Biological Trace Element Research最新文献

{"title":"Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.","authors":"Mohammad Hasan, Pooja Yadav, Mairaj Ahmed Ansari, Shakir Ali, Haider A Khan","doi":"10.1007/s12011-024-04439-3","DOIUrl":"10.1007/s12011-024-04439-3","url":null,"abstract":"<p><p>Zinc aspartate and zinc citrate have been used as zinc supplements in different health conditions. Taking into consideration their anti-inflammatory, immunomodulatory, anti-oxidant and antimicrobial properties, the present study has been designed to analyse the effect of zinc aspartate and zinc citrate treatment at therapeutic dose level on disease severity index, haematological, serological, antimicrobial and radiological markers of rheumatoid arthritis in Wistar rats. Bactericidal potential of the two organic zinc compounds was analysed in vitro in clinically isolated Escherichia coli. Arthritis was induced in male Wistar rats by intradermal injection of an emulsion containing collagen type II and Complete Freund's Adjuvant (CFA) containing 1 mg mL^-1 Mycobacterium tuberculosis H37Ra. Zinc aspartate and zinc citrate were orally administered after the onset of the disease for 4 weeks. Ameliorative effect of zinc aspartate and zinc citrate was evaluated by analysing indices of severity and disease activity markers of rheumatoid arthritis. The liver and kidney function tests were performed to evaluate any possible adverse effect of compounds. Antimicrobial activity of the zinc compounds was assessed in clinically isolated E. coli by MTT assay. Zinc aspartate and zinc citrate equivalent to a therapeutic dose of 50 mg/day of elemental zinc attenuated the clinical characteristic of rheumatoid arthritis in the animal model of arthritis, collagen-induced arthritis (CIA). Both zinc salts also exhibited antimicrobial effects against E. coli. The selected dose of zinc aspartate and zinc citrate showed no adverse effects in treated rats. This study highlights the potentiality of zinc compounds as antiarthritic agents and also point to its preventive effects on microbial growth that has been observed in rheumatoid arthritis patients due to their increased sensitivity for bacterial infection.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3742-3753"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Salivary Iodine Concentration in Elderly Residents of High-iodine Areas.","authors":"Mengxin Liu, Junjing Li, Hexi Zhang, Yantong Liu, Zhangzhao Wang, Zhiyuan Ren, Chunxi Wang, Qi Jin, Ying Zhang, Haohao Meng, Qiuyi Song, Wenxing Guo, Wanqi Zhang","doi":"10.1007/s12011-024-04453-5","DOIUrl":"10.1007/s12011-024-04453-5","url":null,"abstract":"<p><p>Salivary iodine is considered a potential indicator for assessing iodine nutrition status. However, there is currently a lack of research data on the characteristics of salivary iodine concentration (SIC) in the elderly population. To evaluate the characteristics of SIC and assess its efficacy in diagnosing thyroid disorders among the elderly population, a cross-sectional study was conducted in a high-iodine area. Spot urine, 24-h urine, saliva, drinking, and cooking water samples were collected from the elderly participants. Iodine concentrations were measured in all these samples. Fasting venous blood samples were obtained to assess thyroid function. The study included 1387 elderly individuals from urban (n = 707) and rural (n = 680) areas. Rural residents showed significantly higher median concentration of cooking water iodine (CWIC) and SIC compared to urban residents (P < 0.001). The median SIC in rural elderly was 2733.3 μg/L versus 860.4 μg/L in urban elderly. SIC demonstrated a significant positive correlation with age (P < 0.001). Multiple linear regression analysis revealed significant positive associations between SIC and drinking water iodine concentration (β = 0.341, 95% CI 0.312-0.370), CWIC (β = 0.393, 95% CI 0.356-0.431), thyroid dysfunction (β = 0.107, 95% CI 0.050-0.164), and goiter (β = 0.236, 95% CI 0.129-0.342). Logistic regression showed that higher SIC levels were associated with increased risk of thyroid dysfunction, with odds ratios ranging from 1.649 to 1.994 for ascending SIC categories. The elderly residents in high-iodine areas, particularly in rural settings, exhibit elevated salivary iodine concentrations that increase with age. These high-iodine levels are significantly associated with an increased risk of thyroid dysfunction.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3658-3664"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Zinc on Blood Biochemical and mTOR Gene Expression in Rats with Polycystic Ovarian.","authors":"Faeze Fazel Torshizi, Reza Majidzadeh Heravi, Ali Javadmanesh","doi":"10.1007/s12011-024-04452-6","DOIUrl":"10.1007/s12011-024-04452-6","url":null,"abstract":"<p><p>Zinc (Zn) is a significant element of the reproductive system and is associated with several enzymes that regulate different metabolic pathways. Organic Zn can significantly affect polycystic ovarian syndrome (PCOS) pathogenesis. Insulin resistance (IR) is a common complication of PCOS. Mammalian target of rapamycin (mTOR), which controls crucial cell functions, is regulated by insulin and nutrients. It has two complexes, namely, mTORC1 and mTORC2. mTOR associates with its binding partner's regulatory associated protein of mTOR (Raptor) and rapamycin-insensitive companion of mTOR (Rictor), which form these distinct complexes, respectively, and is activated in PCOS. This research aimed to evaluate the effect of Zn on the expression of mTOR signaling genes (Raptor and Rictor) and IR in PCOS model rats. Different Zn supplements, including standard diet (SD): (control - or + , SD without supplementation), Zn25, Zn75, and Zn175 (daily given three levels of 25, 75, and 175 mg Zn methionine (ZnMet)/kg for 6 weeks, respectively), were applied to the control and PCOS groups. Fasting glucose (FG), fasting insulin (FI), IR indices, and Raptor and Rictor expression levels were measured in both groups. The results showed that PCOS induction dramatically increased FG, FI, IR indices, and mTOR-related gene expression; however, different Zn supplementation concentrations, especially at 75 mg/kg, reduced the effects of PCOS induction. Organic Zn collectively exerted positive effects on Estradiol Valerate (EV)-induced PCOS rats by reducing IR and mTOR signaling gene (i.e., Raptor and Rictor) expression. Moreover, this study revealed a correlation between Zn and IR. Therefore, Zn supplementation could be a valuable therapeutic method for treating PCOS.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3793-3802"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Supranutritional Selenium Supplementation During Different Trimesters of Pregnancy on Humoral Immunity in Beef Cattle at Parturition.","authors":"Jean A Hall, Gerd Bobe, William R Vorachek, Joseph J Klopfenstein, Ian O Thompson, Cindy L Zurita Cruz, Brian P Dolan, Ling Jin, T Zane Davis","doi":"10.1007/s12011-024-04457-1","DOIUrl":"10.1007/s12011-024-04457-1","url":null,"abstract":"<p><p>Supranutritional Se supplementation may improve immune responses in beef cattle. Immunity is compromised in beef cattle during the periparturient period. This study aims to determine the best time during pregnancy to supplement beef cows with Se-yeast to optimize humoral immunity at parturition. Multiparous, black Angus and Angus cross cows (n = 79) were used in the study. All cows had ad libitum access to a mineral supplement containing 120 mg/kg Se (US FDA regulations) from Na selenite. In addition, all cows except controls (CTR) received Se supplementation of 105 mg Se/week from Se-yeast boluses administered once weekly during their specific treatment trimester of gestation (TR1, TR2, or TR3) for 13 weeks. This dosage was supranutritional equaling 5 × the upper range of US FDA Se administration regulations. Blood was collected at parturition from all cows. Laboratory analyses studied to assess humoral immunity included measuring IBR, BVD types 1 and 2, PI3, and BRSV serum neutralization titers post vaccination, assessing total IgM and antigen-specific IgM concentrations, and determining complement-mediated bacterial killing percentages. Statistical analyses were performed using GraphPad Prism and SAS 9.4. Supranutritional Se-yeast supplementation increased whole-blood (WB) Se concentrations regardless of trimester of supplementation (all P < 0.0001). Supplementation during TR2 and TR3 was more effective in increasing WB-Se concentrations at parturition than during TR1 or CTR (all P < 0.0001). TR2 cows had higher serum neutralization titers for BRSV compared with CRT cows (P = 0.03). Total serum IgM and Vibrio coralliilyticus-specific IgM concentrations were highly correlated (r = 0.78; P < 0.0001). Compared with CTR cows, TR1, TR2, and TR3 cows had similar total IgM concentrations (all P ≥ 0.19) and similar Vibrio coralliilyticus-specific IgM concentrations (all P ≥ 0.47). Complement-mediated bacterial killing percentages were greater in TR2 and TR3 cows (> 99.6%) compared with TR1 (93.9%) and CTR (89.3%) cows, and all Se-supplemented TR groups were greater than CTR cows (all P ≤ 0.05). The significant group differences in the complement-mediated bacterial killing assay reflected WB-Se concentrations. Supranutritional Se-yeast supplementation during TR2 and TR3 is associated with higher serum neutralization titers for some viral antigens, as well as enhanced complement-mediated bacterial killing in cows at parturition. These findings suggest that Se supplementation during later trimesters of pregnancy may help combat infectious disease challenges during the periparturient period in beef cattle.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3709-3723"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Compositionally Different Substrates on Elemental Properties of Bay Bolete Mushrooms: Case Study of 34 Essential and Non-essential Elements from Six Areas Affected Differently by Industrial Pollution.","authors":"Alexandre V Andronikov, Irina E Andronikova, Ondrej Sebek, Eva Martinkova, Marketa Stepanova, Oksana Perehon","doi":"10.1007/s12011-024-04429-5","DOIUrl":"10.1007/s12011-024-04429-5","url":null,"abstract":"<p><p>We studied concentrations of 34 essential and non-essential elements in samples of edible Bay Bolete (Imleria badia) mushrooms added by samples of the growing substrate and bioavailable fraction. The samples were collected from six forested sites affected differently by industrial pollution and underlain by compositionally contrasting bedrock: granite, amphibolite, and peridotite. In all cases, mushrooms behaved as a bioconcentrating system for elements such as Ag, K, P, Rb, S, and Se (BCF > 1) being a bioexcluding system for the rest of the elements analyzed (BCF < 1). Most analyzed elements displayed moderate to high within-mushroom mobility being accumulated preferably in the apical parts of the mushroom's fruiting body (TF > 1). The highest mobility was demonstrated by Cd and Cu. Sodium was the only element with significantly low mobility (TF < 1), and it accumulated preferably in the stipe. Imleria badia seems to be sensitive to the accumulation of elements such as As, Cd, and Pb from the atmospheric deposits. Specific geochemistry of the growing substrate was reflected to different extend in the accumulation of elements such as Ag, Cu, Rb, S, Al, Ca, Fe, Ba, and Na in the mushroom's fruiting bodies.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3896-3912"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review on Fluoride Contamination in Water Resources of Iran from 2016 to 2023: Spatial Distribution and Probabilistic Risk Assessment (Monte Carlo Simulation).","authors":"Danial Nayeri, Hadis Elyasi, Ali Jafari, Mohammad Rezvani Ghalhari","doi":"10.1007/s12011-024-04422-y","DOIUrl":"10.1007/s12011-024-04422-y","url":null,"abstract":"<p><p>Because of significant variations and existence of high fluoride (F^-) in some waters, Iran has been considered for various fluoride studies in recent decades. Nevertheless, there is a no updated review on fluoride levels especially including F^- risk assessment. Thus, this systematic review is mainly aimed to evaluate the spatial distribution of F^- content in water sources of Iran using geographic information system (GIS) and conduct the health risk assessment. Besides, the Monte-Carlo Simulation technique with 10,000 iterations was applied for determination of the non-carcinogenic effects of F^- in different exposed groups (infant, children, teenagers, and adults). The results indicated that the maximum and minimum concentrations of F^- content were related to Jazmourian (Roudbar plain) (4.8 mg/L) and Sahneh (0.1 mg/L) provinces, respectively, and F^- content of more than ≅ 19% of the samples exceeds the Iranian standard value (1.5 mg/L). The results showed that the HQ of F^- in all groups were higher than 1 with the order of children > infants > teenager > adults in which children were the vulnerable group to F^- consumption in study area. Therefore, it is necessary to monitor and continuously measure water supplies for fluoride content and control measures, including removal steps, be taken for human risk reduction.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3931-3948"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Debated Issue on Tissue Copper Levels in Colorectal Cancer Patients: A Meta-analysis and Replication Study.","authors":"Rosanna Squitti, Amit Pal, Aninda Dhar, Muhammad Aaqib Shamim, Kalyan Goswami, Anastasia De Luca, Gianluca Rizzo, Mauro Rongioletti, Vincenzo Tondolo","doi":"10.1007/s12011-024-04421-z","DOIUrl":"10.1007/s12011-024-04421-z","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is a growing public health problem. Several clinical studies have shown a potentially oncogenic role of copper in CRC progression, but the reports are inconsistent. To examine published evidence on the association between tissue copper status and CRC, we carried out a systematic review and meta-analysis, searching Cochrane Library, EBSCOhost, Embase, ProQuest, PubMed/Medline, Scopus, and Web of Science for studies reporting colon tumor and matched non-cancerous tissue copper concentrations in CRC patients for articles published till June 2023. Based on a random effects model, standardized mean differences (SMD) were assessed. We also completed a replication study on 17 CRC patients that analyzed copper levels in both cancer tissue specimens and healthy mucosa dissected from the same patient. Thirteen studies investigating copper levels (including the replication study) in colorectal specimens from a pooled total of 312 CRC and 298 healthy mucosa were selected. Our meta-analysis estimated a high between-study heterogeneity (I² = 96%) and lower levels of copper in CRC tissue cancer specimens than in matched healthy mucosa: the decrease was equal to - 0.74 (95% CI, - 2.18; 0.71) but was not significant. The replication study showed a significant decrease in tissue cancer specimens. Sensitivity analyses of the meta-analysis revealed that pre-analytical methodology for tissue preparation significantly reduced the between-study heterogeneity strongly influencing copper levels (p < 0.01), indicating a copper decrease in the cytoplasmic copper pool of the tumor tissue suggesting a rapid turnover of the metal in cancer cells.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3479-3493"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142457037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Urinary Cadmium with Body Composition and Fat Distribution in US Adults: Findings from NHANES 2011-2018.","authors":"Yue Teng, Suping Ren","doi":"10.1007/s12011-024-04423-x","DOIUrl":"10.1007/s12011-024-04423-x","url":null,"abstract":"<p><p>The effects of cadmium (Cd) on metabolic physiology remain controversial. Given the varying metabolic impacts associated with different body compositions, investigating the relationship between Cd exposure and body composition may facilitate further research. Here, the associations of body composition and fat distribution with urine Cd (UCd) were evaluated. This analysis included 2979 adult participants from the 2011-2018 National Health and Demographic Survey (NHANES). UCd was measured using inductively coupled plasma mass spectrometry and adjusted for urinary creatinine. Body composition and fat distribution were estimated using dual-energy x-ray absorptiometry (DXA). The study results show that UCd was negatively associated with fat mass index (FMI) and percent fat mass (p for trend < 0.001), and the negative correlation between UCd and FMI was stronger in males and smokers (all p for interaction < 0.05). In terms of abdominal fat distribution, UCd was negatively associated with abdominal subcutaneous adipose tissue (SAT) mass (p for trend < 0.001), but with abdominal visceral adipose tissue (VAT) mass only in those with low percent fat mass (< 32.3%) (p for trend = 0.026 and p for interaction < 0.05). UCd was positively related to percent VAT (p for trend < 0.001) and visceral-to-subcutaneous (VAT/SAT) ratio (p for trend = 0.003). And there was a significant negative association between UCd and android-to-gynoid (A/G) ratio (p for trend = 0.001). Meanwhile, UCd was negatively correlated with fat-free mass index (FFMI) (p for trend < 0.001). And the negative correlation between UCd and FFMI was stronger in males, smokers, and individuals with < 32.3 percent fat mass (all p for interaction < 0.05). We found the association of UCd with body composition and fat distribution, with distinct patterns observed in different demographic groups. These findings underscore the importance of considering UCd exposure in the context of body composition and fat distribution.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3494-3506"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142494139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insufficient Muscle Development Level Associated with Serum Zinc, Manganese and Cobalt Levels in Children Aged 6 to 9 Years in Shenzhen, China.","authors":"Rimei Liang, Haide Zhu, Xiongcheng Cao, Yuheng Zeng, Yingbin You, Pi Guo, Qingying Zhang","doi":"10.1007/s12011-024-04458-0","DOIUrl":"10.1007/s12011-024-04458-0","url":null,"abstract":"<p><p>Some trace elements have been found to be associated with muscle mass and muscle function; however, evidence in children is limited, and it remains unclear which trace elements are more relevant. We aimed to explore the association of levels of individual and combined essential trace elements and muscle development level (MDL) in young children. Muscle mass was measured by body composition analysis, and trace elements were determined by using inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression, restricted cubic spline (RCS) and weighted quantile sum regression (WQS) were used to assess the individual and joint associations between trace element levels and MDL. We enrolled 2851 children: 1595 boys (55.9%) and mean age 7.1 years (range 6.8-7.3). The proportion of insufficient muscle mass in the whole body, limbs, upper and lower limbs was 1.9%, 6.5%, 44.9% and 4.6%, respectively. The odds of insufficient MDL decreased with the fourth versus first quartile of zinc (OR = 0.67, 95% CI: 0.51-0.89), manganese (OR = 0.80, 95% CI: 0.65-1.00), and cobalt (OR = 0.89, 95% CI: 0.81-0.99) and was increased with the fourth quartile of nickel (OR = 2.23, 95% CI: 1.72-2.89) and selenium (OR = 1.51, 95% CI: 1.14-1.98). The RCS yielded similar results, except for the discrepancy in high cobalt levels. The odds of insufficient MDL decreased with the combination of nine trace elements (OR = 0.84, 95% CI: 0.73-0.97), primarily zinc (weight = 0.297), manganese (weight = 0.198) and cobalt (weight = 0.173). Insufficient MDL in young children was mainly in upper limbs. Low levels of zinc, manganese, and cobalt, individually or combined, were significantly associated with risk of insufficient MDL. Further foods rich in zinc, manganese, and cobalt should be suggested to supplement in diet, and increase exercise of upper limbs to improve insufficient MDL in the young children should be needed.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3665-3677"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Test to Evaluate the Cytotoxicity and Genotoxicity of Natural Zeolite (NZ) Functionalized with Silver Nanoparticles (NZ-AgNPs) on Erythrocytes of Yellowtail Tetra Fish Astyanax lacustris.","authors":"Josiane Rodrigues Rocha da Silva, Camila Oliveira de Andrade, Anna Carla Ribeiro, Paula Derksen Macruz, Elizabeth da Costa Neves FernandesAlmeida Duarte, Rosângela Bergamasco, Ana Luiza de Brito Portela-Castro, Carlos Alexandre Fernandes","doi":"10.1007/s12011-024-04451-7","DOIUrl":"10.1007/s12011-024-04451-7","url":null,"abstract":"<p><p>Silver nanoparticles (AgNPs) have unique properties such as chemical stability, malleability, flexibility, high electrical and thermal conductivity, and catalytic activity, making them suitable for various applications. However, they also pose potential toxicity and environmental contamination risks. Natural zeolites (NZs) are considered excellent inorganic support for reducing the toxicity of AgNPs. The scope of this study was to carry out a comparative assessment of the cytotoxic and genotoxic effects of NZ, NZ functionalized with silver nanoparticles (NZ-AgNPs), and commercial AgNPs on fish Astyanax lacustris. Micronucleus (MN) test, cellular morphological change (CMC) test, and the comet assay were used to assess the effects of the nanoparticles. A. lacustris specimens were exposed to a concentrations of 0.1 mg l^-1 in the NZs, NZ-AgNPs, and commercial AgNPs for 96 h during the experiment. The results showed no significant difference between the negative control and NZ. Moreover, NZ-AgNPs exhibited reduced toxicities compared to commercial AgNPs, which caused higher levels of alterations and cellular damage. The study concluded that NZs effectively reduced cytotoxicity/genotoxicity in A. lacustris specimens when used to support AgNPs.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"3884-3895"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}