Beilstein Journal of Nanotechnology最新文献

{"title":"Nanoscale-enabled cross-scale chemical sensing for underwater monitoring and beyond.","authors":"Tatsuhiro Fukuba, Nicolas Clement, Henri Vo Van Qui, Yui Sasaki, Koji Toma, Tsuyoshi Minami","doi":"10.3762/bjnano.17.103","DOIUrl":"10.3762/bjnano.17.103","url":null,"abstract":"<p><p>In aquatic environments, such as oceans, lakes, and rivers, molecular-level chemical reactions and the distribution of chemical species are related to global environmental changes through various biogeochemical processes. Understanding this relationship requires addressing cross-scale challenges at two distinct levels: overcoming interfacial physical constraints, such as Debye screening in high-salinity waters, at the sensing level and bridging local microscale measurements with macroscale environmental dynamics at the observational level. In this paper, we describe sensing technologies that can enable cross-scale sensing in aquatic environments. Here, we focus on nanoscale interfacial sensing and molecular recognition technologies, as well as lab-on-a-chip technologies for <i>in situ</i> measurements including power-efficient pumping technologies. Additionally, underwater observation platforms that link the local chemical sensing and global processes are overviewed. Beyond environmental applications, these sensing technologies offer a cross-disciplinary approach that can be extended to analyze biological systems facing similar physicochemical constraints.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1505-1515"},"PeriodicalIF":3.5,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149317559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin pharmacology and pharmacokinetics: current challenges and future perspectives in nanoemulsion delivery.","authors":"Daniele De Campos, Marciane Zornita Bortolanza, Mohamed Fathi Abdallah, Jean-Marie Colet, Julia de Oliveira Primo, Carla Bittencourt, Najeh Maissar Khalil","doi":"10.3762/bjnano.17.102","DOIUrl":"10.3762/bjnano.17.102","url":null,"abstract":"<p><p>Derived from the rhizome of <i>Curcuma longa L.</i>, curcumin has evolved from a traditional component of South Asian medicine into a prominent topic in modern pharmacology. Curcumin has a pleiotropic pharmacological profile with biological properties including antioxidant, anti-inflammatory, and anticancer effects. However, its clinical translation faces physiological and chemical challenges, characterized by low systemic bioavailability, instability at neutral to alkaline pH, and rapid metabolic clearance. This review examines the molecular mechanisms and biological barriers that limit its efficiency and explores nanotechnology as a strategy to optimize its pharmacokinetic profile. It focuses on nanostructured systems, emphasizing nanoemulsions, to improve stability and prolong systemic circulation. Finally, the current landscape of clinical studies and the prospects for using these nanosystems to manage inflammatory and oncological diseases are discussed to establish curcumin as a therapeutic alternative.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1488-1504"},"PeriodicalIF":3.5,"publicationDate":"2026-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149317558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining laser ablation and sol-gel techniques for the synthesis of nanostructured organic-inorganic matrices.","authors":"Emmanuel Haro-Poniatowski, Cesar Augusto Guarín, Luis Guillermo Mendoza-Luna, Luis Escobar-Alarcón, José Luis Hernández-Pozos, L Irais Vera-Robles, Patricia Castillo, Fátima Cabello, Johann Toudert, Fernando Chacón-Sánchez, Marina García-Pardo, Rosalia Serna, José Gonzalo, Javier Solís","doi":"10.3762/bjnano.17.101","DOIUrl":"10.3762/bjnano.17.101","url":null,"abstract":"<p><p>In this work we report a new and simple method that combines pulsed laser ablation in liquids (PLAL) and sol-gel techniques to obtain nanocomposite glasses and gelatins. Using this combination, we obtained two kinds of materials, bulk glasses on the one hand and gelatin films on the other hand. In the case of glasses, gold nanoparticles (Au-NPs) are generated by PLAL using an Au target submerged in a transparent liquid solution made previously with tetraethyl orthosilicate (TEOS) adding diluted hydrochloric acid as catalyzer. For gelatins, the same procedure is employed; however, in this case only commercial gelatin and tap water are used. We have found that a successful synthesis strongly depends on time and temperature since the viscosity of the gels increases with time. For the drying process the gels are sealed and stored at room temperature for several days. We identify the principal parameters that have to be considered in order to achieve a successful synthesis. The samples are characterized by UV-vis spectroscopy, HRTEM, ellipsometry and AFM microscopy. UV-vis spectra show a surface plasmon resonance band with its maximum at 540 nm indicating the presence of Au-NPs. HRTEM reveals crystalline Au-NPs with an average size of 20 nm. AFM measurements indicate that the glasses have a very smooth surface. In the case of gelatins, self-sustained, transparent, and pink flexible films are obtained. Despite having determined the principal parameters involved in the obtention of these materials, we emphasize that a lot of work remains to be done in order to optimize this novel method of synthesis.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1478-1487"},"PeriodicalIF":3.5,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13701152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149261670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bottom-up assembly of graphene-decorated d-MXene nanoarchitecture for enhanced antibacterial activity against <i>Escherichia coli</i> and <i>Bacillus cereus</i>.","authors":"Avdhesh Kumar, Ankit Singh, Ishani Bharti, Chandra Bhushan, Ram Naraian, Manish Pratap Singh","doi":"10.3762/bjnano.17.100","DOIUrl":"10.3762/bjnano.17.100","url":null,"abstract":"&lt;p&gt;&lt;p&gt;A bottom-up ultrasonication-assisted strategy was employed for the assembly of graphene-decorated d-MXene nanoarchitectures, and their antibacterial activity against &lt;i&gt;Escherichia coli&lt;/i&gt; and &lt;i&gt;Bacillus cereus&lt;/i&gt; was systematically investigated. The formation of the nanoarchitecture was confirmed through complementary morphological, structural, spectroscopic, and surface charge analyses. Scanning electron microscopy, elemental mapping, and high-resolution transmission electron microscopy observations revealed the uniform decoration of graphene nanosheets over layered d-MXene sheets, resulting in a structurally open architecture with suppressed nanosheet restacking. Powder X-ray diffraction (PXRD) analysis exhibited peak broadening, intensity variation, and modification of the low-angle (002) reflection, while comparative PXRD analysis with a composition-matched physical mixture further demonstrated disruption of the d-MXene stacking order following ultrasonication-assisted assembly. Raman spectroscopy exhibited the coexistence of graphene D (1339 cm&lt;sup&gt;-1&lt;/sup&gt;) and G (1581 cm&lt;sup&gt;-1&lt;/sup&gt;) bands together with the characteristic d-MXene vibrational mode at 153 cm&lt;sup&gt;-1&lt;/sup&gt; confirming preservation of defect-associated graphene domains within the assembled nanoarchitecture. Comparative Raman analysis further revealed systematic shifts in the characteristic graphene and d-MXene bands and a decrease in the &lt;i&gt;I&lt;/i&gt; &lt;sub&gt;D&lt;/sub&gt;/&lt;i&gt;I&lt;/i&gt; &lt;sub&gt;G&lt;/sub&gt; ratio from 1.83 for the physical mixture to 1.27 for the nanoarchitecture, supporting intimate interfacial organization. X-ray photoelectron spectroscopy analysis revealed the coexistence of sp&lt;sup&gt;2&lt;/sup&gt; C=C (284.1 eV), sp&lt;sup&gt;3&lt;/sup&gt; C-C (284.7 eV), Ti-C (282.5 eV), and Ti-O (530.5 eV) bonding states, suggesting effective interfacial coupling and defect enriched surface regions after nanoarchitecture formation. Zeta potential analysis demonstrated enhanced colloidal stability of the graphene-decorated d-MXene nanoarchitecture with a highly negative surface charge value of -84.04 mV compared to graphene nanosheets (-54.7 mV) and d-MXene (-44.98 mV), indicating enhanced electrostatic stabilization and improved dispersion stability after nanoarchitecture formation. Dynamic light scattering analysis additionally revealed a reduction in average hydrodynamic size from 1658 nm for pristine d-MXene to 1211 nm after graphene incorporation, confirming suppression of nanosheets agglomeration within the assembled nanoarchitecture. The antibacterial activity was evaluated using colony-forming unit (CFU) and OD&lt;sub&gt;600&lt;/sub&gt; growth assays. The graphene-decorated d-MXene nanoarchitectures exhibited concentration-dependent antibacterial activity, reducing bacterial viability from 4.00 × 10&lt;sup&gt;5&lt;/sup&gt;/4.20 × 10&lt;sup&gt;5&lt;/sup&gt; to 1.80 × 10&lt;sup&gt;4&lt;/sup&gt;/2.10 × 10&lt;sup&gt;4&lt;/sup&gt; CFU/mL after 24 h at 500 µg/mL. Similarly, bacterial growth was significantly suppressed, with OD&lt;sub&gt;600&lt;/sub&gt; decreasing from 2.54/2.80","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1453-1477"},"PeriodicalIF":3.5,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13698924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149261708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of alkaline precipitation chemistry on morphology, colloidal stability, and antibacterial activity of ZnO nanoparticles synthesized using plant extracts.","authors":"Fanny Jauregui González, Dora María Frías Márquez, Susana de la Rosa García, Cinthia García Mendoza, Rosendo López González, Mayra A Álvarez Lemus, Sergio Gómez Cornelio","doi":"10.3762/bjnano.17.99","DOIUrl":"10.3762/bjnano.17.99","url":null,"abstract":"<p><p>The antibacterial performance of plant-mediated ZnO nanoparticles frequently varies despite their similar crystal structure, suggesting that additional synthesis parameters influence their nano-bio interactions. In particular, the influence of alkaline precipitation chemistry on colloidal organization and biological activity remains poorly resolved. In this study, ZnO nanoparticles were synthesized using aqueous leaf extracts of <i>Piper auritum</i> and <i>Mimosa pudica</i> with NaOH or NH₄OH as alkaline precipitating agents to evaluate their role in controlling physicochemical and antibacterial properties. Four materials were obtained, designated ZnO-PA, ZnO-MA, ZnO-PS, and ZnO-MS. FTIR analysis confirmed Zn-O formation and the presence of residual phytochemical functional groups on the nanoparticle surface. XRD confirmed the formation of the hexagonal wurtzite phase with crystallite sizes ranging from 15.4 to 25.5 nm. The precipitating agent strongly influenced nanoparticle morphology and colloidal behavior. NH₄OH produced rod-like particles, whereas NaOH generated quasi-spherical structures. Consistently, ZnO-PS and ZnO-MS exhibited markedly smaller hydrodynamic diameters (214.8-271.5 nm) than ZnO-PA and ZnO-MA (1448-1763 nm), together with more negative zeta potentials and lower polydispersity indices. Antibacterial activity, evaluated by broth microdilution against <i>Staphylococcus aureus</i>, <i>Listeria innocua</i>, <i>Escherichia coli</i>, and <i>Salmonella typhimurium</i>, showed strain-dependent activity, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranging from 156 to 5,000 µg·mL^-1 and from 625 to more than 20,000 µg·mL^-1, respectively. ZnO-PA exhibited bactericidal activity (MBC/MIC ≤ 4) against all tested strains. Overall, these results indicate that alkaline precipitation chemistry governs the colloidal organization and morphology of plant-mediated ZnO nanoparticles, thereby contributing substantially to the antibacterial performance of the resulting nanoparticles.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1438-1452"},"PeriodicalIF":3.5,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13698874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149261705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and machine learning for magnetic nanoparticles and nanocarriers in cancer imaging, drug delivery, and magnetic control: a systematic review.","authors":"Yier Yao, Wanis Nafo","doi":"10.3762/bjnano.17.98","DOIUrl":"10.3762/bjnano.17.98","url":null,"abstract":"<p><p>We reviewed artificial intelligence and machine learning in magnetic resonance imaging-visible magnetic nanoparticles, nanocarriers, and systems for imaging, drug delivery, hyperthermia, targeting, transport, and control. Using \"preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020\" methods, 2,283 records from seven databases yielded 65 studies. Predicted outcomes were colloidal stability, toxicity, uptake, magnetic descriptors, specific absorption rate, relaxivity, MRI signal, superparamagnetic iron oxide nanoparticle (SPION) quantification, drug release, biodistribution, and magnetic navigation. Evidence was strongest in bounded tasks: magnetic-property and relaxivity prediction, image-derived SPION mapping, hyperthermia modelling, and controlled magnetic transport. Most studies optimised isolated endpoints rather than integrating stability, MRI visibility, drug loading, release, tumour delivery, safety, and therapeutic response. External validation across datasets, laboratories, particle batches, biological models, scanners, and patient cohorts remains limited.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1410-1437"},"PeriodicalIF":3.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13701153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149261690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A CuO/ZnFe₂O₄ heterostructure as an efficient catalyst for NaBH₄-assisted reduction of chloramphenicol.","authors":"Le Thi Hoa, Nguyen Thi Thu Huong, Le Quoc Viet, Trinh Ngoc Dat, Nguyen Duc Cuong, Le Thi Thanh Nhi, Tran Thai Hoa","doi":"10.3762/bjnano.17.97","DOIUrl":"10.3762/bjnano.17.97","url":null,"abstract":"<p><p>In this study, a CuO/ZnFe₂O₄ heterostructure in the form of a flower, consisting of rod-like surface features associated with CuO on ZnFe₂O₄ microspheres, was successfully synthesized and evaluated for its catalytic reduction of chloramphenicol (CAP) in the presence of NaBH₄. Structural and morphological analysis confirmed the successful formation of the heterostructure with enhanced contact between ZnFe₂O₄ and CuO. Compared to pure ZnFe₂O₄, the CuO/ZnFe₂O₄ catalyst exhibited significantly improved catalytic activity for CAP reduction. Reaction conditions strongly influenced reduction efficiency, with optimal performance at pH 6, a catalyst dosage of 2.5 g·L^-1, and a short reaction time of 20 min. The enhanced catalytic performance under mild, environmentally friendly conditions highlights CuO's crucial role in promoting surface electron transfer and facilitating reduction. Kinetic analysis at room temperature indicated a change in apparent kinetic behavior during the reaction, with pseudo-first-order behavior in the initial stage and a tendency toward zeroth-order behavior at later times. This evolution is consistent with the involvement of surface-mediated catalytic processes. Overall, the CuO/ZnFe₂O₄ heterostructure shows significant potential as an efficient catalyst for rapid CAP reduction under near-neutral conditions, offering a promising strategy for wastewater treatment.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1396-1409"},"PeriodicalIF":3.5,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel nanoparticle-based co-delivery system of <i>Fritillaria persica L</i>. extract and gemcitabine for inhibiting breast cancer progression.","authors":"Reyhaneh Arefimehr, Mehrad Zibaei Moghadam, Negar Jamshidi, Nazanin Jamshidi","doi":"10.3762/bjnano.17.96","DOIUrl":"10.3762/bjnano.17.96","url":null,"abstract":"<p><p>Breast cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for more effective and less toxic therapeutic strategies. In the present study, a novel nanotherapeutic platform composed of aqueous <i>Fritillaria persica L</i>. (FP) extract and gemcitabine (Gem)-loaded chitosan (CS) nanoparticles (FP/Gem/CS-NPs) was successfully developed and evaluated against MCF-7 and MDA-MB-231 breast cancer cell lines. Physicochemical characterization demonstrated the successful fabrication of spherical FP/Gem/CS-NPs with a mean hydrodynamic diameter of approximately 69 nm, a polydispersity index (PDI) of 0.500, and a zeta potential of -16.2 mV. The nanoparticles demonstrated high entrapment efficiency (78.41%) and sustained drug release behavior, with nearly 50% of Gem released over 72 h, compared with the rapid burst release of free gemcitabine. Biological evaluations revealed that FP/Gem/CS-NPs exerted significantly enhanced anticancer activity compared with free Gem or FP extract alone. MTT assays demonstrated strong dose- and time-dependent cytotoxicity, with markedly reduced IC₅₀ values in both MCF-7 and MDA-MB-231 cells following nanoparticle treatment. Flow cytometry and caspase-3/7 analyses confirmed substantial apoptosis induction, particularly in the highly aggressive MDA-MB-231 cells. Gene expression analysis further demonstrated significant upregulation of pro-apoptotic BAX and cell cycle regulator P21, alongside downregulation of anti-apoptotic BCL-2, indicating activation of mitochondrial apoptotic pathways. Moreover, NRF2 expression was elevated, suggesting modulation of oxidative stress responses. Cell cycle analysis revealed prominent G2/M phase arrest in treated cells. Collectively, these findings indicate that FP/Gem/CS-NPs represent a promising synergistic nanotherapeutic system capable of enhancing gemcitabine efficacy while modulating apoptosis, oxidative stress, and cell cycle pathways in breast cancer cells.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1378-1395"},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13678680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser fragmentation of MoS₂ in ethanol: MoO_3- <i>_x</i> coatings, oxygen vacancies, and photoluminescence with NIR heating.","authors":"José Guillermo Castillo-Lara, Miguel Ángel Camacho-López, Liliana Aranda-Lara, Marco Antonio Camacho-López, Jazmín Fuentes-Becerril, Keila Isaac-Olivé, Nallely Patricia Jiménez-Mancilla, Santiago Camacho-López, Luis Escobar-Alarcón, Noé Zamora-Romero","doi":"10.3762/bjnano.17.95","DOIUrl":"https://doi.org/10.3762/bjnano.17.95","url":null,"abstract":"<p><p>Two-dimensional transition metal dichalcogenides such as MoS₂ are attractive optical nanomaterials because they can exhibit photoluminescence and light-to-heat conversion within the same colloidal system. Here, we synthesize surfactant-free Mo-based nanocolloids by picosecond pulsed laser ablation of a bulk MoS₂ target in ethanol followed by laser-induced colloidal fragmentation. HRTEM shows that the ablation step initially yields 2H-MoS₂ nanosheets with an interplanar spacing of 0.274 nm (assigned to the (100) planes), while subsequent fragmentation produces 12.3 ± 1.7 nm fullerene-like core-shell nanoparticles comprising a curved MoS₂ core and an amorphous/poorly crystalline molybdenum oxide shell. Raman spectroscopy provides evidence consistent with the coexistence of 2H-MoS₂ and sub-stoichiometric molybdenum oxide (MoO_3- <i>_x</i> ). UV-vis spectra analyzed via Tauc plots yield an apparent optical bandgap of <i>E</i> _g ≈ 1.94 eV, suggesting size/curvature-related modifications of the electronic structure. Under 260 nm excitation, the nanocolloids display intense blue-violet photoluminescence with bands centered at 401, 425, and 452 nm. The emission is consistent with contributions from confined/curved MoS₂ domains together with defect-related states associated with oxygen-deficient MoO_3- <i>_x</i> . Finally, irradiation with a 270 W near-infrared lamp produces a temperature rise of ~11 °C in 10 min for the nanocolloids, compared with ~6 °C for ethanol alone, indicating an enhanced photothermal heating response. These results highlight picosecond laser processing in liquids as a straightforward route to MoS₂/MoO_3- <i>_x</i> fullerene-like nanostructures in which heating is obtained under broadband, spatially distributed irradiation rather than focused laser excitation, a configuration of interest for photothermal applications, where the local power densities delivered by focused sources are a recognised constraint.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1368-1377"},"PeriodicalIF":3.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of albumin manganese carbonate hybrid microparticles by confined impinging jet mixing with a tubular maturation section.","authors":"Cinzia-Paulina Draeger, Yu Xiong, Saranya Chaiwaree, Radostina Georgieva, Anja Drews, Hans Bäumler","doi":"10.3762/bjnano.17.94","DOIUrl":"https://doi.org/10.3762/bjnano.17.94","url":null,"abstract":"<p><p>Hybrid protein inorganic microparticles are promising carriers for controlled drug delivery because their size, composition, and surface chemistry can be tailored to therapeutic requirements. In this study, human serum albumin-manganese(II) carbonate hybrid microparticles (MPs) were synthesized for the first time by continuous coprecipitation in a confined impinging jet mixer (CIJM) equipped with a tubular maturation section. Equimolar precursor solutions containing 10 mg·mL^-1 HSA were mixed at total flow rates between 2 and 20 mL·min^-1, and mean maturation residence times of 0, 6, and 12 s were achieved using capillaries of defined length. Particle characteristics were quantified by dynamic light scattering, laser Doppler electrophoresis, confocal laser scanning microscopy, and UV-vis spectrophotometry. Increasing flow rate reduced both the Kolmogorov length scale and the MPs' hydrodynamic diameter, yielding MPs of 240-800 nm with polydispersity indices below 0.25. In contrast, residence time did not significantly affect size but increased the encapsulation efficiency from 43% to 65% and shifted the zeta potential to more negative values, indicating enhanced protein incorporation. These results show that CIJM hydrodynamics determine MP size, while the maturation section provides an independent lever to tune loading and surface properties, offering a robust route for engineering hybrid MPs for biomedical applications.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"17 ","pages":"1359-1367"},"PeriodicalIF":3.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}