Biological Trace Element Research最新文献_第4页

Association of Blood Metals and Metal Mixtures with the Myocardial Enzyme Profile: An Occupational Population-Based Study in China. 血液中金属和金属混合物与心肌酶谱的关系：基于中国职业人群的研究。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-07-29 DOI: 10.1007/s12011-024-04316-z

Xiaoting Ge, Junxiu He, Yuan Zheng, Qiuyue Wang, Hong Cheng, Yu Bao, Sencai Lin, Xiaobo Yang

{"title":"Association of Blood Metals and Metal Mixtures with the Myocardial Enzyme Profile: An Occupational Population-Based Study in China.","authors":"Xiaoting Ge, Junxiu He, Yuan Zheng, Qiuyue Wang, Hong Cheng, Yu Bao, Sencai Lin, Xiaobo Yang","doi":"10.1007/s12011-024-04316-z","DOIUrl":"10.1007/s12011-024-04316-z","url":null,"abstract":"To investigate a cross-sectional association between blood metal mixture and myocardial enzyme profile, we quantified creatine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LD), α-hydroxybutyrate dehydrogenase (α-HBD), and aspartate transaminase (AST) levels among participants from the manganese-exposed workers healthy cohort (MEWHC) (n = 544). The levels of 22 metals in blood cells were determined using inductively coupled plasma mass spectrometry. The least absolute shrinkage and selection operator (LASSO) penalized regression model was utilized for screening metals. The exposure-response relationship between specific metal and myocardial enzyme profile was identified by general linear regression and restricted cubic spline analyses. The overall effect and interactions were evaluated using Bayesian kernel machine regression (BKMR). Manganese was linearly and positively associated with CK (Poverall = 0.019, Pnon-linearity = 0.307), dominating the positive overall effect of mixture exposure (manganese, arsenic, and rubidium) on CK level. Calcium and zinc were linearly and negatively associated with LD levels (Poverall < 0.05, Pnon-linearity > 0.05), and asserted dominance in the negative overall effect of metal mixtures (rubidium, molybdenum, zinc, nickel, cobalt, calcium, and magnesium) on LD level. Interestingly, we observed a U-shaped dose-response relationship of molybdenum with LD level (Poverall < 0.001, Pnon-linearity = 0.015), an interaction between age and calcium on LD level (Pinteration = 0.041), and an interaction between smoking and molybdenum on LD level (Pinteration = 0.035). Our study provides evidence that metal mixture exposure affects the myocardial enzyme profile. Additional investigation is required to confirm these associations, and to reveal the fundamental mechanisms involved.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1991-2000"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health Risk Assessment of Toxic Metal(loids) Consumed Through Plant-Based Anti-diabetic Therapeutics Collected in the Northern Divisional City of Rajshahi, Bangladesh. 孟加拉国拉杰沙希北部分区城市采集的植物性抗糖尿病药物中有毒金属（loids）的健康风险评估。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-08-12 DOI: 10.1007/s12011-024-04338-7

Nazmul Islam, Rausan Zamir, Omar Faruque

{"title":"Health Risk Assessment of Toxic Metal(loids) Consumed Through Plant-Based Anti-diabetic Therapeutics Collected in the Northern Divisional City of Rajshahi, Bangladesh.","authors":"Nazmul Islam, Rausan Zamir, Omar Faruque","doi":"10.1007/s12011-024-04338-7","DOIUrl":"10.1007/s12011-024-04338-7","url":null,"abstract":"The present study investigates human health risks upon consumption of herbal medicines in terms of ten toxic metalloids in 20 plant-based anti-diabetic therapeutics. The analysis of metalloids was determined by an atomic absorption spectrometer after microwave-assisted digestion. The computation of hazard quotients (HQ) and hazard indexes (HI) of metalloids leads to the assessment of non-carcinogenic health risks. Carcinogenic risk was assessed based on cancer slope factor (CSF) and chronic daily intake (CDI) values. Comparison with WHO regulatory cut-off points for each metalloid: seven samples for Mn, 12 samples for Hg, three samples for Cu, eight samples for Ni, four samples for Cd, two samples for Pb, one sample for Cr, and eight samples for Zn are unsafe to consume. Non-carcinogenic human health risk is predicted for Mn in seven samples, Fe in one sample, Hg in ten samples, Cu in three samples, Ni in one sample, and Pb in two samples. HI values greater than 1 predict non-carcinogenic health risk in thirteen samples. Incremental lifetime cancer risk (ILCR) remains for As (inorganic) in 12 samples, Cr (+ 6) in one sample, and Pb in no samples. To guarantee consumer safety, the implementation of strict monitoring is suggested.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2149-2158"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Strontium, Magnesium, and Zinc Ions on the In Vitro Osteogenesis of Maxillary Sinus Membrane Stem Cells. 锶、镁和锌离子对上颌窦膜干细胞体外成骨的影响

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-08-16 DOI: 10.1007/s12011-024-04303-4

Zhihao Zhang, Ning Gong, Ying Wang, Lei Xu, Sinan Zhao, Yanshan Liu, Fei Tan

{"title":"Impact of Strontium, Magnesium, and Zinc Ions on the In Vitro Osteogenesis of Maxillary Sinus Membrane Stem Cells.","authors":"Zhihao Zhang, Ning Gong, Ying Wang, Lei Xu, Sinan Zhao, Yanshan Liu, Fei Tan","doi":"10.1007/s12011-024-04303-4","DOIUrl":"10.1007/s12011-024-04303-4","url":null,"abstract":"Human Maxillary Sinus Membrane Stem Cells (hMSMSCs) contribute significantly to bone formation following maxillary sinus floor augmentation (MSFA). The biological behavior of mesenchymal stem cells is notably influenced by varying concentrations of magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+) ions; however, their specific effects on hMSMSCs have not been comprehensively studied. We isolated hMSMSCs and identified their mesenchymal stem cell characteristics by flow cytometry and multilineage differentiation experiments. Subsequently, the hMSMSCs were cultured in media containing different concentrations of these metal ions. The proliferation and viability of hMSMSCs were assessed using CCK-8 and Calcein AM/PI staining. After osteogenic induction, cells were evaluated for alkaline phosphatase (ALP) activity, ALP staining, and Alizarin Red staining. Additionally, qRT-PCR was used to detect differences in osteogenic gene expression, and immunofluorescence staining was used to observe variations in OCN protein levels. The results indicated that 1 mM Mg2+, 0.01 mM Sr2+, and 0.001 mM Zn2+ significantly improved the proliferation and activity of hMSMSCs. These concentrations also notably enhanced ALP secretion, increased bone-related gene expression, and augmented osteocalcin expression and formation of extracellular calcium nodules, thereby improving osteogenic differentiation. However, higher concentrations of Mg2+, Sr2+, and Zn2+ decreased cell viability and osteogenic differentiation. Mg2+, Sr2+, and Zn2+ promote osteogenic differentiation and proliferation of hMSMSCs in a concentration-dependent manner, indicating that the type and concentration of ions in the extracellular environment can significantly alter hMSMSCs behavior, which is a crucial consideration for material design in maxillary sinus elevation applications.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1922-1933"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elemental Composition and Health Risk Assessment of Deep-Sea Teleost's of the Levantine Basin. 阆中盆地深海远洋鱼类的元素组成和健康风险评估。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-07-06 DOI: 10.1007/s12011-024-04298-y

Nuray Çiftçi, Deniz Ayas

{"title":"Elemental Composition and Health Risk Assessment of Deep-Sea Teleost's of the Levantine Basin.","authors":"Nuray Çiftçi, Deniz Ayas","doi":"10.1007/s12011-024-04298-y","DOIUrl":"10.1007/s12011-024-04298-y","url":null,"abstract":"The determination of metal(loid) (As, Fe, Al, Sr, Zn, Pb, Mn, Cu, Cr, and Cd) levels in the muscle tissue of 23 different deep-sea bony fish sampled off Mersin Bay (NE Levantine Basin) and the assessment of health risks for human consumption were aimed. Tissue metal(loid) concentrations were determined as dry weight and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). The tissue metal(loid) concentrations (µg g dw) were converted to wet weight prior to health risk assessment calculations. Standard mathematical formulas were used to determine the health risk assessment. There was a statistically significant difference between the fish species in terms of tissue metal(loid) levels (p < 0.05). The highest metal(loid) level was found in C. sloani among other species. As and Fe had the highest and Cd the lowest tissue concentrations in the examined species (p < 0.05). The relationships between the metal(loid)s analyzed in the tissue were significant (p < 0.01;0.05). Fe had an antagonistic effect with Cd, while other metal(loid)s had a synergetic effect with each other. Risk assessment analyses were performed for the consumable species, and it was found that the estimated daily and weekly intakes were below the tolerable limits established by the Food and Agriculture Organization (FAO) and the World Health Organization (WHO). The target hazard quotient (THQ) values exceeded the threshold of 1 (THQ > 1) only for As. The target cancer risk (TCR) was below the tolerable limits (> 10-5) except for As, Cd, and Al.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1972-1990"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Cuproptosis-Related Proteins on Macrophage Polarization in Mesothelioma is Revealed by scRNA-seq. scRNA-seq揭示杯突相关蛋白对间皮瘤巨噬细胞极化的影响

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-08-23 DOI: 10.1007/s12011-024-04333-y

Jia-Xin Xu, Li-Jing Ma, Li-Ying Tu, Qi-Sheng Tang, Bian Wu, Li-Hong Jiang

{"title":"The Effect of Cuproptosis-Related Proteins on Macrophage Polarization in Mesothelioma is Revealed by scRNA-seq.","authors":"Jia-Xin Xu, Li-Jing Ma, Li-Ying Tu, Qi-Sheng Tang, Bian Wu, Li-Hong Jiang","doi":"10.1007/s12011-024-04333-y","DOIUrl":"10.1007/s12011-024-04333-y","url":null,"abstract":"High invasiveness mesothelioma is a malignant tumor of the peritoneum or pleura. The effect of cuproptosis on mesothelioma (MESO) is still unknown, though. The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) datasets were used to identify differential genes linked to cuproptosis in mesothelioma. Multigene features were then created to assess the course of the disease. Use single-cell data and in vitro validation to uncover crucial gene regulation mechanisms. In MESO, we found nine differentially expressed genes linked to cuproptosis. Using univariate Cox and LASSO regression techniques, a 3-gene feature (P < 0.05) was created, showing a good predictive potential for survival time. According to the risk score, patients in the low-risk subset had a considerably greater survival rate than those in the high-risk subset (P = 0). The similar survival pattern and prediction performance are also seen in the validation queue. The findings of the drug sensitivity research indicate that in high-risk patients, vinblastine, paclitaxel, gefitinib, and erlotinib are sensitive medications (P < 0.05). Classical monocytes were identified as core cells connected to cuproptosis by the CellChat results. SLC31A1 is implicated in the positive regulation of M2 macrophage polarization, according to cell subtype analysis and in vitro confirmation. Genes linked to cuproptosis have a major influence on tumor immunity and can predict how MESO will progress.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1898-1908"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knockdown of SMYD3 by RNA Interference Regulates the Expression of Autophagy-Related Proteins and Inhibits Bone Formation in Fluoride-Exposed Osteoblasts. 通过 RNA 干扰敲除 SMYD3 可调控自噬相关蛋白的表达并抑制氟暴露成骨细胞的骨形成

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-08-06 DOI: 10.1007/s12011-024-04327-w

Jie Deng, Xiaoxiao Zeng, Kailin Zhang, Ting Zhang, Yangting Dong, Jian Zou, Changxue Wu, Yi Li, Fucheng Li, Zhizhong Guan

{"title":"Knockdown of SMYD3 by RNA Interference Regulates the Expression of Autophagy-Related Proteins and Inhibits Bone Formation in Fluoride-Exposed Osteoblasts.","authors":"Jie Deng, Xiaoxiao Zeng, Kailin Zhang, Ting Zhang, Yangting Dong, Jian Zou, Changxue Wu, Yi Li, Fucheng Li, Zhizhong Guan","doi":"10.1007/s12011-024-04327-w","DOIUrl":"10.1007/s12011-024-04327-w","url":null,"abstract":"This study aimed to explore the role of histone methyltransferase SET and MYND domain containing 3 (SMYD3) in bone metabolism of osteoblasts exposed to fluoride. The levels of urine fluoride, BALP, and OC and the mRNA expression of SMYD3 were determined in patients with skeletal fluorosis and non-fluoride-exposed people on informed consent. The expression of SMYD3 protein, OC contents, and BALP activities were detected in human osteoblast-like MG63 cells and rat primary osteoblasts treated with sodium fluoride (NaF) for 48 h. The autophagosomes were observed by transmission electron microscopy. Then, we knocked down SMYD3 to confirm whether it was involved in the regulation of bone formation and related to autophagy and Wnt/β-catenin pathway. We observed that OC and BALP levels in patients with skeletal fluorosis significantly increased, while the mRNA expression of SMYD3 significantly decreased in the skeletal fluorosis groups. In vitro, the OC contents, BALP activities, and expression of SMYD3 significantly increased, and many autophagosomes were observed in NaF treated osteoblasts. The downregulation of SMYD3 significantly inhibited OC contents, BALP activities, and expression of autophagy-related proteins, but with no significant changes in the Wnt/β-catenin pathway. Our results demonstrated that fluoride exposure with coal-burning pollution caused orthopedic injuries and abnormalities in the levels of OC and BALP and hindered normal bone metabolism. Silencing the SMYD3 gene could significantly reduce OC and BALP levels via inhibiting the increase in autophagy induced by fluoride.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2013-2028"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review. 铁代谢、钙、镁和微量元素：综述。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-07-06 DOI: 10.1007/s12011-024-04289-z

Tara Rolić, Mazyar Yazdani, Sanja Mandić, Sonia Distante

{"title":"Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review.","authors":"Tara Rolić, Mazyar Yazdani, Sanja Mandić, Sonia Distante","doi":"10.1007/s12011-024-04289-z","DOIUrl":"10.1007/s12011-024-04289-z","url":null,"abstract":"Iron (Fe) is fundamental to life on earth. In the human body, it is both essential and harmful if above threshold. A similar balance applies to other elements: calcium (Ca), magnesium (Mg), and trace elements including copper (Cu), zinc (Zn), lead (Pb), cadmium (Cd), mercury (Hg), and nickel (Ni). These elements share some proteins involved in the absorption and transport of Fe. Cu and Cd can inhibit Fe absorption, while excess of Fe may antagonize Cu metabolism and reduce ceruloplasmin (Cp). Excessive Fe can hinder Zn absorption and transferrin (Trf) can bind to both Zn and Ni. Ca is able to inhibit the divalent metal transporter 1 (DMT1) in a dose-dependent manner to reduce Fe absorption and low Mg concentrations can exacerbate Fe deficiency. Pb competitively inhibits Fe distribution and elevated Cd absorption reduces Fe uptake. Exposure to Hg is associated with higher ferritin concentrations and Ni alters intracellular Fe metabolism. Fe removal by phlebotomy in hemochromatosis patients has shown to increase the levels of Cd and Pb and alter the concentrations of trace elements in some types of anemia. Yet, the effects of chronic exposure of most trace elements remain poorly understood.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"2216-2225"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Content of Biogenic Elements in Sheep Wool by the Regions of Slovakia. 斯洛伐克各地区羊毛中的生物元素含量。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-08-08 DOI: 10.1007/s12011-024-04328-9

Martin Janíček, Martin Massányi, Anton Kováčik, Marko Halo, Filip Tirpák, Martyna Blaszczyk-Altman, Marzena Albrycht, Robert Stawarz, Marko Halo, Peter Massányi

{"title":"Content of Biogenic Elements in Sheep Wool by the Regions of Slovakia.","authors":"Martin Janíček, Martin Massányi, Anton Kováčik, Marko Halo, Filip Tirpák, Martyna Blaszczyk-Altman, Marzena Albrycht, Robert Stawarz, Marko Halo, Peter Massányi","doi":"10.1007/s12011-024-04328-9","DOIUrl":"10.1007/s12011-024-04328-9","url":null,"abstract":"The quality of nutrition and environmental pollution are crucial chemical indicators influencing animal health, reflected in element concentrations in animal tissues and coats. This study investigates the concentrations of biogenic elements (calcium, potassium, magnesium, sodium, copper, and iron) in sheep wool from various regions of Slovakia to compare concentrations and identify possible correlations between individual elements. Samples were collected from six different regions, and concentrations of elements were measured using flame atomic absorption spectrometry. Statistical analysis revealed significant differences in element levels among the examined regions. Calcium concentrations ranged from 729.2 to 4065 ppm, with the highest concentrations in the Kysuce region and the lowest in the Šariš region. Potassium concentrations ranged from 2315 to 3282 ppm, with the lowest values in the Zemplín region and the highest in the Liptov region. Magnesium, sodium, copper, and iron also exhibited varying concentrations across the regions. Correlation analysis identified significant associations between several elements. The findings suggest that regional environmental differences influence element concentrations in sheep wool, highlighting the importance of monitoring biogenic elements for assessing environmental pollution and animal health. Further research is warranted to explore the underlying mechanisms driving element accumulation in wool and its implications for animal welfare and environmental management.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1886-1897"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Trace Elements Bioaccumulation in Coastal River Fish and Shellfish: Implications for Human Health and Risk Evaluation. 评估沿海河流鱼类和贝类中微量元素的生物累积性：对人类健康和风险评估的影响。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-07-30 DOI: 10.1007/s12011-024-04325-y

Suprakash Chakma, Md Arifur Rahman, Mst Niloy Jaman, Al-Azim, Sudipta Kumar Nag, Md Kaosher Ali, Md Sazedul Hoque, Kanchan Chakma

{"title":"Assessing Trace Elements Bioaccumulation in Coastal River Fish and Shellfish: Implications for Human Health and Risk Evaluation.","authors":"Suprakash Chakma, Md Arifur Rahman, Mst Niloy Jaman, Al-Azim, Sudipta Kumar Nag, Md Kaosher Ali, Md Sazedul Hoque, Kanchan Chakma","doi":"10.1007/s12011-024-04325-y","DOIUrl":"10.1007/s12011-024-04325-y","url":null,"abstract":"The presence of heavy metal contaminants in fish and shellfish in aquatic environments poses a risk to human health due to trophic transfer. This study determined the levels of various trace elements (Fe, As, Cr, Zn, Cu, Ni, Pb, and Cd) in the muscles, gills, and liver of hilsa (Tenualosa ilisha) and prawn (Macrobrachium rosenbergii) samples obtained from the Tetulia River, Bangladesh. The results showed that the level of trace elements in different body parts differed significantly (P < 0.05) between species, displayed below recommended threshold levels. The cumulative low to higher hierarchic concentration of the trace elements was as follows: Fe > Zn > Cu > Cr > Ni > Pb > As > Cd. Hilsa had significantly (P < 0.05) higher bioaccumulated trace elements compared to prawn. With the exception of Ni and Cd, the estimated daily intakes (EDI) for both adults and children were below the recommended daily allowance (RDA), which exhibits that other trace elements do not cause harm to human health. Furthermore, the hazard index (HI) and total hazard quotient (THQ) were also found to be within acceptable limits, taking into account the higher vulnerability of children to toxicity compared to adults. Notably, the HI suggested that children were approximately four times more susceptible to both carcinogenic and non-carcinogenic effects compared to adults. Ultimately, the levels of carcinogenic risk were deemed acceptable, despite the estimated values suggesting susceptibility to adverse effects in both adults and children. This study concluded that fish and shellfish may not pose a health risk to consumers, highlighting the importance of further monitoring of trace elements in the catchment area.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1859-1870"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's Disease and Circulatory Imbalance of Toxic Heavy Metals: A Systematic Review and Meta-analysis of Clinical Studies. 阿尔茨海默病与有毒重金属的循环失衡：临床研究的系统回顾与元分析》。

IF 3.4 3区生物学

Biological Trace Element Research Pub Date : 2025-04-01 Epub Date: 2024-07-30 DOI: 10.1007/s12011-024-04326-x

Alireza Kooshki, Reyhane Farmani, Omid Mehrpour, Ali Naghizadeh, Alireza Amirabadizadeh, Sepide Kavoosi, Varun Vohra, Samaneh Nakhaee

{"title":"Alzheimer's Disease and Circulatory Imbalance of Toxic Heavy Metals: A Systematic Review and Meta-analysis of Clinical Studies.","authors":"Alireza Kooshki, Reyhane Farmani, Omid Mehrpour, Ali Naghizadeh, Alireza Amirabadizadeh, Sepide Kavoosi, Varun Vohra, Samaneh Nakhaee","doi":"10.1007/s12011-024-04326-x","DOIUrl":"10.1007/s12011-024-04326-x","url":null,"abstract":"The role of heavy metals on human health has often been discussed regarding disease pathogenesis and risk factors. Alzheimer's disease (AD), a prevalent neurodegenerative disease, is no exception. We conducted a comprehensive examination to assess the concentrations of lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) in biological samples of AD patients in comparison with a group of individuals without AD, with the objective of our study being to perform a systematic review on this topic. We performed this systematic review by searching various databases/search engines, including Web of Science, Scopus, PubMed, and Google Scholar, until December 7, 2022. Relevant studies were scrutinized for eligibility. Meta-analysis was performed on studies with sufficient data using STATA software. Twenty-seven out of 3349 studies met pre-defined eligibility criteria and were included in our systematic review. For the meta-analysis, 22 studies with 3346 participants (1291 AD patients and 2055 healthy controls) had sufficient data for inclusion in the analysis. Using a random-effects model, we found that pooled data indicated patients with AD had significantly higher levels of Cd in their biological samples compared to controls (Hedges' g, 0.83; 95% CI, 0.11, 1.54; p = 0.023). However, other heavy metals were not significantly different in circulatory samples of AD patients compared to healthy controls (p > 0.05). This systematic review and meta-analysis indicated that Cd concentrations in AD patients were significantly higher than in healthy controls. Other included heavy metals may not be directly associated with increased risk of AD.","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1871-1885"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0