Biological Trace Element Research最新文献

{"title":"Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis.","authors":"Yuejia Li, Yuanjing Li, Xuan Liu, Jiajie Bi, Junsheng Liu, Wen Li, Huanhuan Li, Shusong Wang, Jing Ma","doi":"10.1007/s12011-024-04473-1","DOIUrl":"https://doi.org/10.1007/s12011-024-04473-1","url":null,"abstract":"<p><p>Bisphenol A (BPA) is a contaminant widely found in food packaging that can reduce sperm quality and impair male fertility. Zinc (Zn) is an important antioxidant involved in many important biological functions. The aim of this study was to explore the protective effect and mechanism of Zn on reproductive toxicity induced by BPA. Male ICR mice were divided into a control group, a BPA group and a BPA + Zn group. The results showed that the body weight, sperm count and sperm motility of the animals in the BPA group were significantly reduced, and testicular structure was damaged. BPA decreased the levels of serum total Zn, testis-free zinc, ADH and ALP, upregulated the expression of ZnT4 protein, and down-regulated the expression levels of ZIP8, ZIP14, ZnT1, MT and MTF1 protein, resulting in the imbalance of testicular Zn homeostasis. BPA down-regulates the antioxidant enzymes SOD and GSH-Px, and increases MDA, leading to oxidative stress. BPA up-regulates TF, TFR and STEAP3 and down-regulates SLC7A11, GPX4, FPN1 and FTH protein levels, resulting in abnormal iron metabolism and ferroptosis. BPA down-regulated anti-apoptotic protein Bcl-2, up-regulated pro-apoptotic markers Bax, caspase-9, caspase-8 and caspase-3, and induced apoptosis. BPA also increased the phosphorylation of JNK and ERK1/2, but did not increase the phosphorylation of P38. Zn significantly increased body weight and sperm quality, improved testicular morphology, down-regulated p-JNK/JNK and p-ERK/ERK levels, improved oxidative stress, and reduced ferroptosis and apoptosis. In conclusion, Zn regulates Zn homeostasis and down-regulates the MAPK signaling pathway, thereby inhibiting ferroptosis and apoptosis, alleviating BPA-induced oxidative stress and ultimately improving male reproductive damage.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Zeolite Zinc on Memory Performance and Hippocampal Cell Death in a Rat Model of Alzheimer's-like Disease Induced by Aβ_1-42.","authors":"Maryam Zaman Fashami, Aida Bajelan, Hamidreza Shakur, Fatemeh Khakpai, Fatemeh Rouhollah, Salar Vaseghi, Batool Ghorbani Yekta","doi":"10.1007/s12011-024-04474-0","DOIUrl":"https://doi.org/10.1007/s12011-024-04474-0","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, characterized by the slow and progressive loss of brain structure and function, primarily affecting older individuals. Evidence has shown that disruption of zinc homeostasis in the brain contributes to synaptic dysfunction, as well as impairments in learning and memory. In this study, we evaluated the effect of zeolite zinc on memory performance and hippocampal cell death in a rat model of Alzheimer's disease (AD) induced by intracerebroventricular administration of Aβ_1-42. We employed the Morris water maze, shuttle box, and open field tests to assess spatial memory, passive avoidance memory, and anxiety-like behavior, respectively. P-Tau and the amyloid precursor protein (APP) expression, along with hippocampal cell death, were also evaluated. Both Aβ_1-42 and zeolite zinc were injected intracerebroventricularly. The results showed that zeolite zinc partially reversed Aβ_1-42-induced impairments in memory performance and mitigated the effects of Aβ_1-42 on locomotor activity, although it did not fully restore baseline levels. In addition, Aβ_1-42 increased the expression of APP and P-Tau, as well as the number of dead cells, whereas zeolite zinc reduced these effects. In conclusion, our findings suggest that while zeolite zinc plays a role in modulating the pathophysiology of AD, its therapeutic effects only partially reverse the progression or symptoms of AD, indicating the need for further investigation into optimal dosing or combination therapies.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.","authors":"Siwen Xie, Meng Yin, Mengting Xiang, Litao Shao, Nan Zhang, Liang Shi, Juan Zhang, Gongchang Yu","doi":"10.1007/s12011-024-04427-7","DOIUrl":"https://doi.org/10.1007/s12011-024-04427-7","url":null,"abstract":"<p><p>Lead (Pb) is the most common contaminant of heavy metals and is widely present in the environment. Destruction of bone structure, malformation of bone development, and loss of bone mass are important pathological features of lead-exposed individuals. However, the exact molecular mechanisms associated with lead exposure and osteogenic injury are still not fully understood. MC3T3-E1 mouse embryonic osteoblast is a cell line widely used in osteoblast cytology. It can differentiate into mature osteoblasts and express bone-specific genes in cell culture. The doses of 1, 2, and 4 mM Pb were adopted to study the toxicity of Pb on MC3T3-E1 proliferation and differentiation. In this study, the results show that Pb increases the expression of apoptosis-related proteins, including PARP1, cleaved caspase-3, Bax, and cleaved caspase-9. More importantly, Pb activated endoplasmic reticulum stress and oxidative stress, as evident by elevated PERK/ATF4/CHOP and ROS/NRF2 signaling pathway. Pb induced ROS production in MC3T3-E1 cells through endoplasmic reticulum stress and produced a lethal effect. NAC mitigated these effects. Endoplasmic reticulum stress inhibitor 4-PBA can block the ER stress pathway, reduce ROS production, and enhance cell viability. In addition, studies have shown that ERO1 activation in the ER stress pathway is responsible for inducing ROS production. ROS produced by the mitochondrial pathway also aggravates ER stress. This study suggests that Pb induces MC3T3-E1 cell apoptosis by inducing PERK-mediated ER stress and NRF2-mediated oxidative stress via mutual enhancement, which may be an important mechanism leading to skeletal toxicity.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BPA Exacerbates Zinc Deficiency-Induced Testicular Tissue Inflammation in Male Mice Through the TNF-α/NF-κB/Caspase8 Signaling Pathway.","authors":"Xinying Wang, Jing Ma, Wen Li, Zhan Hou, Huanhuan Li, Yuanjing Li, Shusong Wang, Yanqing Tie","doi":"10.1007/s12011-024-04464-2","DOIUrl":"https://doi.org/10.1007/s12011-024-04464-2","url":null,"abstract":"<p><p>Bisphenol A (BPA) is an endocrine-disrupting chemical that is toxic to reproduction. Zinc (Zn) plays an important role in male reproductive health. Zn deficiency (ZD) can co-exist with BPA. In order to investigate the specific mechanism of reproductive damage caused by BPA exposure in ZD male mice, a mouse model of ZD, BPA exposure, and their combined exposure was established in this study. Forty 4-week-old SPF male ICR mice with an average body weight of 31.7 ± 4.2 g were divided into four groups including normal Zn diet group 30 mg/(kg•d), BPA exposure group 150 mg/(kg•d), zinc deficiency diet group 7.5 mg/(kg•d), and BPA + ZD combined exposure group (BPA 150 mg/(kg•d) + ZD 7.5 mg/(kg•d)). The mice were kept for 8 weeks. The results showed that the testicular tissue structure was disturbed, and semen quality, serum Zn, testicular tissue Zn, and testicular tissue free Zn ions were decreased in the BPA-exposed and ZD groups. The expression of zinc transporters (ZIP7, ZIP8, ZIP13, and ZIP14) in testicular tissue was changed. The expressions of pro-inflammatory cytokines including TNF-α and IL-1β as well as inflammatory pathway-related proteins (IKB-α, p-IKB-α, NF-κB, p-NF-κB, Caspase8, and Caspase3) were increased, while the expressions of anti-inflammatory cytokines (TGF-β and IL-10) were decreased. The changes in the above indexes in the BPA + ZD group were more obvious. Both BPA exposure and ZD can induce testicular tissue inflammation through the TNF-α/NF-κB/Caspase8 signaling pathway, and BPA further aggravates zinc deficiency-induced testicular tissue inflammation and apoptosis damage.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Magnesium Ions Promote In Vitro Rat Bone Marrow Stromal Cell Angiogenesis Through Notch Signaling.","authors":"Haotian Qin, Jian Weng, Bo Zhou, Weifei Zhang, Guoqing Li, Yingqi Chen, Tiantian Qi, Yuanchao Zhu, Fei Yu, Hui Zeng","doi":"10.1007/s12011-024-04465-1","DOIUrl":"https://doi.org/10.1007/s12011-024-04465-1","url":null,"abstract":"","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Whole Blood Iron Levels and Lipid Profile Parameters in the General Population: Findings from Routine Physical Examination Report.","authors":"Rou-Jun Pan, Zhi Luo, Yu-Shun You, Jun-Dong Wang, Ya-Qi Chen, Rong-Rong Zhou, Shu-Zi-Qi Chen, Lin-Min Wang, Jun-Xiang Zhao, Hua-Qin Su, Cai-Li Wang, Li-Fen Zhang, Feng-Lian Peng, Jezza Joi Meneses, Xiang-Hu Wang, Lian-Ping He, Ting Wang","doi":"10.1007/s12011-024-04459-z","DOIUrl":"https://doi.org/10.1007/s12011-024-04459-z","url":null,"abstract":"<p><p>Dyslipidemia is related to the occurrence and development of many diseases and is a common problem among the general population. A significant link has been identified between dyslipidemia and ferroptosis. Lipid profile parameters are important indicators of dyslipidemia. Iron is the main cause of ferroptosis. However, the relationship between blood lipid parameters and whole blood iron levels has remained unclear. Based on a community population, the study aimed to explore the relationship between whole blood iron levels and blood lipids in Taizhou, China. The blood samples were collected from 1917 community residents, and levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and whole blood iron were measured. Pearson correlation was used to analyze the correlation between whole blood iron levels and lipids profile parameters. The results of the study showed that for both men and women, whole blood iron concentration was positively correlated with total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P < 0.001), but not with high-density lipoprotein cholesterol (P = 0.618, P = 0.083). The positive correlation between whole blood iron and triglycerides was the most significant (P < 0.001, r = 0.138). The above trends were more pronounced among men than among women. Therefore, the study suggested that regulating whole blood iron levels of populations in Taizhou, China, may be a potential strategy for regulating triglycerides, total cholesterol, and low-density lipoprotein. The potential for controlling triglycerides by regulating whole blood iron is more apparent. The result of the study has some implications for the prevention and diagnosis of dyslipidemia among medical staff and residents, especially male residents.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Heavy Metal Exposure from Milk and Steroid Hormones in Mothers.","authors":"Zheng Wang, Caixia Liang, Li Li Shi, Cheng-Sheng Zhu, Shenghang Wang, Shoji F Nakayama, Teruhiko Kido, Xian Liang Sun, Jiancong Shan","doi":"10.1007/s12011-024-04466-0","DOIUrl":"https://doi.org/10.1007/s12011-024-04466-0","url":null,"abstract":"<p><p>Environmental exposure to heavy metals is ubiquitous. However, its relationship with steroid hormone levels is not well understood, particularly in pregnant women. This study investigated the association between prenatal heavy metal exposure and steroid hormone levels in an e-waste disposal area in China. We analyzed the Cd, Cr, Mn, Pb, Cu, and As concentrations in 102 human milk samples collected 4 weeks after delivery. Multiple regression analysis was used to assess the associations and interactions between heavy metals and steroidal hormones. We found positive associations between Mn and estrone and estriol (estrone: β = 0.713, 95%CI = 0.046, 1.381 and estriol: β = 1.290, 95%CI = 0.494, 2.085) and between Cd and progesterone (β = 0.280; 95%CI = 0.053, 0.506). We observed negative associations between Cr and estrone and estriol (estrone: β =  - 0.757, 95%CI =  - 1.473, - 0.041 and estriol: β =  - 1.354, 95%CI =  - 2.209, - 0.499). At last, we found that Pb was negatively associated with estrone (estrone: β =  - 0.537, 95%CI =  - 1.053, - 0.020). Our results suggest that exposure to heavy metals may affect steroid hormone levels in mothers living in an e-waste recycling area in China.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-Doped Nano Hydroxyapatite Grafts for Bone Regeneration in Rat Mandibular Defects.","authors":"Berat Baturay Demirkiran, Zeynep Deniz Sahin Inan, Rasim Hamutoğlu, Kerim Emre Öksüz, Zekiye Hasbek, Emine Elif Altuntaş","doi":"10.1007/s12011-024-04462-4","DOIUrl":"https://doi.org/10.1007/s12011-024-04462-4","url":null,"abstract":"&lt;p&gt;&lt;p&gt;The aim of this study was to evaluate the potential effects of boron-doped nano hydroxyapatite grafts on craniofacial bone regeneration in critical bone defects in the mandibular corpus of rats, in terms of scintigraphic and histopathological aspects. Forty Wistar albino rats, with an average weight of 200-220 g, aged 16-18 weeks, and all male, were used in the study. The rats were randomly assigned to five groups, each containing 8 rats, as follows: group C1 (no procedure applied to the mandible), group C2 (surgical defect created in the mandible but no treatment applied), group nHA (nano hydroxyapatite applied to the surgical defect area), group nHA + B1 (nano hydroxyapatite + 1% boron applied to the surgical defect area), and group nHA + B2 (nano hydroxyapatite + 2% boron applied to the surgical defect area). A standard 4 × 4 mm full-thickness transosseous bone defect was created in the mandibular corpus of all rats, except for those in group C1. The bone defect in the rats in group C2 was left to heal naturally. Nano hydroxyapatite (nHA), nano hydroxyapatite + 1% boron, and nano hydroxyapatite + 2% boron were applied to the surgical defect areas of the other three groups, respectively. Bone scintigraphy was performed on all rats on days 0 (following the surgical procedure) and 28 of the experimental period. At the end of the 28th day, the animals were sacrificed, and tissue samples were collected for histological examination. A standard grading system was used to evaluate fracture healing. When the groups were compared in terms of bone healing histopathological scores, a statistically significant difference was observed between group C1 and the other groups (p &lt; 0.005). In the statistical evaluation made according to the histopathological mean scores, the least improvement was observed in group C2. No statistically significant difference was observed between group nHA and group nHA + B1 and group C2 and between group nHA and group nHA + B1 in terms of bone healing scores (p &gt; 0.005). A statistically significant difference was found between group nHA + B2 and group C2 (p = 0.026). Although there was no statistically significant difference in histopathological scores, the mean score closest to group C1 was observed in group nHA + B2. A statistically significant difference was observed between the groups in the scintigraphic evaluation performed on the 28th day of the experimental procedure, and the difference was between group C1 and group nHA + B1 and between group nHA and group nHA + B1 (p = 0.004; p = 0.028, p &lt; 0.005). In the comparison of the values obtained on days 0 and 28 within the group, a statistically significant change was observed in group nHA + B1 and group nHA + B2 (p &lt; 0.005). When the results of the present study were evaluated, it was thought that the boron-doped nHA graft biomaterials may have positive effects on bone healing. Providing a different perspective for the development of an alternative new treatment modalit","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium Exposure Induces Inflammation Through Oxidative Stress-Mediated Activation of the NF-κB Signaling Pathway and Causes Heat Shock Response in a Piglet Testis.","authors":"Yulong Li, Hongbao Wang, Yanfei Wang","doi":"10.1007/s12011-024-04470-4","DOIUrl":"https://doi.org/10.1007/s12011-024-04470-4","url":null,"abstract":"<p><p>Cadmium (Cd), recognized as an environmental toxin, can cause injury to the testis in humans and animals. Oxidative stress (OS) can trigger an inflammatory response by promoting the activation of nuclear factor kappa beta (NF-κB) signaling pathway. Meanwhile, inflammation can lead to the occurrence of heat shock reaction. Yet, the specific mechanism by which Cd causes testicular injury in piglets, as well as the roles of oxidative stress, NF-κB signaling pathway, and heat shock response, still remained unclear. In this study, 6-week-old male piglets were selected as the experimental subjects, and the testicular injury model was developed by adding CdCl₂ (20 mg/kg) to the feed. After 40 days, piglets were euthanized, and testis tissues were collected for the following experimental analysis (the ultrastructural characteristics, antioxidant levels, trace element concentrations, and molecular-level changes). The findings displayed that Cd exposure caused the widening of the perinuclear space and the fragmentation of the nuclear membrane in testis. In addition, Cd exposure increased the contents of Cd, iron (Fe), and manganese (Mn), while the contents of selenium (Se), calcium (Ca), zinc (Zn), and copper (Cu) were reduced in testis. The activities of oxidative enzymes inducible nitric oxide synthase (iNOS), hydrogen peroxide (H₂O₂), malondialdehyde (MDA), and nitric oxide (NO) were enhanced in testis after Cd exposure; meanwhile, the activities of antioxidant enzymes catalase (CAT), glutathione (GSH), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC) were reduced. And Cd exposure led to an upregulation of NF-κB, iNOS, interleukin 6 (IL-6), and cyclooxygenase-2 (COX-2) at both the mRNA and protein levels and increased the fluorescence intensity of the heat shock proteins (HSPs) HSP60, HSP70, and HSP90 in the testis. Altogether, Cd exposure induced toxic damage to piglet testis and potentially triggered inflammation through the oxidative stress/NF-κB signaling pathway and then resulted in heat shock response.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-of-the-art Investigation on the Role of Indium, Terbium, Yttrium, and Lanthanum in Recurrent Pregnancy Loss.","authors":"Hajera Tabassum, Reem Hamoud Alrashoudi, Manal Abudawood, Sabiha Fatima, May Alrashed, Mir Naiman Ali, Sarah Binhassan, Yaqoot Fatima, Yazeed A AlSheikh","doi":"10.1007/s12011-024-04456-2","DOIUrl":"https://doi.org/10.1007/s12011-024-04456-2","url":null,"abstract":"<p><p>We aimed to explore the role of Indium (In), Terbium (Tb), Yttrium (Y), and Lanthanum (La) in the serum of women with recurrent pregnancy loss (RPL) and compare them to controls. Additionally, the study aimed to examine the relationship between REE levels and oxidative DNA damage, to identify potential risk factors contributing to RPL. This case-control study included 30 RPL cases and 30 controls with uncomplicated pregnancy. Inductively Coupled Plasma Mass Spectrometer was used to evaluate levels of In, Tb, Y, and La in the serum samples in both groups. The relationship between REE levels, Total Antioxidant Capacity (TAC), and DNA damage was studied by correlation analysis. There was a significant increase in levels of In, Tb, Y, and La in the serum of the RPL group in contrast to the control group (P < 0.001). Furthermore, a negative correlation was observed between increased Y, Tb, La, and TAC in RPL cases (significant at P < 0.05), indicative of weakened antioxidant defenses. Moreover, increased levels of Y, Tb, and La exhibited a positive correlation with the DNA damage marker, statistically significant at P < 0.05. These findings highlight the potential role of oxidative stress-induced DNA damage and metal intoxication in the development of RPL, underscoring the importance of further research to clarify underlying mechanisms and develop preventive strategies.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}