Impact of Bifidobacterium adolescentis in patients with abdominal aortic aneurysm: a cross-sectional study.

IF 3.1 4区医学 Q2 Agricultural and Biological Sciences

Bioscience of Microbiota, Food and Health Pub Date : 2023-01-01 DOI:10.12938/bmfh.2022-055

Eisaku Ito, Takao Ohki, Naoki Toya, Hikaru Nakagawa, Ayako Horigome, Toshitaka Odamaki, Jin-Zhong Xiao, Shigeo Koido, Yuriko Nishikawa, Toshifumi Ohkusa, Nobuhiro Sato

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引用次数: 1

Abstract

The relationships between various diseases and the human gut microbiota (GM) have been revealed. However, the relationships between the human abdominal aortic aneurysm (AAA) and GM remains unknown. The aim of this cross-sectional study was to clarify the association between the human AAA and GM. Stool samples from 30 consecutive patients with AAA before aneurysm repair and those of 30 controls without vascular diseases were analyzed by 16S rRNA gene (V3-4) sequencing using an Illumina MiSeq system and QIIME 2. There was no significant difference in age (75 vs. 75 years) or gender (80% vs. 87% males) between the groups. No significant difference in GM composition was observed in principal coordinate analysis between the two groups, whereas the AAA group showed a significantly lower abundance of Bifidobacterium adolescentis (p<0.01) at the species level than the controls. This study demonstrated that the abundance of B. adolescentis decreased in patients with AAA. This is the first study to show the characteristics of the GM in patients with AAA. Studies are needed to reveal if causal relationships exists between the human AAA and GM.

Abstract Image

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双歧杆菌对腹主动脉瘤患者的影响:一项横断面研究。

各种疾病与人体肠道菌群之间的关系已被揭示。然而，人腹主动脉瘤(AAA)与GM之间的关系尚不清楚。本横断面研究的目的是澄清人类AAA与GM之间的关系。使用Illumina MiSeq系统和QIIME 2，通过16S rRNA基因(V3-4)测序分析了30例连续动脉瘤修复前AAA患者和30例无血管疾病的对照组的粪便样本。两组患者在年龄(75岁vs. 75岁)或性别(80% vs. 87%男性)上无显著差异。主坐标分析结果显示，两组间转基因成分无显著差异，而AAA组的青少年双歧杆菌(Bifidobacterium adolescent, pB)丰度显著低于AAA组。这是第一个显示AAA患者中GM特征的研究，需要进一步研究来揭示人类AAA与GM之间是否存在因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

5.50

自引率

3.20%

发文量

期刊介绍： Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.