Biological Trace Element Research最新文献

{"title":"Comparative Effects of Including Inorganic, Organic, and Hydroxy Zinc Sources on Growth Development, Egg Quality, Mineral Excretion, and Bone Health of Laying Quails.","authors":"Osman Olgun, Esra Tuğçe Gül, Gözde Kılınç, Fatih Gökmen, Alpönder Yıldız, Veli Uygur, Ainhoa Sarmiento-García","doi":"10.1007/s12011-024-04137-0","DOIUrl":"10.1007/s12011-024-04137-0","url":null,"abstract":"<p><p>The purpose of this study was to determine the effects of the dietary addition of zinc (Zn) in the form of sulphate (Zn-S), glycine (Zn-G), and hydroxychloride (Zn-H) on quail performance, eggshell quality, antioxidant status, mineral excretion, biomechanical properties and mineralization of bone. A total of 75 female quails (10-weeks-old) were randomly distributed into 3 groups with 5 replications, each with 5 female quails. Treatment groups were set up by adding Zn-S and Zn-H as the inorganic form and Zn-G as the organic form of zinc to the corn-soybean basal diet (34.14 mg/kg Zn) to obtain 50 mg/kg Zn and the feeding experiment lasted for 12 weeks. Performance parameters and egg production were not impaired by the Zn source (P > 0.05). The inclusion of Zn-S in the diet produced a reduction in eggshell thickness, while an improvement in yolk antioxidant capacity (measured as MDA concentration) was detected compared to the other Zn sources (P < 0.05). Shear strength and cortical bone area increased (P < 0.05) with Zn-G supplementation, however, the mineral concentration of the tibia was higher (P < 0.01) in those quails who had received Zn-H. Lower levels of mineral excretion were observed in both types of supplementations compared to Zn-S. Therefore, it can be stated that Zn-G or Zn-H supplementation in the diet of laying quails could be an interesting strategy to reduce mineral excretion and improve bone mineralization without affecting performance compared to Zn-S. However, further studies are needed to determine the differences between Zn-G and Zn-H.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5680-5689"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Silver Nanoparticles for the Control of Anthelmintic Resistance in Small and Large Ruminants.","authors":"Sahar Mustafa, Lafi M Alharbi, Mona Z Abdelraheem, Muhammad Mobashar, Warda Qamar, Amin A Al-Doaiss, Rao Zahid Abbas","doi":"10.1007/s12011-024-04132-5","DOIUrl":"10.1007/s12011-024-04132-5","url":null,"abstract":"<p><p>Helminths are considered a significant threat to the livestock industry, as they cause substantial economic losses in small and large ruminant farming. Their morbidity and mortality rates are also increasing day by day as they have zoonotic importance. Anthelmintic drugs have been used for controlling these parasites; unfortunately, due to the development of resistance of these drugs in helminths (parasites), especially in three major classes like benzimidazoles, nicotinic agonists, and macrocyclic lactones, their use is becoming very low. Although new anthelmintics are being developed, the process is time-consuming and costly. As a result, nanoparticles are being explored as an alternative to anthelmintics. Nanoparticles enhance drug effectiveness, drug delivery, and target specificity and have no resistance against parasites. Different types of nanoparticles are used, such as organic (chitosan) and inorganic (gold, silver, zinc oxide, iron oxide, and nickel oxide). One of them, silver nanoparticles (AgNPs), has unique properties in various fields, especially parasitology. AgNPs are synthesized from three primary methods: physical, chemical, and biological. Their primary mechanism of action is causing stress through the production of ROS that destroys cells, organs, proteins, and DNA parasites. The present review is about AgNPs, their mode of action, and their role in controlling anthelmintic resistance against small and large ruminants.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5502-5521"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140020876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Toxicity of TiO₂ and Sn-Doped TiO₂ Nanoparticles in Zebrafish After Acute and Chronic Exposure.","authors":"Maryam Mahjoubian, Akram Sadat Naeemi, Mehdi Sheykhan","doi":"10.1007/s12011-024-04127-2","DOIUrl":"10.1007/s12011-024-04127-2","url":null,"abstract":"<p><p>This study was conducted to assess the toxicological potential of synthesized pure and Sn-doped TiO₂ NPs (Sn-TiO₂ NPs) in zebrafish after acute and chronic exposure. The pure TiO₂ NPs, 4%, and 8% Sn-TiO₂ NPs were synthesized and characterized using X-ray diffraction, Scanning Electron Microscope, diffuse reflectance spectra, dynamic light scattering, and zeta potential analyses. The pure TiO₂ NPs, 4%, and 8% Sn-TiO₂ NPs were spherical with average sizes of about 40, 28, and 21 nm, respectively, indicating significant size reduction of TiO₂ NPs following Sn doping. According to our results, the LC_50-96h increased in the order of 8% Sn-TiO₂ NPs (45 mg L^-1) < 4% Sn-TiO₂ NPs (80.14 mg L^-1) < pure TiO₂ NPs (105.47 mg L^-1), respectively. Exposure of fish to Sn-TiO₂ NPs after 30 days resulted in more severe histopathological alterations in gills, liver, intestine, and kidneys than pure TiO₂ NPs. Furthermore, Sn-doping significantly elevated malondialdehyde levels and micronuclei frequency, indicating increased oxidative stress and genotoxicity. Expression analysis revealed altered expression of various genes, including upregulation of pro-apoptotic Bax gene and downregulation of anti-apoptotic Bcl-2 gene, suggesting potential induction of apoptosis in response to Sn-doped NPs. Additionally, antioxidant genes (Gpx, Sod, Cat, and Ucp-2) and stress response gene (Hsp70) showed altered expression, suggesting complex cellular responses to mitigate the toxic effects. Overall, this study highlights the concerning impact of Sn-doping on the toxicity of TiO₂ NPs in zebrafish and emphasizes the need for further research to elucidate the exact mechanisms underlying this enhanced toxicity.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"1-19"},"PeriodicalIF":3.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern Recognition of Trace Element vs Heavy Elements in Patients with Membranous Nephropathy.","authors":"Xiaochang Xu, Jing Xu, Weiji Xie, Zhihui Yang, Keping Wu, Shuping Zhao, Yimin Zhang","doi":"10.1007/s12011-024-04461-5","DOIUrl":"https://doi.org/10.1007/s12011-024-04461-5","url":null,"abstract":"<p><p>The objective of the present study was to investigate the role of trace elements and heavy elements in the pattern recognition in patients with membranous nephropathy. Elements such as V, Cr, Mn, Co, Ni, Cu, Zn, Ga, As, Se, Sr, Cd, Cs, Ba, Pb, and Hg were quantified by inductively coupled plasma mass spectrometry in blood and urine of 14 patients with membranous nephropathy, 14 patients with IgA nephropathy, and 13 normal controls. The blood levels of Cr, Co, Ni, Cu, Zn, Ga, As, Cd, and Ba and the urine levels of Co, Ni, Cu, and Zn in patients with membranous nephropathy were significantly lower than those in normal controls (P < 0.05), while the blood levels of Se, Pb, and Hg and the urine level of Hg were higher (P < 0.05). The blood levels of V, Cr, Co, Cu, As, Sr, Cd, and Ba and the urine levels of Sr and Ba in the patients with membranous nephropathy were significantly lower than those in the IgA nephropathy group (P < 0.05), while the blood and the urine levels of Pb and Hg were higher (P < 0.05). Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze the results of elements. The results showed that Co, Zn, Hg, and Ba in the blood and Co and Ni in urine significantly contributed to the discriminant model of membranous nephropathy and normal controls; Sr in the blood and Pb and Sr in urine significantly contributed to the discriminant model of membranous nephropathy and IgA nephropathy.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Zinc on Blood Biochemical and mTOR Gene Expression in Rats with Polycystic Ovarian.","authors":"Faeze Fazel Torshizi, Reza Majidzadeh Heravi, Ali Javadmanesh","doi":"10.1007/s12011-024-04452-6","DOIUrl":"https://doi.org/10.1007/s12011-024-04452-6","url":null,"abstract":"<p><p>Zinc (Zn) is a significant element of the reproductive system and is associated with several enzymes that regulate different metabolic pathways. Organic Zn can significantly affect polycystic ovarian syndrome (PCOS) pathogenesis. Insulin resistance (IR) is a common complication of PCOS. Mammalian target of rapamycin (mTOR), which controls crucial cell functions, is regulated by insulin and nutrients. It has two complexes, namely, mTORC1 and mTORC2. mTOR associates with its binding partner's regulatory associated protein of mTOR (Raptor) and rapamycin-insensitive companion of mTOR (Rictor), which form these distinct complexes, respectively, and is activated in PCOS. This research aimed to evaluate the effect of Zn on the expression of mTOR signaling genes (Raptor and Rictor) and IR in PCOS model rats. Different Zn supplements, including standard diet (SD): (control - or + , SD without supplementation), Zn25, Zn75, and Zn175 (daily given three levels of 25, 75, and 175 mg Zn methionine (ZnMet)/kg for 6 weeks, respectively), were applied to the control and PCOS groups. Fasting glucose (FG), fasting insulin (FI), IR indices, and Raptor and Rictor expression levels were measured in both groups. The results showed that PCOS induction dramatically increased FG, FI, IR indices, and mTOR-related gene expression; however, different Zn supplementation concentrations, especially at 75 mg/kg, reduced the effects of PCOS induction. Organic Zn collectively exerted positive effects on Estradiol Valerate (EV)-induced PCOS rats by reducing IR and mTOR signaling gene (i.e., Raptor and Rictor) expression. Moreover, this study revealed a correlation between Zn and IR. Therefore, Zn supplementation could be a valuable therapeutic method for treating PCOS.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and Validation of Sandell-Kolthoff Method for Saliva Iodine Determination.","authors":"Yue Su, Ming Li, Honglei Xie, Xin Hou, Meng Zhao, Jia Li, Haowen Pan, Zexu Zhang, Zongyu Yue, Wenjing Che, Lanchun Liu, Jiasen Cao, Peng Liu","doi":"10.1007/s12011-024-04468-y","DOIUrl":"https://doi.org/10.1007/s12011-024-04468-y","url":null,"abstract":"<p><p>Saliva iodine is a useful biochemical marker for evaluating iodine status and controlling iodine-related diseases. This study aims to establish and validate a simple, reliable, and low-cost Sandell-Kolthoff (S-K) method for the determination of iodine in saliva. The method was established by considering the digestion solution type, concentration, dosage, digestion time and temperature, the volume of saliva samples, glass tube size, dosage of arsenious acid solution and ammonium ceric sulfate solution, and warm bath time. Then, the effectiveness of the method was examined by the linearity of the standard curve, detection limit, precision, and accuracy. The 1.5 mL 1 Mol/L ammonium persulfate solution at 100 °C for 90 min, the 200 μL saliva sample, glass tubes of 15 mm × 120 mm, 2.5 mL arsenious acid solution, 0.3 mL ammonium ceric sulfate solution, and 15 min for warm bath was selected to determine saliva iodine. In terms of validation of the S-K method, the linearity method has the linear range of the standard curve from 0 to 300 μg/L and the coefficient of determination ≥ 0.999; the detection limit, when the volume of saliva samples was 0.2 mL, was 4.6 μg/L; for precision, the relative standard deviation was from 0.3 to 2.8%; and for accuracy, the total recovery rate ranged from 92.8 to 107.0%. This S-K method is easy to operate, has good precision and accuracy, and can be used as a method to determine saliva iodine. It has great potential practical value in disease prevention, clinical auxiliary diagnosis, and experimental research.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Serum Iodine Concentrations in Early Pregnancy Exhibited Well Diagnostic Ability for Thyroid Dysfunction, Inverse Associations with Gestational Weight Gain, and Birth Size: Longitudinal Analyses Based on Huizhou Mother-Infant Cohort.","authors":"Zhao-Min Liu, Huan-Huan Long, Dan Li, Ai-Ping Fang, Chao-Gang Chen, Cheng Wang, Min-Min Li, Yi Wu, Su-Juan Zhang, Wen-Jing Pan","doi":"10.1007/s12011-024-04443-7","DOIUrl":"https://doi.org/10.1007/s12011-024-04443-7","url":null,"abstract":"<p><p>The study aims to explore the associations of maternal serum iodine concentrations (SIC) with thyroid function, obstetric, and birth outcomes. This was a prospective study embedded in the Huizhou Mother-Infant Cohort. Singleton mothers aged 18-45 years were enrolled at their first antenatal visits. Maternal SIC and thyroid markers were tested by inductively coupled plasma mass spectrometry and electronic chemiluminescent assay, respectively. Obstetric and birth outcomes were retrieved from the Hospital Information System. Two nested 1:1 age and body mass index-matched case-control studies were embedded in the cohort including 224 pairs of mothers with gestational diabetes mellitus (GDM) and 302 paired of newborns with small for gestational age (SGA) and their respective healthy controls. Multivariable linear and conditional logistic regression models were applied to explore the relationship of maternal SIC with obstetric complications and birth outcomes. A total of 1558 mothers were included for analysis. Receiver operating characteristic curve (ROC) analysis showed that maternal SIC in the 1st trimester (T1) had well diagnostic ability for clinical and subclinical hyperthyroidism, clinical hypothyroidism, and hypothyroxinemia with the areas under the curve of 0.907, 0.734, 0.867, and 0.927, respectively (all p < 0.05). Mothers in the highest quartile of SIC at T1 had an increased risk of SGA (OR = 2.043, 95% CI: 1.198-3.483, p = 0.009) but not for GDM risk. Maternal SIC were significantly and inversely associated with gestational weight gain (GWG), birth weight, and Ponderal index (all p < 0.05). SIC at T1 had well diagnostic values for thyroid dysfunction. High gestational SIC during early pregnancy were associated with lowered GWG, birth size, and increased risk of SGA. Study registration no: NCT03922087 at Clinicaltrial.gov.com.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Salivary Iodine Concentration in Elderly Residents of High-iodine Areas.","authors":"Mengxin Liu, Junjing Li, Hexi Zhang, Yantong Liu, Zhangzhao Wang, Zhiyuan Ren, Chunxi Wang, Qi Jin, Ying Zhang, Haohao Meng, Qiuyi Song, Wenxing Guo, Wanqi Zhang","doi":"10.1007/s12011-024-04453-5","DOIUrl":"https://doi.org/10.1007/s12011-024-04453-5","url":null,"abstract":"<p><p>Salivary iodine is considered a potential indicator for assessing iodine nutrition status. However, there is currently a lack of research data on the characteristics of salivary iodine concentration (SIC) in the elderly population. To evaluate the characteristics of SIC and assess its efficacy in diagnosing thyroid disorders among the elderly population, a cross-sectional study was conducted in a high-iodine area. Spot urine, 24-h urine, saliva, drinking, and cooking water samples were collected from the elderly participants. Iodine concentrations were measured in all these samples. Fasting venous blood samples were obtained to assess thyroid function. The study included 1387 elderly individuals from urban (n = 707) and rural (n = 680) areas. Rural residents showed significantly higher median concentration of cooking water iodine (CWIC) and SIC compared to urban residents (P < 0.001). The median SIC in rural elderly was 2733.3 μg/L versus 860.4 μg/L in urban elderly. SIC demonstrated a significant positive correlation with age (P < 0.001). Multiple linear regression analysis revealed significant positive associations between SIC and drinking water iodine concentration (β = 0.341, 95% CI 0.312-0.370), CWIC (β = 0.393, 95% CI 0.356-0.431), thyroid dysfunction (β = 0.107, 95% CI 0.050-0.164), and goiter (β = 0.236, 95% CI 0.129-0.342). Logistic regression showed that higher SIC levels were associated with increased risk of thyroid dysfunction, with odds ratios ranging from 1.649 to 1.994 for ascending SIC categories. The elderly residents in high-iodine areas, particularly in rural settings, exhibit elevated salivary iodine concentrations that increase with age. These high-iodine levels are significantly associated with an increased risk of thyroid dysfunction.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium, a Notable Micronutrient: A Crucial Element in the Context of All-Cause Long-Term Mortality in Renal Failure.","authors":"Duygu Tutan, Jan Ulfberg, Nihal Aydemir, Barış Eser, İbrahim Doğan","doi":"10.1007/s12011-024-04460-6","DOIUrl":"https://doi.org/10.1007/s12011-024-04460-6","url":null,"abstract":"<p><p>Selenium is a trace element involved in crucial antioxidative and anti-inflammatory processes in the body. Low selenium status has been linked to increased mortality due to compromised immune function and heightened risk of cardiovascular events. Patients with chronic kidney disease (CKD) face elevated mortality risks, prompting the need for strategies to mitigate these events. Selenium deficiency is prevalent among CKD patients, yet the long-term implications and its association with mortality in this population remain unclear. This study assessed seventy-five CKD patients' serum selenium levels (SSL) between January and February 2020. The objective was to investigate the correlation between SSL and 36-month all-cause mortality in CKD patients. Baseline laboratory values, dialysis adequacy, Charlson comorbidity index (CCI), serum selenium status, and all-cause mortality at 36 months were subjected to statistical analysis. Significance level was set at p < 0.05. Significant differences were observed in CCI between surviving and deceased groups, with deceased patients being older and afflicted with more comorbidities. SSL also exhibited a significant difference between the groups, with levels in the mortality group significantly lower than those in other patients, suggesting a potential role of selenium in predicting patient outcomes. SSL equal to or lower than 66.35 were associated with approximately 5 times higher likelihood of mortality within three years of follow-up. Our study highlights the significant association between low serum selenium levels and survival in patients with chronic kidney disease, underscoring the potential importance of selenium monitoring in this population. These findings emphasize the need for further research to elucidate the underlying mechanisms and to explore potential interventions aimed at improving outcomes in CKD patients.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Determination of Toxic Trace Metals As, Hg, Tl, and Pb in Hair by Monochromatic Excitation X-ray Fluorescence Spectrometry.","authors":"Shihao Wu, Peng Zhao, Aihua Wang, Linpei Dong, Xiaojun Wu, Jifen Wang, Yunfeng Zhang","doi":"10.1007/s12011-024-04455-3","DOIUrl":"https://doi.org/10.1007/s12011-024-04455-3","url":null,"abstract":"<p><p>Monochromatic excitation X-ray fluorescence (ME-XRF) spectrometry emerges as a novel technique in trace element analysis, distinguished by its simplicity, rapidity, and efficiency. Its application in forensic toxicology has grown significantly for identifying toxic trace metals in biological samples. This study further expands its utility by developing a method for the rapid determination of arsenic (As), mercury (Hg), thallium (Tl), and lead (Pb) in hair samples. Calibration curves were established using analytical reference samples, and optimal detection conditions were determined and validated. The LODs for As, Hg, Tl, and Pb were 0.03, 0.03, 0.03, and 0.05 μg g^-1, respectively. Method precision was evaluated through seven parallel analyses of samples within the concentration range of 0.27 to 20.051 μg g⁻¹, with relative standard deviations (RSDs) consistently below 10%. The feasibility of the ME-XRF technique for forensic toxicology analysis was validated through the analysis of authentic poisoned hair samples collected from the animal experiment.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}