Biological Trace Element Research最新文献

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Dietary Iron Alleviates Dextran Sodium Sulfate-Induced Intestinal Injury by Regulating Regeneration of Intestinal Stem Cells in Weaned Mice. 膳食铁通过调节肠道干细胞再生减轻右旋糖酐硫酸钠诱导的断奶小鼠肠道损伤。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-02-25 DOI: 10.1007/s12011-025-04546-9
Xianglin Zeng, Lanmei Yin, Yitong Zhang, Qianqian Wang, Jun Li, Yuebang Yin, Qiye Wang, Jianzhong Li, Huansheng Yang
{"title":"Dietary Iron Alleviates Dextran Sodium Sulfate-Induced Intestinal Injury by Regulating Regeneration of Intestinal Stem Cells in Weaned Mice.","authors":"Xianglin Zeng, Lanmei Yin, Yitong Zhang, Qianqian Wang, Jun Li, Yuebang Yin, Qiye Wang, Jianzhong Li, Huansheng Yang","doi":"10.1007/s12011-025-04546-9","DOIUrl":"10.1007/s12011-025-04546-9","url":null,"abstract":"<p><p>Iron deficiency is the most common comorbidity of inflammatory bowel disease (IBD), but the effect of iron supplementation on the repair processes of intestinal injury in weaned mice is unknown. This study aimed to evaluate the potential mechanism of dietary iron on intestinal injury and intestinal regeneration in the dextran sodium sulfate (DSS)-induced colitis of the weaned mouse model. The mice were fed either a control diet containing (45.00 mg/kg Fe) or iron supplemental (448.30 mg/kg Fe) diet for 14 days, followed by a 7-day oral administration of 2.5% DSS to all mice. The result showed that at day 0 of the recovery period (0 DRP), the impact of iron on the gut index and intestinal morphology was found to be more significant in weaned mice compared to adult mice. At 3 DRP, the iron diet alleviated inflammation-induced weight loss, shortening of colon length, thickening of the muscle layer, and disruption of gut morphology. At 0, 3, and 7 DRP, we found that an iron diet increased intestinal stem cell (ISC) viability and protected epithelial integrity. Furthermore, FeSO<sub>4</sub> significantly enhanced organoid viability and increased mRNA expression of differentiation, ISC, and retinol metabolism-related marker genes in the organoids compared with the control group. Overall, this study demonstrates that the iron diet accelerates intestinal regeneration after intestinal injury in weaned mice by activating the retinol metabolic pathway to regulate the proliferation and differentiation of ISCs.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5219-5234"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lamb Performance and Meat Quality: The Impact of Chromium in High-Concentrate Diets and Its Molecular Effects on Skeletal Muscle During Finishing Phase. 羔羊生产性能和肉品质:高精料饲粮中铬的影响及其对肥育期骨骼肌的分子效应。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-02-26 DOI: 10.1007/s12011-025-04556-7
Helena Viel Alves Bezerra, German Darío Ramírez-Zamudio, Miguel Henrique de Almeida Santana, Guilherme Henrique Gebim Polizel, Regner Ítalo Gonçalves de Oliveira, Guilherme Pegoraro Rissi, André Ricardo Frujuelle Filho, Mirele Daiana Poleti, Leonardo Velloso, Thiago Henrique da Silva, Sarita Bonagurio Gallo, Saulo da Luz E Silva, Nara Regina Brandão Cônsolo, Paulo Roberto Leme
{"title":"Lamb Performance and Meat Quality: The Impact of Chromium in High-Concentrate Diets and Its Molecular Effects on Skeletal Muscle During Finishing Phase.","authors":"Helena Viel Alves Bezerra, German Darío Ramírez-Zamudio, Miguel Henrique de Almeida Santana, Guilherme Henrique Gebim Polizel, Regner Ítalo Gonçalves de Oliveira, Guilherme Pegoraro Rissi, André Ricardo Frujuelle Filho, Mirele Daiana Poleti, Leonardo Velloso, Thiago Henrique da Silva, Sarita Bonagurio Gallo, Saulo da Luz E Silva, Nara Regina Brandão Cônsolo, Paulo Roberto Leme","doi":"10.1007/s12011-025-04556-7","DOIUrl":"10.1007/s12011-025-04556-7","url":null,"abstract":"<p><p>Chromium is an essential trace mineral in insulin-mediated glucose metabolism, potentially affecting protein synthesis and improving performance and meat quality. This study aimed to assess the impact of chromium on performance, carcass characteristics, meat quality, and the gene expression in the skeletal muscle of lambs fed a high-concentrate diet. Sixteen just just-weaned Dorper × Santa Inês crossbred lambs, weighing 24.95 ± 1.97 kg, were allocated into a control group, a basal diet without chromium in the diet supplementation (CTL) or chromium supplementation (Cr3.0), with the addition of 3.0 mg of chromium per kg of dry matter (Cr3.0DM). The animals were housed in individual pens and fed a diet comprising 6% forage and 94% concentrate for 60 days. We evaluated average daily gain (ADG), dry matter intake (DMI), feed efficiency (FE), carcass characteristics, meat quality, and muscle transcriptome. Chromium supplementation increased ADG (P = 0.048) and tended to improve FE (P = 0.08). Further, chromium supplementation increased kidney, pelvic, and heart fat (P ≤ 0.05). In meat, a reduction in cooking losses and an increase in shear force were observed in the meat of lambs treated with chromium-treated lambs (P ≤ 0.05). Transcriptome analysis revealed 21 differentially expressed genes, with 9 downregulated genes, including COX6C, TMED5, ODC1, HNRNPA1, and 12 upregulated genes, such as RPL39, RPL35A, RPS25, NSA2, RRM2, GCNT1, associated with pathways of ribosome biogenesis, protein synthesis, collagen remodeling, and fat metabolism. In conclusion, dietary chromium supplementation at 3.0 mg/kg DM can improve performance and efficiency without affecting carcass characteristics. In meat, chromium reduced cooking losses, potentially increasing its juiciness, but reduced its juiciness-related tenderness, negatively impacting the tenderness of the meat.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5195-5208"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Elements by ICP-OES Method in Ice-Cream and Cream Samples: A Risk Assessment Study by Monte Carlo Simulation. ICP-OES法测定冰淇淋和奶油样品中的元素:蒙特卡罗模拟风险评估研究。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-04-08 DOI: 10.1007/s12011-025-04578-1
Mojtaba Moazzen, Nabi Shariatifar, Sara Sohrabvandi, Amir Mohammad Mortazavian, Khadijeh Khoshtinat, Seyedeh Mahsa Khodaei, Elham Khanniri
{"title":"Determination of Elements by ICP-OES Method in Ice-Cream and Cream Samples: A Risk Assessment Study by Monte Carlo Simulation.","authors":"Mojtaba Moazzen, Nabi Shariatifar, Sara Sohrabvandi, Amir Mohammad Mortazavian, Khadijeh Khoshtinat, Seyedeh Mahsa Khodaei, Elham Khanniri","doi":"10.1007/s12011-025-04578-1","DOIUrl":"10.1007/s12011-025-04578-1","url":null,"abstract":"<p><p>Since the consumption of dairy products, especially ice cream and cream, is very high in Iran and the world, either directly or indirectly, and no study has been conducted so far on measuring elements in different types of ice cream and cream, the aim of the present study was to investigate levels of 15 elements (Co, Mn, Fe, Cr, Se, Mg, P, Ca, Zn, Hg, Al, Ni, Cd, As, and Pb) by using ICP-OES (Inductively Coupled Plasma Optical Emission Spectroscopy) technique in the mentioned products along with a health risk assessment by Monte Carlo Simulation. Based on our findings, in all samples, the highest average level of toxic elements was related to Al (29.2 ± 23.9 µg/kg fw or fresh weight), and the lowest mean level of toxic elements was related to Hg (not found). Moreover, the highest average level of essential elements was related to P (8895 ± 4369 µg/kg fw) and the lowest mean level of essential elements was related to Se (0.610 ± 0.150 µg/kg fw). Also, the highest averages of toxic elements in cream was related to As (12.5 µg/kg fw) and in ice cream was related to Al (43.9 µg/kg fw), and the lowest averages were obtained for Hg (not found) in both products. Also, the highest and lowest averages of essential elements in cream were related to P (10641 µg/kg fw) and Se (not found), respectively, and in the ice cream were related to Ca (8135 µg/kg fw) and Se (0.630 µg/kg fw), respectively. In the end, the levels of elements in all ice cream and cream samples were below the standard level. The Monte Carlo method risk assessment reveals that the non-carcinogenic risks from consuming cream and ice cream pose no threat to children or adults (TTHQ < 1.00), but on the contrary, the outcomes of the carcinogenic risk assessment show the TILCR values for both groups exceed acceptable limits, that this indicating a potential risk threat from these products. The principal component analysis (PCA) results revealed the categorization of various toxic and essential elements in all samples. Based on the results obtained, it can be concluded that the consumption of these products is somewhat safe, but more monitoring is needed in the food cycle from farm to fork.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5461-5477"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Potential of Green Synthesized Polyherbal Formulated Silver Nanoparticles in Alloxan-Induced Diabetes Mellitus-An In Vivo Strategy. 绿色合成多草药配方银纳米颗粒对四氧嘧啶诱导糖尿病的体内治疗潜力
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-03-12 DOI: 10.1007/s12011-025-04566-5
Noshaba Afshin, Nadia Mushtaq, Mushtaq Ahmed, Saboor Badshah, Sultan Mehmood Wazir, Farhad Badshah, Naila Sher, Jawaher Alkahtani, Sezai Ercisli, Mohamed S Elshikh, Riaz Hussain, Noor Ul Huda, Hajra Hameed
{"title":"Therapeutic Potential of Green Synthesized Polyherbal Formulated Silver Nanoparticles in Alloxan-Induced Diabetes Mellitus-An In Vivo Strategy.","authors":"Noshaba Afshin, Nadia Mushtaq, Mushtaq Ahmed, Saboor Badshah, Sultan Mehmood Wazir, Farhad Badshah, Naila Sher, Jawaher Alkahtani, Sezai Ercisli, Mohamed S Elshikh, Riaz Hussain, Noor Ul Huda, Hajra Hameed","doi":"10.1007/s12011-025-04566-5","DOIUrl":"10.1007/s12011-025-04566-5","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a non-communicable, life-threatening syndrome prevalent worldwide. One effective treatment for DM is the medicinal use of green synthesized silver nanoparticles (AgNPs), which are eco-friendly and cost-effective. This study investigates the antidiabetic potential of greensynthesizedAgNPs derived from a polyherbal formulation (PHF). Characterization of PHF-AgNPs included UV-Vis spectroscopy, FTIR, XRD, SEM, and EDX. Diabetes was induced in albino Wistar rats (N = 30, n = 6/group, 150-200 g, 8 weeks old) via intraperitoneal alloxan injection (150 mg). Groups are as follows: 1) untreated control, 2) diabetic control (150 mg/kg b.w. alloxan), 3) glibenclamide (0.5 mg/kg), 4) PHF-AgNPs (10 mg/kg), and 5) PHF-AgNPs (20 mg/kg). Blood glucose levels (BGL) were monitored on days 0, 7, 14, and 21. Blood samples were collected for the liver, kidney, and lipid profile analysis before euthanization. The results showed that PHF-AgNPs had an average size of 20 nm and exhibited significant reductions in BGL, with PHF-AgNPs at both 10 mg/kg and 20 mg/kg demonstrating superior effects compared to glibenclamide. Histopathological analysis revealed tissue regeneration in the liver, kidney, and pancreas, indicating healing of alloxan-induced damage. Additionally, treatment improved liver and kidney function markers, and lipid profiles, with reductions in cholesterol, triglycerides, ALT, AST, and creatinine levels compared to the diabetic control group. These findings suggest that green synthesized PHF-AgNPs effectively improved blood glucose control, body weight, and organ health, positioning them as a promising antidiabetic agent with potential for further clinical development.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5281-5298"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends? 揭示微量营养素与自身免疫性甲状腺炎之间的联系:它们是真正的朋友吗?
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-02-18 DOI: 10.1007/s12011-025-04548-7
Yunfeng Yu, Keke Tong, Juan Deng, Jingyi Wu, Rong Yu, Qin Xiang
{"title":"Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends?","authors":"Yunfeng Yu, Keke Tong, Juan Deng, Jingyi Wu, Rong Yu, Qin Xiang","doi":"10.1007/s12011-025-04548-7","DOIUrl":"10.1007/s12011-025-04548-7","url":null,"abstract":"<p><p>The role of micronutrients in autoimmune thyroiditis (AIT) has been controversial and lacks sufficient genetic evidence. This study aimed to assess the relationships between various micronutrients and AIT by Mendelian randomization (MR). The single nucleotide polymorphisms (SNPs) of micronutrients and AIT were acquired from IEU Open GWAS project and FinnGen, and were screened according to the basic assumptions of MR. Subsequently, inverse variance weighted was set as the primary tool for MR analysis, with weighted median, simple mode, MR-Egger, and weighted mode set as secondary tools. Next, the MR-Egger intercept was used to assess the horizontal pleiotropy of results. Finally, Cochran's Q test and sensitivity analysis were used to assess the heterogeneity and robustness of the results, respectively. MR analysis showed that vitamin B12 reduced genetic susceptibility to AIT by 83.6% (odds ratio 0.164, 95% confidence interval 0.030 to 0.910, p = 0.039), whereas magnesium, calcium, carotene, copper, folate, iron, potassium, selenium, zinc, vitamin A, vitamin B6, vitamin C, vitamin D, and vitamin E were not associated with genetic susceptibility to AIT (p ≥ 0.05). The MR-Egger intercept showed that these results had no horizontal pleiotropy (p ≥ 0.05). Cochran's Q test and sensitivity analysis showed that these results were not heterogeneous (p ≥ 0.05) and were robust. This study demonstrated that vitamin B12 reduced the risk of AIT, whereas other micronutrients were not associated with the risk of AIT. It provides a new genetic perspective on the pathogenesis of AIT and strengthens the evidence for vitamin B12 as a potential treatment for AIT.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"4994-5005"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Tradition to Innovation: Pinellia ternata Extracts Stabilized Selenium Nanoparticles for Enhanced Bioactivity. 从传统到创新:半夏提取物稳定硒纳米颗粒增强生物活性。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-03-06 DOI: 10.1007/s12011-025-04569-2
Quanxiu Wang, Zijin Chen, Xinya Xu, Kaixin Dai, Xiujie Li, Hui Lu, Shujun Wei, Zhenyu Lian, Leilei Guo
{"title":"From Tradition to Innovation: Pinellia ternata Extracts Stabilized Selenium Nanoparticles for Enhanced Bioactivity.","authors":"Quanxiu Wang, Zijin Chen, Xinya Xu, Kaixin Dai, Xiujie Li, Hui Lu, Shujun Wei, Zhenyu Lian, Leilei Guo","doi":"10.1007/s12011-025-04569-2","DOIUrl":"10.1007/s12011-025-04569-2","url":null,"abstract":"<p><p>Selenium nanoparticles (SeNPs) are widely used for their effective antioxidative, anti-tumor, and antibacterial properties with minimal toxicity. Developing eco-friendly and simple synthesis methods for SeNPs with improved bioactivity, biocompatibility, and stability is crucial. This study synthesized bioactive SeNPs using extracts from the traditional Chinese medicine Pinellia ternata as a stabilizing agent. SeNPs were characterized to have an amorphous structure, spherical shape, uniform dispersion, and an average diameter of 54.6 nm. They had a surface charge of - 28.2 mV, enhancing stability through interactions with compounds in Pinellia ternata extracts. The synthesized SeNPs demonstrated strong antioxidant and antibacterial properties in vitro, outperforming Na<sub>2</sub>SeO<sub>3</sub> and Pinellia ternata extracts. Specifically, SeNPs showed bacteriostatic activity against Escherichia coli (E. coli) at 120, 240, and 480 µg/mL, with a lasting effect at 480 µg/mL after 23 h. Staphylococcus aureus (S. aureus) was more sensitive, with significant antimicrobial and bactericidal effects at 15, 30, and 60 µg/mL, achieving complete inhibition at 60 µg/mL after 20 h. In zebrafish exposure experiments, SeNPs at low (0.2 mg/L) and medium (0.5 mg/L) concentrations enhanced antioxidant enzyme activities in the liver without inducing significant acute toxicity, whereas high concentrations (1 mg/L) resulted in oxidative damage to the liver and gills. This study introduces a novel method for synthesizing a stable SeNP-herbal medicine extracts composite with outstanding biological activity and biosafety, potentially expanding the applications of herbal medicine beyond traditional antioxidant and antimicrobial treatments.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5383-5400"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deterministic and Probabilistic Risk Assessment of Elemental Composition in Pistachios and Hazelnuts from Iran. 伊朗开心果和榛子元素组成的确定性和概率风险评估。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-03-03 DOI: 10.1007/s12011-025-04564-7
Zahra Hadian, Nabi Shariatifar, Majid Arabameri, Mojtaba Moazzen, Amin Mousavi Khaneghah
{"title":"Deterministic and Probabilistic Risk Assessment of Elemental Composition in Pistachios and Hazelnuts from Iran.","authors":"Zahra Hadian, Nabi Shariatifar, Majid Arabameri, Mojtaba Moazzen, Amin Mousavi Khaneghah","doi":"10.1007/s12011-025-04564-7","DOIUrl":"10.1007/s12011-025-04564-7","url":null,"abstract":"<p><p>In the present study, concentrations of 28 elements (Ca, Cu, Li, Co, Sn, Fe, S, Pt, Au, Bi, B, Sr, W, Si, P, Mg, K, Mn, Na, Ni, Se, Zn, Al, Ba, Cd, Pb and As) in pistachios and hazelnuts collected from local markets in Tehran, Iran, were assessed using ICP-OES. The elemental risk assessments were carried out by estimating recommended dietary allowance, chronic daily intake, target hazard quotient, and incremental lifetime cancer risk. Results revealed that the highest and the lowest concentrations of elements in all samples included K (4700 ± 3473 μg Kg<sup>-1</sup>) and Li (0.173 ± 0.40 μg Kg<sup>-1</sup>), respectively. In addition, results showed that Cd, As, Pb, Co, Bi, Au, Pt, and Sn were not detected in the samples. In all the nuts samples, quantities of the elements (μg Kg<sup>-1</sup>) were less than the standard levels (Pb = 20, Cd = 10, As = 140, Al = 500, Fe = 2700 and Mn = 100). The principal component analysis results highlighted the distinguishing characteristics of the nuts. Cluster analysis helped distinguish four subgroups based on their ability to accumulate elements. Therefore, chemometric analysis could be a practical method for classifying nut samples based on their elements. Based on the results of health risk indicators, no risks of exposure to heavy metals from the consumption of Iranian pistachio and hazelnut samples are reported.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5440-5452"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Arsenic and Nickel with Markers of Insulin Resistance and Beta Cell Dysfunction: A Case-Control Study in Indo Gangetic Plain. 砷和镍与胰岛素抵抗和β细胞功能障碍标志物的关系:印度恒河平原的病例对照研究。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-03-25 DOI: 10.1007/s12011-025-04574-5
Shefali Singh, Juhi Verma, Nikhil Gupta, Anumesh K Pathak, Manish Singh Rajput, Vandana Tiwari, Manish Raj Kulshrestha
{"title":"Association of Arsenic and Nickel with Markers of Insulin Resistance and Beta Cell Dysfunction: A Case-Control Study in Indo Gangetic Plain.","authors":"Shefali Singh, Juhi Verma, Nikhil Gupta, Anumesh K Pathak, Manish Singh Rajput, Vandana Tiwari, Manish Raj Kulshrestha","doi":"10.1007/s12011-025-04574-5","DOIUrl":"10.1007/s12011-025-04574-5","url":null,"abstract":"<p><p>Environmental exposure to toxic metals/metalloids (TM) has been linked to type 2 diabetes mellitus (T2DM) via mechanisms involving insulin resistance and beta cell dysfunction, especially in regions with significant industrial and agricultural activities. This study assessed the relationship between serum toxic element levels and glycemic markers, including HbA1c, insulin resistance (HOMA-IR), and beta cell function (HOMA-β%). In total, 783 participants (480 T2DM patients and 303 controls) were recruited. TM (Ni, As, Al, Pb, Cd, and Hg) was quantified using inductively coupled plasma mass spectrometry. HbA1c was measured using ion exchange high-performance liquid chromatography, while fasting insulin and glucose levels were measured using a Cobas 6000 Roche autoanalyzer to calculate HOMA-IR and HOMA-β%. Among the tested TM, As (72.2%) and Ni (66.2%) were the most prevalent and associated with T2DM. On multivariate analysis, Ni and As levels were significantly positively correlated with HbA1c (Ni: β = 0.13, As: β = 0.16) and IR (Ni: β = 0.31, As: β = 0.24), and negatively correlated with β-cell function (Ni: β = -0.09, As: β = -0.19). A significant decline in beta cell function (Ni: Q1:55.96, Q4:34.27; As: Q1:58.61, Q4:27.88) and increased IR (Ni: Q1:2.75, Q4:3.97; As: Q1:2.77, Q4:3.76) was observed across exposure quartiles. Nonfiltered water consumption and smoking were associated with higher levels of Ni, As, and IR. The risk (adjusted odds ratio) of T2DM increased 2.18-fold and 6.81-fold with Ni and As exposure, respectively. The district with the highest exposure (Bahraich) to Ni (82%) and As (88%) had the highest prevalence (82%) of T2DM among the study population. Arsenic and nickel exposure are strongly associated with impaired glycemic markers in T2DM and correspond to drinking water in the Indo-Gangetic Plain. Smoking was also associated with high Ni and As levels.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5108-5126"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorating Nickel-Induced Stress in Hypophthalmichthys molitrix (Silver Carp) Through Piper nigrum Extract Supplementation. 添加胡椒提取物改善镍诱导的鲢鱼应激。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-02-26 DOI: 10.1007/s12011-025-04560-x
Syed Muhammad Farhan Ali Shah, Syed Makhdoom Hussain, Shafaqat Ali, Pallab K Sarker, Khalid A Al-Ghanim, Sunakbaeva Dilara
{"title":"Ameliorating Nickel-Induced Stress in Hypophthalmichthys molitrix (Silver Carp) Through Piper nigrum Extract Supplementation.","authors":"Syed Muhammad Farhan Ali Shah, Syed Makhdoom Hussain, Shafaqat Ali, Pallab K Sarker, Khalid A Al-Ghanim, Sunakbaeva Dilara","doi":"10.1007/s12011-025-04560-x","DOIUrl":"10.1007/s12011-025-04560-x","url":null,"abstract":"<p><p>The current study examined the damaging implications of nickel (Ni) toxicity on body composition, growth responses, histology and hematology of Hypophthalmichthys molitrix, as well as the potential mitigating effects of Piper nigrum extract. For this purpose, H. molitrix were distributed into six groups, namely T1, T2, T3, T4, T5, and T6. All treatments were assessed in triplicates. T1 was designated as the negative control treatment, receiving no Ni exposure or dietary supplementation, whereas T2 acted as the positive control treatment, exposed to sub-lethal concentrations of nickel chloride (NiCl<sub>2</sub>) at 3.6 mg/L. Groups T3-T6 received diets enriched with 1%, 2%, 3% and 4% P. nigrum extract, respectively and were also exposed to 3.6 mgL<sup>-1</sup> NiCl<sub>2</sub> toxicity. The findings of this investigation revealed that T2 exhibited decreased growth responses, characterized by a weight gain (WG) of 8.12 g, percentage weight gain (WG%) of 77.83% and specific growth rate (SGR) of 0.96. Additionally, T2 displayed altered hematological parameters such as reduced red blood cells (RBC: 1.3 × 10<sup>6</sup> mm<sup>-3</sup>) and hemoglobin levels (Hb: 5.8 g/100 ml), and increased white blood cell counts (WBC: 75.31 × 10<sup>3</sup> mm<sup>-3</sup>). Also, T2 showed reduced protein (13.14%), fat (2.15%), and moisture content (73.44%), hepatocyte degeneration, and Ni bioaccumulation in hepatic tissues. In contrast, T1 (control negative) and T3 (1% P. nigrum extract) demonstrated improved growth performance with WG of 18.49 g and 16.92 g, respectively. They also showed increased RBC (1.77 × 10<sup>6</sup> mm<sup>-3</sup> and 2.77 × 10<sup>6</sup> mm<sup>-3</sup>) and Hb levels (9.65 g/100 ml and 8.15 g/100 ml), decreased WBC counts (6.12 × 10<sup>3</sup> mm<sup>-3</sup> and 7.79 × 10<sup>3</sup> mm<sup>-3</sup>), and elevated protein (16.42% and 15.29%), fat (3.22% and 3.11%), and moisture content (76.92% and 76.6%), respectively. Furthermore, liver histological analysis revealed that dietary supplementation with 1% P. nigrum extract (T3) effectively minimized the adverse effects of NiCl2 toxicity, characterized by a normal central vein structure and significantly reduced histological damage. In conclusion, the results show that 1% P. nigrum extract supplementation significantly ameliorates the adverse effects on carcass composition, elevates growth responses, enhances hematological indices, and mitigates the toxic effects of Ni on the histology of H. molitrix. This comprehensive improvement in nutritional quality, growth rates, blood health, and tissue integrity suggests that P. nigrum extract has tremendous potential as a natural remedy for mitigating the adverse effects of Ni toxicity in aquatic species.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5359-5369"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the Impact of Bismuth Oxide Nanoparticles on Dazl Gene Expression and Spermatogenesis Indices in Male Mice. 氧化铋纳米颗粒对雄性小鼠Dazl基因表达及精子发生指标的影响。
IF 3.6 3区 生物学
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-02-26 DOI: 10.1007/s12011-025-04554-9
Mohadese Farahani, Amir Jalali, Samira Moghadasi, Marziyeh Rezaei, Reyhaneh Khodadadi
{"title":"Investigating the Impact of Bismuth Oxide Nanoparticles on Dazl Gene Expression and Spermatogenesis Indices in Male Mice.","authors":"Mohadese Farahani, Amir Jalali, Samira Moghadasi, Marziyeh Rezaei, Reyhaneh Khodadadi","doi":"10.1007/s12011-025-04554-9","DOIUrl":"10.1007/s12011-025-04554-9","url":null,"abstract":"<p><p>Bismuth (Bi) exposure has been linked to various health effects, but its direct impact on male fertility remains largely unexplored. This study investigated the effects of bismuth oxide nanoparticles (Bi₂O₃ NPs) on male reproductive function in Naval Medical Research Institute (NMRI) mice. The mice were randomly allocated to seven groups: one control receiving physiological saline and six treatment groups receiving Bi₂O₃ NPs (25, 50, 100, 200, 400, and 800 mg/kg body weight/day) for 35 days. Treatment was administered via oral gavage. Following treatment, we evaluated body weight, blood serum biochemistry, Dazl gene expression, sperm quality, testicular histology, and cell counts (spermatogenic, Leydig, and Sertoli cells). Compared with the control, Bi₂O₃ NPs exposure resulted in significant reductions in testosterone levels, total antioxidant capacity, superoxide dismutase activity, Dazl gene expression, sperm motility, count, viability, normal morphology, and DNA integrity, and the level of malondialdehyde (MDA) increased. Additionally, testicular tissue and seminiferous tubule volume decreased, whereas interstitial tissue volume increased. Notably, sperm production was impaired, as evidenced by reduced numbers of spermatogonia, spermatocytes, spermatids, Sertoli cells, and Leydig cells. Body weight and seminiferous tubule basement membrane parameters remained largely unaffected. These findings suggest that Bi₂O₃ NPs induce oxidative stress, leading to lipid peroxidation and ultimately compromising male fertility. Our study highlights the potential detrimental effects of Bi₂O₃ NPs exposure on male reproductive health and warrants further investigation into their impact on human fertility at relevant concentrations.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5245-5261"},"PeriodicalIF":3.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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