in the environment. Although they significantly reduce environmental pollutants, catalytic converters are known to increase the environmental loads of PGEs (platinum group elements), which are also detected in exhaust gases as micro and nano-sized particles. PGEs are generally regarded to be harmless for human health; nevertheless, their widespread usage in different applications, particularly in catalytic converters, and the consequent discharge of these elements into the environment, increases the concentration of Pt and Pt NPs in the environment. It also increases the chance of human exposure to Pt and Pt NPs, revealing a new risk factor. Based on the aforementioned concept, the pulmonary toxicity of size and morphology-dependent Pt NPs were investigated in this study, as well as the modulating effect of naringin on pulmonary toxicity imposed by the exposure of Pt NPs. Highly mono-dispersed Pt NPs of varied sizes and morphology were synthesized using the micro-emulsion method. Various techniques were used to characterize the synthesized Pt NPs. The present study aimed to evaluate the toxicity induced due to the exposure of different sizes and morphology-based Pt NPs to the lungs, following oral administration in Wistar rats for 28 days. Due to the continuous exposure of different size and morphology-dependent Pt NPs, the Wistar rats showed weakness and continuous decrease in body weight at different time intervals. Pulmonary toxicity induced due to the exposure of size and morphology-dependent Pt NPs was detected by the change in levels of biochemical markers (SOD, CAT, GSH-Px, and MDA) and pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α). The histological alterations in the lung tissues of Wistar rats, as compared to control, determined the toxicity imposed by their exposure. Furthermore, Naringin, a prominent flavanone glycoside found in many citrus fruits and plants, has been researched for its potential to mitigate the toxic effects of Pt NPs. Naringin was administered intraperitoneally and treatment also continued for 28 days. It was found that the prior exposure of naringin modulated the pulmonary toxicity of size and morphology-dependent Pt NPs. As an outcome of this study, we concluded that it is important to take into account the health risks of Pt and Pt NPs, in order to fully comprehend their environmental fate.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Copper Is Associated with Dyslipidemia, and This Association Is Mediated by Inflammation.","authors":"Sisi Xie, Zoltan Kutalik, Aurélien Thomas, Maïwenn Perrais, Julien Vaucher, Pedro Marques-Vidal","doi":"10.1007/s12011-025-04581-6","DOIUrl":"https://doi.org/10.1007/s12011-025-04581-6","url":null,"abstract":"<p><p>Dyslipidemia is an important public health issue. Copper may influence lipid metabolism, possibly via inflammation, but the mechanisms remain unclear. This study aimed to assess the association between urinary copper concentrations and blood lipids (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)), and the possible mediating role of inflammation, assessed via high-sensitivity C-reactive protein (hs-CRP). We conducted a cross-sectional, population-based study using baseline data from Switzerland's CoLaus|PsyCoLaus cohort. Urinary copper was measured from spot urine using inductively coupled plasma mass spectrometry and adjusted for creatinine. Lipid markers and hs-CRP were measured using standardized biochemical assays. Multiple linear regression assessed associations, and mediation effects were evaluated using the SGmediation2 package. A total of 6284 adults (mean age 52.6 years, 53.4% female) were included. Urinary copper was positively associated with TG (beta=0.08, 95%CI 0.04, 0.12) and negatively associated with HDL-C (- 0.04, 95%CI - 0.07, - 0.003). Additionally, urinary copper was positively associated with hs-CRP (0.51, 95%CI 0.42, 0.60), which in turn was positively associated with TG (0.05, 95%CI 0.04, 0.06) and negatively associated with HDL-C (- 0.04, 95%CI - 0.05, - 0.03). Mediation analysis revealed that urinary copper exerts partial indirect effects on TG (mediation effect 31.4%) and HDL-C (56.9%) through hs-CRP. hs-CRP partially mediated the associations between urinary copper and HDL-C and TG, with a robust effect for TG but statistical uncertainty for HDL-C. No mediation was observed for TC or LDL-C. These findings suggest hs-CRP's role in lipid metabolism, especially in TG regulation.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Intake of Minerals and Potential Human Exposure to Toxic Elements via Coffee Consumption.","authors":"Aleksandra Savić, Jelena Mutić, Milica Lučić, Antonije Onjia","doi":"10.1007/s12011-024-04315-0","DOIUrl":"10.1007/s12011-024-04315-0","url":null,"abstract":"<p><p>In this study, we investigated the levels of macro, minor, and trace elements in roasted ground and instant coffees (n = 56). We assessed dietary mineral intake and health risks associated with potentially toxic elements (PTEs) using deterministic and probabilistic approaches. The limits of detection (LOD) ranged from 0.13 µg/kg for Be to 3.7 mg/kg for K, with corresponding limits of quantification (LOQ) at 0.43 µg/kg and 12.2 mg/kg. The recovery values (R%) ranged from 89 to 107%. The most abundant element was K, followed by Mg, Ca, and Na. Other elements followed this order: Fe > Mn > B > Cu > Sr > Zn > Al > Ba > Ni > Cr > Co > Se > Sn > Pb > Li > Ag > V > As > Cd > Hg > Be. Instant coffees generally exhibited higher K, Mg, and Na levels than ground-roasted coffees. Notably, Hg, Li, and Se were not detected in 34, 2, and 1 samples, respectively. Coffee samples were generally a good source of dietary elements such as Cu, Mn, Cr, and Se. The PTEs found in coffee products posed negligible risks to human health. The total target hazard quotient (TTHQ) remained below 1, and the incremental lifetime cancer risk (ILCR) did not exceed the threshold of 1 × 10^-6. Nevertheless, coffee consumption contributed to Pb and As levels below 15% of the benchmark dose lower confidence limit (BMDL) values, and Sn, Hg, and Cd levels below 0.90% of the provisional tolerable weekly intake (PTWI).</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1817-1829"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization, Phytochemistry, and Therapeutic Potential of Azadirachta indica Conjugated Silver Nanoparticles: A Comprehensive Study on Antidiabetic and Antioxidant Properties.","authors":"Hunaiza Tahir, Farzana Rashid, Shaukat Ali, Muhammad Summer, Misha Afzal","doi":"10.1007/s12011-024-04293-3","DOIUrl":"10.1007/s12011-024-04293-3","url":null,"abstract":"<p><p>Nanotechnology has become a major topic of study, particularly in the medical and health domains. Because nanomedicine has a higher recovery rate than other conventional drugs, it has attracted more attention. Green synthesis is the most efficient and sustainable method of creating nanoparticles. The current work used ultraviolet-visible spectroscopy, Fourier-transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, and X-ray diffraction to thoroughly characterize the synthesized silver nanoparticles (AgNPs) from Azadirachta indica leaf extract. Characterization confirmed the synthesis of the AgNPs along with the possible linkage of the phytochemicals with the silver as well as the quantitative analysis and nature of NPs. The antioxidant activity of AgNPs and neem extract was measured by the 2,2-diphenyl-1-picrylhydrazyl assay using various concentrations (20, 40, 60, 80, and 100 µg/ml). Additionally, using diabetic mice that had been given alloxan, the in vivo antidiabetic potential of biosynthesized AgNPs was assessed. Eight groups of mice were used to assess the antidiabetic activity: one control group and seven experimental groups (untreated, extract-treated, AgNPs at low and high doses, standard drug, low dose of AgNPs + drug, and high dose of AgNPs + drug). At days 0, 7, 14, 21, and 28, blood glucose levels and body weight were measured. After 28 days, the mice were dissected, and the liver, kidney, and pancreas were examined histologically. The results depicted that the AgNPs showed higher (significant) radical scavenging activity (IC₅₀ = 35.2 µg/ml) than extract (IC₅₀ = 93.0 µg/ml) and ascorbic acid (IC₅₀ = 64.6 µg/ml). The outcomes demonstrated that biosynthesized AgNPs had a great deal of promise as an antidiabetic agent and exhibited remarkable effects in diabetic mice given AgNPs, extract, and drug. Remarkable improvement in the body weight and blood glucose level of mice treated with high doses of AgNPs and drug was observed. The body weight and blood glucose level of diabetic mice treated with a high dose of AgNPs + standard drug showed significant improvement, going from 28.7 ± 0.2 to 35.6 ± 0.3 g and 248 ± 0.3 to 109 ± 0.1 mg/dl, respectively. Significant regeneration was also observed in the histomorphology of the kidney, liver's central vein, and islets of Langerhans after treatment with biosynthesized AgNPs. Diabetic mice given a high dose of AgNPs and drug displayed architecture of the kidney, liver, and pancreas that was nearly identical to that of the control group. According to the current research, biosynthesized AgNPs have strong antioxidant and antidiabetic potential and may eventually provide a less expensive option for the treatment of diabetes.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2170-2185"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic Metal Element Concentration in 31 Food Fishes from River Ganga: Risk Assessment on Human Consumption.","authors":"Basanta Kumar Das, Satabdi Ganguly, Dhruba Jyoti Sarkar, Supriti Bayen, Subhamoy Dutta, Sanatan Paul, Archisman Ray, Shubhadeep Das Gupta, Shreya Roy, Suraj Kumar Chauhan","doi":"10.1007/s12011-024-04309-y","DOIUrl":"10.1007/s12011-024-04309-y","url":null,"abstract":"<p><p>Consumption of toxic metal contaminated fish is a significant risk to human health. The Ganga river is one of the vital river systems in India, and it nurtures a rich biodiversity of flora and fauna. In the present study, screening of potential toxic metal elements (Cd, Cr, Mn, Cu, Pb, Ni, Zn, and As) was undertaken in 31 food fishes, especially the small indigenous fishes (SIFs) from the lower stretch of river Ganga by inductively coupled plasma mass spectrometry (ICP-MS). The concentration of toxic metal elements varied among different fish species. Among the toxic metal elements studied, Cr, Zn, and As were found to be dominant in Eleotris fusca; Cd, Ni, and Pb were highest in Securicula gora; Cu was highest in Cabdio morar; and Mn was highest in Coilia dussumieri. The average pollution load index values (APLI) for all the fishes analyzed were less than one except for Eleotris fusca, which indicated no serious toxic metal element pollution load. The estimated daily intake values (EDI) for the toxic metal elements were found to be within the permissible maximum tolerable daily intake (MTDI). Among the fishes studied, only a few species showed hazard index (HI) greater than one, indicating non-carcinogenic health risks. Similarly, the target carcinogenic values (TCR) for most of the toxic metal elements were below the permissible limit (10^-4) in the fishes that assures minimal cancer risk. This study provides a comprehensive data on the composition of potential toxic metal elements of 31 food fishes from the lower stretch of the river Ganga, the first of its kind, and suggests the necessity of periodic monitoring of these in the aquatic ecosystem.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2339-2354"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc Oxide Nanoparticles Induced Testicular Toxicity Through Inflammation and Reducing Testosterone and Cell Viability in Adult Male Rats.","authors":"Dina H Ahmed, Nadia M El-Beih, Enas A El-Hussieny, Wael M El-Sayed","doi":"10.1007/s12011-024-04330-1","DOIUrl":"10.1007/s12011-024-04330-1","url":null,"abstract":"<p><p>Zinc oxide nanoparticles (ZnO NPs) have wide applications in daily life. Therefore, there is growing interest in the potential harmful impacts of these particles on human health. The present study was conducted to investigate the potential toxic effects of ZnO NPs (40 and 70 nm) compared to ZnO on the testes of rats. ZnO NPs were synthesized and characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). Adult male rats were randomly divided into four groups (n = 8): Group I (control), Group II (ZnO) received daily oral administration of ZnO (50 mg/kg), and Groups III and IV received daily oral administration of ZnO NPs of 40 nm or 70 nm at 50 mg/kg, respectively. All treatments continued for 50 consecutive days. ZnO and ZnO NPs reduced body and testis weights, sperm count and motility, serum luteinizing hormone (LH) and testosterone levels, testicular cytochrome p450 17A1 (CYP17A1) and cytochrome p450 1B1 (CYP1B1) concentrations, and the expression of p53 and cdk1. These treatments elevated testicular myeloperoxidase and serum acid phosphatase activities as well as sperm abnormalities. ZnO NPs reduced LH levels, which decreased CYP17A1 and CYP1B1, resulting in reduced synthesis of testosterone. ZnO NPs enhanced testicular inflammation and reduced cell viability. All these effects were manifested as reduced sperm motility and increased sperm deformities. Compared to macromolecules, nanoparticles exhibited significantly higher toxicity. The larger diameter ZnO NPs had more profound toxicity than the smaller-sized particles.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1934-1948"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Impacts of Dietary Selenium, Iodine and their Interaction on Egg Performance, and Antioxidant Profile in Laying Longyuan Duck Breeders.","authors":"Md Touhiduzzaman Sarker, Xiuguo Shang, Wei Chen, Runsheng Xu, Shuang Wang, Weiguang Xia, Yanan Zhang, Chenglong Jin, Shenglin Wang, Chuntian Zheng, Abdelmotaleb Elokil","doi":"10.1007/s12011-024-04308-z","DOIUrl":"10.1007/s12011-024-04308-z","url":null,"abstract":"<p><p>The present study aimed to optimize the combined effect of dietary selenium (SE) and iodine (ID) on the productive and reproductive performance and antioxidant capacity of Longyuan breeding ducks. A total of 288 Longyan duck breeders aged 20 wk were randomly assigned to four groups with six replicates (n = 72 ducks/group; 12 ducks/replicate). A 2 × 2 factorial arrangement experiment was performed and included 2 supplementation levels of each SE and ID for 200 days of the experimental period. The first group (SE0/ID0) received a basal diet without SE or ID supplementation and was considered to be the control group, whereas the other three groups, SE0/ID4, SE2/ID0 and SE2/ID4, received a basal diet supplemented with 0.4 mg ID/kg, 0.2 mg SE/kg or 0.2 mg SE supplemented with 0.4 mg ID/kg, respectively. The results indicated that the albumin height of the SE2/ID0 group was lower (P < 0.05) than that of the control group, that the egg shape index of the SE2/ID4 and SE0/ID4 groups were lower (P < 0.05) than that of the control group (SE0/ID0), and that the SE concentration significantly increased (P < 0.05) in the SE2/ID0 and SE2/ID4 groups. Hatchability and embryonic mortality improved (P < 0.05) in the SE2/ID0 group. Plasma GSH-Px activity was increased (P < 0.05) by reducing the concentration of malondialdehyde (MDA) in the SE groups. In addition, the tibia length significantly increased (P < 0.05) in the ID (SE0/ID4 and SE2/ID4) groups compared with that in the control group, the plasma content of IGF-1 in the SE2/ID4 and SE0/ID4 groups were greater (P < 0.05) than that in the control group, and the bone mineral content increased (P > 0.05) in the SE2/ID0 and SE0/ID0 groups. Compared with those in the other groups, the mRNA expression of antioxidant-related genes, including Nrf2 and SHMT1 in the SE2/ID4 group was upregulated (P > 0.05), especially in the SE2/ID4 group. Overall, dietary treatment with SE2/ID4 (0.2 mg SE in 0.4 mg ID/kg diet) could be a suitable feed supplement for improving the the egg quality, health status, endogenous antioxidant content, antioxidant-related gene expression and pre-hatching quality of Longyuan duck breeders.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2257-2270"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Levels of Rare Earth Elements in Food and Human Dietary Exposure: A Review.","authors":"Neus González, Jose L Domingo","doi":"10.1007/s12011-024-04297-z","DOIUrl":"10.1007/s12011-024-04297-z","url":null,"abstract":"<p><p>Rare earth elements (REEs) are a group consisting of the following 17 metals: Ce, Dy, Er, Eu, Gd, Ho, La, Lu, Nd, Pr, Pm, Sc, Sm, Tb, Tm, Y and Yb. In the current century, the number of applications of REEs has significantly increased. They are being used as components in high technology devices of great importance industrial/economic. However, information on the risk of human exposure to REEs, as well as the potential toxic effects of these elements is still limited. In general terms, dietary intake is the main route of exposure to metals for non-occupationally exposed individuals, which should be also expected for REEs. The current paper aimed at reviewing the studies -conducted over the world- that focused on determining the levels of REEs in foods, as well as the dietary intake of these elements. Most studies do not suggest potential health risk for consumers of freshwater and marine species of higher consumption, or derived from the intake of a number of vegetables, fruits, mushrooms, as well as other various foodstuffs (honey, tea, rice, etc.). The current estimated daily intake (EDI) of REEs does not seem to be of concern. However, considering the expected wide use of these elements in the next years, it seems to be clearly recommendable to assess periodically the potential health risk of the dietary exposure to REEs. This is already being done with well-known toxic elements such as As, Cd, Pb and Hg, among other potentially toxic metals.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2240-2256"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}