Biomimetics最新文献

{"title":"Flash Memory for Synaptic Plasticity in Neuromorphic Computing: A Review.","authors":"Jisung Im, Sangyeon Pak, Sung-Yun Woo, Wonjun Shin, Sung-Tae Lee","doi":"10.3390/biomimetics10020121","DOIUrl":"10.3390/biomimetics10020121","url":null,"abstract":"<p><p>The rapid expansion of data has made global access easier, but it also demands increasing amounts of energy for data storage and processing. In response, neuromorphic electronics, inspired by the functionality of biological neurons and synapses, have emerged as a growing area of research. These devices enable in-memory computing, helping to overcome the \"von Neumann bottleneck\", a limitation caused by the separation of memory and processing units in traditional von Neumann architecture. By leveraging multi-bit non-volatility, biologically inspired features, and Ohm's law, synaptic devices show great potential for reducing energy consumption in multiplication and accumulation operations. Within the various non-volatile memory technologies available, flash memory stands out as a highly competitive option for storing large volumes of data. This review highlights recent advancements in neuromorphic computing that utilize NOR, AND, and NAND flash memory. This review also delves into the array architecture, operational methods, and electrical properties of NOR, AND, and NAND flash memory, emphasizing its application in different neural network designs. By providing a detailed overview of flash memory-based neuromorphic computing, this review offers valuable insights into optimizing its use across diverse applications.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid BCI for Meal-Assist Robot Using Dry-Type EEG and Pupillary Light Reflex.","authors":"Jihyeon Ha, Sangin Park, Yaeeun Han, Laehyun Kim","doi":"10.3390/biomimetics10020118","DOIUrl":"10.3390/biomimetics10020118","url":null,"abstract":"<p><p>Brain-computer interface (BCI)-based assistive technologies enable intuitive and efficient user interaction, significantly enhancing the independence and quality of life of elderly and disabled individuals. Although existing wet EEG-based systems report high accuracy, they suffer from limited practicality. This study presents a hybrid BCI system combining dry-type EEG-based flash visual-evoked potentials (FVEP) and pupillary light reflex (PLR) designed to control an LED-based meal-assist robot. The hybrid system integrates dry-type EEG and eyewear-type infrared cameras, addressing the preparation challenges of wet electrodes, while maintaining practical usability and high classification performance. Offline experiments demonstrated an average accuracy of 88.59% and an information transfer rate (ITR) of 18.23 bit/min across the four target classifications. Real-time implementation uses PLR triggers to initiate the meal cycle and EMG triggers to detect chewing, indicating the completion of the cycle. These features allow intuitive and efficient operation of the meal-assist robot. This study advances the BCI-based assistive technologies by introducing a hybrid system optimized for real-world applications. The successful integration of the FVEP and PLR in a meal-assisted robot demonstrates the potential for robust and user-friendly solutions that empower the users with autonomy and dignity in their daily activities.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating White Spot Lesions and Non-Carious Cervical Lesions with Amelogenin Peptide-Based Hydrogel.","authors":"Erika Bauza Nowotny, Salony Jassar, Jin-Ho Phark, Janet Moradian-Oldak","doi":"10.3390/biomimetics10020120","DOIUrl":"10.3390/biomimetics10020120","url":null,"abstract":"<p><p>Peptide-based biomimetic treatments have gained increased attention in the dental field due to their biocompatibility and minimally invasive qualities. These biomimetic approaches can replicate the native architecture of dental tissues, thus contributing to higher success rates and improved longevity of restorations. The aim of this study was first to examine the biocompatibility and stability of an amelogenin peptide-based chitosan hydrogel (P26-CS) against salivary enzymes. Second, we aimed to evaluate its efficacy in biomimetically repairing human dental lesions in situ. White spot lesions (WSLs) in enamel and non-carious cervical lesions (NCCLs) in dentin were artificially created. Chitosan (CS) improved peptide stability, while remineralization of enamel sections with P26-CS was not impeded by salivary enzymes. The peptide was not cytotoxic, irritating, or sensitizing. Fluorescently labeled P26-CS penetrated ~300 μm into the enamel of WSLs and ~100 μm into the dentin of NCCLs. After peptide treatment, quantitative light-induced fluorescence (QLF) and microcomputed tomography (μCT) indicated a gain in mineral density of WSLs. In NCCLs, scanning electron microscopy showed that the dentin was covered by a mineral layer of needle-shaped crystals. Our results show that the repair of artificial WSLs and NCCLs was achieved by P26 peptide-guided remineralization and demonstrate its potential to repair dental lesions.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimicry-Based Design of Underground Cold Storage Facilities: Energy Efficiency and Sustainability.","authors":"Mugdha Kshirsagar, Sanjay Kulkarni, Ankush Kumar Meena, Danby Caetano D'costa, Aroushi Bhagwat, Md Irfanul Haque Siddiqui, Dan Dobrotă","doi":"10.3390/biomimetics10020122","DOIUrl":"10.3390/biomimetics10020122","url":null,"abstract":"<p><p>Underground cold storage gives rise to special challenges that require innovative solutions to ensure maximum energy efficiency. Conventional energy systems tend to be based on high energy use, so sustainable solutions are crucial. This study explores the novel idea of biomimetics and how it might be used in the planning and building of underground cold storage facilities as well as other infrastructure projects. Biomimetic strategies, inspired by termite mounds, gentoo penguin feathers, and beehive structures, are applied to minimize reliance on energy-intensive cooling systems. These natural models offer efficient thermal regulation, airflow optimization, and passive cooling mechanisms such as geothermal energy harvesting. The integration of naturally driven convection and ventilation ensures stable internal temperatures under varying conditions. Biomimicry was employed in Revit Architecture, coupled with structural optimization, to eliminate urban space's limitations and further increase energy efficiency. The analytical work for this paper utilized a set of formulas that represent heat flow, thermal resistance, R-value, thermal transmittance, U-value, solar absorption, and G-value. The results pointed to very good insulation, with exterior walls having an R-value of 10.2 m²K/W and U-value of 0.98 W/m²K. Among the chosen 3-layer ETFE cushion with a U-value of 1.96 W/m²K, with a G-value of 0.50, showed good heat regulation and daylight management. Furthermore, bagasse-cement composites with a very low thermal conductivity of 0.10-0.30 W/m·K provided good insulation. This research proposes a scalable and sustainable approach in the design of underground cold storage by merging modelling based on Revit with thermal simulations. Biomimicry has been demonstrated to have the potential for changing subterranean infrastructure, conserving energy consumption, and creating eco-friendly construction practices.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Vascularization of Cell-Supplemented Spider Silk-Based Hydrogels in the Arteriovenous Loop Model.","authors":"Justus Osterloh, Stefanie Heltmann-Meyer, Vanessa T Trossmann, Aijia Cai, Yvonne Kulicke, Klara Terörde, Celena A Sörgel, Isabell Lang, Harald Wajant, Thomas Scheibel, Tobias Fey, Dominik Steiner, Andreas Arkudas, Raymund E Horch","doi":"10.3390/biomimetics10020117","DOIUrl":"10.3390/biomimetics10020117","url":null,"abstract":"<p><p>The goal of reconstructive surgery in treating tissue defects is to achieve a stable reconstructive outcome while minimizing donor site morbidity. As a result, tissue engineering has emerged as a key focus in the pursuit of this goal. One approach is to create a tissue container that can be preconditioned and later transplanted into the defect area. The characteristics of the matrices used in the tissue container are critical to this approach's success. Matrices generated with recombinant, functionalized spider silk (eADF4(C16)-RGD) have been reported to be biocompatible and easy to vascularize. However, the effect of exogenously added proangiogenic cells, such as endothelial cells (T17b), on the vascularization process of matrices generated with this hydrogel in vivo has not been described yet. In this study, we implanted arteriovenous (AV) loop containers filled with a spider silk hydrogel consisting of an eADF4(C16)-RGD matrix and encapsulated, differentiated endothelial T17b cells producing the reporter protein TNFR2-Fc-Flag-GpL. The histological and µCT analyses revealed spontaneous angiogenesis and fibrovascular tissue formation in the container at 2 and 4 weeks post-implantation. The reporter protein was detected after 4 weeks. No severe immune response was observed. Altogether, this study demonstrates that cell-supplemented recombinant spider silk is a highly promising hydrogel to produce matrices for tissue engineering applications.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Bacterial Properties and Hemocompatibility of Alkali Treated Nano-Structured Micro-Porous Titanium Surfaces.","authors":"Aniruddha Vijay Savargaonkar, Emma Holloway, Liszt Y C Madruga, Bruno L Pereira, Paulo Soares, Ketul C Popat","doi":"10.3390/biomimetics10020115","DOIUrl":"10.3390/biomimetics10020115","url":null,"abstract":"<p><p>Titanium and its alloys have been the material of choice for orthopedic implants due to their excellent physical properties as well as biocompatibility. However, titanium is not able to integrate with bone due to the mismatch of mechanical properties. Additionally, bone has a micro-nano hierarchy, which is absent on titanium's surface. A potential solution to the former is to make the surfaces porous to bring the mechanical properties closer to that of the bone, and a solution for the latter is to fabricate nanostructures. In this study, micro-porous titanium surfaces were hydrothermally treated using an alkali medium to fabricate nanostructures on the existing micro-porosity of the surface. The surface properties were evaluated using scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and nanoindentation. The anti-bacterial properties of the surfaces were evaluated against Gram-positive and Gram-negative bacteria using fluorescence microscopy and scanning electron microscopy. Blood clotting is shown to improve the surface-to-bone integration; hence, whole blood clotting and platelet adhesion and activation were evaluated using a whole blood clotting assay, fluorescence microscopy, and scanning electron microscopy. The results indicate that nanostructured micro-porous titanium surfaces display significantly enhanced anti-bacterial properties as well as equivalent blood clotting characteristics compared to non-porous titanium surfaces.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing and Assisting Finger Motions for Spoon Scooping.","authors":"Yuto Tanizaki, Pablo E Tortós-Vinocour, Fuko Matsunaga, Naoki Kamijo, Koki Yoshida, Shota Kokubu, Jose Gomez-Tames, Wenwei Yu","doi":"10.3390/biomimetics10020116","DOIUrl":"10.3390/biomimetics10020116","url":null,"abstract":"<p><p>Assisting patients with weakened hand and wrist strength during meals is essential. While various feeding devices have been developed, many do not utilize patients' residual finger functions, leading to an increase in the risk of disuse syndrome and loss of joy in life. Recently, assist-as-needed support for spoon grasping by soft hand rehabilitation devices has been studied. Moreover, in our previous study, we investigated finger motions for the required scooping angle and verified them with a dummy hand driven by soft actuators. However, eating with a spoon requires not only spoon grasping and rotating but also plunging the spoon into food and lifting it afterward. The goal of this study is to achieve self-feeding with spoons using soft actuators for individuals with partial finger disabilities. To address this, we measured scooping movements using inertial measurement units, identified feasible finger motions for spoon plunging and lifting, and verified our findings through experiments with a dummy hand driven by soft actuators. As a result, we found a way to achieve the two motions by regulating the moment applied to the spoon. These results highlight the potential of soft actuators for assisting scooping movements. This study marks an important step toward feeding assistance that leverages patients' residual finger functions.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Motor Function and Quality of Life Combining Advanced Robotics and Biomechatronics in an Adult with Dystonic Spastic Tetraparesis: A Case Report.","authors":"Elisabetta Leogrande, Sara Piccoli, Francesco Dell'Olio, Nicola Smania, Stefano Mazzoleni, Marialuisa Gandolfi","doi":"10.3390/biomimetics10020113","DOIUrl":"10.3390/biomimetics10020113","url":null,"abstract":"<p><p>This case report explores the innovative integration of robotic and biomechatronic technologies, including the Motore and Ultra+ devices and neuro-suits, in a 10-session rehabilitation program for a young adult with dystonic spastic tetraparesis. Notable improvements were observed in upper limb motor function, coordination, and quality of life as measured by an increase of 18 pints on the Fugl-Meyer scale and a 25% improvement in the Bartle Index. Range of motion measurements showed consistent improvements, with task execution times improving by 10 s. These findings suggest the potential of combining wearable, robotic, and biomechatronic systems to enhance neurorehabilitation. Further refinement of these technologies might support clinicians in maximizing their integration in therapeutics, despite technical issues like synchronization issues that must be overcome.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Online Controller Tuning for Omnidirectional Mobile Robots Using a Multivariate-Multitarget Polynomial Prediction Model and Evolutionary Optimization.","authors":"Alam Gabriel Rojas-López, Miguel Gabriel Villarreal-Cervantes, Alejandro Rodríguez-Molina, Jesús Aldo Paredes-Ballesteros","doi":"10.3390/biomimetics10020114","DOIUrl":"10.3390/biomimetics10020114","url":null,"abstract":"<p><p>The growing reliance on mobile robots has resulted in applications where users have limited or no control over operating conditions. These applications require advanced controllers to ensure the system's performance by dynamically changing its parameters. Nowadays, online bioinspired controller tuning approaches are among the most successful and innovative tools for dealing with uncertainties and disturbances. Nevertheless, these bioinspired approaches present a main limitation in real-world applications due to the extensive computational resources required in their exhaustive search when evaluating the controller tuning of complex dynamics. This paper develops an online bioinspired controller tuning approach leveraging a surrogate modeling strategy for an omnidirectional mobile robot controller. The polynomial response surface method is incorporated as an identification stage to model the system and predict its behavior in the tuning stage of the indirect adaptive approach. The comparative analysis concerns state-of-the-art controller tuning approaches, such as online, offline robust, and offline non-robust approaches, based on bioinspired optimization. The results show that the proposal reduces its computational load by up to 62.85% while maintaining the controller performance regarding the online approach under adverse uncertainties and disturbances. The proposal also increases the controller performance by up to 93% compared to offline tuning approaches. Then, the proposal retains its competitiveness on mobile robot systems under adverse conditions, while other controller tuning approaches drop it. Furthermore, a posterior comparison against another surrogate tuning approach based on Gaussian process regression corroborates the proposal as the best online controller tuning approach by reducing the competitor's computational load by up to 91.37% while increasing its performance by 63%. Hence, the proposed controller tuning approach decreases the execution time to be applied in the evolution of the control system without deteriorating the closed-loop performance. To the best of the authors' knowledge, this is the first time that such a controller tuning strategy has been tested on an omnidirectional mobile robot.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Efficient Multi-Objective White Shark Algorithm.","authors":"Wenyan Guo, Yufan Qiang, Fang Dai, Junfeng Wang, Shenglong Li","doi":"10.3390/biomimetics10020112","DOIUrl":"10.3390/biomimetics10020112","url":null,"abstract":"<p><p>To balance the diversity and stringency of Pareto solutions in multi-objective optimization, this paper introduces a multi-objective White Shark Optimization algorithm (MONSWSO) tailored for multi-objective optimization. MONSWSO integrates non-dominated sorting and crowding distance into the White Shark Optimization framework to select the optimal solution within the population. The uniformity of the initial population is enhanced through a chaotic reverse initialization learning strategy. The adaptive updating of individual positions is facilitated by an elite-guided forgetting mechanism, which incorporates escape energy and eddy aggregation behavior inspired by marine organisms to improve exploration in key areas. To evaluate the effectiveness of MONSWSO, it is benchmarked against five state-of-the-art multi-objective algorithms using four metrics: inverse generation distance, spatial homogeneity, spatial distribution, and hypervolume on 27 typical problems, including 23 multi-objective functions and 4 multi-objective project examples. Furthermore, the practical application of MONSWSO is demonstrated through an example of optimizing the design of subway tunnel foundation pits. The comprehensive results reveal that MONSWSO outperforms the comparison algorithms, achieving impressive and satisfactory outcomes.</p>","PeriodicalId":8907,"journal":{"name":"Biomimetics","volume":"10 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}