Biological Trace Element Research最新文献_第2页

Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats. 利用由硼酸、镁、维生素D3和特级初榨橄榄油组成的补充剂组合来改善绝经后切除卵巢的大鼠的新陈代谢。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-28 DOI: 10.1007/s12011-024-04476-y

Hebatallah Husseini Atteia, Salwa Fares Ahmed, Mervat El-Sayed Askar, Amr Tawfik Sakr

{"title":"Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium, Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in Menopausal Ovariectomized Rats.","authors":"Hebatallah Husseini Atteia, Salwa Fares Ahmed, Mervat El-Sayed Askar, Amr Tawfik Sakr","doi":"10.1007/s12011-024-04476-y","DOIUrl":"10.1007/s12011-024-04476-y","url":null,"abstract":"Metabolic syndrome during menopause can lead to diabetes, cardiovascular problems, and increased mortality rates. Hormone replacement therapy is recommended to manage climacteric complications, but it has serious adverse effects. This study, therefore, investigated the potential of supplementing some minerals, vitamins, and natural products like boric acid, magnesium, vitamin D3, and extra virgin olive oil on metabolic status of menopausal ovariectomized rats. Fourty-two female adult rats were randomly assigned to seven groups: a) Sham Control, b) Ovariectomized Control, c) Ovariectomized + Boric acid, d) Ovariectomized + Magnesium, e) Ovariectomized + Vitamin D3, f) Ovariectomized + Extra virgin olive oil, and g) Ovariectomized + Combined treatment groups. Serum inflammatory and oxidative stress markers, serum lipogram pattern, hepatic triglycerides, body weight, fasting blood glucose, serum insulin, leptin, and adiponectin, as well as hepatic insulin signaling cascade, IRS1/pAKT/GLUT4 were measured in each group to assess metabolic function. Results revealed a significant improvement in inflammation, oxidative stress, and metabolic parameters by individual and concomitant treating ovariectomized rats with boric acid, magnesium, vitamin D3, and extra virgin olive oil. Interestingly, the concurrent use of these supplements displayed a better impact than individual use, suggesting their valuable therapeutic potential for managing metabolic syndrome in menopausal women. However, the necessity of all four supplements for optimal therapeutic effects remains unsubstantiated.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4240-4255"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mercury Levels in the Worldwide Farmed Fish: A Systematic Review. 全球养殖鱼类中的汞含量：一项系统综述。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-24 DOI: 10.1007/s12011-024-04493-x

Enzo de Oliveira Novaes, Adriano Teixeira de Oliveira, Letícia Torrão Araruna, Júlia Scarpa de Souza, Júlia Vianna de Pinho, Paloma de Almeida Rodrigues, Italo Rennan Sousa Vieira, Carlos Adam Conte-Junior

{"title":"Mercury Levels in the Worldwide Farmed Fish: A Systematic Review.","authors":"Enzo de Oliveira Novaes, Adriano Teixeira de Oliveira, Letícia Torrão Araruna, Júlia Scarpa de Souza, Júlia Vianna de Pinho, Paloma de Almeida Rodrigues, Italo Rennan Sousa Vieira, Carlos Adam Conte-Junior","doi":"10.1007/s12011-024-04493-x","DOIUrl":"10.1007/s12011-024-04493-x","url":null,"abstract":"Aquaculture, specifically farmed fish, contributes to global aquatic fish stuff production. The present study systematically reviewed mercury levels in farmed fish. One hundred two scientific articles were found in four databases. Only seven were considered appropriate, and eleven articles were added. In total, 18 articles are eligible for this review. Papers determining Hg in farmed fish were reported in seven countries: China, Korea, Pakistan, India, Brazil, the USA, and Poland. Fifty species from farmed fish were evaluated worldwide, and Ctenopharyngodon idella Glass carp, Oreochromis niloticus Tilapia, and Hypophthalmichthys nobilis (synonym of Aristichthys nobilis) Bighead carp have registered the highest frequency. The mercury values found in fish from the production system were low. For the risk analysis, only India presented values within tolerable limits; however, Korea and Pakistan showed high values, indicating a potential risk of consuming protein from farmed fish in these countries. Therefore, farmed fish are not Hg-free but safer than fish in nature due to greater control of biotic and abiotic factors in ponds, thus contributing to sustainable, productive economic activity.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4361-4375"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hazard Analysis and Human Health Risk Assessment in the Mytilus Galloprovincialis and Rapana Venosa Species in the Black Sea's Türkiye Coastline by Multivariate Analysis. 通过多变量分析法对黑海图尔基耶海岸线的贻贝（Mytilus Galloprovincialis）和鳐鱼（Rapana Venosa）物种进行危害分析和人类健康风险评估。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-18 DOI: 10.1007/s12011-024-04482-0

Evrim Sibel Önel, Mustafa Türkmen, Erkan Kalıpcı

{"title":"Hazard Analysis and Human Health Risk Assessment in the Mytilus Galloprovincialis and Rapana Venosa Species in the Black Sea's Türkiye Coastline by Multivariate Analysis.","authors":"Evrim Sibel Önel, Mustafa Türkmen, Erkan Kalıpcı","doi":"10.1007/s12011-024-04482-0","DOIUrl":"10.1007/s12011-024-04482-0","url":null,"abstract":"In this study; fourteen potentially toxic elements (PTEs) levels are measured in Mytilus galloprovincialis (MG) and in Rapana venosa (RV) intensively consumed in eight cities on the Black Sea coast of Türkiye. Additionally, human health risk levels from mollusks species consumption were assessed using multiple approaches and by Geographical Information Systems, spatial distribution map of PTEs of the region was prepared. The average PTEs levels in the two mollusks species are listed in the following order: Fe > Al > Zn > Cu > As > Mn > B > Cd > Se > Ni > Cr > Pb > Co > Hg with the levels of 114.8 > 79.7 > 39.49 > 9.75 > 5.74 > 3.22 > 2.97 > 2.74 > 0.72 > 0.40 > 0.24 > 0.22 > 0.11 > 0.015 µg g-1 ww, respectively. The average concentration level of essential metals (Cu, Mn, Zn, Co and Fe) and toxic metals (Cr, Hg, Ni, Pb, Cd and As) was measured as 238.73 µg g-1 ww in RV and 114.86 µg g-1 ww in MG. The cities with the highest metal pollution index (MPI) levels were Rize, Samsun, Kastamonu and Sinop, respectively. The MPI values in mollusks soft tissue were 1.25 in MG and 2.51 in RV. For fourteen PTEs, the MPI from metal intake by ingesting two crustacea species were over than 1, indicating risk from consumption. In addition to this, since the THQ value of Cd and hazard index (HI) were determined above 1, it can be said that it does pose public health risk for RV.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4347-4360"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis. 锌通过改善锌体内平衡抑制铁下垂和细胞凋亡，减轻双酚a诱导的雄性小鼠生殖毒性。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-08 DOI: 10.1007/s12011-024-04473-1

Yuejia Li, Yuanjing Li, Xuan Liu, Jiajie Bi, Junsheng Liu, Wen Li, Huanhuan Li, Shusong Wang, Jing Ma

{"title":"Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis.","authors":"Yuejia Li, Yuanjing Li, Xuan Liu, Jiajie Bi, Junsheng Liu, Wen Li, Huanhuan Li, Shusong Wang, Jing Ma","doi":"10.1007/s12011-024-04473-1","DOIUrl":"10.1007/s12011-024-04473-1","url":null,"abstract":"Bisphenol A (BPA) is a contaminant widely found in food packaging that can reduce sperm quality and impair male fertility. Zinc (Zn) is an important antioxidant involved in many important biological functions. The aim of this study was to explore the protective effect and mechanism of Zn on reproductive toxicity induced by BPA. Male ICR mice were divided into a control group, a BPA group and a BPA + Zn group. The results showed that the body weight, sperm count and sperm motility of the animals in the BPA group were significantly reduced, and testicular structure was damaged. BPA decreased the levels of serum total Zn, testis-free zinc, ADH and ALP, upregulated the expression of ZnT4 protein, and down-regulated the expression levels of ZIP8, ZIP14, ZnT1, MT and MTF1 protein, resulting in the imbalance of testicular Zn homeostasis. BPA down-regulates the antioxidant enzymes SOD and GSH-Px, and increases MDA, leading to oxidative stress. BPA up-regulates TF, TFR and STEAP3 and down-regulates SLC7A11, GPX4, FPN1 and FTH protein levels, resulting in abnormal iron metabolism and ferroptosis. BPA down-regulated anti-apoptotic protein Bcl-2, up-regulated pro-apoptotic markers Bax, caspase-9, caspase-8 and caspase-3, and induced apoptosis. BPA also increased the phosphorylation of JNK and ERK1/2, but did not increase the phosphorylation of P38. Zn significantly increased body weight and sperm quality, improved testicular morphology, down-regulated p-JNK/JNK and p-ERK/ERK levels, improved oxidative stress, and reduced ferroptosis and apoptosis. In conclusion, Zn regulates Zn homeostasis and down-regulates the MAPK signaling pathway, thereby inhibiting ferroptosis and apoptosis, alleviating BPA-induced oxidative stress and ultimately improving male reproductive damage.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4198-4210"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Causal Association Between 15 Micronutrients and 12 Obstetric-Related Diseases: A Mendelian Randomization Study. 15种微量营养素与12种产科相关疾病的遗传因果关系：一项孟德尔随机研究

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-09 DOI: 10.1007/s12011-024-04479-9

Lele Pan, Jing Zhang, Mingwei Chen, Li Yuan, Rong Chen, Lina Zhao

{"title":"Genetic Causal Association Between 15 Micronutrients and 12 Obstetric-Related Diseases: A Mendelian Randomization Study.","authors":"Lele Pan, Jing Zhang, Mingwei Chen, Li Yuan, Rong Chen, Lina Zhao","doi":"10.1007/s12011-024-04479-9","DOIUrl":"10.1007/s12011-024-04479-9","url":null,"abstract":"Micronutrients, namely vitamins and minerals, are associated with pregnancy outcomes. However, the effects reported in previous observational studies and randomized controlled trials have been inconsistent. Using publicly available genetic data, we conducted a two-sample MR analysis to estimate the causal association between 15 micronutrient levels and 12 obstetric-related diseases. Sensitivity analysis was performed to assess the robustness of the results, detect heterogeneity, and examine the potential existence of horizontal pleiotropy. Iron was protective against gestational diabetes mellitus (GDM) (OR = 0.597, 95% CI 0.438-0.814, P = 0.001), while zinc increased the risk of pregnancy hypertension (OR = 1.064, 95% CI 1.004-1.128, P = 0.035). Vitamin B6 was associated with increased risk of spontaneous abortion (OR = 1.222, 95% CI 1.001-1.490, P = 0.047), and vitamin D was linked to poor fetal growth (OR = 1.612, 95% CI 1.018-2.552, P = 0.041). Conversely, vitamin B12 showed protective effects against preterm birth (OR = 0.686, 95% CI 0.482-0.976, P = 0.036). Selenium and vitamin E were protective against polyhydramnios (OR = 0.828, 95% CI 0.698-0.981, P = 0.030; OR = 0.441, 95% CI 0.213-0.910, P = 0.026), whereas selenium increased the risk of premature rupture of membranes (OR = 1.083, 95% CI 1.007-1.164, P = 0.030).However, no causal links were found between the other micronutrients analyzed and obstetric-related diseases. Sensitivity analyses revealed no significant heterogeneity or pleiotropy. Our research has clarified the causal link between micronutrients and obstetric-related diseases, assisting clinicians in offering personalized guidance on the appropriate intake of micronutrients for women preparing for pregnancy and those who are pregnant. These findings are essential for screening and preventing pregnancy complications, and they also provide new insights and evidence for improving pregnancy outcomes through nutritional interventions.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4027-4035"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper Intake and Mortality Among Asthmatic Adults: A Cohort Study. 哮喘成人的铜摄入量和死亡率：一项队列研究。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-22 DOI: 10.1007/s12011-024-04495-9

Linlin Huang, Hegan Zhang, Rongjuan Zhuang, Jun Wen

{"title":"Copper Intake and Mortality Among Asthmatic Adults: A Cohort Study.","authors":"Linlin Huang, Hegan Zhang, Rongjuan Zhuang, Jun Wen","doi":"10.1007/s12011-024-04495-9","DOIUrl":"10.1007/s12011-024-04495-9","url":null,"abstract":"Previous studies have proved trace mineral disorders to be related to changes in oxidative stress, inflammatory state, and immune response in asthmatics. However, there is a scarcity of studies that examine the correlation between copper intake with mortality in asthmatic people. The aim of this research was to investigate the effect of copper intake on the asthmatic population's mortality. This investigation included 3175 individuals from the NHANES. Multiple statistical models were used in this investigation to discuss the correlation between copper intake and the asthmatic population's mortality. These models included Cox proportional hazards models, trend tests, restricted cubic splines (RCS), threshold effect model, and CoxBoost model. Three Cox hazard models showed an inverse relationship between copper intake and the risk of death in asthmatics. Statistical tests, such as trend tests, RCS models, and threshold effect models, proved an inverse and linear link between dietary copper and the risk of death. Through Kaplan-Meier analysis, asthmatic adults who had higher copper intake had a higher survival rate compared to asthmatics with lower copper intake. The CoxBoost model indicated that the intake of copper, selenium, and zinc had a protective effect on mortality, whereas iron was associated with an increased risk of death. The research proved an inverse and linear correlation between dietary copper intake and the risk of death among asthmatic people. Improving copper intake may have a positive impact on the long-term survival of individuals with asthma.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4079-4086"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Health Risks from Heavy Metal in Green Mussels (Perna Viridis) From the Southeastern Part of the Bay of Bengal. 来自孟加拉湾东南部的绿贻贝（Perna Viridis）中重金属的潜在健康风险。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2025-01-02 DOI: 10.1007/s12011-024-04471-3

Mohammed Ashraful Azam Khan, Sarif Ullah, Amena Akter Alpona

{"title":"Potential Health Risks from Heavy Metal in Green Mussels (Perna Viridis) From the Southeastern Part of the Bay of Bengal.","authors":"Mohammed Ashraful Azam Khan, Sarif Ullah, Amena Akter Alpona","doi":"10.1007/s12011-024-04471-3","DOIUrl":"10.1007/s12011-024-04471-3","url":null,"abstract":"The Southeastern part of the Bay of Bengal is increasingly threatened by heavy metal pollution, posing significant risks to both aquatic life and human health. In this context, the contamination levels of six heavy metals-Cadmium (Cd), Lead (Pb), Zinc (Zn), Copper (Cu), Manganese (Mn), and Iron (Fe)-were assessed in the soft tissues of Green mussels (Perna viridis) from five key sites: Matamuhuri, Moheshkhali, Bakhkhali, Naf, and St. Martin. The aim was to assess the public health risks associated with the consumption of these mussels. The metal concentrations detected across the sites were as follows: Cd ranged from 0.65 to 2.99 μg/g, Pb from 1.20 to 4.00 μg/g, Zn from 20.16 to 117.17 μg/g, Cu from 3.52 to 23.21 μg/g, Mn from 10.34 to 63.36 μg/g, and Fe from 104 to 1102 μg/g. The assessments conducted include the Estimated Daily Intake (EDI), Target Hazard Quotient (THQ), Hazard Index (HI), and Carcinogenic Risk (CR) for evaluating both non-carcinogenic and carcinogenic health impacts. Consumers were classified as Average-Level Mussel consumers (ALM) and High-Level Mussel consumers (HLM) based on consumption rates to estimate the health risks for different exposure levels. The results showed that Bakhkhali exhibited the highest concentrations of Cd and Pb, surpassing the safety limits, with a CR value (6.76E-04, 2.02E-05) indicating a heightened cancer risk for HLM. St. Martin, on the other hand, was identified as the safest site, with metal concentrations within permissible limits.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4376-4396"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons. cGAS/STING 通路在砷诱导的神经毒性中的作用：从星形胶质细胞和神经元之间的串扰中获得启示

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-18 DOI: 10.1007/s12011-024-04475-z

Daopeng Luo, Baofei Sun, Wenjuan Wang, Aihua Zhang

{"title":"The Role of the cGAS/STING Pathway in Arsenic-Induced Neurotoxicity: Insights from the Crosstalk Between Astrocytes and Neurons.","authors":"Daopeng Luo, Baofei Sun, Wenjuan Wang, Aihua Zhang","doi":"10.1007/s12011-024-04475-z","DOIUrl":"10.1007/s12011-024-04475-z","url":null,"abstract":"Arsenic is a detrimental environmental toxicant linked to neurological damage; however, the mechanisms involved remain incompletely understood. Chronic proinflammatory responses are thought to play a central role in arsenic-induced neurotoxicity. Astrocytes, which are the predominant glial cells in the central nervous system (CNS), release significant amounts of proinflammatory cytokines upon overactivation. However, the molecular mechanisms driving this response remain to be elucidated. This study aimed to elucidate the mechanisms underlying arsenic-induced astrocyte activation and the subsequent neuronal damage, both in vivo and in vitro. In a rat model of arsenic exposure, significant neuropathological damage was detected in the CA3 region of the hippocampus. Specifically, markers of astrocyte activation, such as glial fibrillary acidic protein (GFAP) and inducible nitric oxide synthase (iNOS), as well as the inflammatory cytokine interleukin (IL)-1β, were significantly upregulated, and apoptosis was markedly increased, indicating neurotoxic damage. Furthermore, in vitro experiments revealed that arsenic exposure induced substantial upregulation of cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), GFAP, iNOS, and IL-1β in astrocytes, accompanied by an increase in IL-1β secretion into the culture supernatant. In addition, co-culturing neurons with conditioned medium from arsenic-exposed astrocytes resulted in significant neuronal apoptosis. Importantly, the cGAS-STING pathway inhibitor H-151 effectively suppressed the arsenic-induced astrocyte activation and IL-1β secretion, while also reducing neuronal apoptosis in the conditioned medium. Collectively, these results indicate that arsenic exposure activates the cGAS-STING signaling pathway in astrocytes, enhancing proinflammatory activation and IL-1β expression, which in turn mediates neuronal apoptosis, representing a critical mechanism underlying arsenic-induced neurotoxicity.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4224-4239"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety Considerations of Trace Metals in Locally Produced Nutritive Food-Drinks Consumed in Yenagoa Metropolis, Nigeria. 在尼日利亚叶纳戈阿市消费的当地生产的营养食品饮料中微量金属的安全考虑。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-27 DOI: 10.1007/s12011-024-04488-8

Tamaraukepreye Catherine Odubo, Sylvester Chibueze Izah

{"title":"Safety Considerations of Trace Metals in Locally Produced Nutritive Food-Drinks Consumed in Yenagoa Metropolis, Nigeria.","authors":"Tamaraukepreye Catherine Odubo, Sylvester Chibueze Izah","doi":"10.1007/s12011-024-04488-8","DOIUrl":"10.1007/s12011-024-04488-8","url":null,"abstract":"This study assessed the safety of trace metal concentrations in locally produced nutritive food-drinks consumed in Yenagoa metropolis, Bayelsa State, Nigeria. Three different drink types (viz, tiger nut juice, a mixture of tiger nut and soya bean juice and soya bean juice) were purchased from various locations in Yenagoa metropolis, Bayelsa State, Nigeria, between January and February 2024. Thirty samples were analyzed for trace metals using atomic absorption spectrophotometry. Detected metal concentrations ranged from 0.077 to 0.458 mg/L for iron, 0.159 to 1.251 mg/L for copper, 0.000 to 0.070 mg/L for zinc, 0.000 to 0.080 mg/L for cadmium, and 0.000 to 0.068 mg/L for manganese. Three (zinc, manganese, and copper) of the five detected metals had concentrations below the World Health Organization (WHO) and/or Standard Organization of Nigeria (SON) permissible limits using drinking water guidelines. Pearson correlation analysis indicated diverse metal sources, while principal component analysis (PCA) revealed significant variance driven by essential and trace metals. At the same time, crucial metals like zinc and iron dominate, and the presence of cadmium raises health concerns. The results suggest that while iron, zinc, and manganese generally pose minimal health risks, elevated copper and cadmium levels present potential non-carcinogenic risks in some samples. Hazard Index (HI) values (0.673-5.349) highlight the need for regulatory attention due to the cumulative effects of multiple trace metals. Although the calculated cancer risk (CR) values suggest no significant carcinogenic threat, continuous monitoring and mitigation are crucial, particularly for vulnerable populations who may experience prolonged exposure.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4408-4419"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metalomics Revealed that Changes of Serum Elements were Associated with Oxidative Stress-Induced Inflammation of Cortex in a Mouse Model of Autism. 金属组学揭示了自闭症小鼠模型中血清元素的变化与氧化应激诱导的皮层炎症有关。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-08-01 Epub Date: 2024-12-28 DOI: 10.1007/s12011-024-04501-0

Can Cao, Jian Li, Wenqi Cui, Jiaohua Dai, Zhiyu Guan, Dan Wang, Xiujuan Zhao

{"title":"Metalomics Revealed that Changes of Serum Elements were Associated with Oxidative Stress-Induced Inflammation of Cortex in a Mouse Model of Autism.","authors":"Can Cao, Jian Li, Wenqi Cui, Jiaohua Dai, Zhiyu Guan, Dan Wang, Xiujuan Zhao","doi":"10.1007/s12011-024-04501-0","DOIUrl":"10.1007/s12011-024-04501-0","url":null,"abstract":"Autism spectrum disorder (ASD) is a neurodevelopmental disorder emerging during early childhood. However, the mechanism underlying the pathogenesis of ASD remains unclear. This study investigated the alterations of elements in serum and prefrontal cortex of BTBR T + tf/J (BTBR) mice and potential mechanisms. The male BTBR mice were used for experimental group and C57BL/6 J (C57) mice were used for control group (n = 15). After behavioral tests were monitored, serum and prefrontal cortex of mice were analyzed by ICP-MS. The results demonstrated that the level of copper (Cu) was increased, and the levels of calcium (Ca), magnesium (Mg), selenium (Se), cobalt (Co), iron (Fe) and zinc (Zn) were decreased in BTBR mice compared to C57 mice (p < 0.01). The levels of above differential elements in serum demonstrated positive correlations with those in prefrontal cortex. Meanwhile, differential elements in prefrontal cortex had correlations with the total distance traveled (open field test) and the number of marbles buried (marble burying test) in BTBR mice (p < 0.05 or p < 0.01). The abnormally changed elements in serum might cross blood-brain-barrier into the brain and lead to oxidative stress, causing inflammation. Furtherly, the levels of inflammation-related indicators including tumor necrosis factor-alpha (TNF-α), nuclear factor kappa-B (NF-κB), interleukin-6 (IL-6) and interleukin-1β (IL-1β) were increased in prefrontal cortex of BTBR mice (p < 0.01), which were consistent with the aforementioned results. Our study suggested that the abnormal elements in the serum of BTBR mice may cause oxidative stress and inflammation in prefrontal cortex, which might contribute to increase the understanding of ASD pathogenesis.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4296-4307"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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