Beilstein Journal of Nanotechnology最新文献

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Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar+ ion beam: a comparative study 100 keV Ar+ 离子束在硅和 Ge 中诱导的波纹图案形成和损伤轮廓:比较研究
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-04-05 DOI: 10.3762/bjnano.15.33
I. Sulania, Harpreet Sondhi, Tanuj Kumar, Sunil Ojha, G. R. Umapathy, Ambuj Mishra, Ambuj Tripathi, Richa Krishna, D. K. Avasthi, Yogendra Kumar Mishra
{"title":"Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar+ ion beam: a comparative study","authors":"I. Sulania, Harpreet Sondhi, Tanuj Kumar, Sunil Ojha, G. R. Umapathy, Ambuj Mishra, Ambuj Tripathi, Richa Krishna, D. K. Avasthi, Yogendra Kumar Mishra","doi":"10.3762/bjnano.15.33","DOIUrl":"https://doi.org/10.3762/bjnano.15.33","url":null,"abstract":"Desired modifications of surfaces at the nanoscale may be achieved using energetic ion beams. In the present work, a complete study of self-assembled ripple pattern fabrication on Si and Ge by 100 keV Ar+ ion beam bombardment is discussed. The irradiation was performed in the ion fluence range of ≈3 × 1017 to 9 × 1017 ions/cm2 and at an incident angle of θ ≈ 60° with respect to the surface normal. The investigation focuses on topographical studies of pattern formation using atomic force microscopy, and induced damage profiles inside Si and Ge by Rutherford backscattering spectrometry and transmission electron microscopy. The ripple wavelength was found to scale with ion fluence, and energetic ions created more defects inside Si as compared to that of Ge. Although earlier reports suggested that Ge is resistant to structural changes upon Ar+ ion irradiation, in the present case, a ripple pattern is observed on both Si and Ge. The irradiated Si and Ge targets clearly show visible damage peaks between channel numbers (1000–1100) for Si and (1500–1600) for Ge. The clustering of defects leads to a subsequent increase of the damage peak in irradiated samples (for an ion fluence of ≈9 × 1017 ions/cm2) compared to that in unirradiated samples.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140737828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulated critical currents of spin-transfer torque-induced resistance changes in NiCu/Cu multilayered nanowires 镍铜/铜多层纳米线自旋转移扭矩诱导电阻变化的调制临界电流
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-04-03 DOI: 10.3762/bjnano.15.32
Mengqi Fu, R. Hartmann, Julian Braun, Sergej Andreev, Torsten Pietsch, Elke Scheer
{"title":"Modulated critical currents of spin-transfer torque-induced resistance changes in NiCu/Cu multilayered nanowires","authors":"Mengqi Fu, R. Hartmann, Julian Braun, Sergej Andreev, Torsten Pietsch, Elke Scheer","doi":"10.3762/bjnano.15.32","DOIUrl":"https://doi.org/10.3762/bjnano.15.32","url":null,"abstract":"We present a novel method combining anodic aluminum oxide template synthesis and nanolithography to selectively deposit vertically patterned magnetic nanowires on a Si substrate. With this approach we fabricated three-dimensional nanowire-based spin valve devices without the need of complex etching processes or additional spacer coating. Through this method, we successfully obtained NiCu/Cu multilayered nanowire arrays with a controlled sequence along the long axis of the nanowires. Both magnetic switching and excitation phenomena driven by spin-polarized currents were clearly demonstrated in our NiCu/Cu multilayered nanowires. Moreover, the critical currents for switching and excitation were observed to be modulated in an oscillatory manner by the magnetic field in the nanowire-based devices. We present a toy model to qualitatively explain these observations.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controllable physicochemical properties of WOx thin films grown under glancing angle 闪烁角下生长的 WOx 薄膜的可控物理化学特性
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-04-02 DOI: 10.3762/bjnano.15.31
Rupam Mandal, Aparajita Mandal, Alapan Dutta, Rengasamy Sivakumar, Sanjeev Kumar Srivastava, T. Som
{"title":"Controllable physicochemical properties of WOx thin films grown under glancing angle","authors":"Rupam Mandal, Aparajita Mandal, Alapan Dutta, Rengasamy Sivakumar, Sanjeev Kumar Srivastava, T. Som","doi":"10.3762/bjnano.15.31","DOIUrl":"https://doi.org/10.3762/bjnano.15.31","url":null,"abstract":"In this work, various physicochemical properties are investigated in nanostructured WOx thin films prepared by radio-frequency magnetron sputtering for optoelectronic applications. A glancing angle of 87° is employed to grow films of different thicknesses, which are then exposed to post-growth annealing. Detailed local probe analyses in terms of morphology and work function of WOx films are carried out to investigate thickness-dependent property modulations of the as-deposited and annealed films. The analyses show a reasonably good correlation with photoelectron spectroscopic measurements on the films and the bulk I–V characteristics acquired on a series of WOx/p-Si heterojunction diodes. The presence of a critical WOx thickness is identified to regulate the rectification ratio values at the WOx/p-Si heterostructures and increase in series resistance within the bulk of the films. The present study provides valuable insights to correlate optical, electrical, and structural properties of WOx thin films, which will be beneficial for fabricating WOx-based optoelectronic devices, including photovoltaic cells.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicines against Chagas disease: a critical review 抗击南美锥虫病的纳米药物:重要综述
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-03-27 DOI: 10.3762/bjnano.15.30
M. Morilla, Kajal Ghosal, E. Romero
{"title":"Nanomedicines against Chagas disease: a critical review","authors":"M. Morilla, Kajal Ghosal, E. Romero","doi":"10.3762/bjnano.15.30","DOIUrl":"https://doi.org/10.3762/bjnano.15.30","url":null,"abstract":"Chagas disease (CD) is the most important endemic parasitosis in South America and represents a great socioeconomic burden for the chronically ill and their families. The only currently available treatment against CD is based on the oral administration of benznidazole, an agent, developed in 1971, of controversial effectiveness on chronically ill patients and toxic to adults. So far, conventional pharmacological approaches have failed to offer more effective and less toxic alternatives to benznidazole. Nanomedicines reduce toxicity and increase the effectiveness of current oncological therapies. Could nanomedicines improve the treatment of the neglected CD? This question will be addressed in this review, first by critically discussing selected reports on the performance of benznidazole and other molecules formulated as nanomedicines in in vitro and in vivo CD models. Taking into consideration the developmental barriers for nanomedicines and the degree of current technical preclinical efforts, a prospect of developing nanomedicines against CD will be provided. Not surprisingly, we conclude that structurally simpler formulations with minimal production cost, such as oral nanocrystals and/or parenteral nano-immunostimulants, have the highest chances of making it to the market to treat CD. Nonetheless, substantive political and economic decisions, key to facing technological challenges, are still required regarding a realistic use of nanomedicines effective against CD.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative electron microscopy particle sizing of TiO2 pigments: sample preparation and measurement 二氧化钛颜料的比较电子显微镜颗粒测定:样品制备和测量
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-03-25 DOI: 10.3762/bjnano.15.29
Ralf Theissmann, Christopher Drury, Markus Rohe, Thomas Koch, Jochen Winkler, Petr Pikal
{"title":"Comparative electron microscopy particle sizing of TiO2 pigments: sample preparation and measurement","authors":"Ralf Theissmann, Christopher Drury, Markus Rohe, Thomas Koch, Jochen Winkler, Petr Pikal","doi":"10.3762/bjnano.15.29","DOIUrl":"https://doi.org/10.3762/bjnano.15.29","url":null,"abstract":"Titanium dioxide (TiO2) pigment is a non-toxic, particulate material in widespread use and found in everyone’s daily life. The particle size of the anatase or rutile crystals are optimised to produce a pigment that provides the best possible whiteness and opacity. The average particle size is intentionally much larger than the 100 nm boundary of the EU nanomaterial definition, but the TiO2 pigment manufacturing processes results in a finite nanoscale content fraction. This optically inefficient nanoscale fraction needs to be quantified in line with EU regulations. In this paper, we describe the measurement procedures used for product quality assurance by three TiO2 manufacturing companies and present number-based primary particle size distributions (PSDs) obtained in a round-robin study performed on five anatase pigments fabricated by means of sulfate processes in different plants and commonly used worldwide in food, feed, pharmaceutical and cosmetic applications. The PSDs measured by the three titanium dioxide manufacturers based on electron micrographs are in excellent agreement with one another but differ significantly from those published elsewhere. Importantly, in some cases, the PSDs result in a different regulatory classification for some of the samples tested. The electron microscopy results published here are supported by results from other complementary methods including surface area measurements. It is the intention of this publication to contribute to an ongoing discussion on size measurements of TiO2 pigments and other particulate materials and advance the development of widely acceptable, precise, and reproducible measurement protocols for measuring the number-based PSDs of particulate products in the size range of TiO2 pigments.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140382968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating structural and electronic properties of neutral zinc clusters: a G0W0 and G0W0Г0(1) benchmark. 研究中性锌团簇的结构和电子特性:G0W0 和 G0W0Г0(1) 基准。
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI: 10.3762/bjnano.15.28
Sunila Bakhsh, Muhammad Khalid, Sameen Aslam, Muhammad Sohail, Muhammad Aamir Iqbal, Mujtaba Ikram, Kareem Morsy
{"title":"Investigating structural and electronic properties of neutral zinc clusters: a <i>G</i><sub>0</sub><i>W</i><sub>0</sub> and <i>G</i><sub>0</sub><i>W</i><sub>0</sub>Г<sub>0</sub><sup>(1)</sup> benchmark.","authors":"Sunila Bakhsh, Muhammad Khalid, Sameen Aslam, Muhammad Sohail, Muhammad Aamir Iqbal, Mujtaba Ikram, Kareem Morsy","doi":"10.3762/bjnano.15.28","DOIUrl":"https://doi.org/10.3762/bjnano.15.28","url":null,"abstract":"<p><p>The structural and electronic properties of zinc clusters (Zn<i><sub>n</sub></i>) for a size range of <i>n</i> = 2-15 are studied using density functional theory. The particle swarm optimization algorithm is employed to search the structure and to determine the ground-state structure of the neutral Zn clusters. The structural motifs are optimized using the density functional theory approach to ensure that the structures are fully relaxed. Results are compared with the literature to validate the accuracy of the prediction method. The binding energy per cluster is obtained and compared with the reported literature to study the stability of these structures. We further assess the electronic properties, including the ionization potential, using the all-electron FHI-aims code employing <i>G</i><sub>0</sub><i>W</i><sub>0</sub> calculations, and the <i>G</i><sub>0</sub><i>W</i><sub>0</sub><i>Г</i><sub>0</sub><sup>(1)</sup> correction for a few smaller clusters, which provides a better estimation of the ionization potential compared to other methods.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors. 利用基于周期表的简单描述符,探索纳米粒子的理化特性与细胞损伤之间的关系,以对抗癌症生长。
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-03-12 eCollection Date: 2024-01-01 DOI: 10.3762/bjnano.15.27
Joyita Roy, Kunal Roy
{"title":"Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors.","authors":"Joyita Roy, Kunal Roy","doi":"10.3762/bjnano.15.27","DOIUrl":"https://doi.org/10.3762/bjnano.15.27","url":null,"abstract":"<p><p>A comprehensive knowledge of the physical and chemical properties of nanomaterials (NMs) is necessary to design them effectively for regulated use. Although NMs are utilized in therapeutics, their cytotoxicity has attracted great attention. Nanoscale quantitative structure-property relationship (nano-QSPR) models can help in understanding the relationship between NMs and the biological environment and provide new ways for modeling the structural properties and bio-toxic effects of NMs. The goal of the study is to construct fully validated property-based models to extract relevant features for estimating and influencing the zeta potential and obtaining the toxicity profile regarding cell damage in the treatment of cancer cells. To achieve this, QSPR modeling was first performed with 18 metal oxide (MeOx) NMs to measure their materials properties using periodic table-based descriptors. The features obtained were later applied for zeta potential calculation (imputation for sparse data) for MeOx NMs that lack such information. To further clarify the influence of the zeta potential on cell damage, a QSPR model was developed with 132 MeOx NMs to understand the possible mechanisms of cell damage. The results showed that zeta potential, along with seven other descriptors, had the potential to influence oxidative damage through free radical accumulation, which could lead to changes in the survival rate of cancerous cells. The developed QSPR and quantitative structure-activity relationship models also give hints regarding safer design and toxicity assessment of MeOx NMs.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining by Raman spectroscopy the average thickness and N-layer-specific surface coverages of MoS2 thin films with domains much smaller than the laser spot size 通过拉曼光谱测定畴面积远小于激光光斑尺寸的 MoS2 薄膜的平均厚度和 N 层特定表面覆盖率
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-03-07 DOI: 10.3762/bjnano.15.26
F. Wasem Klein, J. Huntzinger, Vincent Astié, Damien Voiry, R. Parret, Houssine Makhlouf, Sandrine Juillaguet, J. Decams, Sylvie Contreras, P. Landois, A. Zahab, J. Sauvajol, M. Paillet
{"title":"Determining by Raman spectroscopy the average thickness and N-layer-specific surface coverages of MoS2 thin films with domains much smaller than the laser spot size","authors":"F. Wasem Klein, J. Huntzinger, Vincent Astié, Damien Voiry, R. Parret, Houssine Makhlouf, Sandrine Juillaguet, J. Decams, Sylvie Contreras, P. Landois, A. Zahab, J. Sauvajol, M. Paillet","doi":"10.3762/bjnano.15.26","DOIUrl":"https://doi.org/10.3762/bjnano.15.26","url":null,"abstract":"Raman spectroscopy is a widely used technique to characterize nanomaterials because of its convenience, non-destructiveness, and sensitivity to materials change. The primary purpose of this work is to determine via Raman spectroscopy the average thickness of MoS2 thin films synthesized by direct liquid injection pulsed-pressure chemical vapor deposition (DLI-PP-CVD). Such samples are constituted of nanoflakes (with a lateral size of typically 50 nm, i.e., well below the laser spot size), with possibly a distribution of thicknesses and twist angles between stacked layers. As an essential preliminary, we first reassess the applicability of different Raman criteria to determine the thicknesses (or layer number, N) of MoS2 flakes from measurements performed on reference samples, namely well-characterized mechanically exfoliated or standard chemical vapor deposition MoS2 large flakes deposited on 90 ± 6 nm SiO2 on Si substrates. Then, we discuss the applicability of the same criteria for significantly different DLI-PP-CVD MoS2 samples with average thicknesses ranging from sub-monolayer up to three layers. Finally, an original procedure based on the measurement of the intensity of the layer breathing modes is proposed to evaluate the surface coverage for each N (i.e., the ratio between the surface covered by exactly N layers and the total surface) in DLI-PP-CVD MoS2 samples.","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasensitive and ultrastretchable metal crack strain sensor based on helical polydimethylsiloxane. 基于螺旋状聚二甲基硅氧烷的超灵敏、超拉伸金属裂纹应变传感器。
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-03-01 eCollection Date: 2024-01-01 DOI: 10.3762/bjnano.15.25
Shangbi Chen, Dewen Liu, Weiwei Chen, Huajiang Chen, Jiawei Li, Jinfang Wang
{"title":"Ultrasensitive and ultrastretchable metal crack strain sensor based on helical polydimethylsiloxane.","authors":"Shangbi Chen, Dewen Liu, Weiwei Chen, Huajiang Chen, Jiawei Li, Jinfang Wang","doi":"10.3762/bjnano.15.25","DOIUrl":"10.3762/bjnano.15.25","url":null,"abstract":"<p><p>The majority of crack sensors do not offer simultaneously both a significant stretchability and an ultrahigh sensitivity. In this study, we present a straightforward and cost-effective approach to fabricate metal crack sensors that exhibit exceptional performance in terms of ultrahigh sensitivity and ultrahigh stretchability. This is achieved by incorporating a helical structure into the substrate through a modeling process and, subsequently, depositing a thin film of gold onto the polydimethylsiloxane substrate via sputter deposition. The metal thin film is then pre-stretched to generate microcracks. The sensor demonstrates a remarkable stretchability of 300%, an exceptional sensitivity with a maximum gauge factor reaching 10<sup>7</sup>, a rapid response time of 158 ms, minimal hysteresis, and outstanding durability. These impressive attributes are attributed to the deliberate design of geometric structures and careful selection of connection types for the sensing materials, thereby presenting a novel approach to fabricating stretchable and highly sensitive crack-strain sensors. This work offers a universal platform for constructing strain sensors with both high sensitivity and stretchability, showing a far-reaching significance and influence for developing next-generation practically applicable soft electronics.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910384/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study. 作为抗癌药物输送系统的长春瑞滨负载多功能磁性纳米颗粒:合成、表征和体外释放研究。
IF 3.1 4区 材料科学
Beilstein Journal of Nanotechnology Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.3762/bjnano.15.24
Zeynep Özcan, Afife Binnaz Hazar Yoruç
{"title":"Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study.","authors":"Zeynep Özcan, Afife Binnaz Hazar Yoruç","doi":"10.3762/bjnano.15.24","DOIUrl":"10.3762/bjnano.15.24","url":null,"abstract":"<p><p>In this study, a multifunctional therapeutic agent combining chemotherapy and photothermal therapy on a single platform has been developed in the form of vinorelbine-loaded polydopamine-coated iron oxide nanoparticles. Vinorelbine (VNB) is loaded on the surface of iron oxide nanoparticles produced by a solvothermal technique after coating with polydopamine (PDA) with varying weight ratios as a result of dopamine polymerisation and covalent bonding of thiol-polyethylene glycol (SH-PEG). The VNB/PDA/Fe<sub>3</sub>O<sub>4</sub> nanoparticles have a saturation magnetisation value of 60.40 emu/g in vibrating sample magnetometry, which proves their magnetisation. Vinorelbine, which is used as an effective cancer therapy agent, is included in the nanocomposite structure, and in vitro drug release studies under different pH conditions (pH 5.5 and 7.4) and photothermal activity at 808 nm NIR laser irradiation are investigated. The comprehensive integration of precise multifunctional nanoparticles design, magnetic response, and controlled drug release with photothermal effect brings a different perspective to advanced cancer treatment research.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10910576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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