Bioscience of Microbiota, Food and Health最新文献

Phylogenomic analysis in Latilactobacillus sakei by using polymorphisms detected by next-generation sequencing. 利用新一代测序检测的多态性分析酒井乳酸杆菌的系统基因组学。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-017

Chisato Nishiyama, Suguru Sekiguchi, Yu Sugihara, Minami Nishikawa, Natsu Makita, Tenta Segawa, Momoka Terasaki, Hiroki Takagi, Takashi Koyanagi

引用次数: 0

Consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 augments serum antibody titers against seasonal influenza vaccine in healthy adults. 饮用用德氏乳杆菌发酵的酸奶。OLL1073R-1增强健康成人抗季节性流感疫苗的血清抗体滴度。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-037

Jun Hemmi, Seiya Makino, Takehiro Yokoo, Hiroshi Kano, Yukio Asami, Kazuyoshi Takeda, Yoshio Suzuki, Sachio Kawai, Isao Nagaoka, Keisuke Sawaki, Ko Okumura

{"title":"Consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 augments serum antibody titers against seasonal influenza vaccine in healthy adults.","authors":"Jun Hemmi, Seiya Makino, Takehiro Yokoo, Hiroshi Kano, Yukio Asami, Kazuyoshi Takeda, Yoshio Suzuki, Sachio Kawai, Isao Nagaoka, Keisuke Sawaki, Ko Okumura","doi":"10.12938/bmfh.2022-037","DOIUrl":"https://doi.org/10.12938/bmfh.2022-037","url":null,"abstract":"Seasonal influenza is a major upper respiratory tract infection occurring in winter. Vaccination is the best method for preventing this infection. We conducted two randomized, double-blind, placebo-controlled trials to examine whether consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1, which has been reported to reduce the risk of catching the common cold, augments serum antibody titers against seasonal influenza vaccines. In the first trial, which included university students, serum antibody titers against influenza A (H3N2) and B viruses were significantly higher in the yogurt group than in the placebo group. According to the guidelines established by the European Medicines Agency (EMA) for the assessment of vaccines, the seroconversion rate and mean geometric increase of influenza A (H3N2) and seroprotection of influenza B met the criteria only in the yogurt group. In the second trial, which included healthy adults, serum antibody titers against influenza A (H1N1) and B viruses were significantly higher in the yogurt group than in the placebo group. The seroconversion rate and mean geometric increase of influenza B met the EMA criteria only in the yogurt group. Furthermore, the cumulative days of ill health, such as throat complaints, upper respiratory inflammation, and cold, were significantly lower in the yogurt group than in the placebo group. Therefore, daily intake of yogurt fermented with L. bulgaricus OLL1073R-1 could reduce the duration of symptoms caused by respiratory infections and act as a mucosal adjuvant enhancing acquired immune responses against vaccines, leading to the improvement of public health.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"42 1","pages":"73-80"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a8/08/bmfh-42-073.PMC9816052.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10607723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Gut microbial stability in older Japanese populations: insights from the Mykinso cohort 日本老年人肠道微生物稳定性:来自Mykinso队列的见解

4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-047

Satoshi WATANABE, Naofumi YOSHIDA, Kairi BABA, Hiroyuki YAMASAKI, Natsuko O. SHINOZAKI, Masato OGAWA, Tomoya YAMASHITA, Aya K. TAKEDA

{"title":"Gut microbial stability in older Japanese populations: insights from the Mykinso cohort","authors":"Satoshi WATANABE, Naofumi YOSHIDA, Kairi BABA, Hiroyuki YAMASAKI, Natsuko O. SHINOZAKI, Masato OGAWA, Tomoya YAMASHITA, Aya K. TAKEDA","doi":"10.12938/bmfh.2022-047","DOIUrl":"https://doi.org/10.12938/bmfh.2022-047","url":null,"abstract":"Gut microbiota imbalance plays an important role in the pathogenesis of various diseases. Here, we determined microbe–microbe interactions and gut microbiome stability in a Japanese population with varying body mass indices (BMIs) and enterotypes. Using 16S ribosomal RNA gene sequencing, we analyzed gut microbial data from fecal samples obtained from 3,365 older Japanese individuals. The individuals were divided into lean, normal, and obese groups based on their BMIs. They were further categorized according to their gut microbiota enterotypes: Bacteroides (enterotype B), Prevotella (enterotype P), and Ruminococcus (enterotype R). We obtained data on different host factors, such as age, BMI, and disease status, using a survey questionnaire evaluated by the Mykinso gut microbiome testing service. Subsequently, we evaluated the co-occurrence network. Individual differences in BMI were associated with differences in co-occurrence networks. By exploring the network topology based on BMI status , we observed that the network density was lower in the lean group than that in the normal group. Furthermore, a simulation-based stability analysis revealed a lower resistance index in the lean group than those in the other two groups. Our results provide insights into various microbe–microbe interactions and gut microbial stability and could aid in developing appropriate therapeutic strategies targeting gut microbiota modulation to manage frailty.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"499 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136373572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations. 妊娠前母体肠道菌群缺失对后代肠道菌群、食物过敏易感性和表观遗传修饰的影响。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-093

Shinta Aizawa, Takashi Uebanso, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi

{"title":"Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations.","authors":"Shinta Aizawa, Takashi Uebanso, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi","doi":"10.12938/bmfh.2022-093","DOIUrl":"https://doi.org/10.12938/bmfh.2022-093","url":null,"abstract":"Maternal environments affect the health of offspring in later life. Changes in epigenetic modifications may partially explain this phenomenon. The gut microbiota is a critical environmental factor that influences epigenetic modifications of host immune cells and the development of food allergies. However, whether changes in the maternal gut microbiota affect the development of food allergies and related epigenetic modifications in subsequent generations remains unclear. Here, we investigated the effects of antibiotic treatment before pregnancy on the development of the gut microbiota, food allergies, and epigenetic modifications in F1 and F2 mice. We found that pre-conception antibiotic treatment affected the gut microbiota composition in F1 but not F2 offspring. F1 mice born to antibiotic-treated mothers had a lower proportion of butyric acid-producing bacteria and, consequently, a lower butyric acid concentration in their cecal contents. The methylation level in the DNA of intestinal lamina propria lymphocytes, food allergy susceptibility, and production of antigen-specific IgE in the F1 and F2 mice were not different between those born to control and antibiotic-treated mothers. In addition, F1 mice born to antibiotic-treated mothers showed increased fecal excretion related to the stress response in a novel environment. These results suggest that the maternal gut microbiota is effectively passed onto F1 offspring but has little effect on food allergy susceptibility or DNA methylation levels in offspring.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"42 3","pages":"203-212"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7a/36/bmfh-42-203.PMC10315195.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a lactic acid bacteria strain that suppresses chronic inflammation and improves glucose and lipid metabolism. 乳酸菌菌株的发展，抑制慢性炎症和改善糖脂代谢。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-054

Takayuki Toshimitsu

{"title":"Development of a lactic acid bacteria strain that suppresses chronic inflammation and improves glucose and lipid metabolism.","authors":"Takayuki Toshimitsu","doi":"10.12938/bmfh.2022-054","DOIUrl":"https://doi.org/10.12938/bmfh.2022-054","url":null,"abstract":"Chronic inflammation caused by aging, obesity, and lifestyle disturbances can lead to the production of inflammatory cytokines and insulin resistance, reducing glucose and lipid metabolism. Lactic acid bacteria (LAB) have various bioactivities, and certain types of LAB have been reported to exhibit anti-inflammatory effects. We hypothesized that LAB strains, which can strongly induce the production of anti-inflammatory cytokines by immune cells in the intestinal tract, may improve glucose and lipid metabolism by suppressing chronic inflammation. We selected Lactiplantibacillus plantarum OLL2712 (OLL2712) from the LAB library owned by Meiji Co., Ltd. based on its ability to induce the production of interleukin-10 (IL-10), optimized the culture conditions of OLL2712 for industrial applications, and verified the efficacy of the strain in animal and clinical studies. The results showed that OLL2712 bacterial cells in the exponential phase had notably higher anti-inflammatory properties than the cells in the stationary phase and led to the inhibition of chronic inflammation and improvement of glucose and lipid metabolism in animal studies. Two randomized controlled trials consisting of healthy adults with elevated blood glucose levels or body mass indices (BMIs) also showed that the intake of OLL2712 suppressed the aggravation of chronic inflammation and improved glucose and lipid metabolism. This review identified a novel LAB strain that may contribute to diabetes and obesity prevention and demonstrated its clinical efficacy. In addition, the mechanism of action of this LAB strain through the intestinal immune system was partially elucidated, and the importance of optimizing the culture conditions of LAB was clarified.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"42 1","pages":"3-7"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/eb/bmfh-42-003.PMC9816046.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10607724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of poly-γ-glutamic acid and galactooligosaccharide improves intestinal microbiota, defecation status, and relaxed mood in humans: a randomized, double-blind, parallel-group comparison trial. 聚γ-谷氨酸和低聚半乳糖联合应用可改善人类肠道菌群、排便状态和放松情绪:一项随机、双盲、平行组比较试验。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2021-084

Kentaro Umeda, Atsuko Ikeda, Ryo Uchida, Ikuko Sasahara, Tomoyuki Mine, Hitoshi Murakami, Keishi Kameyama

{"title":"Combination of poly-γ-glutamic acid and galactooligosaccharide improves intestinal microbiota, defecation status, and relaxed mood in humans: a randomized, double-blind, parallel-group comparison trial.","authors":"Kentaro Umeda, Atsuko Ikeda, Ryo Uchida, Ikuko Sasahara, Tomoyuki Mine, Hitoshi Murakami, Keishi Kameyama","doi":"10.12938/bmfh.2021-084","DOIUrl":"https://doi.org/10.12938/bmfh.2021-084","url":null,"abstract":"The genus Bifidobacterium comprises beneficial intestinal bacteria that play a crucial role in the regulation of human health. Traditional prebiotics are known to increase intestinal bifidobacteria by supplying a carbon source necessary for their growth. However, intestinal bifidobacteria need not only a carbon source but also a nitrogen source for growth. Moreover, the growth of bifidobacteria is known to be inhibited in a culture medium that does not contain glutamic acid. Based on these reports, we hypothesized that the combined intake of traditional prebiotics and glutamic acid would be beneficial for growth of bifidobacteria in the gut. In this study, we investigated the effects of the combination of galactooligosaccharide (GOS; traditional prebiotic material) and poly-γ-glutamic acid (γ-PGA; source of glutamic acid) and only GOS on the intestinal microbiota and health conditions (including intestinal regulation, mood status, gastrointestinal condition, skin condition, and sleep quality) in a randomized, double-blind, parallel-group comparison trial in healthy subjects. The combined intake of GOS and γ-PGA significantly increased the prevalence of B. longum compared to the intake of GOS alone. A minimum effective dose of 2.0 g GOS and 0.3 g γ-PGA improved defecation and mood status. We revealed the combined effects of GOS and γ-PGA on intestinal microbiota as well as physical condition and concluded that the delivery of glutamic acid to the large intestine with traditional prebiotics is useful as an advanced prebiotic.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"42 1","pages":"34-48"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/46/df/bmfh-42-034.PMC9816053.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study. 双歧杆菌对腹主动脉瘤患者的影响:一项横断面研究。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-055

Eisaku Ito, Takao Ohki, Naoki Toya, Hikaru Nakagawa, Ayako Horigome, Toshitaka Odamaki, Jin-Zhong Xiao, Shigeo Koido, Yuriko Nishikawa, Toshifumi Ohkusa, Nobuhiro Sato

{"title":"Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study.","authors":"Eisaku Ito, Takao Ohki, Naoki Toya, Hikaru Nakagawa, Ayako Horigome, Toshitaka Odamaki, Jin-Zhong Xiao, Shigeo Koido, Yuriko Nishikawa, Toshifumi Ohkusa, Nobuhiro Sato","doi":"10.12938/bmfh.2022-055","DOIUrl":"https://doi.org/10.12938/bmfh.2022-055","url":null,"abstract":"The relationships between various diseases and the human gut microbiota (GM) have been revealed. However, the relationships between the human abdominal aortic aneurysm (AAA) and GM remains unknown. The aim of this cross-sectional study was to clarify the association between the human AAA and GM. Stool samples from 30 consecutive patients with AAA before aneurysm repair and those of 30 controls without vascular diseases were analyzed by 16S rRNA gene (V3-4) sequencing using an Illumina MiSeq system and QIIME 2. There was no significant difference in age (75 vs. 75 years) or gender (80% vs. 87% males) between the groups. No significant difference in GM composition was observed in principal coordinate analysis between the two groups, whereas the AAA group showed a significantly lower abundance of Bifidobacterium adolescentis (p<0.01) at the species level than the controls. This study demonstrated that the abundance of B. adolescentis decreased in patients with AAA. This is the first study to show the characteristics of the GM in patients with AAA. Studies are needed to reveal if causal relationships exists between the human AAA and GM.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"42 1","pages":"81-86"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/ac/bmfh-42-081.PMC9816055.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Establishment of porcine fecal-derived ex vivo microbial communities to evaluate the impact of livestock feed on gut microbiome 建立猪粪源性离体研究体系;微生物群落评价家畜饲料对肠道微生物组的影响

4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2023-085

Yuji TSUJIKAWA, Keita NISHIYAMA, Fu NAMAI, Yoshiya IMAMURA, Taiga SAKUMA, Sudeb SAHA, Masahiko SUZUKI, Mitsuki SAKURAI, Ryo IWATA, Kengo MATSUO, Hironori TAKAMORI, Yoshihito SUDA, Binghui ZHOU, Itsuko FUKUDA, Julio VILLENA, Iwao SAKANE, Ro OSAWA, Haruki KITAZAWA

{"title":"Establishment of porcine fecal-derived ex vivo microbial communities to evaluate the impact of livestock feed on gut microbiome","authors":"Yuji TSUJIKAWA, Keita NISHIYAMA, Fu NAMAI, Yoshiya IMAMURA, Taiga SAKUMA, Sudeb SAHA, Masahiko SUZUKI, Mitsuki SAKURAI, Ryo IWATA, Kengo MATSUO, Hironori TAKAMORI, Yoshihito SUDA, Binghui ZHOU, Itsuko FUKUDA, Julio VILLENA, Iwao SAKANE, Ro OSAWA, Haruki KITAZAWA","doi":"10.12938/bmfh.2023-085","DOIUrl":"https://doi.org/10.12938/bmfh.2023-085","url":null,"abstract":"Sustainable livestock production requires reducing competition for food and feed resources and increasing the utilization of food by-products in livestock feed. This study describes the establishment of an anaerobic batch culture model to simulate pig microbiota and evaluate the effects of a food by-product, wakame seaweed stalks, on ex vivo microbial communities. We selected one of the nine media to support the growth of a bacterial community most similar in composition and diversity to that observed in pig donor feces. Supplementation with wakame altered the microbial profile and short-chain fatty acid composition in the ex vivo model, and a similar trajectory was observed in the in vivo pig experimental validation. Notably, the presence of wakame increased the abundance of Lactobacillus species, which may have been due to cross-feeding with Bacteroides. These results suggest the potential of wakame as a livestock feed capable of modulating the pig microbiome. Collectively, this study highlights the ability to estimate the microbiome changes that occur when pigs are fed a specific feed using an ex vivo culture model.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135703754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Faecalibacterium prausnitzii is not decreased in symptomatic uncomplicated diverticular disease of the colon. 在症状性无并发症的结肠憩室疾病中，prausnitzfaecalibacterium并未减少。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-046

Antonio Tursi, Paola Mastromarino, Daniela Capobianco, Walter Elisei, Giuseppe Campagna, Marcello Picchio, GianMarco Giorgetti, Federica Fabiocchi, Giovanni Brandimarte

引用次数: 3

Metagenome data-based phage therapy for intestinal bacteria-mediated diseases. 基于宏基因组数据的噬菌体治疗肠道细菌介导的疾病。

IF 3.1 4区医学

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI: 10.12938/bmfh.2022-061

Kosuke Fujimoto

{"title":"Metagenome data-based phage therapy for intestinal bacteria-mediated diseases.","authors":"Kosuke Fujimoto","doi":"10.12938/bmfh.2022-061","DOIUrl":"https://doi.org/10.12938/bmfh.2022-061","url":null,"abstract":"Improvements in genome analysis technology using next-generation sequencing have revealed that abnormalities in the composition of the intestinal microbiota are important in numerous diseases. Furthermore, intestinal commensal pathogens that are directly involved in the onset and exacerbation of disease have been identified. Specific control of them is strongly desired. However, antibiotics are not appropriate for the control of intestinal commensal pathogens because they may kill beneficial bacteria as well. The intestinal tract contains many viruses: most are bacteriophages (phages) that infect intestinal bacteria rather than viruses that infect human cells. Phages have very high specificity for their host bacteria. Therefore, phage therapy is considered potentially useful for controlling intestinal commensal pathogens. However, the intestinal tract is a specialized, anaerobic environment, and it is impossible to isolate phages that infect host intestinal bacteria if the bacteria cannot be cultured. Furthermore, genomic analysis methods for intestinal phages have not been well established, so until recently, a complete picture of the intestinal phage has not been clear. In this review, I summarize the importance of next-generation phage therapy based on metagenomic data and describe a novel therapy against Clostridioides difficile developed using such data.","PeriodicalId":8867,"journal":{"name":"Bioscience of Microbiota, Food and Health","volume":"42 1","pages":"8-12"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/5e/bmfh-42-008.PMC9816054.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10554211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0