Development of a lactic acid bacteria strain that suppresses chronic inflammation and improves glucose and lipid metabolism.

IF 3.1 4区 医学 Q2 Agricultural and Biological Sciences
Takayuki Toshimitsu
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Abstract

Chronic inflammation caused by aging, obesity, and lifestyle disturbances can lead to the production of inflammatory cytokines and insulin resistance, reducing glucose and lipid metabolism. Lactic acid bacteria (LAB) have various bioactivities, and certain types of LAB have been reported to exhibit anti-inflammatory effects. We hypothesized that LAB strains, which can strongly induce the production of anti-inflammatory cytokines by immune cells in the intestinal tract, may improve glucose and lipid metabolism by suppressing chronic inflammation. We selected Lactiplantibacillus plantarum OLL2712 (OLL2712) from the LAB library owned by Meiji Co., Ltd. based on its ability to induce the production of interleukin-10 (IL-10), optimized the culture conditions of OLL2712 for industrial applications, and verified the efficacy of the strain in animal and clinical studies. The results showed that OLL2712 bacterial cells in the exponential phase had notably higher anti-inflammatory properties than the cells in the stationary phase and led to the inhibition of chronic inflammation and improvement of glucose and lipid metabolism in animal studies. Two randomized controlled trials consisting of healthy adults with elevated blood glucose levels or body mass indices (BMIs) also showed that the intake of OLL2712 suppressed the aggravation of chronic inflammation and improved glucose and lipid metabolism. This review identified a novel LAB strain that may contribute to diabetes and obesity prevention and demonstrated its clinical efficacy. In addition, the mechanism of action of this LAB strain through the intestinal immune system was partially elucidated, and the importance of optimizing the culture conditions of LAB was clarified.

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乳酸菌菌株的发展,抑制慢性炎症和改善糖脂代谢。
由衰老、肥胖和生活方式紊乱引起的慢性炎症可导致炎症细胞因子和胰岛素抵抗的产生,从而降低葡萄糖和脂质代谢。乳酸菌(LAB)具有多种生物活性,某些类型的乳酸菌已被报道具有抗炎作用。我们推测,能够强烈诱导肠道免疫细胞产生抗炎细胞因子的LAB菌株可能通过抑制慢性炎症来改善糖脂代谢。我们根据其诱导白细胞介素-10 (IL-10)产生的能力,从明治株公司LAB文库中选择了植物乳杆菌OLL2712 (OLL2712),优化了其工业应用的培养条件,并在动物和临床研究中验证了该菌株的有效性。结果表明,在动物实验中,指数期的OLL2712细菌细胞具有明显高于固定期细胞的抗炎特性,从而抑制慢性炎症,改善糖脂代谢。两项由血糖水平或体重指数(bmi)升高的健康成年人组成的随机对照试验也表明,摄入OLL2712可以抑制慢性炎症的加重,改善糖脂代谢。本综述鉴定了一种可能有助于糖尿病和肥胖预防的新型LAB菌株,并证明了其临床疗效。此外,还部分阐明了该乳酸菌通过肠道免疫系统的作用机制,并阐明了优化乳酸菌培养条件的重要性。
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来源期刊
Bioscience of Microbiota, Food and Health
Bioscience of Microbiota, Food and Health Immunology and Microbiology-Applied Microbiology and Biotechnology
CiteScore
5.50
自引率
3.20%
发文量
24
期刊介绍: Bioscience of Microbiota, Food and Health (BMFH) is a peer-reviewed scientific journal with a specific area of focus: intestinal microbiota of human and animals, lactic acid bacteria (LAB) and food immunology and food function. BMFH contains Full papers, Notes, Reviews and Letters to the editor in all areas dealing with intestinal microbiota, LAB and food immunology and food function. BMFH takes a multidisciplinary approach and focuses on a broad spectrum of issues.
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