Biological Trace Element Research最新文献

{"title":"Zinc-Biofortified Rice Improves Growth in Zinc-Deficient Rats.","authors":"Venu Konda, Ravindranadh Palika, Ananthan Rajendran, C N Neeraja, R M Sundaram, Raghu Pullakhandam","doi":"10.1007/s12011-024-04487-9","DOIUrl":"https://doi.org/10.1007/s12011-024-04487-9","url":null,"abstract":"<p><p>Biofortification of staple food crops with zinc (Zn) is considered a sustainable strategy to prevent deficiency, but evidence on their health impact is awaited. The weaning Wistar/Kyoto male rats were fed on a Zn-deficient diet (ZDD, < 0.1 ppm) for 4 weeks followed by repletion (pair feeding) with control rice diet without (CRD; 5.0 ± 0.23 ppm) or with additional Zn (CRD + Zn, 30.3 ± 0.60 ppm) or biofortified rice diet (BRD; 8.54 ± 0.51 ppm) for 3 weeks. Body weights, plasma, liver, pancreatic, fecal Zn levels, and intestinal ZIP4 and ZnT1 mRNA expression were measured at the end of the experiment. The body weight of rats fed on CRD or CRD + Zn or BRD significantly increased (p < 0.01) compared to rats fed on ZDD. The body weight BRD was significantly higher compared to CRD (P < 0.01), both of which remained lower compared to CRD + Zn (p < 0.03). Repletion of Zn through either CRD or BRD significantly increased the plasma Zn concentration (PZC), tissue, and fecal Zn excretion compared to ZDD, without significant between-group differences. However, PZC, tissue, and fecal Zn of CRD + Zn was significantly higher compared to the rest of the groups. The intestinal ZIP4 and ZnT1 mRNA expressions are consistent with Zn status and/or dietary Zn exposure. A similar PZC, tissue, and fecal Zn in CRD compared to BRD, despite higher Zn intakes in the latter, could be due to preferential shuttling of Zn for growth. Together, these results indicate that Zn from biofortified rice is efficiently utilized for promoting the growth in Zn-deficient rats.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium Biofortification of Vegetables Grown in Calcareous Soil: A Pot Experiment Using ⁷⁷Se as a Tracer.","authors":"Abdolbaset B K Baset, Karzan A M Hawrami, Elizabeth H Bailey, Scott D Young","doi":"10.1007/s12011-024-04483-z","DOIUrl":"10.1007/s12011-024-04483-z","url":null,"abstract":"<p><p>Dietary selenium (Se) is vital for human health and can be provided through consumption of Se-rich vegetables. Soil Se is often poorly available and so biofortification using Se-enriched fertilizers is used to enhance dietary intake. This study aimed to (a) evaluate the feasibility of biofortifying vegetables, commonly grown in the calcareous soils of Kurdistan, with a single application of Se (10 g ha^-1) as selenate and, (b) trace the fate of applied Se using an enriched stable isotope, ⁷⁷Se. A randomized block pot experiment was conducted with five vegetable species: celery, chard, lettuce, radish, and spring onion. Soils were spiked with 2 µg ⁷⁷Se per pot, simulating 10 g ha^-1. Plants were harvested after 8 weeks, and both plant tissues and soils underwent sequential extraction and isotopic analysis to determine Se fractionation and source apportionment. Across all species, plant uptake of native soil Se (Se_s) exceeded that of fertilizer-derived Se (Se_f). Shoot concentrations of Se_s ranged from 58.2 to 115 µg kg^-1, while ⁷⁷Se_f concentrations varied between 10.5 and 46.9 µg kg^-1. Post-harvest soil analyses indicated immobilization of applied ⁷⁷Se: 55% transitioned to organically bound forms, 40% became recalcitrant, and only 5% remained in plant-available fractions. The study underscores the challenges of Se biofortification in calcareous soils, where interaction with CaCO₃ may reduce Se availability. Variations in Se uptake among vegetable species highlight the importance of application timing. To enhance biofortification efficacy for fast-growing leafy vegetables, mid-season or foliar Se applications are recommended to counteract rapid soil immobilization.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium Ameliorates Aluminum Poisoning-Induced Impaired Production of Neutrophil Extracellular Traps in Chicken.","authors":"Changyu Cao, Nixin Chen, Huquan Zhu, Huimin Ouyang, Xinran Li","doi":"10.1007/s12011-024-04485-x","DOIUrl":"https://doi.org/10.1007/s12011-024-04485-x","url":null,"abstract":"<p><p>Neutrophil extracellular traps (NETs) are released by neutrophils to modulate the immune response. Aluminum (Al) poisoning is linked to immunotoxicity, and selenium (Se) can maintain immune homeostasis. In this study, we investigated the toxic effects of Al on the release of NETs, the antagonistic effect of Se on Al-induced toxicity, and the potential molecular mechanisms underlying these processes. We assessed the cytotoxicity of aluminum on neutrophils using CCK-8 assay, visualized the structure of selenium/aluminum-induced NETs through immunofluorescence and scanning electron microscope, quantified ROS release during NETs formation using fluorescence microplate analysis, and employed the selenoprotein levels to dissect the mechanisms underlying selenium and aluminum-induced NETs release. Peripheral blood neutrophils were exposed to zymosan for a duration of 3 h to induce the formation of NETs. Microscopic analysis indicated that NETs formation was inhibited in the presence of aluminum. Furthermore, assessments using a multifunctional microplate reader demonstrated that aluminum suppressed both the production of extracellular DNA and the reactive oxygen species burst in neutrophils. Western blot analysis revealed that aluminum altered the levels of cellular selenoproteins. In contrast, Se reduced the Al-induced toxic reaction including restored NETs production, ROS burst, and selenoprotein levels. These results indicate that Al decreases the formation of NETs induced by Zym, while Se inhibits the Al toxicity, promoting the formation of NETs by modulating the expression of selenoprotein.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Chromium Supplementation on Serum Levels of Inflammatory Mediators: An Updated Systematic Review and Meta-analysis on Randomized Clinical Trials.","authors":"Ali Gholami, Masoudreza Sohrabi, Hamid Reza Baradaran, Mitra Hariri","doi":"10.1007/s12011-024-04486-w","DOIUrl":"https://doi.org/10.1007/s12011-024-04486-w","url":null,"abstract":"<p><p>Chromium has been recognized for its beneficial effects on inflammation reduction; therefore, we conducted a systematic review and meta-analysis to find the effect of chromium supplementation on serum levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in subjects aged 18 years and older. Related articles were identified by searching databases such as the Cochrane Library, ClinicalTrials.gov, ISI Web of Science, Scopus, and PubMed up until Agust 2024. We computed the mean differences (MD) along with their standard deviations (SDs) to carry out the meta-analysis. Statistical heterogeneity of the intervention effects was assessed using I-squared statistics and Cochran's Q test. In total, twelve and eleven studies were included in the present systematic review and meta-analysis, respectively. The pooled results indicated that the differences in serum levels of CRP and TNF-α between chromium group and the comparison group were statistically significant (CRP: weighted mean difference (WMD) = -0.58 mg/L; 95% confidence interval (CI) = -0.95, -0.22 mg/L; P = 0.002; TNF-α: WMD = -1.22 pg/ml; 95% CI = -1.91, -0.53 pg/ml; p = 0.001). In contrast, chromium supplementation resulted in a non-significant decrease in serum levels of IL-6 (WMD = -0.63 pg/ml; 95% CI: -1.67, 0.4 pg/ml; P < 0.001). Our study supports the beneficial effect of chromium supplementation on serum concentration of CRP and TNF-α, but our results showed that chromium supplementation non-significantly reduced the serum levels of IL-6. However, it seems that chromium formulation, participants' BMI, sample size, and geographical region are strong variables that predict the effect of chromium supplementation on inflammatory mediators.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Subacute Toxicity of Ulexite in Rats: Behavioral, Hematological, and Biochemical Insights.","authors":"Hasan Türkez, Özlem Özdemir Tozlu, Edanur Yıldız, Melik Saraçoğlu, Cem Baba, Burak Çınar, Serkan Yıldırım, Metin Kılıçlıoğlu, Kübra Çelik Topkara, Kenan Çadırcı","doi":"10.1007/s12011-024-04489-7","DOIUrl":"https://doi.org/10.1007/s12011-024-04489-7","url":null,"abstract":"<p><p>Ulexite (UX), a naturally occurring borate mineral, has gained interest for its diverse industrial applications, yet its toxicological profile remains inadequately characterized. This study aimed to evaluate the subacute toxicity of UX in rats, focusing on behavioral, hematological, and biochemical parameters. Rats were administered UX via gavage at doses of 10, 30, and 300 mg/kg for 7 days. No mortality or significant signs of toxicity were observed, although body weight measurements indicated a notable reduction in the UX-treated groups compared to controls. Behavioral assessments demonstrated increased exploratory activity in the 10 and 300 mg/kg UX treated groups, suggesting low anxiety levels. Likewise, hematological analysis revealed that 30 and 300 mg/kg UX led a significant (P < 0.001) increase in hematocrit and a decrease in mean corpuscular hemoglobin concentration (P < 0.001), indicating potential changes in erythropoiesis. Additionally, serum biochemistry showed elevated aspartate aminotransferase (P < 0.05), lactate dehydrogenase (P < 0.001), and uric acid levels (P < 0.01), suggesting liver stress. Histopathological examinations indicated dose-dependent alterations, with mild hepatocellular degeneration and neuronal changes observed at the highest dose. Also, MN levels in the blood of rats exposed to 10 and 30 mg/kg UX showed no significant differences. These results suggest that UX is relatively safe at lower doses, though higher exposures may pose health risks. Further research is warranted to elucidate the mechanisms underlying UX-induced effects and to evaluate its safety for therapeutic and occupational applications.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of Hypomagnesemia in Primary Hyperparathyroidism: A Turkish Nationwide Retrospective Cohort Study.","authors":"Bekir Ucan, Naim Ata, Muhammed Kizilgul, Rifat Bozkus, Suayip Birinci","doi":"10.1007/s12011-024-04481-1","DOIUrl":"https://doi.org/10.1007/s12011-024-04481-1","url":null,"abstract":"<p><p>Patients with primary hyperparathyroidism (PHPT) are predisposed to hypomagnesemia as well as hypophosphatemia. In the current literature, scarce data was available on the clinical significance of hypomagnesemia in PHPT. The present study aimed to investigate the prevalence of hypomagnesemia and its association with complications of PHPT in a large nationwide cohort. A nationwide population-based retrospective study was conducted using anonymized data from the Turkish Ministry of Health National Electronic Database (E-nabız). The International Statistical Classification of Diseases and Related Health Problems (ICD)-10 codes were used to identify patient cohort with PHPT (E21) and 96,337 patients with PHPT were reviewed. Female patients (74,650 (77.488%)) comprised the vast majority of the cohort and the mean age was 58.3 ± 15.3 years. It was observed that 38,709 (40.181%) of the patients had osteoporosis and 11,153 (11.577%) had renal stones. The prevalence of hypomagnesemia was 23.783%. While the frequency of osteoporosis increased significantly in patients with hypomagnesemia (45.435% vs. 38.541%, p < 0.0001), there was no difference between the two groups in terms of the frequency of renal stones. In terms of its possible effects on the presence of hypomagnesemia, the presence of osteoporosis, hypercalcemia (≥ 11.2 mg/dL), lower eGFR levels (< 60 mL/min), higher PTH levels (≥ 150 pg/mL), and advanced age (≥ 50 years) were found to be significantly effective in multivariate logistic regression analyses. Hypomagnesemia is observed in approximately one-quarter of patients with PHPT. The presence of hypomagnesemia in a PHPT patient may indicate a more severe form of hyperparathyroidism and an increased risk of osteoporosis.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel Sulfate-Induced GSIS Injury in MIN6 Cells by Activating the JNK Pathway Through Oxidative Stress.","authors":"Bo Sun, Hui Chen","doi":"10.1007/s12011-024-04477-x","DOIUrl":"https://doi.org/10.1007/s12011-024-04477-x","url":null,"abstract":"<p><p>Nickel has an impact on human health, especially in the context of the new energy industries. Nickel's influence on glycemia remains controversial, and the effects and mechanisms of nickel on islet function still need further exploration. MIN6 cells were treated with different concentrations of nickel sulfate (NiSO₄) (0, 75, 150, and 300 µg/mL) for different durations (0, 12, 24, and 48 h). The study measured cell cycle progression, apoptosis, reactive oxygen species (ROS) production, oxidative stress-related indexes (T-SOD, TBARS, 8-OHdG, and GSH), glucose-induced insulin secretion (GSIS), and the expression of JNK pathway-related proteins, pancreaticoduodenal homeobox-1 (PDX-1), glucose transporter 2 (GLUT2), and forkhead box protein O1 (FOXO1). NiSO₄ damaged MIN6 cells in a time- and dose-dependent manner. NiSO₄ blocked the cell cycle, induced apoptosis, and reduced insulin secretion in the GSIS experiment. NiSO₄ also induced ROS production, increased oxidative stress-related indexes (TRABS and 8-OHdG), and decreased antioxidant stress-related indexes (GSH and T-SOD). In addition, NiSO₄ activated the JNK pathway, upregulated FOXO1 protein expression, and inhibited PDX-1 and GLUT2 protein expression, affecting insulin release during GSIS. NiSO₄ inhibited the proliferation of MIN6 cells through oxidative stress, aggravated apoptosis, caused functional impairment, upregulated the expression of FOXO1 by activating the JNK pathway, inhibited the expression of PDX-1 and GLUT2 proteins, and impaired the GSIS function of islets.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats.","authors":"Hossam Ebaid, Samir A E Bashandy, Iftekhar Hassan, Jameel Al-Tamimi, Shimaa Abdallah Haredy, Tharwat Imbabi, Enayat A Omara, Yousef S Bashandy, Ezzat M Awad","doi":"10.1007/s12011-024-04442-8","DOIUrl":"https://doi.org/10.1007/s12011-024-04442-8","url":null,"abstract":"<p><p>Male infertility is a complex and multifactorial clinical condition affecting a large population attributed to several factors, including perturbation in oxidative stress and the level of essential trace elements. Oxidative stress exerts multiple issues related to reproductive health, including male infertility, decreased sperm motility, sperm DNA damage, and an increased susceptibility to genetic disorders. Besides chemical toxins and food allergens in junk food items, many drugs can also lead to male infertility. Olanzapine (OLZ), a general antipsychotic drug, has also been reported to induce male fertility. A great deal of literature entails that supplementation of zinc can alleviate oxidative stress-related clinical complications, including male infertility. This study investigates the potential protective effects of zinc sulfate (ZnSO4) on OLZ-induced male infertility. In the present study, there were four treatment groups (n = 6): group 1 as control (without any treatment); group 2 treated with OLZ (10 mg/kg) orally daily for 6 weeks; groups 3 and 4 treated with 50 mg/kg and 100 mg/kg of ZnSO4 respectively in pre-exposed OLZ (10 mg/kg) orally daily for 6 weeks. After completion of the treatment, the biochemical analysis of serum and tissue samples demonstrated that group 2 had compromised levels of antioxidant parameters (superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH)) as well as elevated levels of stress parameters (oxidized glutathione (GSSG), malondialdehyde (MDA), and nitric oxide (NO)) as compared to the control by a significant extent (p ≤ 0.05). However, supplementation of ZnSO4 significantly corrected all these parameters in a dose-dependent way in groups 3 and 4 (p ≤ 0.05). Other health indicators, like taurine, enzyme Q10, phosphatidylcholine, ascorbic acid, and vitamin E, were also observed to improve prominently with the supplementation of ZnSO4. Intriguingly, all the fertility parameters (sperm motility, count and level of testosterone) were also found to be significantly enhanced with decreased sperm abnormalities in both the combination groups. The histological evaluation of the testis section also agreed with the biochemical analysis in this investigation. Therefore, the study strongly advocates that supplementation of Zn can ameliorate OLZ-induced male infertility to a significant extent.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Causal Association Between 15 Micronutrients and 12 Obstetric-Related Diseases: A Mendelian Randomization Study.","authors":"Lele Pan, Jing Zhang, Mingwei Chen, Li Yuan, Rong Chen, Lina Zhao","doi":"10.1007/s12011-024-04479-9","DOIUrl":"https://doi.org/10.1007/s12011-024-04479-9","url":null,"abstract":"<p><p>Micronutrients, namely vitamins and minerals, are associated with pregnancy outcomes. However, the effects reported in previous observational studies and randomized controlled trials have been inconsistent. Using publicly available genetic data, we conducted a two-sample MR analysis to estimate the causal association between 15 micronutrient levels and 12 obstetric-related diseases. Sensitivity analysis was performed to assess the robustness of the results, detect heterogeneity, and examine the potential existence of horizontal pleiotropy. Iron was protective against gestational diabetes mellitus (GDM) (OR = 0.597, 95% CI 0.438-0.814, P = 0.001), while zinc increased the risk of pregnancy hypertension (OR = 1.064, 95% CI 1.004-1.128, P = 0.035). Vitamin B6 was associated with increased risk of spontaneous abortion (OR = 1.222, 95% CI 1.001-1.490, P = 0.047), and vitamin D was linked to poor fetal growth (OR = 1.612, 95% CI 1.018-2.552, P = 0.041). Conversely, vitamin B12 showed protective effects against preterm birth (OR = 0.686, 95% CI 0.482-0.976, P = 0.036). Selenium and vitamin E were protective against polyhydramnios (OR = 0.828, 95% CI 0.698-0.981, P = 0.030; OR = 0.441, 95% CI 0.213-0.910, P = 0.026), whereas selenium increased the risk of premature rupture of membranes (OR = 1.083, 95% CI 1.007-1.164, P = 0.030).However, no causal links were found between the other micronutrients analyzed and obstetric-related diseases. Sensitivity analyses revealed no significant heterogeneity or pleiotropy. Our research has clarified the causal link between micronutrients and obstetric-related diseases, assisting clinicians in offering personalized guidance on the appropriate intake of micronutrients for women preparing for pregnancy and those who are pregnant. These findings are essential for screening and preventing pregnancy complications, and they also provide new insights and evidence for improving pregnancy outcomes through nutritional interventions.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fate and Effects of Heavy Metals in Fishes: Antioxidant Defense System, miRNA/Gene Expression Response, and Histopathological Reproductive Manifestations.","authors":"Rayees Ahmad Bhat, Absar Alam, Dharm Nath Jha, Vikas Kumar, Jeetendra Kumar, Venkatesh Ramrao Thakur, Basanta Kumar Das","doi":"10.1007/s12011-024-04478-w","DOIUrl":"https://doi.org/10.1007/s12011-024-04478-w","url":null,"abstract":"<p><p>Heavy metal pollution is a major environmental concern and in particular for aquatic ecosystems. With heavy metals exceeding safe and recommended limits, they pose significant threats to the environment and its inhabitants, including fish. Heavy metals, when accumulated in the different organs of the fish, result in toxicity in fish by producing reactive oxygen species (ROS) through the generation of oxidizing radicals. This oxidative stress mechanism is a key factor in the detrimental effects of heavy metal pollution on aquatic life. Heavy metal exposure profoundly affects fish behavior and physiology. In this review, an attempt was made to report the effects of heavy metals on fish physiology, focusing on toxicological effects on antioxidant enzymes, microRNAs (miRNAs) and molecular genetic responses, histopathology of organs, and underlying molecular mechanisms. This review also highlighted the heavy metal impact on fish gonads (testes and ovaries) and the hormones associated with it. The detection methods and the incorporation of latest developments in AI-based technology for the detection of heavy metals are also included in this review. Understanding the above effects is important for assessing the ecological impact of heavy metal pollution and developing strategies to mitigate its adverse effects on aquatic life. Understanding the consequences listed above is important for analyzing the ecological impact of heavy metal pollution and devising measures to reduce its negative effects on aquatic life and human health.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}