用于植物化学物质输送的聚合物脂质混合纳米颗粒:挑战、进展和未来前景。

IF 2.6 4区 材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Beilstein Journal of Nanotechnology Pub Date : 2024-11-22 eCollection Date: 2024-01-01 DOI:10.3762/bjnano.15.118
Iqra Rahat, Pooja Yadav, Aditi Singhal, Mohammad Fareed, Jaganathan Raja Purushothaman, Mohammed Aslam, Raju Balaji, Sonali Patil-Shinde, Md Rizwanullah
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引用次数: 0

摘要

植物化学物质是植物中天然存在的化合物,具有广泛的治疗特性,包括抗氧化、抗炎、抗癌和抗菌活性。然而,由于水溶性差、生物利用率低、新陈代谢快以及在生理条件下不稳定等原因,它们在临床上的应用往往受到阻碍。聚合物脂质杂化纳米颗粒(PLHNPs)是一种新型的给药系统,它结合了聚合物纳米颗粒和脂质纳米颗粒的优点,可以克服这些难题。本综述探讨了 PLHNPs 在生物医学应用中提高植物化学物质的递送和功效的潜力。我们讨论了植物化学物质传统递送的障碍、PLHNPs 的基本结构和 PLHNPs 的类型,重点介绍了它们提高封装效率、稳定性和控制封装植物化学物质释放的能力。此外,我们还讨论了通过特定位点递送封装植物化学物质来提高整体疗效的表面修饰策略。此外,我们还广泛讨论了植物化学物质封装的 PLHNPs 用于治疗不同疾病的临床前研究。此外,我们还探讨了 PLHNPs 在临床广泛应用方面面临的挑战和前景。总之,PLHNPs 在有效传递植物化学物质的生物医学应用方面具有强大的潜力。根据临床前研究的结果,这可能会为治疗各种疾病提供一种前景广阔的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects.

Phytochemicals, naturally occurring compounds in plants, possess a wide range of therapeutic properties, including antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, their clinical application is often hindered by poor water solubility, low bioavailability, rapid metabolism, and instability under physiological conditions. Polymer lipid hybrid nanoparticles (PLHNPs) have emerged as a novel delivery system that combines the advantages of both polymeric and lipid-based nanoparticles to overcome these challenges. This review explores the potential of PLHNPs to enhance the delivery and efficacy of phytochemicals for biomedical applications. We discuss the obstacles in the conventional delivery of phytochemicals, the fundamental architecture of PLHNPs, and the types of PLHNPs, highlighting their ability to improve encapsulation efficiency, stability, and controlled release of the encapsulated phytochemicals. In addition, the surface modification strategies to improve overall therapeutic efficacy by site-specific delivery of encapsulated phytochemicals are also discussed. Furthermore, we extensively discuss the preclinical studies on phytochemical encapsulated PLHNPs for the management of different diseases. Additionally, we explore the challenges ahead and prospects of PLHNPs regarding their widespread use in clinical settings. Overall, PLHNPs hold strong potential for the effective delivery of phytochemicals for biomedical applications. As per the findings from pre-clinical studies, this may offer a promising strategy for managing various diseases.

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来源期刊
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
5.70
自引率
3.20%
发文量
109
审稿时长
2 months
期刊介绍: The Beilstein Journal of Nanotechnology is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in nanoscience and nanotechnology. The journal is published and completely funded by the Beilstein-Institut, a non-profit foundation located in Frankfurt am Main, Germany. The editor-in-chief is Professor Thomas Schimmel – Karlsruhe Institute of Technology. He is supported by more than 20 associate editors who are responsible for a particular subject area within the scope of the journal.
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