Bioscience of Microbiota, Food and Health最新文献

{"title":"Fucosylated human milk oligosaccharide-utilizing bifidobacteria regulate the gut organic acid profile of infants","authors":"Kana YAHAGI","doi":"10.12938/bmfh.2023-069","DOIUrl":"https://doi.org/10.12938/bmfh.2023-069","url":null,"abstract":"Bifidobacteria are the predominant bacteria in the infant gut and have beneficial effects on host physiology. Infant cohort studies have demonstrated that a higher abundance of bifidobacteria in the gut is associated with a reduced risk of disease. Recently, bifidobacteria-derived metabolites, such as organic acid, have been suggested to play crucial roles in host physiology. This review focuses on an investigation of longitudinal changes in the gut microbiota and organic acid concentrations over 2 years of life in 12 Japanese infants and aims to identify bifidobacteria that contribute to the production of organic acid in healthy infants. Acetate, lactate, and formate, which are rarely observed in adults, are characteristically observed during breast-fed infancy. Bifidobacterium longum subspecies infantis and the symbiosis of Bifidobacterium bifidum and Bifidobacterium breve efficiently produce these organic acids through metabolization of human milk oligosaccharide (HMO) with different strategies. These findings confirmed that HMO-utilizing bifidobacteria play an important role in regulating the gut organic acid profiles of infants.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135319744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of <i>Bifidobacterium longum</i> BB536 against nausea caused by pirfenidone in a mouse model of pellagra.","authors":"Koji Kuronuma,&nbsp;Natsumi Susai,&nbsp;Tomohiro Kuroita,&nbsp;Takeshi Yoshioka,&nbsp;Atsushi Saito,&nbsp;Hirofumi Chiba","doi":"10.12938/bmfh.2022-042","DOIUrl":"https://doi.org/10.12938/bmfh.2022-042","url":null,"abstract":"<p><p>Pellagra is caused by abnormal intake and/or use of nicotinic acid and is known in part to be induced by the use of medications such as isoniazid or pirfenidone. We previously investigated atypical phenotypes of pellagra, such as nausea, using a mouse model of pellagra and found that gut microbiota play an important role in the development of these phenotypes. Here, we investigated the effect of <i>Bifidobacterium longum</i> BB536 on pellagra-related nausea caused by pirfenidone in our mouse model. Our pharmacological data indicated that pirfenidone (PFD) causes modulation of the gut microbiota profile, which appeared to play an important role in the development of pellagra-related nausea. A gut microbiota-mediated protective effect of <i>B. longum</i> BB536 against nausea caused by PFD was also identified. Finally, the urinary ratio of nicotinamide/N-methylnicotinamide was shown to be a biomarker of pellagra-like adverse effects induced by PFD, and it may contribute to the prevention of these effects in patients with idiopathic pulmonary fibrosis.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/07/bmfh-42-195.PMC10315189.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening of the most efficacious lactic acid bacteria strain for myocardial infarction recovery and verification and exploration of its functions and mechanisms.","authors":"Shanshan Qi,&nbsp;Donghua Liu,&nbsp;Bo Ma,&nbsp;Lei Yang,&nbsp;Haitao Yu","doi":"10.12938/bmfh.2021-044","DOIUrl":"https://doi.org/10.12938/bmfh.2021-044","url":null,"abstract":"<p><p>Screening efficient strains by cell platform is cost-effective, but to date, no screening experiments have been performed for targeted lactic acid bacteria with hypoxic/reoxygenation (H/R)-treated cardiomyocytes, and their effects on the phosphoinositide 3-kinase (PI3K)/protein kinase b (Akt)/endothelial nitric oxide synthase (eNOS) pathway in myocardial infarction (MI) are unclear. Here we activated 102 strains of lactic acid bacteria and inoculated them into MRS medium for fermentation. The fermentation supernatants of the lactic acid bacteria were incubated with an H/R model of H9C2 cells. We found that <i>Bifidobacterium longum</i> ZL0210 had the greatest potential for inhibiting the apoptosis of H/R-induced H9C2 cells. Furthermore, it significantly increased the expression of heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO1) in H9C2 cardiomyocytes, as well as the Bcl-2/Bax protein ratio, protecting damaged myocardial cells via an anti-apoptotic pathway. Intragastric administration of <i>B. longum</i> ZL0210 to mice for one week before and after establishment of an MI model drastically attenuated the myocardial cell hypertrophy and fibrosis of the MI mice. Meanwhile, <i>B. longum</i> ZL0210 significantly reduced the secretion of myocardial enzymes, increased the activity of antioxidant enzymes, and inhibited lipid-oxidative malondialdehyde (MDA) levels. Moreover, it upregulated the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein and the phosphorylation levels of PI3K, Akt, and eNOS, resulting in increased NO contents. In summary, we screened 102 strains of lactic acid bacteria with a cell platform and determined that <i>B. longum</i> ZL0210 was a favorable candidate for protecting the myocardium. We are the first to reveal the protective effects of <i>B. longum</i> ZL0210 for MI via activation of the PI3K/Akt/eNOS pathway through TRAIL.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/fa/bmfh-42-013.PMC9816043.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amounts and species of probiotic lactic acid bacteria affect stimulation of short-chain fatty acid production in fecal batch culture.","authors":"Yuji Ohashi,&nbsp;Tomohiko Fujisawa","doi":"10.12938/bmfh.2022-048","DOIUrl":"https://doi.org/10.12938/bmfh.2022-048","url":null,"abstract":"<p><p>The effects of lactate and probiotic lactic acid bacteria (LAB) on intestinal fermentation were analyzed using a fecal batch culture. Lactate was efficiently metabolized to butyrate and propionate by butyrate-utilizing bacteria in fecal fermentation. Probiotic LAB could stimulate butyrate and propionate production through their lactate production in fecal fermentation. It was considered that 10⁹ cfu/g or more of probiotic LAB would be required to stimulate butyrate and propionate production in the large intestine. Due to the low production of lactate, a larger number of heterofermentative LAB than homofermentative LAB would be required for this stimulation.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/85/bmfh-42-100.PMC9816051.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Enterococcus faecium</i> 129 BIO 3B is classified as <i>Enterococcus lactis</i> 129 BIO 3B.","authors":"Kiyofumi Ohkusu","doi":"10.12938/bmfh.2022-088","DOIUrl":"https://doi.org/10.12938/bmfh.2022-088","url":null,"abstract":"<p><p><i>Enterococcus faecium</i> 129 BIO 3B is a lactic acid bacterium that has been safely used as a probiotic product for over 100 years. Recently, concerns about its safety have arisen because some species of <i>E. faecium</i> belong to the vancomycin-resistant enterococci. The groups of <i>E. faecium</i> with less pathogenic potential have been split into a separate species (<i>Enterococcus lactis</i>). In this study, I investigated the phylogenetic classification and safety of <i>E. faecium</i> 129 BIO 3B as well as <i>E. faecium</i> 129 BIO 3B-R, which is naturally resistant to ampicillin. Mass spectrometry and basic local alignment search tool analysis using specific gene regions failed to differentiate 3B and 3B-R into <i>E. faecium</i> or <i>E. lactis</i>. However, multilocus sequence typing successfully identified 3B and 3B-R as the same sequence types as <i>E. lactis</i>. Overall genome relatedness indices showed that 3B and 3B-R have high degrees of homology with <i>E. lactis</i>. Gene amplification was confirmed for 3B and 3B-R with <i>E. lactis</i> species-specific primers. The minimum inhibitory concentration of ampicillin was confirmed to be 2 µg/mL for 3B, which is within the safety standard for <i>E. faecium</i> set by the European Food Safety Authority. Based on the above results, <i>E. faecium</i> 129 BIO 3B and <i>E. faecium</i> 129 BIO 3B-R were classified as <i>E. lactis</i>. The absence of pathogenic genes except for <i>fms21</i> in this study demonstrates that these bacteria are safe for use as probiotics.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/70/bmfh-42-180.PMC10315194.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turmeronols (A and B) from <i>Curcuma longa</i> have anti-inflammatory effects in lipopolysaccharide-stimulated BV-2 microglial cells by reducing NF-κB signaling.","authors":"Ryosuke Saji,&nbsp;Ryusei Uchio,&nbsp;Arisa Fuwa,&nbsp;Chinatsu Okuda-Hanafusa,&nbsp;Kengo Kawasaki,&nbsp;Koutarou Muroyama,&nbsp;Shinji Murosaki,&nbsp;Yoshihiro Yamamoto,&nbsp;Yoshitaka Hirose","doi":"10.12938/bmfh.2022-071","DOIUrl":"https://doi.org/10.12938/bmfh.2022-071","url":null,"abstract":"Turmeronols (A and B), bisabolane-type sesquiterpenoids found in turmeric, reduce inflammation outside the brain in animals; however, their effects on neuroinflammation, a common pathology of various neurodegenerative diseases, are not understood. Inflammatory mediators produced by microglial cells play a key role in neuroinflammation, so this study evaluated the anti-inflammatory effects of turmeronols in BV-2 microglial cells stimulated with lipopolysaccharide (LPS). Pretreatment with turmeronol A or B significantly inhibited LPS-induced nitric oxide (NO) production; mRNA expression of inducible NO synthase; production of interleukin (IL)-1β, IL-6, and tumor necrosis factor α and upregulation of their mRNA expression; phosphorylation of nuclear factor-κB (NF-κB) p65 proteins and inhibitor of NF-κB kinase (IKK); and nuclear translocation of NF-κB. These results suggest that these turmeronols may prevent the production of inflammatory mediators by inhibiting the IKK/NF-κB signaling pathway in activated microglial cells and can potentially treat neuroinflammation associated with microglial activation.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6c/ce/bmfh-42-172.PMC10315188.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administration of <i>Bifidobacterium pseudolongum</i> suppresses the increase of colonic serotonin and alleviates symptoms in dextran sodium sulfate-induced colitis in mice.","authors":"Misa Tatsuoka,&nbsp;Riku Shimada,&nbsp;Fumina Ohsaka,&nbsp;Kei Sonoyama","doi":"10.12938/bmfh.2022-073","DOIUrl":"https://doi.org/10.12938/bmfh.2022-073","url":null,"abstract":"<p><p>Previous studies suggested that altered gut serotonin (5-HT) signaling is implicated in the pathophysiology of inflammatory bowel disease (IBD). Indeed, 5-HT administration reportedly exacerbated the severity of murine dextran sodium sulfate (DSS)-induced colitis that mimics human IBD. Our recent study suggested that <i>Bifidobacterium pseudolongum</i>, one of the most predominant bifidobacterial species in various mammals, reduces the colonic 5-HT content in mice. The present study thus tested whether the administration of <i>B. pseudolongum</i> prevents DSS-induced colitis in mice. Colitis was induced by administering 3% DSS in drinking water in female BALB/c mice, and <i>B. pseudolongum</i> (10⁹ CFU/day) or 5-aminosalicylic acid (5-ASA, 200 mg/kg body weight) was intragastrically administered once daily throughout the experimental period. <i>B. pseudolongum</i> administration reduced body weight loss, diarrhea, fecal bleeding, colon shortening, spleen enlargement, and colon tissue damage and increased colonic mRNA levels of cytokine genes (<i>Il1b</i>, <i>Il6</i>, <i>Il10</i>, and <i>Tnf</i>) almost to an extent similar to 5-ASA administration in DSS-treated mice. <i>B. pseudolongum</i> administration also reduced the increase of colonic 5-HT content, whereas it did not alter the colonic mRNA levels of genes that encode the 5-HT synthesizing enzyme, 5-HT reuptake transporter, 5-HT metabolizing enzyme, and tight junction-associated proteins. We propose that <i>B. pseudolongum</i> is as beneficial against murine DSS-induced colitis as the widely used anti-inflammatory agent 5-ASA. However, further studies are needed to clarify the causal relationship between the reduced colonic 5-HT content and reduced severity of DSS-induced colitis caused by <i>B. pseudolongum</i> administration.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/78/bmfh-42-186.PMC10315192.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse impact of a probiotic strain, <i>Lacticaseibacillus paracasei</i> Shirota, on peripheral mononuclear phagocytic cells in healthy Japanese office workers: a randomized, double-blind, controlled trial.","authors":"Tomoaki Naito,&nbsp;Masatoshi Morikawa,&nbsp;Mayuko Yamamoto-Fujimura,&nbsp;Akira Iwata,&nbsp;Ayaka Maki,&nbsp;Noriko Kato-Nagaoka,&nbsp;Kosuke Oana,&nbsp;Junko Kiyoshima-Shibata,&nbsp;Yumi Matsuura,&nbsp;Rumi Kaji,&nbsp;Osamu Watanabe,&nbsp;Kan Shida,&nbsp;Satoshi Matsumoto,&nbsp;Tetsuji Hori","doi":"10.12938/bmfh.2022-043","DOIUrl":"https://doi.org/10.12938/bmfh.2022-043","url":null,"abstract":"<p><p>Mononuclear phagocytic cells (MPCs) are classified into monocytes (Mos)/macrophages and dendritic cells (DCs) based on their functions. Cells of MPCs lineage act as immune modulators by affecting effector cells, such as NK cells, T cells, and B cells. This study aimed to investigate the effects of <i>Lacticaseibacillus paracasei</i> strain Shirota (LcS) ingestion on peripheral MPCs, particularly on their expression of functional cell-surface molecules enhanced in healthy adults. Thus, twelve healthy office workers consumed a fermented milk drink containing 1.0 × 10¹¹ cfu of LcS (LcS-FM) or a control unfermented milk drink (CM) once a day for 6 weeks. Peripheral blood mononuclear cells (PBMCs) were prepared from blood samples, and immune cells and functional cell-surface molecules were analyzed. We observed remarkable differences in the expression of HLAABC, MICA, CD40, and GPR43 in plasmacytoid DCs (pDCs) between the LcS-FM and CM groups, whereas no difference was found in CD86 or HLADR expression. The LcS-FM group exhibited higher CD40 expression in both conventional DCs (cDCs) and Mos, especially in type 2 conventional DCs (cDC2s) and classical monocytes (cMos); higher percentages of cMos, intermediate monocytes (iMos), and nonclassical monocytes; and higher numbers of cMos and iMos in PBMCs than the CM group. LcS ingestion increased the expression of HLAABC, MICA, CD40, and GPR43 in pDCs and CD40 in cDCs and Mos, particularly cDC2s and cMos. These results suggest that LcS modulates the function of MPCs that may lead to the regulation of immune effector functions in healthy adults.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/78/bmfh-42-065.PMC9816042.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of the high polyamine-producing bacterium <i>Staphylococcus epidermidis</i> FB146 from fermented foods and identification of polyamine-related genes.","authors":"Hideto Shirasawa,&nbsp;Chisato Nishiyama,&nbsp;Rika Hirano,&nbsp;Takashi Koyanagi,&nbsp;Shujiro Okuda,&nbsp;Hiroki Takagi,&nbsp;Shin Kurihara","doi":"10.12938/bmfh.2022-011","DOIUrl":"https://doi.org/10.12938/bmfh.2022-011","url":null,"abstract":"<p><p>It has been reported that the intake of polyamines contributes to the extension of healthy life span in animals. Fermented foods contain high concentrations of polyamines thought to be derived from fermentation bacteria. This suggests that bacteria that produce high levels of polyamines could be isolated from fermented foods and utilized as a source of polyamines for human nutrition. In this study, <i>Staphylococcus epidermidis</i> FB146 was isolated from miso, a Japanese fermented bean paste, and found to have a high concentration of putrescine in its culture supernatant (452 μM). We analyzed the presence of polyamines in the culture supernatants and cells of the type strains of 21 representative <i>Staphylococcus</i> species in addition to <i>S. epidermidis</i> FB146, and only <i>S. epidermidis</i> FB146 showed high putrescine productivity. Furthermore, whole-genome sequencing of <i>S. epidermidis</i> FB146 was performed, and the ornithine decarboxylase gene (<i>odc</i>), which is involved in putrescine synthesis, and the putrescine:ornithine antiporter gene (<i>potE</i>), which is thought to contribute to the release of putrescine into the culture supernatant, were present on plasmid DNA harbored by <i>S. epidermidis</i> FB146.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/6d/bmfh-42-024.PMC9816048.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-gut-brain axis impairment in the pathogenesis of stroke: implication as a potent therapeutic target.","authors":"Mubarak Muhammad,&nbsp;Supaporn Muchimapura,&nbsp;Jintanaporn Wattanathorn","doi":"10.12938/bmfh.2022-067","DOIUrl":"https://doi.org/10.12938/bmfh.2022-067","url":null,"abstract":"<p><p>The human microbiota-gut-brain axis has an enormous role in the maintenance of homeostasis and health. Over the last two decades, it has received concerted research attention and focus due to a rapidly emerging volume of evidence that has established that impairment within the microbiota-gut-brain axis contributes to the development and progression of various diseases. Stroke is one of the entities identified to be associated with microbiota-gut-brain axis impairment. Currently, there are still limitations in the clinical treatment of stroke, and the presence of a non-nervous factor from gut microbiota that can alter the course of stroke presents a novel strategy towards the search for a therapeutic silver bullet against stroke. Hence, the aim herein, was to focus on the involvement of microbiota-gut-brain axis impairment in the pathogenesis stroke as well as elucidate its implications as a potent therapeutic target against stroke. The findings of studies to date have revealed and extended the role microbiota-gut-brain axis impairment in the pathogenesis of stroke, and studies have identified from both clinical and pre-clinical perspectives targets within the microbiota-gut-brain axis and successfully modulated the outcome of stroke. It was concluded that the microbiota-gut-brain axis stands as potent target to salvage the neurons in the ischemic penumbra for the treatment of stroke. Assessment of the microbiota profile and its metabolites status holds enormous clinical potentials as a non-invasive indicator for the early diagnosis and prognosis of stroke.</p>","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/56/bmfh-42-143.PMC10315190.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10160018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}