Biological Trace Element Research最新文献

{"title":"Human Mercury Biomonitoring Under the Minamata Convention: Blood, Urine, Hair, and Tissue Biomarkers (2000-2026).","authors":"Jose L Domingo, Marília Cristina Oliveira Souza, Martí Nadal, Fernando Barbosa","doi":"10.1007/s12011-026-05347-4","DOIUrl":"https://doi.org/10.1007/s12011-026-05347-4","url":null,"abstract":"<p><p>Mercury (Hg) is a globally ubiquitous environmental pollutant classified by the World Health Organization among the chemicals of major public health concern. It occurs as elemental mercury, inorganic mercury, and organic mercury, each with distinct toxicokinetics and target organs. Human exposure arises mainly from fish and seafood consumption. Additional important sources include dental amalgam restorations, occupational settings, mercury-containing skin-lightening cosmetics, artisanal and small-scale gold mining (ASGM), and environmental remobilization of Hg naturally stored in soils and sediments through erosion, flooding dynamics, biomass burning, and soil mobility processes, especially in tropical regions such as the Amazon Basin. This is a narrative review of the scientific literature published from January 1, 2000 to June 15, 2026 on Hg concentrations measured in human blood and other biological tissues. Background blood Hg concentrations in general populations are commonly below 1-3 µg/L, while values exceeding 5 µg/L are uncommon in unexposed populations and may approach biomonitoring guidance thresholds. NHANES data show a progressive decline in blood Hg among women of reproductive age. Markedly elevated levels are consistently reported in high-fish-consuming coastal and Arctic Indigenous communities, ASGM workers, users of mercury-containing skin-lightening products, and individuals with extensive amalgam restorations. Mercury accumulates in the kidney cortex (inorganic Hg) and brain (inorganic and organic forms), with concentrations that may persist long after exposure cessation. Cardiovascular and renal effects of chronic Hg exposure are increasingly documented, complementing neurotoxicological evidence that remains most firmly established at high-level exposures, such as Minamata disease and occupational poisoning, whereas associations reported at typical environmental exposure levels are largely statistical rather than indicative of overt clinical neurotoxicity. A recurring pattern across the reviewed literature is that biomarker concentrations and temporal trends differ markedly between high-income and low- and middle-income countries, with declining exposure and denser monitoring coverage in the former contrasting with persistently elevated levels and sparse surveillance data in the latter, a gap directly relevant to evaluating the effectiveness of the Minamata Convention under its Article 22. Continued biomonitoring, strict regulatory enforcement, and full implementation of the Minamata Convention are essential to protect vulnerable populations worldwide.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review and Meta-Analysis on the Association Between Cadmium and Mercury, with Polycystic Ovary Syndrome.","authors":"Mehrnoush Matin, Mehdi Koupaee, Mohammad Javad Khodayar","doi":"10.1007/s12011-026-05349-2","DOIUrl":"https://doi.org/10.1007/s12011-026-05349-2","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with multifactorial etiology. Cadmium (Cd) and mercury (Hg) are potent endocrine-disrupting metals, yet their association with PCOS remains inconsistent. These metals were targeted due to their high prevalence, established ovarian toxicity, and shared mechanistic pathways relevant to PCOS. Following PRISMA guidelines, we searched PubMed, Scopus, Web of Science, and Embase through December 2025 for observational studies comparing Cd/Hg concentrations between women with PCOS and controls. Quality was assessed via the Newcastle-Ottawa Scale; pooled standardized mean differences (SMDs) were calculated using random-effects models. Eleven studies (1,960 cases; 2,696 controls) were included. Women with PCOS exhibited significantly higher cadmium (SMD = 0.42, 95% CI: 0.09-0.75; I²=95.6%) and mercury (SMD = 0.57, 95% CI: 0.23-0.91; I²=95.8%) concentrations than controls. Egger's test indicated potential publication bias; trim-and-fill adjustment yielded corrected SMDs of 0.78 (95% CI: 0.34-1.22) for cadmium and 0.76 (95% CI: 0.41-1.11) for mercury, indicating slight underestimation of true effects. Meta-regression for mercury identified biological matrix (p = 0.002) and geographical location (p = 0.026) as significant moderators; bubble plots confirmed attenuation of the Hg-PCOS association when shifting from serum to whole blood or urine. No significant predictors explained cadmium's heterogeneity, suggesting unmeasured individual factors. This meta-analysis provides quantitative evidence linking Cd and Hg exposure to PCOS. The choice of biological matrix is a critical determinant in assessing mercury's impact. These findings advocate for standardized environmental exposure assessments and longitudinal studies to establish causality and inform preventive public health strategies.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: p-Coumaric Acid Attenuates Lead Acetate-induced Neurotoxicity in Rats by Improving Behavioral Dysfunction and Suppressing Oxidative Stress, Neuroinflammation, Apoptosis, and Plasticity-related Molecular Alterations.","authors":"Tuba Karaarslan, Merve Bolat, İsmail Bolat, Betul Orhan, Esra Aktas Senocak, Samet Tekin, Burak Batuhan Lacin, Ayse Golgeli, Aslıhan Atasever","doi":"10.1007/s12011-026-05351-8","DOIUrl":"https://doi.org/10.1007/s12011-026-05351-8","url":null,"abstract":"","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium Deficiency is a Significant Risk Factor for Sarcopenia: Evidence and Selenoprotein-Mediated Mechanisms.","authors":"Qingqing Ni, Huadong Wang, Jinsong Zhang, Huali Wang","doi":"10.1007/s12011-026-05350-9","DOIUrl":"https://doi.org/10.1007/s12011-026-05350-9","url":null,"abstract":"<p><p>This review systematically maps the causal and mechanistic connections between selenium status and sarcopenia, a debilitating condition characterized by age-related loss of muscle mass, strength, and function. Current evidence reveals a strong and consistent association across studies. Epidemiological data demonstrate that lower levels of various selenium biomarkers, including serum/plasma selenium, whole blood selenium, the selenium transport protein SELENOP, and dietary selenium intake, are significantly associated with poorer muscle outcomes, such as decreased grip strength, reduced muscle mass, and a higher prevalence of sarcopenia, following a dose-response pattern. A clinical study further confirms significantly lower serum selenium levels and glutathione peroxidase activity in patients with sarcopenia, linking elevated muscle oxidative stress to depleted selenium status. In animal models, sarcopenia is associated with reduced muscle selenium content, whereas selenium supplementation effectively prevents this decline and attenuates muscle atrophy and weakness. The underlying protective mechanisms are primarily mediated through specific selenoproteins. GPX4 preserves mitochondrial function and muscle mass by detoxifying lipid peroxides, suppressing inflammation, and preventing ferroptosis. SELENOP, secreted by macrophages, resolves inflammation and supports muscle stem cell-mediated regeneration. SELENOW, highly expressed in skeletal muscle, maintains protein homeostasis by regulating the RAC1-mTOR pathway to counteract atrophy. Additionally, SELENOT and SELENON are critical for maintaining intracellular calcium homeostasis, which is essential for normal muscle contraction. In conclusion, selenium deficiency constitutes a significant risk factor for sarcopenia. Ensuring adequate selenium intake supports a network of selenoproteins that combat oxidative stress, regulate inflammation, promote muscle regeneration, and maintain protein and calcium homeostasis, underscoring its importance in nutritional strategies for preserving muscle health in aging populations.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Metformin, Boric Acid, and Lithium Chloride on Oxidative Stress-Mediated Cytotoxicity in HepG2 Hepatocarcinoma Cells.","authors":"Burcu Biltekin, Sevgin Değirmencioğlu, Naile Misirlioglu, Hafize Uzun","doi":"10.1007/s12011-026-05311-2","DOIUrl":"https://doi.org/10.1007/s12011-026-05311-2","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, highlighting the need for novel therapeutic strategies targeting tumor growth, migration, and oxidative stress. Metformin, boric acid (BA), and lithium chloride (LiCl) have been reported to exert anticancer properties through diverse molecular mechanisms; however, their combined effects on HCC cells remain insufficiently characterized. In this study, we investigated the effects of metformin, BA, and LiCl, alone and in combination, on cell viability, migration, oxidative stress, inflammation, and apoptosis in HepG2 hepatocarcinoma cells. Cell viability was assessed using the CCK-8 assay, while cell migration was evaluated by wound healing analysis. Oxidative stress status was examined through catalase (CAT) activity (Aebi method) and superoxide dismutase (SOD) levels measured by ELISA. Inflammatory responses were assessed by determining IL-17 and NF-κB p105 levels. Apoptotic activity was evaluated via immunocytochemical analysis of caspase-3 and caspase-9 expression. Our results demonstrated that metformin, BA, and LiCl significantly reduced HepG2 cell viability and migration in a time- and concentration-dependent manner. These effects were accompanied by marked alterations in antioxidant enzyme activity, suppression of IL-17 and NF-κB signaling, and robust activation of intrinsic apoptotic pathways, as evidenced by increased caspase-3 and caspase-9 immunoreactivity. Notably, combinatorial treatments, particularly metformin with LiCl, exerted more pronounced antiproliferative and pro-apoptotic effects than monotherapies. Collectively, these findings suggest that metformin, BA, and LiCl modulate oxidative stress, inflammatory signaling, and apoptosis in HepG2 cells, supporting their potential utility as complementary agents in HCC treatment strategies.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: The Preventive Effect of Zinc Sulfate Against Olanzapine-Induced Testicular Toxicity in Male Rats.","authors":"Hossam Ebaid, Samir A E Bashandy, Iftekhar Hassan, Jameel Al-Tamimi, Shimaa Abdallah Haredy, Tharwat Imbabi, Enayat A Omara, Yousef S Bashandy, Ezzat M Awad","doi":"10.1007/s12011-026-05344-7","DOIUrl":"https://doi.org/10.1007/s12011-026-05344-7","url":null,"abstract":"","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Potentially Toxic and Essential Metals in Commonly Consumed Tomato Ketchup Brands from Local Markets in Faisalabad, Pakistan, and Associated Health Risks.","authors":"Muhammad Bilal, Muhammad Abdul Qayyum, Ghulam Ali, Kashif Naeem","doi":"10.1007/s12011-026-05328-7","DOIUrl":"https://doi.org/10.1007/s12011-026-05328-7","url":null,"abstract":"<p><p>Tomato ketchup is susceptible to contamination by potentially toxic metals, which may pose a risk to human health. Present study was intendant to quantify 17 potentially toxic/essential elemental concentrations in 15 commercial brands of tomato (Lycopersicon esculentum L.) ketchup samples. Health risks were evaluated using estimated daily intake, health risk index (HRI), target hazard quotient (THQ), and the target cancer risk (TCR) indices for adults and children. The samples were quantified by using ICP OES technique after acid digestion method. The elements were determined in mg/kg: Al (3.375-16.25), Pb (0.374-3.125), Zn (0.625-3.750), Cr (0.091-2.602), Cu (0.345-1) and Cd (0.125-0.34). The HRI values for Al, Cd, Pb and Cr were greater than unity. The TCR values exhibited Cd, Pb and Cr as the most potent contaminants in the samples. Principal component analysis, hierarchal clustering and correlations revealed that metals sources may be common origin. Cd, Cr, Pb, Al were found higher than the acceptable limits. Multivariate CA and PCA revealed significant anthropogenic contributions of the metals in tomato ketchup. HRI values for Cd, Al, Cr, and Pb exceeded safe limits indicating a high non-carcinogenic risk. TCR shows that Cr and Cd concentration may cause cancer to consumers over long-time ingestion. Hence, it is of utmost importance that healthcare providers, researchers, and policy makers may use these results to monitor and identify sources of toxic and essential elements in tomato ketchup brands, for ensuring public health, food safety and regulatory issues.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper Promotes Myogenic Differentiation of Bovine Skeletal Muscle-Derived Cells by Activating the HIF-1α/β-catenin Signaling Axis.","authors":"Bai Han Liu, Jin Ge Zhang, Dong Qiao Peng, Yong Cheng Jin","doi":"10.1007/s12011-026-05339-4","DOIUrl":"https://doi.org/10.1007/s12011-026-05339-4","url":null,"abstract":"<p><p>Copper is an essential trace element for beef cattle, yet its muscle developmental regulatory mechanism remains unclear. This study investigated the effects of copper sulfate (CuSO₄) on myogenic differentiation of bovine skeletal muscle-derived cells (BSMC) and the underlying molecular mechanisms. BSMC were isolated from the longissimus thoracis muscle of three 30-month-old crossbred steers, with each steer defined as an independent experimental unit corresponding to a separate biological replicate (n = 3). Based on cell viability, CuSO₄ was used at 0, 0.1, 1, and 10 µM. All cell samples were harvested at differentiation day 6 (D6). The 0.1 µM CuSO₄ treatment during cell growth significantly promoted D6 myotube formation (P = 0.049), and upregulated mRNA and protein expression of myogenic differentiation 1 (MyoD) (P = 0.044, P = 0.030), as well as protein expression of hypoxia-inducible factor-1α (HIF-1α) (P = 0.037) and β-catenin (P = 0.050). During differentiation, 1 µM CuSO₄ significantly facilitated D6 myotube formation (P = 0.0004), increased myogenic factor 5(Myf5) mRNA and protein expression (P = 0.030, P = 0.006), and elevated HIF-1α (P = 0.025) and β-catenin (P = 0.004) protein levels, whereas Wnt10b protein expression remained unaltered (P = 0.930). Single or combined pharmacological inhibition of HIF-1α and β-catenin markedly reversed copper's pro-myogenic effect on BSMC. In conclusion, copper modulates BSMC myogenic differentiation via the HIF-1α/β-catenin axis by enhancing β-catenin protein stability independent of Wnt10b transcription. HIF-1α acts upstream to drive β-catenin, and a reciprocal regulatory relationship may exist in which β-catenin in turn helps sustain HIF-1α abundance, thereby supporting cascade signaling and downstream myogenic transcription. This study elucidates copper's molecular mechanism governing muscle development and provides theoretical support for precise copper supplementation to improve beef production performance.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cd-IMAC-MS Enables Exploratory Profiling of Cadmium-Associated Proteins in Rat Brain after Cadmium Exposure.","authors":"Shaoxin Huang, Yong Yang, Yinghui Yin, Ruifeng Cheng, Xinyu Zhou, Sheng Wan, Hao Gao, Maoqin Tian, Qiwen Chen, Zhenzhong Liu, Zhaokui Dan, Hui Liu, Jianjun Xiong","doi":"10.1007/s12011-026-05340-x","DOIUrl":"https://doi.org/10.1007/s12011-026-05340-x","url":null,"abstract":"<p><p>Cadmium (Cd²⁺) is a persistent neurotoxic metal, but the brain proteins recoverable by cadmium-affinity enrichment after exposure remain incompletely defined. We developed cadmium-immobilized metal affinity chromatography coupled with mass spectrometry (Cd-IMAC-MS), which combines non-denaturing Cd²⁺-charged nitrilotriacetic acid (Cd-NTA) affinity recovery, blank-NTA controls, and data-independent acquisition (DIA) proteomics. The discovery experiment comprised 12 independent animals in a balanced 2 × 2 exposure-by-affinity-matrix design (n = 3 per cell). For 2,119 proteins quantified across all four cells, an ordinary least-squares interaction screen identified 26 nominal candidates (10 positive and 16 negative interaction effects); none met Benjamini-Hochberg-adjusted q < 0.05. A separate Cd-NTA-only CH - CL branch identified 23 nominal candidates (six positive and 17 negative effects), yielding a 49-protein exploratory union; no protein met q < 0.05 after pooled adjustment across 2,988 discovery tests. In a lower-dose prefrontal-cortex cohort, 775 of 8,209 proteins met nominal P < 0.05 and none met q < 0.05. Six symbols overlapped the discovery set, and CTBP1 and PDHA1 also occurred in the Comparative Toxicogenomics Database list. Because no standalone sample-ID-to-treatment key was available, the reported meanCon-meanCase signs were not assigned an exposure direction. The functional-context analysis, protein-association network, database annotations, and residue-level predictions are interpreted as secondary, hypothesis-generating evidence. Cd-IMAC-MS therefore prioritizes candidates for orthogonal binding and functional validation rather than establishing direct in vivo Cd²⁺ binding.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental composition of the three poisonous Digitalis L. species of Moldovan origin determined by instrumental neutron activation analysis.","authors":"Alexandru Ciocarlan, Aculina Aricu, Lidia Lungu, Inga Zinicovscaia, Dmitrii Grozdov, Nina Ciocarlan","doi":"10.1007/s12011-026-05346-5","DOIUrl":"https://doi.org/10.1007/s12011-026-05346-5","url":null,"abstract":"<p><p>Digitalis species play a significant role in the treatment of congestive heart failure and other cardiac diseases. Instrumental neutron activation analysis was employed to determine the elemental composition of three species: Digitalis ferruginea L., Digitalis lanata Ehrh., and Digitalis purpurea L. (n = 9). Analytical quality was assured using certified reference materials. Among the major elements, potassium exhibited the highest mass fractions, with values ranging from 1.52 ± 0.1% in D. purpurea to 2.79 ± 0.2% in D. ferruginea. Chlorine and iron were identified as the most abundant minor elements. Among potentially toxic elements, arsenic was detected in Digitalis ferruginea and Digitalis purpurea, whereas antimony and other elements were determiend in all species. The range of elements quantified in the present study considerably exceeds that reported in previous investigations on other Digitalis species. Notably, the mass fractions of nearly all determined elements were found to be higher in D. purpurea, which may be attributed to its biological properties and high metal uptake capacity-a finding that warrants further investigation.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}