Beilstein Journal of Nanotechnology最新文献

{"title":"High-temperature epitaxial growth of tantalum nitride thin films on MgO: structural evolution and potential for SQUID applications.","authors":"Michelle Cedillo Rosillo, Oscar Contreras López, Jesús Antonio Díaz, Agustín Conde Gallardo, Harvi A Castillo Cuero","doi":"10.3762/bjnano.16.53","DOIUrl":"10.3762/bjnano.16.53","url":null,"abstract":"<p><p>The growth of superconducting tantalum nitride (TaN) thin films on magnesium oxide (MgO) substrates has been studied using pulsed laser deposition (PLD). This research investigates the influence of varying deposition parameters, including substrate temperature and ambient gas composition, on the structural, morphological, and superconducting properties of the films. X-ray photoelectron spectroscopy, X-ray diffraction, atomic force microscopy, and transmission electron microscopy analyses revealed that the TaN films exhibit excellent crystallinity and smooth surface morphology, when deposited at optimal temperatures of 750 and 850 °C. The films exhibit superconducting transition temperatures (<i>T</i> _c) ranging from 5.0 to 6.3 K, depending on the stoichiometry and deposition conditions. Resistance-temperature curves further confirm the high quality of the films, as evidenced by their low residual resistivity ratios. These findings demonstrate that PLD is a suitable technique for producing high-quality TaN superconducting films.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"690-699"},"PeriodicalIF":2.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of tris(pentafluorophenyl)borane hole transport layer doping on interfacial charge extraction and recombination.","authors":"Konstantinos Bidinakis, Stefan A L Weber","doi":"10.3762/bjnano.16.52","DOIUrl":"10.3762/bjnano.16.52","url":null,"abstract":"<p><p>Selective charge transport layers have a strong influence on the overall efficiency and stability in perovskite solar cell devices. Specifically, the charge extraction and recombination occurring at the interfaces between the perovskite and these materials can be a limiting factor for performance. A lot of effort has been put into improving the conductivity of selective contacts, as well as the junction quality and energetic alignment with the absorber. On the hole extracting side, organic semiconductors have been extensively used due to their flexibility and favorable properties. Two of such compatible materials that have yielded high performing devices are the small molecule 2,2',7,7'-tetrakis[<i>N</i>,<i>N</i>-di(4-methoxyphenyl)amino]-9,9'-spirobifluorene (spiro-OMeTAD) and the polymer poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] (PTAA). In this work, we investigate the impact of hole transport layer doping on the performance and potential distribution in solar cells based on these materials. To do so on operating solar cells, we created samples with exposed cross-sections and examined their potential profile distributions with Kelvin probe force microscopy (KPFM), implementing our comprehensive measurement protocol. Using the Lewis acid tris(pentafluorophenyl)borane (BCF), we enhanced the hole extracting material/perovskite junction quality in spiro-OMeTAD and in PTAA based devices. Measurements under illumination show that the improvement is caused by a reduced recombination rate at the perovskite/hole transporter interface.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"678-689"},"PeriodicalIF":2.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colloidal few layered graphene-tannic acid preserves the biocompatibility of periodontal ligament cells.","authors":"Teissir Ben Ammar, Naji Kharouf, Dominique Vautier, Housseinou Ba, Nivedita Sudheer, Philippe Lavalle, Vincent Ball","doi":"10.3762/bjnano.16.51","DOIUrl":"10.3762/bjnano.16.51","url":null,"abstract":"<p><p>Dental diseases pose a global health concern. In addition to medication and care, the use of biocompatible and even bioactive dental materials can contribute to global oral health. Among such materials, nanomaterials begin to be used. In this context, the incorporation of graphene-based materials into dental biomaterials could offer advantages such as increased mechanical strength. Nevertheless, biocompatibility issues still hinder their adoption. In this study, a biocomposite of few-layered graphene and tannic acid (FLG-TA) was synthesized through a straightforward, bio-based methodology. Physicochemical characterizations elucidated the structural and morphological attributes of the biocomposite. By incorporating antioxidant TA molecules onto the FLG surface, the biocomposite dynamically mitigated reactive oxygen species, demonstrating no cytotoxicity to periodontal ligament cells up to 200 µg·mL^-1 while promoting cellular adhesion and maintaining chromatin integrity. Overall, because of its favorable biocompatibility FLG-TA holds promise as a novel biomaterial for dental applications.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"664-677"},"PeriodicalIF":2.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability.","authors":"Mazhar Hussain, Muhammad Farooq, Muhammad Asad Saeed, Muhammad Ijaz, Sherjeel Adnan, Zeeshan Masood, Muhammad Waqas, Wafa Ishaq, Nabeela Ameer","doi":"10.3762/bjnano.16.50","DOIUrl":"10.3762/bjnano.16.50","url":null,"abstract":"<p><p>Objectives of the present study are the development of aprepitant (APT)-loaded solid lipid nanoparticles (SLNs) using the polymers poloxamer 407 and β-cyclodextrin for enhanced solubility and their pharmacokinetic analysis. APT-loaded SLNs were prepared by the precipitation method and characterized by physicochemical studies including particle size and zeta potential measurements, drug content, encapsulation efficiency and solubility studies, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), in vitro drug release in 0.1 M HCl (pH 1.2) and phosphate-buffered saline (PBS, pH 7.4), and pharmacokinetic studies. The optimal formulation (APT-CD-NP4) containing the highest concentration of β-CD showed the highest drug solubility (93.50% ± 3.73%) in PBS (pH 7.4) and drug content (96.75% ± 0.24%); particle size, zeta potential, and polydispersity index of APT-CD-NP4 were 121.1 ± 0.72 nm, -18.8 ± 0.94 mV, and 0.15 ± 0.35, respectively. SEM analysis showed that APT was converted from the crystal state into an amorphous state after SLN preparation. FTIR results indicated compatibility between APT and the polymers. XRD, TGA, and DSC results indicated no physical interaction between drug and polymers. In vitro drug release studies showed that APT-CD-NP4 yielded the maximum drug release (98.89% ± 4.11%) in PBS (pH 7.4) and followed the Higuchi release model (with exponent <i>n</i> = 0.542), indicating non-Fickian diffusion (anomalous transport). The maximum concentration of drug in plasma and the bioavailability of optimal formulation APT-CD-NP4 were higher than those of pure APT. Therefore, the optimal SLN formulation APT-CD-NP4 is a promising tool for oral administration with sustained release to improve the bioavailability of the BCS class-IV drug APT.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"652-663"},"PeriodicalIF":2.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoscale capacitance spectroscopy based on multifrequency electrostatic force microscopy.","authors":"Pascal N Rohrbeck, Lukas D Cavar, Franjo Weber, Peter G Reichel, Mara Niebling, Stefan A L Weber","doi":"10.3762/bjnano.16.49","DOIUrl":"https://doi.org/10.3762/bjnano.16.49","url":null,"abstract":"<p><p>We present multifrequency heterodyne electrostatic force microscopy (MFH-EFM) as a novel electrostatic force microscopy method for nanoscale capacitance characterization at arbitrary frequencies above the second cantilever resonance. Besides a high spatial resolution, the key advantage of the multifrequency approach of MFH-EFM is that it measures the second-order capacitance gradient at almost arbitrary frequencies, enabling the measurement of the local dielectric function over a wide range of frequencies. We demonstrate the reliable operation of MFH-EFM using standard atomic force microscopy equipment plus an external lock-in amplifier up to a frequency of 5 MHz, which can in principle be extended to gigahertz frequencies and beyond. Our results show a significant reduction of signal background from long-range electrostatic interactions, resulting in highly localized measurements. Combined with refined tip-sample capacitance models, MFH-EFM will enhance the precision of quantitative studies on dielectric effects in nanoscale systems across materials science, biology, and nanotechnology, complementing established methods in the field.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"637-651"},"PeriodicalIF":2.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A formulation containing <i>Cymbopogon flexuosus</i> essential oil: improvement of biochemical parameters and oxidative stress in diabetic rats.","authors":"Ailton Santos Sena-Júnior, Cleverton Nascimento Santana Andrade, Pedro Henrique Macedo Moura, Jocsã Hémany Cândido Dos Santos, Cauãn Torres Trancoso, Eloia Emanuelly Dias Silva, Deise Maria Rego Rodrigues Silva, Ênio Pereira Telles, Luiz André Santos Silva, Isabella Lima Dantas Teles, Sara Fernanda Mota de Almeida, Daniel Alves de Souza, Jileno Ferreira Santos, Felipe José Aidar Martins, Ana Mara de Oliveira E Silva, Sandra Lauton-Santos, Guilherme Rodolfo Souza de Araujo, Cristiane Bani Correa, Rogéria De Souza Nunes, Lysandro Pinto Borges, Ana Amélia Moreira Lira","doi":"10.3762/bjnano.16.48","DOIUrl":"https://doi.org/10.3762/bjnano.16.48","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a highly prevalent public health problem characterized by hyperglycemia that causes complications due to the generation of reactive oxygen species and oxidative damage. Studies have shown that essential oils containing citral, such as lemongrass, have various biological activities, including bactericidal, antiviral, antifungal, antioxidant, and hypoglycemic effects. Therefore, this study aims to obtain a microemulsified formulation containing the essential oil of <i>Cymbopogon flexuosus</i> (EOCF) and to evaluate its antioxidant and antidiabetic activity in diabetic rats. The microemulsion (ME) was obtained after consulting the corresponding pseudoternary phase diagram and showed stability, isotropy, Newtonian behavior, nanometric size (15.2 nm), and pH 4.2. Both EOCF and the ME showed high antioxidant activity, but the ME resulted in greater antioxidant activity, potentiating the activity of isolated EOCF. Finally, male Wistar rats (3 months old, 200-250 g) with streptozotocin-induced type-1 DM were supplemented with EOCF and ME (32 mg/kg) for 21 days. Both EOCF and ME supplementation resulted in reduced blood glucose levels and improved lipid profiles when compared to the control group. Additionally, the ME was able to provide additional benefits, such as reduced liver damage, improved renal function, reduced systemic inflammation, and increased high-density lipoprotein levels. Overall, the results show that EOCF was efficiently incorporated into the microemulsion, improving its antioxidant activity and showing promising results for use in the treatment of DM via the oral route.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"617-636"},"PeriodicalIF":2.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused ion and electron beams for synthesis and characterization of nanomaterials.","authors":"Aleksandra Szkudlarek","doi":"10.3762/bjnano.16.47","DOIUrl":"https://doi.org/10.3762/bjnano.16.47","url":null,"abstract":"","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"613-616"},"PeriodicalIF":2.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications.","authors":"Iqra Zainab, Zohra Naseem, Syeda Rubab Batool, Muhammad Waqas, Ahsan Nazir, Muhammad Anwaar Nazeer","doi":"10.3762/bjnano.16.46","DOIUrl":"https://doi.org/10.3762/bjnano.16.46","url":null,"abstract":"<p><p>The importance of electrospun membranes for biomedical applications has increased, especially when it comes to skin regeneration and wound healing. This review presents the production and applications of electrospun membranes based on polyurethane (PU) and silk fibroin (SF) and highlights their benefits as a skin substitute. This review also highlights the electrospinning technique used to prepare nanofibers for these biomedical applications. Silk, well-known for its excellent biocompatibility, biodegradability, structural properties, and low immunogenic response, is extensively investigated by addressing its molecular structure, composition, and medical uses. PU is a candidate for potential biomedical applications because of its strength, flexibility, biocompatibility, cell-adhesive properties, and high resistance to biodegradation. PU combined with silk offers a number of enhanced properties. The study offers a comprehensive overview of the advanced developments and applications of PU/SF composites, highlighting their significant potential in wound healing. These composite membranes present promising advancements in wound healing and skin regeneration by combining the unique properties of silk and PU, opening up the possibilities for innovative treatments.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"591-612"},"PeriodicalIF":2.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility analysis of carbon nanofiber synthesis and morphology control using a LPG premixed flame.","authors":"Iftikhar Rahman Bishal, Muhammad Hilmi Ibrahim, Norikhwan Hamzah, Mohd Zamri Mohd Yusop, Faizuan Bin Abdullah, I Putu Tedy Indrayana, Mohd Fairus Mohd Yasin","doi":"10.3762/bjnano.16.45","DOIUrl":"https://doi.org/10.3762/bjnano.16.45","url":null,"abstract":"<p><p>Flame synthesis using liquefied petroleum gas (LPG) as the precursor gas to produce carbon nanofibers (CNFs) is an economical alternative to conventional chemical vapor deposition methods using single-component fuels such as methane and ethylene. Though LPG is a commercially viable source for carbon-based nanomaterials, the understanding of the effects of a LPG flame on CNF growth is very limited. Therefore, the present study is to analyze the feasibility of CNF growth in a premixed LPG flame using a one-dimensional flame at varying equivalence ratios. The effects of flame equivalence ratio on the CNF morphology and crystallinity are then analyzed systematically. In the present study, a diffusion flame was used to check the stability of the flame at different flow rates, followed by establishing a premixed flat flame of LPG. An optimum height above burner of 10 mm at which the temperature is around 650 °C was used in the synthesis process. Zirconia beads impregnated with nickel nitrate catalyst have been employed. Dense CNF growth with an average diameter of 77.9 nm was observed at an equivalence ratio of 1.8; as the equivalence ratio was reduced to 1.6, the average diameter of CNF increased by 46% to 114 nm, with amorphous carbon observed. The said observation is due to the effects of the increased flame temperature as the equivalence ratio approaches stoichiometry conditions from the rich side. This increases the nucleation rate, which in turn increases the catalyst particle size and the amount of free carbon atoms, producing CNFs with larger diameters and amorphous carbon. According to Raman analysis, the grown CNFs have a high number of defects, which may be good for applications where defective nanomaterials are desirable to improve the component performance. The work has proven that flame synthesis of CNFs using commercial LPG is feasible, paving the way for further exploration into cost-efficient CNF production with potential industrial applications.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"581-590"},"PeriodicalIF":2.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy.","authors":"Shiwani Randhawa, Trilok Chand Saini, Manik Bathla, Rahul Bhardwaj, Rubina Dhiman, Amitabha Acharya","doi":"10.3762/bjnano.16.44","DOIUrl":"https://doi.org/10.3762/bjnano.16.44","url":null,"abstract":"<p><p>The amyloid cascade hypothesis posits that amyloid-β oligomers (AβOs) are the most neurotoxic species in Alzheimer's disease (AD). These oligomers, characterized by their high β-sheet content, have been shown to significantly disrupt cell membranes, induce local inflammation, and impair autophagy processes, which collectively contribute to neuronal loss. As such, targeting AβOs specifically, rather than solely focusing on amyloid-β fibrils (AβFs), may offer a more effective therapeutic approach for AD. Recent advances in detection and diagnosis have emphasized the importance of accurately identifying AβOs in patient samples, enhancing the potential for timely intervention. In recent years, nanomaterials (NMs) have emerged as promising agents for addressing AβOs regarding their multivalent interactions, which can more effectively detect and inhibit AβO formation. This review provides an in-depth analysis of various nanochaperones developed to target AβOs, detailing their mechanisms of action and therapeutic potential via focusing on two main strategies, namely, disruption of AβOs through direct interaction and the inhibition of AβO nucleation by binding to intermediates of the oligomerization process. Evidence from in vivo studies indicate that NMs hold promise for ameliorating AD symptoms. Additionally, the review explores the different interaction mechanisms through which nanoparticles exhibit their inhibitory effects on AβOs, providing insights into their potential for clinical application. This comprehensive overview highlights the current advancements in NM-based therapies for AD and outlines future research directions aimed at optimizing these innovative treatments.</p>","PeriodicalId":8802,"journal":{"name":"Beilstein Journal of Nanotechnology","volume":"16 ","pages":"561-580"},"PeriodicalIF":2.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}